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Director Toxicology Jobs (NOW HIRING)

Immunome, Inc.

Director, Toxicology

Bothell, WA · On-site

Position Overview The Director, Toxicology provides scientific and strategic leadership for the nonclinical safety assessment of oncology therapeutics from discovery through commercialization. This ...

Tarsus Pharmaceuticals

Director, Toxicology

Irvine, CA · On-site +1

  • Medical

  • Dental

  • Vision

  • PTO

About the Role The Director, Toxicology Translational Science will serve as a scientific and strategic leader driving team and pipeline development at Tarsus, leveraging expertise in toxicology ...

Immunome, Inc.

Director, Toxicology

Bothell, WA

Position Overview The Director, Toxicology provides scientific and strategic leadership for the nonclinical safety assessment of oncology therapeutics from discovery through commercialization. This ...

Evommune, Inc.

Director, Toxicology

Palo Alto, CA · On-site

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

The Director will serve as the toxicology representative on cross-functional program teams and will be responsible for the design, oversight, interpretation, and reporting of nonclinical safety ...

Inotivco

Director, Toxicology

Gaithersburg, MD

$120.20 - $175K/hr

  • Medical

  • Dental

  • Retirement

  • PTO

The Director of Toxicology is the scientific leader for the site and serves as a mentor and manager for a group of Study Directors overseeing general toxicology and safety pharmacology studies. As a ...

BASI GAITHERSBURG LLC

Director, Toxicology

Gaithersburg, MD · On-site

$120.20 - $175/hr

  • Medical

  • Dental

  • Retirement

  • PTO

Director of Toxicology The Director of Toxicology is the scientific leader for the site and serves as a mentor and manager for a group of Study Directors overseeing general toxicology and safety ...

Inotiv

Director, Toxicology

Gaithersburg, MD · On-site

$120.20 - $175K/hr

  • Medical

  • Dental

  • Retirement

  • PTO

The Director of Toxicology is the scientific leader for the site and serves as a mentor and manager for a group of Study Directors overseeing general toxicology and safety pharmacology studies. As a ...

Tarsus Pharmaceuticals

Director, Toxicology

Irvine, CA · On-site

  • Medical

  • Dental

  • Vision

  • PTO

About the Role The Director, Toxicology Translational Science will serve as a scientific and strategic leader driving team and pipeline development at Tarsus, leveraging expertise in toxicology ...

Vir Biotechnology

Director, Toxicology

San Francisco, CA · On-site

$203K - $284K/yr

  • Medical

  • Retirement

  • PTO

THE OPPORTUNITY Vir Biotechnology is seeking an experienced Director, Toxicology to lead nonclinical safety strategies across our infectious disease and oncology portfolio. In this role, you will ...

Calibr

SENIOR DIRECTOR, TOXICOLOGY

San Diego, CA

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Senior Director, Toxicology POSITION SUMMARY: The Senior Director of Toxicology will be the primary toxicology expert across our pipeline, driving the design, execution, and interpretation of non ...

OnKure Therapeutics

Senior Director, Toxicology

Boulder, CO · On-site

$280K - $300K/yr

  • Medical

  • Dental

  • Life

  • Retirement

  • PTO

The Senior Director of Toxicology provides strategic and scientific leadership for all nonclinical safety assessment activities across the company's drug discovery and early development portfolio ...

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Director Toxicology information

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$30.5K

$141.8K

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How much do director toxicology jobs pay per year?

As of Aug 16, 2026, the average yearly pay for director toxicology in the United States is $141,825.00, according to ZipRecruiter salary data. Most workers in this role earn between $95,000.00 and $185,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the director toxicology position, and why are they important?

To thrive as a Director Toxicology, you need deep expertise in toxicology, pharmacology, regulatory compliance, and laboratory management, typically backed by an advanced degree in toxicology or a related field. Familiarity with safety assessment tools, regulatory submission platforms (such as EPA or FDA eCTD systems), and certifications like DABT (Diplomate of the American Board of Toxicology) are commonly expected. Strong leadership, strategic thinking, and cross-functional communication skills help you manage teams and collaborate with internal and external stakeholders. These competencies are critical for ensuring safe product development and meeting regulatory standards across diverse scientific projects.

What are the main challenges a director of toxicology might encounter in this role?

A Director of Toxicology often faces the challenge of balancing complex regulatory requirements with efficient project timelines, especially when overseeing multiple studies simultaneously. Ensuring consistent data quality, interpreting emerging scientific data, and staying current with shifting global regulations can be demanding. The role also involves mentoring teams, resolving safety concerns quickly, and collaborating with diverse groups such as R&D, regulatory affairs, and external partners. Successfully managing these challenges requires strong leadership, adaptability, and up-to-date technical knowledge.

Are directors of toxicology in high demand?

Directors of toxicology are in high demand due to the increasing need for safety assessments in pharmaceuticals, chemicals, and consumer products. They typically require advanced degrees and expertise in regulatory compliance, with employment opportunities available in research organizations, industry, and government agencies.

What does a director of toxicology do?

A Director of Toxicology leads toxicology programs to assess the safety of chemicals, pharmaceuticals, or consumer products. They oversee study design, regulatory compliance, and risk assessment while managing scientific teams and collaborating with regulatory agencies. This role requires strong expertise in toxicology, regulatory frameworks, and data interpretation to ensure product safety and compliance with industry regulations.

