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Manager Dmpk Jobs (NOW HIRING)

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Head of DMPK

San Francisco, CA · On-site

Establish and manage CRO partnerships for outsourced ADME studies, including vendor qualification ... Represent DMPK modeling expertise in cross-functional project teams, governance reviews, and ...

Recursion

Head of DMPK

New York, NY · Hybrid

$321K - $402K/yr

You won't just manage - you will amplify the talents of your team, fostering an environment of ... Deep expertise in small molecule DMPK is essential. Experience with related modalities (ADCs ...

Recursion

Head of DMPK

New York, NY · On-site

$321K - $402K/yr

You won't just manage - you will amplify the talents of your team, fostering an environment of ... Deep expertise in small molecule DMPK is essential. Experience with related modalities (ADCs ...

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All JobsManager Dmpk Jobs

Manager Dmpk information

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$23K

$61.4K

$102.5K

How much do manager dmpk jobs pay per year?

As of Jun 21, 2026, the average yearly pay for manager dmpk in the United States is $61,351.00, according to ZipRecruiter salary data. Most workers in this role earn between $44,000.00 and $69,000.00 per year, depending on experience, location, and employer.

What is the difference between Manager Dmpk vs Pharmacovigilance Manager?

AspectManager DmpkPharmacovigilance Manager
Required CredentialsBachelor's or Master’s in Life Sciences, experience in DMPKBachelor's or Master’s in Pharmacy, Pharmacology, or Life Sciences
Work EnvironmentResearch labs, drug development teamsRegulatory agencies, clinical safety teams
Employer & Industry UsagePharmaceutical R&D, biotech companiesPharmaceutical companies, regulatory bodies
Common Search & ComparisonYesYes

The Manager Dmpk focuses on drug metabolism and pharmacokinetics studies within drug development, while the Pharmacovigilance Manager oversees drug safety and adverse event monitoring. Both roles require scientific backgrounds but differ in their focus areas and work environments, with Dmpk managers more involved in research and pharmacovigilance managers in safety regulation compliance.

What are some common challenges faced by a Manager DMPK when leading cross-functional drug development teams?

A Manager DMPK often encounters challenges in aligning the goals and timelines of different departments, such as pharmacology, toxicology, and clinical development. Coordinating complex data from multiple sources and ensuring clear communication between teams is crucial for successful project progression. Additionally, staying updated with regulatory requirements and integrating new scientific methodologies can require proactive problem-solving and adaptability. Building strong relationships across functions helps address these challenges and keeps projects on track.

What are Manager DMPK roles and responsibilities?

A Manager DMPK (Drug Metabolism and Pharmacokinetics) oversees studies and teams that evaluate how drugs are absorbed, distributed, metabolized, and excreted in the body. They design and manage experiments, interpret data, and ensure regulatory compliance. This role often includes collaborating with project teams, supporting drug development decisions, and mentoring junior scientists. Managers in DMPK play a key part in delivering safe and effective drug candidates for clinical development.

What are the key skills and qualifications needed to thrive as a Manager in Drug Metabolism and Pharmacokinetics (DMPK), and why are they important?

To thrive as a Manager DMPK, you need advanced knowledge in pharmacokinetics, drug metabolism, and a relevant advanced degree (PhD or MS) in pharmaceutical sciences or a related field. Expertise with analytical tools like LC-MS/MS, pharmacokinetic modeling software, and familiarity with regulatory guidelines are typically required. Strong leadership, communication, and project management skills help you guide teams and collaborate effectively across departments. These expertise and qualities are essential for ensuring the safe and efficient progression of drug candidates through development pipelines.
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Manager Dmpk jobs near you
Infographic showing various Manager Dmpk job openings in the United States as of June 2026, with employment types broken down into 85% Full Time, 14% Part Time, and 1% Contract. Highlights an 92% Physical, 3% Hybrid, and 5% Remote job distribution, with an average salary of $61,351 per year, or $29.5 per hour.
Senior Director, DMPK

Senior Director, DMPK

Crinetics Pharmaceuticals

San Diego, CA • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 16 days ago

Job description

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.
Position Summary:
The Senior Director, DMPK, reporting to the Vice President, DMPK, will apply their strong scientific training in DMPK and hands-on experience addressing ADME liabilities across drug discovery and development programs. The ideal candidate will have a demonstrated history of leading high-performing DMPK teams within the biotechnology or pharmaceutical industry and contributing to the development of strategic plans, objectives, and practices for the broader DMPK function. In this role, the individual will work closely with chemists, biologists, and toxicologists to develop strategies that advance discovery programs into the clinic. The role also includes close collaboration with Clinical Pharmacology and CMC teams, providing scientific leadership to address drug metabolism and clinical drug-drug interaction issues arising during both early and late-stage development. Overall, this individual will partner across functions to support all stages of preclinical pharmacokinetic assessment, from compound screening through IND- and NDA-enabling activities and regulatory submissions. This role is based out of the headquarters in San Diego.
Essential Job Functions and Responsibilities:
These may include but are not limited to:
  • Provide strategic leadership and oversight for the Drug Metabolism and Pharmacokinetics function within Discovery.
  • Lead the development and execution of DMPK strategies for candidate evaluation, including the continued expansion and optimization of training, methodologies, and equipment.
  • Serve as the DMPK representative on multifunctional discovery and early development program teams.
  • Partner with Discovery colleagues to define optimal lead candidate characteristics, establish appropriate testing strategies, and design, conduct, and report preclinical studies that efficiently characterize potential drug candidates.
  • Foster effective cross-functional collaboration, particularly with in vitro and in vivo Pharmacology and Toxicology, and provide guidance on lead optimization, PK/PD understanding, and human dose projections.
  • Oversee and contribute to the preparation of preclinical pharmacokinetic sections of regulatory documents, including INDs, NDAs, briefing books, and Investigator Brochures.
  • Foster a team culture that promotes continuous improvement, accountability, professional growth, and inclusion.
  • Recommend, initiate, and lead innovative technologies and approaches that enhance scientific impact and operational efficiency while ensuring the application of cutting-edge science to project-related challenges.
  • Build strong partnerships across Crinetics, serve as a subject matter expert, and educate cross-functional teams on the application of DMPK principles to drug development.
  • Identify the need for clinical drug interaction studies based on a strong understanding of metabolic and transporter-mediated drug interactions.
  • Serve as a subject matter expert and support responses to regulatory queries related to DMPK.
  • Partner with Discovery leadership to recruit scientists and build teams that supports the DMPK strategy and advances the discovery and development portfolio.
  • Perform other duties as assigned.
  • This role is based at our headquarters in San Diego.

Education and Experience:
Required:
  • PhD in relevant discipline with 13+ years of relevant experience in pharmaceutical or life sciences industry. Applicants with BS or MS degrees may apply, but must demonstrate a minimum of 15+ years of significant and relevant experience.
  • Minimum supervisory experience of 10+ years.
  • Excellent verbal, written, and interpersonal communication skills are required.
  • Prior experience working at a small to mid-sized company with wide ranging related responsibilities is desired.
  • Excellent problem-solving ability.
  • Demonstration of cross-functional understanding related to drug discovery and development.
  • Good judge of risks and a keen ability to analyze options and manage outcomes.
  • Leadership and management skills and demonstrated qualities in this area.
  • Excellent negotiation skills and a tactful approach that leads to high value on outcomes achieved.

Physical Demands and Work Environment:
Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.
Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply.
Travel:
You may be required to travel for up to 5% of your time.
Equal Opportunity Employer:
Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws.
Salary Range
The salary range for this position is: $230,000 - $288,000.
In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

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