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Director Toxicology Jobs (NOW HIRING)

Vir Biotechnology

Director, Toxicology

San Francisco, CA · On-site

$203K - $284K/yr

  • Medical

  • Retirement

  • PTO

THE OPPORTUNITY Vir Biotechnology is seeking an experienced Director, Toxicology to lead nonclinical safety strategies across our infectious disease and oncology portfolio. In this role, you will ...

Ionis

Associate Director, Toxicology

Carlsbad, CA · On-site

ASSOCIATE DIRECTOR, TOXICOLOGY SUMMARY: Ionis is seeking a talented and highly motivated Toxicologist to join the Preclinical Development Department and provide scientific leadership in the non ...

Calibr

SENIOR DIRECTOR, TOXICOLOGY

San Diego, CA · On-site

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Senior Director, Toxicology POSITION SUMMARY: The Senior Director of Toxicology will be the primary toxicology expert across our pipeline, driving the design, execution, and interpretation of non ...

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How much do director toxicology jobs pay per year?

As of Aug 15, 2026, the average yearly pay for director toxicology in the United States is $141,825.00, according to ZipRecruiter salary data. Most workers in this role earn between $95,000.00 and $185,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the director toxicology position, and why are they important?

To thrive as a Director Toxicology, you need deep expertise in toxicology, pharmacology, regulatory compliance, and laboratory management, typically backed by an advanced degree in toxicology or a related field. Familiarity with safety assessment tools, regulatory submission platforms (such as EPA or FDA eCTD systems), and certifications like DABT (Diplomate of the American Board of Toxicology) are commonly expected. Strong leadership, strategic thinking, and cross-functional communication skills help you manage teams and collaborate with internal and external stakeholders. These competencies are critical for ensuring safe product development and meeting regulatory standards across diverse scientific projects.

What are the main challenges a director of toxicology might encounter in this role?

A Director of Toxicology often faces the challenge of balancing complex regulatory requirements with efficient project timelines, especially when overseeing multiple studies simultaneously. Ensuring consistent data quality, interpreting emerging scientific data, and staying current with shifting global regulations can be demanding. The role also involves mentoring teams, resolving safety concerns quickly, and collaborating with diverse groups such as R&D, regulatory affairs, and external partners. Successfully managing these challenges requires strong leadership, adaptability, and up-to-date technical knowledge.

Are directors of toxicology in high demand?

Directors of toxicology are in high demand due to the increasing need for safety assessments in pharmaceuticals, chemicals, and consumer products. They typically require advanced degrees and expertise in regulatory compliance, with employment opportunities available in research organizations, industry, and government agencies.

What does a director of toxicology do?

A Director of Toxicology leads toxicology programs to assess the safety of chemicals, pharmaceuticals, or consumer products. They oversee study design, regulatory compliance, and risk assessment while managing scientific teams and collaborating with regulatory agencies. This role requires strong expertise in toxicology, regulatory frameworks, and data interpretation to ensure product safety and compliance with industry regulations.

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Director Toxicology jobs near you
Infographic showing various Director Toxicology job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 85% Full Time, 12% Part Time, 1% Temporary, and 1% Contract. Highlights an 92% Physical, 3% Hybrid, and 5% Remote job distribution, with an average salary of $141,825 per year, or $68.2 per hour.

Executive Director, Toxicology

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company

Boston, MA • On-site

$175K - $275K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 20 days ago

Job description

Description of Role
Centessa Pharmaceuticals is seeking an Executive Director, Toxicology to provide scientific and strategic leadership as well as operational management for nonclinical safety across discovery and development programs, with an emphasis on small-molecule therapeutics. This role leads toxicology and safety pharmacology strategy to support target selection, lead optimization, IND/NDA enabling activities. Reporting to our Head of Nonclinical & Translational Development, the Executive Director partners closely with cross-functional teams and represents nonclinical safety in regulatory interactions while building a strong, high-performing toxicology organization.
Key Responsibilities
  • Lead and mentor a team of toxicologists and technical/operational staff, fostering scientific excellence and professional growth
  • Define and execute nonclinical safety strategies across discovery, preclinical, and clinical stages
  • Provide expert toxicology and safety pharmacology input to cross-functional development teams
  • Lead nonclinical sub-teams as an integrated development head, providing cross-functional oversight across Toxicology, DMPK, Bioanalytical Sciences, and Clinical Pharmacology to ensure aligned, program-ready nonclinical strategies.
  • Serve as the primary nonclinical representative on Program Development Teams (PDTs) and at internal governance and external forums, effectively championing program strategy, presenting to regulatory authorities, and holding scientific ground with senior leadership, partners, CROs, and health authorities.
  • Design, oversee, and interpret GLP, non-GLP, investigative, and in vitro toxicology studies
  • Develop safety strategies for new targets, lead optimization programs, and platform technologies
  • Oversee toxicology and safety pharmacology studies conducted internally and at CROs
  • Ensure high scientific quality, compliance, and timely delivery of nonclinical study outputs
  • Author and critically review toxicology sections of regulatory documents (e.g., pre-IND, IND, IBs)
  • Partner with biology, DMPK, pathology, pharmacology, clinical, and regulatory colleagues to drive integrated decision-making
  • Present nonclinical safety data and risk assessments to project teams and senior R&D leadership
  • Serve as the primary nonclinical safety representative in regulatory agency interactions
  • Support product defense and regulatory submissions through robust scientific rationale
  • Provide strategic guidance on safety issue resolution and investigational toxicology approaches
  • Contribute to portfolio-level planning and prioritization of nonclinical safety resources
  • Build scalable toxicology capabilities to support a growing and diverse pipeline

Qualifications
  • PhD in Toxicology, Pharmacology, Pathology, DVM, or related discipline; board certification (e.g., DABT, ERT) preferred
  • 18+ years of experience in pharmaceutical or biotechnology R&D with a strong track record in nonclinical and regulatory toxicology
  • Proven ability to function as an upward-facing nonclinical leader and generalist, with the credibility and judgment to represent PDTs at governance, engage confidently with regulatory agencies, and serve as a trusted development partner to senior leadership.
  • Deep expertise supporting small-molecule programs across discovery, IND-enabling, and early clinical development
  • Strong working knowledge of national and international GLP guidelines
  • Demonstrated experience defining and executing nonclinical safety strategies to support diverse pipelines and novel biology
  • Proven leadership experience building, managing, and mentoring toxicology teams within a collaborative, matrixed environment
  • Extensive experience preparing and reviewing nonclinical sections of global regulatory submissions and engaging with health authorities (FDA, EMA)
  • Strong ability to integrate complex nonclinical datasets across toxicology, pathology, DMPK, and pharmacology to inform development decisions
  • Experience overseeing outsourced toxicology and safety pharmacology studies and managing CRO partnerships
  • Excellent communication and influencing skills, with the ability to partner effectively across Early Development, Research, and Regulatory functions in a fast-paced environment

Compensation
The annual base salary range for this position is $175,000.00 to $275,000.00. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, job knowledge and location.
In addition to base pay, this role is eligible for a discretionary annual bonus. Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program.
Work Location
The Executive Director, Toxicology role is based in the US, with occasional travel.
POSITION: Full-Time, Exempt
EEOC Statement: Centessa Pharmaceuticals, a wholly owned subdisary of Eli Lilly and Company believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. We will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.

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