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Pbpk Modeling Jobs (NOW HIRING)

Georgia Tech

Postdoctoral Fellow

Atlanta, GA · On-site

$47K - $64K/yr

Computational fluid dynamics and/or computational aerosol transport Monte Carlo radiation transport Internal dosimetry, biokinetic modeling, PBPK modeling, and/or dose reconstruction Scientific ...

Gilead

Pharmacometrics Manager

Foster City, CA

$146K - $189K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • PTO

Experience on the application of physiologically basedpharmacokinetic (PBPK) modeling analysis to support dose decisions in clinical trials and simulation of drug-drug interactions for quantitative ...

Gilead

Pharmacometrics Manager

Foster City, CA

$146K - $189K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • PTO

Experience on the application of physiologically basedpharmacokinetic (PBPK) modeling analysis to support dose decisions in clinical trials and simulation of drug-drug interactions for quantitative ...

Revolution Medicines

Scientist I, DMPK

Redwood City, CA · On-site

$119K - $149K/yr

Previous experience with PBPK modeling and DDI risk assessment is preferred. * Effective communication and documentation skills. #LI-Hybrid #LI-CT1 The base pay salary range for this full-time ...

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Novo Nordisk

Senior Scientist I - Drug Metabolism

Lexington, MA · On-site

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Apply fit-for-purpose in silico models, PK/PD, PBPK, exposure-response, to predict human pharmacokinetics/dose and derisk programs. * Integrate DMPK data with medicinal chemistry and pharmacology to ...

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How much do pbpk modeling jobs pay per hour?

As of Aug 16, 2026, the average hourly pay for pbpk modeling in the United States is $40.33, according to ZipRecruiter salary data. Most workers in this role earn between $31.25 and $43.51 per hour, depending on experience, location, and employer.

What is a pbpk modeling?

A PBPK (Physiologically Based Pharmacokinetic) Modeling job involves developing mathematical models to predict the absorption, distribution, metabolism, and excretion (ADME) of drugs in the human body. Professionals in this role use computational tools to integrate physiological, biochemical, and drug-specific data to support drug development, dose optimization, and regulatory submissions. PBPK modelers work in pharmaceutical companies, regulatory agencies, and research institutions to improve drug safety and efficacy predictions. Strong expertise in pharmacokinetics, coding (e.g., MATLAB, R, Python), and data analysis is essential for this role.

What are the typical responsibilities and daily activities of someone working in pbpk modeling?

Professionals in PBPK Modeling are responsible for designing and validating physiologically-based pharmacokinetic models to predict the absorption, distribution, metabolism, and excretion of drugs in various populations. Daily activities often include gathering and analyzing experimental data, coding or customizing models using specialized software, and preparing technical reports or presentations for stakeholders. Collaboration with clinical pharmacologists, toxicologists, and regulatory teams is common, as modelers help inform study design and regulatory strategy. The role involves both independent research and teamwork, providing valuable insight throughout the drug development process.

What are the key skills and qualifications needed to thrive in the pbpk modeling position, and why are they important?

To thrive in PBPK Modeling, you need a strong background in pharmacokinetics, mathematics, and systems pharmacology, typically supported by an advanced degree in pharmacy, pharmacology, or a related field. Expertise in specialized software such as Simcyp, GastroPlus, or MATLAB, along with familiarity with regulatory guidelines, is important. Strong analytical skills, attention to detail, and effective communication abilities help you interpret data and present modeling results to multidisciplinary teams. These abilities ensure accurate predictive models that support drug development and regulatory submissions.

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Pbpk Modeling jobs near you
Infographic showing various Pbpk Modeling job openings in the United States as of August 2026, with employment types broken down into 100% Full Time. Highlights an 76% In-person, 20% Hybrid, and 4% Remote job distribution, with an average salary of $83,896 per year, or $40.3 per hour.

Director, Clinical Pharmacology

Revolution Medicines

Redwood City, CA • Hybrid

Full-time

Re-posted 29 days ago

Job description

The Opportunity:

  • We are seeking a passionate and experienced Clinical Pharmacologist with strong early development background to be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization.

  • As a member of the Early Development Clinical Pharmacology group, you will:

  • Provide strategic insight and technical leadership within the Clinical Pharmacology function.

  • Author technical reports and/or regulatory documents for major milestones of clinical development, specifically IND, EOP1 & EOP2 Briefing Documents. Participate in regulatory interactions and responses to regulatory questions.

  • Apply state-of-the-art quantitative modeling, including translational PK/PD, population PK, and exposure-response analyses, to guide recommended phase 2 dose/schedule (RP2Ds) selection for pivotal studies.

  • Work with the Discovery organization to support assets in the IND-enabling stage, including collaboration with DMPK and Toxicology groups in assessment of human start dose and assessment of the need for human DDI studies.

  • Work with the Clinical Development team in designing FIH study.

  • Design and report Clin Pharm studies such as hADME, Food-Effect and DDI studies.

  • Engage and work with CROs on clinical pharmacology activities.

  • Represent the Clinical Pharmacology function in project teams and build strong working relationships with cross-functional teams to impact critical decisions.

Required Skills, Experience and Education:

  • A Ph.D. or Pharm.D (with Fellowship) with Pharmaceutical Sciences background with 8+ years of relevant industry experience in Clinical Pharmacology.

  • Prior experience with small molecules oncology drug development.

  • Familiar with FDA's Project Optimus guidance.

  • Well-informed in current and emerging standards of regulatory requirements and expectations for clinical pharmacology.

  • Hands-on experience with WinNonlin and Clin Pharm study designs.

  • Strong understanding of DMPK, CMC and Toxicology and related regulatory guidance is required.

  • Excellent verbal and written communication skills, and ability to clearly convey complex concepts and findings to both non-specialist and specialist audiences.

  • A critical thinker and passionate team player and quick learner with high energy who thrives in a dynamic and fast-paced environment.

  • Prior management experience.

Preferred Skills:

  • Prior experience interacting with FDA on dose optimization.

  • Hand-on experience with PBPK models.

#LI-Hybrid #LI-CT1

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