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Manager Dmpk Jobs (NOW HIRING)

Vrtx

Executive Director, Biotherapeutics DMPK

Boston, MA

$268K - $402K/yr

This leader will be based in Boston but manage and oversee the work of DMPK-BA teams at our Vertex Biologics and Cell and Genetic Therapies sites in Boston and Seattle and will be part of the Global ...

Frontage Laboratories

QA Manager

Exton, PA · On-site

Quality Assurance (QA) Specialist / Manager - DMPK Location: Exton, PA Department ... DMPK (Drug Metabolism & Pharmacokinetics) Reports To : Senior VP, DMPK Employment Type: Full-Time ...

Evommune, Inc.

Director, DMPK

Palo Alto, CA · On-site

The Director, DMPK will serve as the DMPK program lead, responsible for establishing and executing ... Manage and collaborate with CROs, consultants, and external partners to ensure high-quality ...

Exelixis

DMPK Director

Alameda, CA · On-site

Conduct scientific presentations to senior management, project teams, and internal/external collaborators * Stay up-to-date with advancements in DMPK research and identify and integrate emerging ...

Exelixis

DMPK Director

Alameda, CA · On-site

Conduct scientific presentations to senior management, project teams, and internal/external collaborators * Stay up-to-date with advancements in DMPK research and identify and integrate emerging ...

Atavistik Bio

Senior Scientist, DMPK

Cambridge, MA

$130K - $150K/yr

Manage consultants and vendors to support DMPK studies. * Partner with the discovery group to optimize preclinical models and inform on first in human clinical dosing strategies. * Review preclinical ...

Atavistik Bio

Senior Scientist, DMPK

Cambridge, MA · On-site

$130K - $150K/yr

Manage consultants and vendors to support DMPK studies. * Partner with the discovery group to optimize preclinical models and inform on first in human clinical dosing strategies. * Review preclinical ...

Atavistik Bio

Senior Scientist, DMPK

Cambridge, MA

$130K - $150K/yr

Manage consultants and vendors to support DMPK studies. * Partner with the discovery group to optimize preclinical models and inform on first in human clinical dosing strategies. * Review preclinical ...

Wave Life Sciences

Senior Scientist I, DMPK

Lexington, MA · Hybrid

$157K - $213K/yr

Manage internal and external (CRO) DMPK activities including DDI, PPB, to ensure timely delivery of high-quality data * Deliver robust IND/CTA-enabling DMPK packages to support regulatory filings

Wave Life Sciences

Senior Scientist I, DMPK

Lexington, MA · On-site

$157K - $213K/yr

Manage internal and external (CRO) DMPK activities including DDI, PPB, to ensure timely delivery of high-quality data * Deliver robust IND/CTA-enabling DMPK packages to support regulatory filings

Recursion

Head of DMPK

New York, NY · Hybrid

$321K - $402K/yr

You won't just manage - you will amplify the talents of your team, fostering an environment of ... Deep expertise in small molecule DMPK is essential. Experience with related modalities (ADCs ...

Initial Therapeutics, Inc.

Head of DMPK

Salt Lake City, UT · On-site

$321.80 - $402.80/hr

You will lead the DMPK strategy to transition our internal and partnered programs from early ... You won't just manage - you will amplify the talents of your team, fostering an environment of ...

Wave Life Sciences

Senior Scientist I, DMPK

Lexington, MA · On-site

$157 - $213/hr

Manage internal and external (CRO) DMPK activities including DDI, PPB, to ensure timely delivery of high‑quality data * Deliver robust IND/CTA‑enabling DMPK packages to support regulatory filings

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Manager Dmpk information

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$23K

$61.4K

$102.5K

How much do manager dmpk jobs pay per year?

As of Aug 21, 2026, the average yearly pay for manager dmpk in the United States is $61,351.00, according to ZipRecruiter salary data. Most workers in this role earn between $44,000.00 and $69,000.00 per year, depending on experience, location, and employer.

What does a manager DMPK do?

A Manager DMPK (Drug Metabolism and Pharmacokinetics) oversees studies and teams that evaluate how drugs are absorbed, distributed, metabolized, and excreted in the body. They design and manage experiments, interpret data, and ensure regulatory compliance. This role often includes collaborating with project teams, supporting drug development decisions, and mentoring junior scientists. Managers in DMPK play a key part in delivering safe and effective drug candidates for clinical development.

What skills and qualifications are needed to be a manager DMPK?

To thrive as a Manager DMPK, you need advanced knowledge in pharmacokinetics, drug metabolism, and a relevant advanced degree (PhD or MS) in pharmaceutical sciences or a related field. Expertise with analytical tools like LC-MS/MS, pharmacokinetic modeling software, and familiarity with regulatory guidelines are typically required. Strong leadership, communication, and project management skills help you guide teams and collaborate effectively across departments. These expertise and qualities are essential for ensuring the safe and efficient progression of drug candidates through development pipelines.

What challenges does a manager DMPK face when leading cross-functional drug development teams?

A Manager DMPK often encounters challenges in aligning the goals and timelines of different departments, such as pharmacology, toxicology, and clinical development. Coordinating complex data from multiple sources and ensuring clear communication between teams is crucial for successful project progression. Additionally, staying updated with regulatory requirements and integrating new scientific methodologies can require proactive problem-solving and adaptability. Building strong relationships across functions helps address these challenges and keeps projects on track.

