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Pbpk Modeling Jobs (NOW HIRING)

The University of Alabama

Experience applying PKPD/PBPK modeling to complex scenarios, such as targeted nanomedicines, biologics, cell/gene therapies, or chronic disease models. Proven ability to communicate fluently across ...

Madrigalpharma

Senior Director, ADME

Conshohocken, PA · On-site

$250/hr

Experience with PBPK modeling and human ADME (mass balance) studies preferred*Core Competencies** Strong scientific judgment and attention to detail* Hands-on, execution-focused approach* Effective ...

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How much do pbpk modeling jobs pay per hour?

As of Sep 7, 2026, the average hourly pay for pbpk modeling in the United States is $40.33, according to ZipRecruiter salary data. Most workers in this role earn between $31.25 and $43.51 per hour, depending on experience, location, and employer.

What is a pbpk modeling?

A PBPK (Physiologically Based Pharmacokinetic) Modeling job involves developing mathematical models to predict the absorption, distribution, metabolism, and excretion (ADME) of drugs in the human body. Professionals in this role use computational tools to integrate physiological, biochemical, and drug-specific data to support drug development, dose optimization, and regulatory submissions. PBPK modelers work in pharmaceutical companies, regulatory agencies, and research institutions to improve drug safety and efficacy predictions. Strong expertise in pharmacokinetics, coding (e.g., MATLAB, R, Python), and data analysis is essential for this role.

What are the typical responsibilities and daily activities of someone working in pbpk modeling?

Professionals in PBPK Modeling are responsible for designing and validating physiologically-based pharmacokinetic models to predict the absorption, distribution, metabolism, and excretion of drugs in various populations. Daily activities often include gathering and analyzing experimental data, coding or customizing models using specialized software, and preparing technical reports or presentations for stakeholders. Collaboration with clinical pharmacologists, toxicologists, and regulatory teams is common, as modelers help inform study design and regulatory strategy. The role involves both independent research and teamwork, providing valuable insight throughout the drug development process.

What are the key skills and qualifications needed to thrive in the pbpk modeling position, and why are they important?

To thrive in PBPK Modeling, you need a strong background in pharmacokinetics, mathematics, and systems pharmacology, typically supported by an advanced degree in pharmacy, pharmacology, or a related field. Expertise in specialized software such as Simcyp, GastroPlus, or MATLAB, along with familiarity with regulatory guidelines, is important. Strong analytical skills, attention to detail, and effective communication abilities help you interpret data and present modeling results to multidisciplinary teams. These abilities ensure accurate predictive models that support drug development and regulatory submissions.

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Pbpk Modeling jobs near you
Infographic showing various Pbpk Modeling job openings in the United States as of August 2026, with employment types broken down into 88% Full Time, 10% Part Time, and 2% Contract. Highlights an 85% Physical, 4% Hybrid, and 11% Remote job distribution, with an average salary of $83,896 per year, or $40.3 per hour.

Sr. Scientist - Translational PBPK Modeling

F. Hoffmann-La Roche AG

South San Francisco, CA • On-site

$150 - $200/hr

Other

Posted 18 days ago

Job description

The Drug Metabolism and Pharmacokinetics (DMPK) group is dedicated to enabling the discovery, development and commercialization of safe and effective medicines by elucidating the absorption, distribution, metabolism, excretion and pharmacokinetic properties of small molecule drug candidates. We accomplish this through the application of state-of-the-art technologies and sciences of bioanalysis, drug metabolism, drug transport and pharmacokinetics. The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

The Opportunity

The DMPK department at Genentech is seeking a Ph.D. level Senior Scientist who is highly motivated to apply cutting edge translational modeling approaches to support the advancement of small molecule drug discovery and development projects. Physiologically-based Pharmacokinetic (PBPK) modeling will be a key focus of this position.

Key technical responsibilities are to strategize, plan, execute, and report PBPK modeling and simulations independently, as well as to present work at cross-functional teams, department meetings, senior management review committees, regulatory interactions, and scientific conferences.

Other responsibilities may also include representing DMPK at multi-functional discovery and development project teams and leading the DMPK strategy, including designing, executing and reporting non-clinical studies.

Who You Are

You hold a PhD in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or a related scientific field, paired with 2 years relevant industry or post-doctoral experience in drug discovery/development.

  • You bring expertise in PBPK modeling and quantitative pharmacology, with hands-on experience using platforms such as Simcyp, GastroPlus, or PK-Sim.
  • You demonstrate strong communication and organizational skills, with a track record of thriving within cross-functional team environments.
  • Preferred Experience with additional modeling and simulation tools, such as Phoenix, R, NONMEM, SimBiology, Python.
  • Prior pharmaceutical industry experience as a DMPK project leader.
  • Experience supporting diverse modalities (small/large molecules, peptides, etc.) in drug development or modeling.

Together, we’ll advance along the whole patient journey with the aspiration to prevent, stop and cure diseases.

This position does offer domestic relocation.

The expected salary range for this position based on the primary location of San Francisco, CA is 124,300.00 - 230,900.00 USD. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. The next step is yours.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

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