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Director Dmpk Jobs (NOW HIRING)

Recursion

Head of DMPK

New York, NY · On-site

$321K - $402K/yr

You will lead the DMPK strategy to transition our internal and partnered programs from early hit-identification through to IND-enabling studies and early clinical development. But this is not a ...

Merck & Co.

... director-level equivalent) to contribute to our company drug discovery and early clinical ... Project-team representative and subject matter expert on multiple modality DMPK activities within ...

Merck & Co., Inc.

Principal Scientist, DMPK

Boston, MA · On-site

... director-level equivalent) to contribute to our company drug discovery and early clinical ... The ideal candidate will lead drug metabolism and pharmacokinetic (DMPK) efforts across multiple ...

MSD Malaysia

Principal Scientist, DMPK

Boston, MA · On-site

$176 - $277/hr

... director-level equivalent) to contribute to our company drug discovery and early clinical ... The ideal candidate will lead drug metabolism and pharmacokinetic (DMPK) efforts across multiple ...

New

Pharmaron

Scientist II, Discovery DMPK

Exton, PA · On-site

$55K - $65K/yr

Scientist II, Discovery DMPK Location: Exton, PA (onsite) Salary Range: $55,000-$65,000 About ... Serve as a Principal Investigator (PI) or Study Director (SD) within areas of expertise, as ...

Pharmaron

Scientist II, Discovery DMPK

Exton, PA

$55K - $65K/yr

Scientist II, Discovery DMPK Location: Exton, PA (onsite) Salary Range: $55,000-$65,000 About ... Serve as a Principal Investigator (PI) or Study Director (SD) within areas of expertise, as ...

Alkermes, Inc.

Director, Clinical Pharmacology

Waltham, MA · On-site

$130 - $180/hr

... DMPK and BA department. He/she will represent as a Clinical Pharmacology Lead and provide subject matter expertise on cross-functional project teams. The Clinical Pharmacology Director provides ...

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How much do director dmpk jobs pay per year?

As of Aug 15, 2026, the average yearly pay for director dmpk in the United States is $246,666.00, according to ZipRecruiter salary data. Most workers in this role earn between $230,000.00 and $261,000.00 per year, depending on experience, location, and employer.

What does a director DMPK do?

A Director of Drug Metabolism and Pharmacokinetics (DMPK) leads efforts to understand the absorption, distribution, metabolism, and excretion (ADME) of drug candidates. They design and oversee preclinical and clinical studies to optimize drug properties, ensuring efficacy and safety. This role involves collaborating with pharmacology, toxicology, and regulatory teams to drive drug development. Additionally, they interpret data, guide strategy, and contribute to regulatory submissions.

What are the key skills and qualifications needed to thrive as a director DMPK?

To thrive as a Director DMPK (Drug Metabolism and Pharmacokinetics), you need advanced expertise in pharmacokinetics, drug metabolism, and bioanalytical methods, typically supported by a PhD in pharmaceutical sciences, chemistry, or a related field. Familiarity with regulatory guidelines, data analysis platforms like WinNonlin or Phoenix, and validated laboratory systems is crucial. Strong leadership, cross-functional collaboration, and effective communication skills help in guiding multidisciplinary teams and driving complex projects forward. These capabilities ensure the development and regulatory success of new drug candidates in a highly competitive and compliant environment.

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Director Dmpk jobs near you
Infographic showing various Director Dmpk job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 85% Full Time, 12% Part Time, 1% Temporary, and 1% Contract. Highlights an 92% Physical, 3% Hybrid, and 5% Remote job distribution, with an average salary of $246,666 per year, or $118.6 per hour.

Head of DMPK

Recursion

New York, NY • On-site

$321K - $402K/yr

Full-time

Re-posted 27 days ago

Job description

Your work will change lives. Including your own.
The Opportunity
At Recursion we are redefining drug discovery by uniting industrial-scale data generation with sophisticated computational models. We are seeking a visionary Head of DMPK to join our leadership team.
You will lead the DMPK strategy to transition our internal and partnered programs from early hit-identification through to IND-enabling studies and early clinical development.
But this is not a traditional DMPK role. You will be a key architect in an environment that is pushing the boundaries of "predict more, test less" - bridging the gap between high-throughput, experimentally derived data generation and predictive modeling.
Your Impact
  • Strategic Leadership. Define and execute the overarching DMPK strategy for a diverse therapeutic area portfolio, primarily focused on small molecules with the agility to support emerging modalities (e.g. peptides, ADCs, proximity-inducing therapeutics)
  • Scientific Rigor and Project Acceleration. Ensure high degree of scientific excellence as programs move from early discovery into development ensuring robust human dose projections, DDI assessments, and supporting translational PK/PD strategies.
  • Tech-Forward Collaboration. Partner with Data Science and ML teams to refine our predictive ADME models, transforming how we prioritize compounds and de-risking the portfolio.
  • External Partnerships. Act as a strategic subject matter expert for high-stakes external partnerships by collaborating with internal scientific leaders and external counterparts with transparency and technical rigor.
  • Talent Development. Develop and lead a high-performing team. You won't just manage - you will amplify the talents of your team, fostering an environment of active learning and rapid adaptation.
  • Cross-Functional Synergy. A critical component of multidisciplinary project teams. A critical partner to Toxicology, Translation and Design ensuring that DMPK insights are integrated into the earliest stages of target validation and lead optimization.

