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Director Clinical Biomarker Jobs (NOW HIRING)

Exelixis

Sr Director, Biostatistics

Alameda, CA · On-site

Partners in early clinical development program study design, biomarker strategy and translational medicine strategy establishing standards for clinical conduct, and the collection, management and/or ...

Exelixis, Inc.

Sr Director, Biostatistics

Alameda, CA · On-site

$248 - $352.50/hr

Partners in early clinical development program study design, biomarker strategy and translational medicine strategy establishing standards for clinical conduct, and the collection, management and/or ...

Exelixis

Sr Director, Biostatistics

Alameda, CA · On-site

Partners in early clinical development program study design, biomarker strategy and translational medicine strategy establishing standards for clinical conduct, and the collection, management and/or ...

Exelixis

Sr Director, Biostatistics

Alameda, CA · On-site

Partners in early clinical development program study design, biomarker strategy and translational medicine strategy establishing standards for clinical conduct, and the collection, management and/or ...

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Director Clinical Biomarker information

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$51.5K

$100.1K

$167K

How much do director clinical biomarker jobs pay per year?

As of Aug 4, 2026, the average yearly pay for director clinical biomarker in the United States is $100,124.00, according to ZipRecruiter salary data. Most workers in this role earn between $80,000.00 and $109,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a director clinical biomarker, and why are they important?

To excel as a Director Clinical Biomarker, you need advanced expertise in molecular biology, translational medicine, and clinical research, often supported by a PhD or MD and extensive experience in biomarker discovery and validation. Familiarity with bioinformatics tools, laboratory information management systems (LIMS), and regulatory guidelines such as GCP are typically required. Leadership, strategic thinking, and strong communication skills set outstanding candidates apart by enabling effective cross-functional collaboration and decision-making. These competencies are critical for guiding biomarker strategy, ensuring scientific rigor, and driving successful clinical development programs.

What does a director clinical biomarker do?

A Director of Clinical Biomarker leads the development and implementation of biomarker strategies in clinical trials, particularly for drug development. They oversee the identification, validation, and use of biological markers that help understand disease mechanisms, predict patient response, or monitor treatment effectiveness. This role collaborates closely with clinical, translational, and regulatory teams to ensure biomarkers are effectively integrated into clinical studies. They also manage teams, budgets, and partnerships with external laboratories or research organizations.

What are some common challenges faced by a director clinical biomarker when overseeing multi-site clinical trials?

A Director of Clinical Biomarker often manages biomarker strategy and implementation across multiple clinical trial sites, which can present challenges such as ensuring consistency in sample collection, processing, and data interpretation. Coordinating with cross-functional teams—including clinical operations, laboratory scientists, and regulatory affairs—requires strong communication and project management skills. Additionally, adapting to evolving regulatory requirements and integrating new biomarker technologies can add complexity. Overcoming these challenges is key to supporting successful trial outcomes and advancing drug development.

What is the difference between Director Clinical Biomarker vs Clinical Research Scientist?

AspectDirector Clinical BiomarkerClinical Research Scientist
Required CredentialsAdvanced degree (PhD, MD, or equivalent), experience in biomarker developmentTypically a master's or PhD in life sciences, with research experience
Work EnvironmentLeadership role overseeing biomarker projects, collaborating with cross-functional teamsHands-on research, data analysis, and clinical trial support
Employer & Industry UsagePharmaceutical, biotech, and clinical research organizationsResearch institutions, CROs, pharmaceutical companies

The Director Clinical Biomarker focuses on leading biomarker development and strategy, while the Clinical Research Scientist conducts experimental research and supports clinical trials. Both roles require scientific expertise but differ in leadership scope and responsibilities.

More about Director Clinical Biomarker jobs
What cities are hiring for Director Clinical Biomarker jobs? Cities with the most Director Clinical Biomarker job openings:
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Director Clinical Biomarker jobs near you
Infographic showing various Director Clinical Biomarker job openings in the United States as of July 2026, with employment types broken down into 41% Locum Tenens, 31% Full Time, 1% Contract, 26% Nights, and 1% Summer. Highlights an 79% Physical, 5% Hybrid, and 16% Remote job distribution, with an average salary of $100,124 per year, or $48.1 per hour.

Senior Director, Clinical Biomarker Operations

Revolution Medicines

Redwood City, CA • Hybrid

Other

Re-posted 11 days ago

Job description

The Opportunity:

Revolution Medicines is seeking a strategic and experienced leader to serve as Senior Director, Clinical Biomarker Operations, responsible for leading the operational execution of biomarker and companion diagnostic (CDx) strategies across early- and late-stage clinical development programs. This role will oversee end-to-end biospecimen workflows, including vendor contract setup, oversight, and sample shipments in support of precision oncology clinical trials. The position will lead a team and partner cross-functionally with Clinical Operations and Clinical Development to ensure successful collection of biospecimens for clinical biomarker and CDx testing. This role is a people leader role with organizational impact.

Responsibilities:

  • Oversee planning and execution of operational strategies for clinical biomarker development and CDx across multiple clinical-stage programs.

  • Partner with Clinical Biomarker Development team in Translational Medicine to operationalize testing of samples using state-of-art molecular assays; e.g., next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) and tumor tissues.

  • Partner with Precision Medicine & CDx team in Translational Medicine to implement testing for patient selection/stratification and clinical validation for regulatory submissions.

  • Collaborate with Clinical Operations and Clinical Development teams to integrate biomarker and CDx strategies into study protocols, informed consent forms, and lab manuals.

  • Partner with Biospecimen Management to establish and maintain robust sample tracking systems, chain-of-custody procedures, and reconciliation processes to ensure data integrity and audit readiness.

  • Identify risks and implement mitigation strategies to ensure successful execution of biomarker and CDx deliverables.

  • Build, mentor, and lead a high-performing clinical biomarker operations team.

Required Skills, Experience and Education:

  • Bachelor's, Master's, or PhD degree in life sciences or a related field.

  • Minimum of 15 years of experience in biomarker operations, clinical operations, or translational research within biotechnology or pharmaceutical industry.

  • Demonstrated experience leading biospecimen operations in phase 1 and global phase 3 clinical trials.

  • Strong understanding of biospecimen management and global clinical trial logistics.

  • Experience managing external vendors, including central labs and testing labs.

  • Knowledge of GCP, GLP, and regulatory requirements related to biospecimen handling.

  • Proven leadership experience managing teams and cross-functional initiatives.

  • Strong problem-solving skills with the ability to manage complex operational challenges.

  • Excellent written and verbal communication and interpersonal skills.

  • Ability to operate effectively in a fast-paced, collaborative, and innovative environment.

Preferred Skills:

  • Advanced degree (Master's or PhD) with relevant experience in oncology.

  • Experience supporting regulatory submissions involving CDx tests.

  • Familiarity with a broad range of biomarker assays (NGS of ctDNA and tumor tissues).

  • Prior experience building or scaling clinical biomarker operations functions in a rapidly growing organization.

#LI-SH1 #LI-Hybrid

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