What is a DNA encoded library?

DNA Encoded Libraries (DELs) are collections of small molecules that are each attached to a unique DNA sequence acting as a molecular barcode. This technology allows researchers to rapidly screen millions to billions of compounds simultaneously to identify those that bind to a biological target, which is especially useful in early-stage drug discovery. The DNA tags make it possible to track and identify active compounds using DNA sequencing techniques, greatly increasing throughput and efficiency compared to traditional screening methods.