Who You Are
  • The Academic Foundation: You hold a PhD (or equivalent) in Pharmacokinetics, Drug Metabolism, Pharmacology, or a related field.
  • The Industry Veteran: You have a proven track record of moving multiple programs from Discovery into Development (typically 15+ years) in the pharmaceutical or biotech industry.
  • The Nimble Mindset: You are comfortable working at the intersection of biology and technology. You are cautiously optimistic that data-driven, computational approaches are the future of drug discovery.
  • The Modality Expert: Deep expertise in small molecule DMPK is essential. Experience with related modalities (ADCs, proximity-inducing or peptides) is a distinct advantage.
  • The Regulatory Navigator: You are intimately familiar with IND submission requirements and have a history of successfully navigating regulatory interactions.
  • The Collaborative Leader: You value "One Team" over silos. You are known for strong, transparent working relationships and the ability to influence cross-functional stakeholders.

Technical Skills & Expertise
  • Expertise in in vitro & in vivo ADME as well as contemporary PK/PD modeling. Extending to the properties and data sets commensurate with CNS exposure (or conversely restricting exposure to peripheral tissues).
  • Experience with human PK and efficacious dose prediction.
  • Proficiency in managing CROs to ensure high-quality data and timely delivery.
  • Knowledge of biotransformation and metabolic pathways.
  • Extensive experience in working with external collaborators in all shapes and forms (CROs, SMEs, Large Pharma)

Working Location & Compensation:
This is an office-based, hybrid position at any either of our offices located in Salt Lake City or New York City. Employees are expected to work in the office at least 50% of the time.
At Recursion, we believe that every employee should be compensated fairly. Based on the skills, experience, and qualifications needed for this role, the estimated annual base salary range is:
  • New York City, Boston, & San Francisco Bay Area(s): $353,980-$443,080
  • Salt Lake City & all other U.S. locations: $321,800-$402,800

In addition to base salary, this role is eligible for an annual bonus, equity compensation, and a comprehensive benefits package.
#LI-EP1
The Values We Hope You Share:
  • We act boldly with integrity. We are unconstrained in our thinking, take calculated risks, and push boundaries, but never at the expense of ethics, science, or trust.
  • We care deeply and engage directly. Caring means holding a deep sense of responsibility and respect - showing up, speaking honestly, and taking action.
  • We learn actively and adapt rapidly. Progress comes from doing. We experiment, test, and refine, embracing iteration over perfection.
  • We move with urgency because patients are waiting. Speed isn't about rushing but about moving the needle every day.
  • We take ownership and accountability. Through ownership and accountability, we enable trust and autonomy-leaders take accountability for decisive action, and teams own outcomes together.
  • We are One Recursion. True cross-functional collaboration is about trust, clarity, humility, and impact. Through sharing, we can be greater than the sum of our individual capabilities.

Our values underpin the employee experience at Recursion. They are the character and personality of the company demonstrated through how we communicate, support one another, spend our time, make decisions, and celebrate collectively.
More About Recursion
Recursion (NASDAQ: RXRX) is a clinical-stage TechBio company decoding biology to radically improve lives. Recursion is advancing a portfolio of differentiated investigational medicines across its wholly owned and partnered pipeline in oncology, rare disease, neuroscience, immunology, and other therapeutic areas with significant unmet need. Enabling its mission is the Recursion OS, an AI-native, end-to-end drug discovery and development platform integrating biology, chemistry, and clinical development into a unified intelligence system. Powered by proprietary multimodal data, purpose-built AI models, and bilingual teams fluent in both science and AI, the Recursion OS is designed to translate complex science into medicines that matter - faster, better, and at scale - for patients who are waiting.
Recursion's platform infrastructure is anchored in Salt Lake City, Utah and Milton Park, Oxfordshire, where its automated biology and chemistry laboratories generate proprietary data at industrial scale. Recursion also maintains offices in New York, Montréal, and London, three global hubs for talent and leadership at the intersection of AI and scientific innovation. Learn more at www.recursion.com, or connect on X and LinkedIn.
Recursion is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, veteran status, or any other characteristic protected under applicable federal, state, local, or provincial human rights legislation.
Accommodations are available on request for candidates taking part in all aspects of the selection process.
Recursion leverages AI in our hiring process. We use Greenhouse's Talent Matching AI technology feature to help review applications against the skills and experience we've identified as important for this role. It analyzes your resume and application responses to assess how closely your qualifications match our criteria - but all decisions are made by our human recruiters and hiring managers, including whether to move to the next phase of review. Talent Matching does not automatically advance or reject any candidate. By submitting your application, you acknowledge that you have been informed about and consent to this use of the Talent Matching tool in our review process. Please refer to our Recursion Privacy Policy at https://www.recursion.com/privacy-notice/ for more information about our processing of personal data and your rights.
Recruitment & Staffing Agencies: Recursion Pharmaceuticals and its affiliate companies do not accept resumes from any source other than candidates. The submission of resumes by recruitment or staffing agencies to Recursion or its employees is strictly prohibited unless contacted directly by Recursion's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Recursion, and Recursion will not owe any referral or other fees. Our team will communicate directly with candidates who are not represented by an agent or intermediary unless otherwise agreed to prior to interviewing for the job.

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