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What are the most commonly searched types of Toxicology jobs?

The most popular types of Toxicology jobs are:

What states have the most Director Toxicology jobs?

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Director Toxicology jobs near you
Infographic showing various Director Toxicology job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 85% Full Time, 12% Part Time, 1% Temporary, and 1% Contract. Highlights an 92% Physical, 3% Hybrid, and 5% Remote job distribution, with an average salary of $141,825 per year, or $68.2 per hour.

Director, Toxicology

Immunome, Inc.

Bothell, WA • On-site

Full-time

Posted 17 days ago

Job description

Company Overview
Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.
Position Overview
The Director, Toxicology provides scientific and strategic leadership for the nonclinical safety assessment of oncology therapeutics from discovery through commercialization. This individual serves as the toxicology lead on multidisciplinary project teams and is responsible for developing scientifically rigorous, phase-appropriate nonclinical safety strategies that enable efficient progression of pipeline assets while meeting global regulatory expectations.
The Director partners closely with Research, Clinical Development, Translational Science (DMPK, Biomarkers), Regulatory Affairs, CMC, Biometrics, Pathology, and external CROs to design and execute toxicology programs supporting INDs, CTAs, BLAs, NDAs, lifecycle management activities, and responses to health authorities. The successful candidate combines deep scientific expertise with strategic judgment to identify and mitigate development risks while advancing innovative oncology therapeutics.
Responsibilities
Scientific Leadership
  • Serve as the nonclinical safety lead for multiple oncology development programs from candidate selection through regulatory approval.
  • Develop integrated, phase-appropriate nonclinical safety strategies that support efficient clinical development while meeting global regulatory expectations.
  • Provide scientific leadership on target-, platform-, and modality-related safety risks and develop mitigation strategies.
  • Lead interpretation of complex toxicology findings and translate results into actionable recommendations for project teams and executive leadership.
  • Integrate toxicology, pharmacology, DMPK, pathology, biomarker, and clinical data into comprehensive benefit-risk assessments.

Regulatory Strategy
  • Design nonclinical development plans supporting INDs, CTAs, NDAs, BLAs, and global regulatory interactions.
  • Author and review nonclinical sections of regulatory submissions including INDs, Investigator's Brochures, CTDs, briefing packages, orphan drug applications, pediatric plans, and responses to regulatory questions.
  • Represent Toxicology during FDA, EMA, PMDA, and other global health authority interactions.
  • Ensure nonclinical programs comply with ICH, FDA, EMA, OECD, and applicable global regulatory guidance.

Study Oversight
  • Design, oversee, and interpret GLP and non-GLP toxicology studies conducted at external CROs.
  • Provide scientific oversight of study protocols, amendments, pathology peer review, data interpretation, and final reports.
  • Oversee study monitoring activities to ensure high-quality execution and data integrity.
  • Manage CRO performance, timelines, budgets, and scientific deliverables.

Cross-Functional Leadership
  • Represent Toxicology on cross-functional project teams.
  • Partner with Clinical Pharmacology, Translational Sciences (DMPK, Biomarkers), Regulatory Affairs, CMC, Clinical Development, Biometrics, and Research to optimize development strategies.
  • Communicate complex scientific issues effectively to technical and executive audiences.
  • Mentor junior scientists and contribute to development of departmental capabilities and scientific standards.

Innovation
  • Identify opportunities to incorporate emerging technologies including AI-enabled data analysis, predictive toxicology, in vitro models, large language models for scientific workflows, quantitative systems toxicology, and novel biomarkers.
  • Drive implementation of innovative approaches that improve decision-making, reduce development timelines, and align with regulatory expectations.

Qualifications
  • PhD, DVM, PharmD, MD, or equivalent in Toxicology, Pharmacology, Pathology, Biology, or related scientific discipline.
  • 12+ years of progressively responsible experience in biotechnology or pharmaceutical drug development, or equivalent experience.
  • Extensive experience supporting oncology drug development programs through IND and late-stage clinical development.
  • Demonstrated success supporting multiple IND, CTA, NDA and/or BLA submissions.
  • Deep understanding of ICH, FDA, EMA and global regulatory expectations for nonclinical safety assessment.
  • Ability to travel approximately 10%, domestic and international.

Knowledge and Skills
  • Experience authoring relevant sections of global regulatory submissions and interacting with global health authorities in all stages of development and post-approval.
  • Excellent skills in assessment of the appropriate toxicology experiments to support clinical development at all stages of product development. Demonstrated experience supporting regulatory compliant nonclinical development plans, with excellent working knowledge of the regulatory process.
  • Experience in deployment of AI and other innovative technologies which improve decision making and align with regulatory partners.
  • Working knowledge of the most advanced exploratory and investigative toxicology methods to interrogate putative target and/or platform-related liabilities.
  • Excellent critical thinking skills, ability, and desire to oversee multiple projects simultaneously in a demanding environment.
  • Demonstrated experience in leading cross-functional teams in the development and execution of biomarker and diagnostics plans to support preclinical and clinical development.
  • Outstanding interpersonal and communication skills (written and oral) with ability to communicate complex information succinctly.
  • Experience with developing, leading, and executing translational strategies, such as the transition from discovery research into clinical development.
  • Ability to drive collaboration, achieve results, influence, and resolve conflicts across internal and external project teams.

Washington State Pay Range
$216,197-$270,100 USD
E/E/O
Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
E-Verify
Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).

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