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Pbpk Modeling Jobs (NOW HIRING)

Iambic Therapeutics, Inc

$164K - $245K/yr

Apply quantitative approaches (e.g., PBPK, population PK, exposure-response modeling) to inform dose selection and DDI risk assessment, with working knowledge of relevant software (e.g., SimCyp ...

Iambic Therapeutics, Inc.

$200 - $250/hr

Apply quantitative approaches (e.g., PBPK, population PK, exposure-response modeling) to inform dose selection and DDI risk assessment, with working knowledge of relevant software (e.g., SimCyp ...

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How much do pbpk modeling jobs pay per hour?

As of Sep 7, 2026, the average hourly pay for pbpk modeling in the United States is $40.33, according to ZipRecruiter salary data. Most workers in this role earn between $31.25 and $43.51 per hour, depending on experience, location, and employer.

What is a pbpk modeling?

A PBPK (Physiologically Based Pharmacokinetic) Modeling job involves developing mathematical models to predict the absorption, distribution, metabolism, and excretion (ADME) of drugs in the human body. Professionals in this role use computational tools to integrate physiological, biochemical, and drug-specific data to support drug development, dose optimization, and regulatory submissions. PBPK modelers work in pharmaceutical companies, regulatory agencies, and research institutions to improve drug safety and efficacy predictions. Strong expertise in pharmacokinetics, coding (e.g., MATLAB, R, Python), and data analysis is essential for this role.

What are the typical responsibilities and daily activities of someone working in pbpk modeling?

Professionals in PBPK Modeling are responsible for designing and validating physiologically-based pharmacokinetic models to predict the absorption, distribution, metabolism, and excretion of drugs in various populations. Daily activities often include gathering and analyzing experimental data, coding or customizing models using specialized software, and preparing technical reports or presentations for stakeholders. Collaboration with clinical pharmacologists, toxicologists, and regulatory teams is common, as modelers help inform study design and regulatory strategy. The role involves both independent research and teamwork, providing valuable insight throughout the drug development process.

What are the key skills and qualifications needed to thrive in the pbpk modeling position, and why are they important?

To thrive in PBPK Modeling, you need a strong background in pharmacokinetics, mathematics, and systems pharmacology, typically supported by an advanced degree in pharmacy, pharmacology, or a related field. Expertise in specialized software such as Simcyp, GastroPlus, or MATLAB, along with familiarity with regulatory guidelines, is important. Strong analytical skills, attention to detail, and effective communication abilities help you interpret data and present modeling results to multidisciplinary teams. These abilities ensure accurate predictive models that support drug development and regulatory submissions.

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Pbpk Modeling jobs near you
Infographic showing various Pbpk Modeling job openings in the United States as of August 2026, with employment types broken down into 88% Full Time, 10% Part Time, and 2% Contract. Highlights an 85% Physical, 4% Hybrid, and 11% Remote job distribution, with an average salary of $83,896 per year, or $40.3 per hour.

Associate Director, Quantitative Pharmacology

Incyte Corporation

Wilmington, DE • On-site

Full-time

Re-posted 17 days ago

Key responsibilities

  • Perform PK/PD analysis, population PK/PD analysis, and PBPK modeling for biologics and small molecules.

  • Conduct model-based simulations using PBPK methods to design studies that provide high-value PK/PD information.

  • Report data interpretations and findings to clinical teams and management, and advise on PK and PK/PD study design.

Job description

Overview
A global biopharmaceutical company on a mission to Solve On, Incyte follows science to find solutions for patients with unmet medical needs. Through the discovery, development, and commercialization of proprietary therapeutics, Incyte has established a portfolio of first-in-class medicines for patients and a strong pipeline of products in Hematology, Oncology and Inflammation and Autoimmunity
Headquartered in Wilmington, Delaware, Incyte has operations in North America, Europe, and Asia.
Job Summary (Primary function)
The Research Investigator, Pharmacokinetics is responsible for performing PK/PD analysis, population PK/PD analysis, and PBPK for Biologics and small molecules in the clinical pharmacokinetics group.
Essential Functions of the Job (Key responsibilities)
  • Present work at internal and external scientific meetings and publish manuscripts in peer-reviewed journals.
  • Work with clinician, biostatistician, and data manager to provide deliverables on time.
  • Represent clinical pharmacokinetics on clinical project teams.
  • Conduct model based simulations using PBPK method to design studies that yield high value PK/PD information for future critical decisions.
  • Perform PK/PD analyses, pop PK/PD analyses, interpret and report data to clinical teams and management in a timely manner.
  • Advise clinical teams on PK and PK/PD study design.

Qualifications (Minimal acceptable level of education, work experience, and competency)
  • Ability to work both independently and collaboratively with diverse teams.
  • Excellent written and verbal communication skills.
  • Experience with writing reports for regulatory submissions is desired.
  • Experience with a range of software packages, such as but not limited to: WinNonlin, NONMEM, R, SimCyp and GastroPlus.
  • Experience in large molecule development is highly preferable.
  • Experience in analyzing clinical pharmacology data.
  • Experience in clinical PK, population PK analysis, and PBPK modeling.
  • Advanced degree (e.g., Ph.D., Master's) in Pharmacokinetics, Pharmacometrics, Pharmacology, Engineering, Statistics, or related fields, or equivalent experience.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.
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Learn more at: http://www.incyte.com/privacy-policy
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During the process, you may be asked to respond to questions that will screen out your application if you do not meet certain objective criteria required by the job. You can learn more about this process here.
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