Cambridge, MA · Hybrid
$160K - $201K/yr
Experience in developing advanced pharmacometrics, PK/PD, PBPK models to aid in research and development decision making. Skilled in using pharmacometrics analysis software (e.g., NONMEM, R, Phoenix)
Cambridge, MA · Hybrid
$160K - $201K/yr
Experience in developing advanced pharmacometrics, PK/PD, PBPK models to aid in research and development decision making. Skilled in using pharmacometrics analysis software (e.g., NONMEM, R, Phoenix)
Develop translational modeling approaches - including PBPK, IVIVE, and PK/PD simulation - to bridge preclinical and clinical settings and generate actionable predictions for biotech partners across ...
Develop translational modeling approaches - including PBPK, IVIVE, and PK/PD simulation - to bridge preclinical and clinical settings and generate actionable predictions for biotech partners across ...
Develop translational modeling approaches - including PBPK, IVIVE, and PK/PD simulation - to bridge preclinical and clinical settings and generate actionable predictions for biotech partners across ...
Develop translational modeling approaches - including PBPK, IVIVE, and PK/PD simulation - to bridge preclinical and clinical settings and generate actionable predictions for biotech partners across ...
Develop translational modeling approaches - including PBPK, IVIVE, and PK/PD simulation - to bridge preclinical and clinical settings and generate actionable predictions for biotech partners across ...
Develop translational modeling approaches - including PBPK, IVIVE, and PK/PD simulation - to bridge preclinical and clinical settings and generate actionable predictions for biotech partners across ...
Develop translational modeling approaches - including PBPK, IVIVE, and PK/PD simulation - to bridge preclinical and clinical settings and generate actionable predictions for biotech partners across ...
Develop translational modeling approaches - including PBPK, IVIVE, and PK/PD simulation - to bridge preclinical and clinical settings and generate actionable predictions for biotech partners across ...
Build and validate advanced modeling approaches (e.g., AI/ML and/or mechanistic models such as PBPK) to help understand and predict pharmacokinetics and variability. * Design and help lead non ...
Build and validate advanced modeling approaches (e.g., AI/ML and/or mechanistic models such as PBPK) to help understand and predict pharmacokinetics and variability. * Design and help lead non ...
Build and validate advanced modeling approaches (e.g., AI/ML and/or mechanistic models such as PBPK) to help understand and predict pharmacokinetics and variability. * Design and help lead non ...
Build and validate advanced modeling approaches (e.g., AI/ML and/or mechanistic models such as PBPK) to help understand and predict pharmacokinetics and variability. * Design and help lead non ...
Burnet, TX · On-site
Experience with PBPK/PKPD/QSP modeling platforms, multi-omics integration, or translational bioinformatics and big data analysis. * Familiarity with regulatory science or industry-academic ...
Burnet, TX · On-site
Experience with PBPK/PKPD/QSP modeling platforms, multi-omics integration, or translational bioinformatics and big data analysis. * Familiarity with regulatory science or industry-academic ...
Redwood City, CA · On-site
$211K - $264K/yr
Hand-on experience with PBPK models. #LI-Hybrid #LI-CT1 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below.
Redwood City, CA · On-site
$211K - $264K/yr
Hand-on experience with PBPK models. #LI-Hybrid #LI-CT1 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below.
Lexington, MA · On-site
$148K - $259K/yr
Develop and apply in silico models (e.g., PK/PD, PBPK, exposure-response, and other simulation tools) to predict human pharmacokinetics, support dose selection, and de risk programs. Integrate DMPK ...
Lexington, MA · On-site
$148K - $259K/yr
Develop and apply in silico models (e.g., PK/PD, PBPK, exposure-response, and other simulation tools) to predict human pharmacokinetics, support dose selection, and de risk programs. Integrate DMPK ...
Manhattan, NY · On-site
$190K - $240K/yr
Population PK/PD modeling (NONMEM, Monolix), PBPK (Simcyp, GastroPlus), and exposure-response methods. * Bioanalytical method development/validation oversight and data integrity in GxP contexts.
Quick apply
Manhattan, NY · On-site
$190K - $240K/yr
Population PK/PD modeling (NONMEM, Monolix), PBPK (Simcyp, GastroPlus), and exposure-response methods. * Bioanalytical method development/validation oversight and data integrity in GxP contexts.
... PBPK) innovation while partnering closely with clients, key opinion leaders, regulators, and ... data integration, model translation, predictive performance, and platform evolution.
... PBPK) innovation while partnering closely with clients, key opinion leaders, regulators, and ... data integration, model translation, predictive performance, and platform evolution.
Working knowledge of modeling approaches, including PBPK, QSP, and semi-mechanistic PK/PD frameworks. * Proven track record of leading, mentoring, and developing scientific talent within ...
Working knowledge of modeling approaches, including PBPK, QSP, and semi-mechanistic PK/PD frameworks. * Proven track record of leading, mentoring, and developing scientific talent within ...
Develop PK/PD, QSP, PBPK, or other appropriate models to capture preclinical data, enable clinical scaling and first in human dose projection. * Author high quality Regulatory documents including ...
Develop PK/PD, QSP, PBPK, or other appropriate models to capture preclinical data, enable clinical scaling and first in human dose projection. * Author high quality Regulatory documents including ...
PBPK, PK/PD modeling, population PK, and exposure-response analyses. * Excellent communication and interpersonal skills, with the ability to work collaboratively in a team environment. Compensation ...
PBPK, PK/PD modeling, population PK, and exposure-response analyses. * Excellent communication and interpersonal skills, with the ability to work collaboratively in a team environment. Compensation ...
