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DMPK and Bioanalytical Associate Director

Seattle, WA

$166.50K - $249.70K/yr

Plans, implements, and manages a broad range of bioanalytical testing activities for biotherapeutic ... Deep expertise in DMPK and bioanalytical science , with demonstrated ability to integrate in vitro ...

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How much do manager dmpk jobs pay per year?

As of May 29, 2026, the average yearly pay for manager dmpk in the United States is $61,351.00, according to ZipRecruiter salary data. Most workers in this role earn between $44,000.00 and $69,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Manager in Drug Metabolism and Pharmacokinetics (DMPK), and why are they important?

To thrive as a Manager DMPK, you need advanced knowledge in pharmacokinetics, drug metabolism, and a relevant advanced degree (PhD or MS) in pharmaceutical sciences or a related field. Expertise with analytical tools like LC-MS/MS, pharmacokinetic modeling software, and familiarity with regulatory guidelines are typically required. Strong leadership, communication, and project management skills help you guide teams and collaborate effectively across departments. These expertise and qualities are essential for ensuring the safe and efficient progression of drug candidates through development pipelines.

What are some common challenges faced by a Manager DMPK when leading cross-functional drug development teams?

A Manager DMPK often encounters challenges in aligning the goals and timelines of different departments, such as pharmacology, toxicology, and clinical development. Coordinating complex data from multiple sources and ensuring clear communication between teams is crucial for successful project progression. Additionally, staying updated with regulatory requirements and integrating new scientific methodologies can require proactive problem-solving and adaptability. Building strong relationships across functions helps address these challenges and keeps projects on track.

What are Manager DMPK roles and responsibilities?

A Manager DMPK (Drug Metabolism and Pharmacokinetics) oversees studies and teams that evaluate how drugs are absorbed, distributed, metabolized, and excreted in the body. They design and manage experiments, interpret data, and ensure regulatory compliance. This role often includes collaborating with project teams, supporting drug development decisions, and mentoring junior scientists. Managers in DMPK play a key part in delivering safe and effective drug candidates for clinical development.

What is the difference between Manager Dmpk vs Pharmacovigilance Manager?

AspectManager DmpkPharmacovigilance Manager
Required CredentialsBachelor's or Master’s in Life Sciences, experience in DMPKBachelor's or Master’s in Pharmacy, Pharmacology, or Life Sciences
Work EnvironmentResearch labs, drug development teamsRegulatory agencies, clinical safety teams
Employer & Industry UsagePharmaceutical R&D, biotech companiesPharmaceutical companies, regulatory bodies
Common Search & ComparisonYesYes

The Manager Dmpk focuses on drug metabolism and pharmacokinetics studies within drug development, while the Pharmacovigilance Manager oversees drug safety and adverse event monitoring. Both roles require scientific backgrounds but differ in their focus areas and work environments, with Dmpk managers more involved in research and pharmacovigilance managers in safety regulation compliance.

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Manager Dmpk jobs near you
Infographic showing various Manager Dmpk job openings in the United States as of May 2026, with employment types broken down into 83% Full Time, 15% Part Time, 1% Temporary, and 1% Contract. Highlights an 100% Physical job distribution, with an average salary of $61,351 per year, or $29.5 per hour.
Director, DMPK- Pharmacokinetics & Clinical Pharmacology

Director, DMPK- Pharmacokinetics & Clinical Pharmacology

Ionis Pharmaceuticals

Carlsbad, CA • On-site, Remote

$216.44K - $265.20K/yr

Full-time

Posted 18 days ago

Job description

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs.  With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals.

At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. 

With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. 

We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!

DIRECTOR, DMPK - PHARMACOKINETICS & CLINICAL PHARMACOLOGY

RESPONSIBILITIES:

  • Drive DMPK strategy for programs in Discovery and Development phases and represent the DMPK function to project management and leadership teams 
  • Coordinate, design, and interpret Discovery and Development phase CRO-based ADME evaluations of novel RNA therapeutics including radio-labelled, CYP and transporter related DDI assessment, protein binding, plasma blood cell partition, and PK studies by working with PK scientists/project leads and provide guidance to Discovery and Development project teams 
  • Lead an internal lab for metabolism evaluation to provide guidance and expertise on metabolite ID with innovative methodologies and bioanalytical methodologies for new chemical entities including ASO, siRNA, ligand-conjugated targeting strategies, and other molecular modalities 
  • Interact with medicinal analytical chemistry team to support structural modifications to optimize ADME characteristics of compounds in lead optimization 
  • Provide expert advice and guidance on IND enabling ADME and PK studies from protocol to finalized reports 
  • Author DMPK sections of regulatory submissions (IND/CTA, IB, NDA, etc) 
  • Successfully identify and manage CROs regarding DMPK study execution and reporting to meet program timelines, develop effective relationships with external consultants 
  • Support PK modeling to inform clinical dosing strategies by working with PK/clin pharm scientists
  • This position will have direct report(s) 

REQUIREMENTS: 

  • Ph.D. in relevant biomedical research with 12+ years DMPK experience in pharmaceutical drug discovery and development 
  • Strong track record of publications and authoring submission documents, addressing regulatory questions 
  • Proven ability to drive drug discovery projects from early development through candidate selection and IND 
  • In-depth conceptual and technical expertise in drug metabolism and bioanalysis in NME discovery and development programs, especially ASO, siRNA and RNA therapeutics experiences are highly desirable 
  • Experience with in vitro/in vivo cross species ADME, mass balance, and DDI studies 
  • Expertise on metabolite ID and method development, extensive experience in LC-MS/MS, LC-ToF MS, and LC-HRMS. 
  • Strong understanding and experience in interpreting DMPK data and the relationships between metabolism and pharmacokinetics. 
  • Excellent verbal and written communication skills, as well as the ability to contribute effectively in fast-moving inter-disciplinary project teams 
  • Experience with external vendor management such as CROs and consultants
  • Must have solid grasp of ICH regulatory guidance documents relevant to DMPK activities

Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position; reference requisition #IONIS004002

Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits

Full Benefits Link: https://ionis.com/careers#:~:text=Highly%20competitive%20benefits

The pay scale for this position is $216,439 to $265,200

NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

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