What is the difference between Manager Dmpk vs Pharmacovigilance Manager?

AspectManager DmpkPharmacovigilance Manager
Required CredentialsBachelor's or Master’s in Life Sciences, experience in DMPKBachelor's or Master’s in Pharmacy, Pharmacology, or Life Sciences
Work EnvironmentResearch labs, drug development teamsRegulatory agencies, clinical safety teams
Employer & Industry UsagePharmaceutical R&D, biotech companiesPharmaceutical companies, regulatory bodies
Common Search & ComparisonYesYes

The Manager Dmpk focuses on drug metabolism and pharmacokinetics studies within drug development, while the Pharmacovigilance Manager oversees drug safety and adverse event monitoring. Both roles require scientific backgrounds but differ in their focus areas and work environments, with Dmpk managers more involved in research and pharmacovigilance managers in safety regulation compliance.

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Manager Dmpk jobs near you
Infographic showing various Manager Dmpk job openings in the United States as of August 2026, with employment types broken down into 88% Full Time, 11% Part Time, and 1% Contract. Highlights an 81% Physical, 2% Hybrid, and 17% Remote job distribution, with an average salary of $61,351 per year, or $29.5 per hour.

Executive Director, Biotherapeutics DMPK

Vertex Pharmaceuticals

Boston, MA • On-site

$268K - $402K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 16 days ago

Vertex Pharmaceuticals rating

6.5

Company rating: 6.5 out of 10

Based on 5 frontline employees who took The Breakroom Quiz

78th of 86 rated pharmaceutical

Job description

Job Description
General Summary:
We are seeking an accomplished and strategic leader to serve as Executive Director, Biotherapeutics DMPK-Bioanalysis (DMPK-BA), to guide the DMPK-BA strategy for our rapidly growing Biotherapeutics portfolio that includes protein, antibody, ADC, and cell and genetic therapies. The responsibilities will span from early research through development. This leader will be based in Boston but manage and oversee the work of DMPK-BA teams at our Vertex Biologics and Cell and Genetic Therapies sites in Boston and Seattle and will be part of the Global DMPK leadership team. He/she will play a central role in integrating PK, bioanalysis, ADME, and translational PKPD data and insights into cross-functional program decision-making and development plans and help shape the direction of overall Vertex portfolio.
The ideal candidate will bring deep strategic and scientific expertise in DMPK-BA for one or more biotherapeutic modalities described above, have demonstrated record of people management and leadership in a direct line as well as matrixed environment, and will have the ability to influence cross-functional teams and governance bodies at Vertex.
Key Responsibilities
  • Develop vision, strategy, and capabilities for the Biotherapeutics DMPK-BA teams across Boston and Seattle sites that is aligned with the Global DMPK-BA and Vertex R&D vision/mission.
  • Develop and execute DMPK-BA scientific strategies from discovery through clinical development including design, execution, and interpretation of preclinical PK, ADME, bioanalytical and immunogenicity assays for biotherapeutics, and translational PKPD approaches to support dose selection and clinical projections.
  • Provide clear communication of DMPK-BA findings, implications, and recommendations to team members, senior leadership, and Vertex R & D governance bodies to advance Vertex programs through discovery and development.
  • Build and maintain strong collaborative partnerships with Biology, Preclinical Safety, Clinical Pharmacology, CMC, and other R & D disciplines to align DMPK-BA strategy with overall program goals.
  • Implement innovative technologies and approaches to enhance scientific impact and/or efficiencies.
  • Provide scientific and managerial leadership to the team in prioritizing and executing on key deliverables and project needs.
  • Ensure scientific excellence and regulatory compliance in all necessary DMPK regulatory documents and reports to support drug development including investigator brochures, INDs (or equivalent), and marketing applications.
  • Hire, develop, manage, and retain key talent to maintain a high-performing team.
  • Develop internal and external sourcing strategies and liaise across sites to best meet project needs. Contribute to developing Global DMPK-BA resource allocation, staffing needs, expenses, and capital budget and implementation plans.
  • Participate in review of business development opportunities.

Qualifications
  • PhD in Pharmacokinetics, Biochemistry, Biology, or related field, with 15+ years of industry experience at the management level
  • Successful track record and experience managing DMPK-BA teams across more than one therapeutic area. Extensive experience working with one or more biotherapeutic modalities (e.g., protein, antibody and nucleic acid therapeutics, cell and gene therapies) is a must.
  • Deep scientific and strategic expertise in various components of DMPK science such as PK, ADME, bioanalysis, immunogenicity, biotransformation, and translational PKPD modeling approaches for biologics.
  • Excellent communication skills and ability to develop and grow strong cross-site/function collaborations.
  • Ability to critically evaluate and implement new science and technology as it relates to the discovery and development of new medicines.
  • Experience preparing regulatory submissions and interacting with health authorities.
  • Strong management and leadership skills, with emphasis on developing and mentoring emerging talent.

#LI-KM4
Pay Range:
$268,000 - $402,000
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
On-Site Designated
Flex Eligibility Status:
In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.
#LI-Onsite
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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