... PK, PBPK, and QSP modeling. * Oversee the development of statistical and PK analysis plans, standalone PK/PD reports, and PK/PD sections of clinical study reports, and take the lead in reviewing ...
Quick apply
... PK, PBPK, and QSP modeling. * Oversee the development of statistical and PK analysis plans, standalone PK/PD reports, and PK/PD sections of clinical study reports, and take the lead in reviewing ...
Cary, NC · On-site +1
... PK, PBPK, and QSP modeling. * Oversee the development of statistical and PK analysis plans, standalone PK/PD reports, and PK/PD sections of clinical study reports, and take the lead in reviewing ...
Cary, NC · On-site +1
... PK, PBPK, and QSP modeling. * Oversee the development of statistical and PK analysis plans, standalone PK/PD reports, and PK/PD sections of clinical study reports, and take the lead in reviewing ...
... PK, PBPK, and QSP modeling. * Oversee the development of statistical and PK analysis plans, standalone PK/PD reports, and PK/PD sections of clinical study reports, and take the lead in reviewing ...
... PK, PBPK, and QSP modeling. * Oversee the development of statistical and PK analysis plans, standalone PK/PD reports, and PK/PD sections of clinical study reports, and take the lead in reviewing ...
Cambridge, MA · On-site
$75K - $100K/yr
... and model-informed decision support PBPK, QSP, drug-drug interaction, and other quantitative modeling environments used in CPP workflows Clinical PK/PD systems and operational tooling that support ...
Cambridge, MA · On-site
$75K - $100K/yr
... and model-informed decision support PBPK, QSP, drug-drug interaction, and other quantitative modeling environments used in CPP workflows Clinical PK/PD systems and operational tooling that support ...
Brisbane, CA · On-site
$75K - $100K/yr
... and model-informed decision support PBPK, QSP, drug-drug interaction, and other quantitative modeling environments used in CPP workflows Clinical PK/PD systems and operational tooling that support ...
Brisbane, CA · On-site
$75K - $100K/yr
... and model-informed decision support PBPK, QSP, drug-drug interaction, and other quantitative modeling environments used in CPP workflows Clinical PK/PD systems and operational tooling that support ...
$22.12 - $27.05
6% of jobs
$30.98 is the 25th percentile. Wages below this are outliers.
$27.05 - $31.99
23% of jobs
The median wage is $34.75 / hr.
$31.99 - $36.93
36% of jobs
$40.16 is the 75th percentile. Wages above this are outliers.
$36.93 - $41.87
14% of jobs
$41.87 - $46.81
5% of jobs
$46.81 - $51.75
4% of jobs
$51.75 - $56.69
4% of jobs
$56.69 - $61.63
2% of jobs
$61.63 - $66.56
1% of jobs
$66.56 - $71.50
0% of jobs
$71.50 - $76.44
3% of jobs
$22
$40
$76
Professionals in PBPK Modeling are responsible for designing and validating physiologically-based pharmacokinetic models to predict the absorption, distribution, metabolism, and excretion of drugs in various populations. Daily activities often include gathering and analyzing experimental data, coding or customizing models using specialized software, and preparing technical reports or presentations for stakeholders. Collaboration with clinical pharmacologists, toxicologists, and regulatory teams is common, as modelers help inform study design and regulatory strategy. The role involves both independent research and teamwork, providing valuable insight throughout the drug development process.
A PBPK (Physiologically Based Pharmacokinetic) Modeling job involves developing mathematical models to predict the absorption, distribution, metabolism, and excretion (ADME) of drugs in the human body. Professionals in this role use computational tools to integrate physiological, biochemical, and drug-specific data to support drug development, dose optimization, and regulatory submissions. PBPK modelers work in pharmaceutical companies, regulatory agencies, and research institutions to improve drug safety and efficacy predictions. Strong expertise in pharmacokinetics, coding (e.g., MATLAB, R, Python), and data analysis is essential for this role.
To thrive in PBPK Modeling, you need a strong background in pharmacokinetics, mathematics, and systems pharmacology, typically supported by an advanced degree in pharmacy, pharmacology, or a related field. Expertise in specialized software such as Simcyp, GastroPlus, or MATLAB, along with familiarity with regulatory guidelines, is important. Strong analytical skills, attention to detail, and effective communication abilities help you interpret data and present modeling results to multidisciplinary teams. These abilities ensure accurate predictive models that support drug development and regulatory submissions.
$160K - $201K/yr
Full-time
Posted 3 days ago
Why Sarepta? Why Now?
The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.
We're looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
What Sarepta Offers
At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:
Physical and Emotional Wellness
Financial Wellness
Support for Caregivers
For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
The Importance of the Role
The Associate Director, Quantitative Clinical Pharmacology is responsible for providing translational, clinical pharmacology, and pharmacometrics deliverables for development assets from pre-IND to Phase III. This incumbent will apply quantitative modeling methodologies inclusive of population PK, PKPD, disease progression modeling using multivariate statistical and empirical approaches to integrate, analyze and interpret diverse data sources (e.g., pharmacokinetics, pharmacodynamics including biomarker & imaging, electronic health records). The Associate Director will drive and support pharmacology and pharmacometrics activities involved for dose selection and characterizing the interactions between drugs, patients, and biological systems to identify key predictors. This is a highly visible and team-facing role.The Opportunity to Make a Difference
More about You
What Now?
We're always looking for solution-oriented, critical thinkers.
So, if you're comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
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Biotechnology research and development
1,001 - 5,000 Employees
Cambridge, MA, US
1980
