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Weekend Rn Jobs in Charleston, SC (NOW HIRING)

Registered Nurse (RN)

North Charleston, SC · On-site

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

RNs will be scheduled 7 shifts in a two week period with alternating weekend days. Day Shift: 7:00am to 7:30pm Night Shift: 7:00pm to 7:30am Benefits include: • Tuition Assistance • Career ...

Registered Nurse (RN)

North Charleston, SC · On-site

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

RNs will be scheduled 7 shifts in a two week period with alternating weekend days. Day Shift: 7:00am to 7:30pm Night Shift: 7:00pm to 7:30am Benefits include: • Tuition Assistance • Career ...

Registered Nurse (RN)

North Charleston, SC · On-site

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

RNs will be scheduled 6 shifts in a two week period with alternating weekend days. Day Shift: 7:00am to 7:30pm Night Shift: 7:00pm to 7:30am Benefits include: • Tuition Assistance • Career ...

Registered Nurse RN

Summerville, SC · On-site

$35 - $39/hr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Registered Nurse Rn Opportunity Working in harmony with the entire nursing staff, the Registered Nurse RN strives to provide the very best care possible. If you are a Registered Nurse RN with a true ...

Travel Registered Nurse (RN) - Weekend Hospice Location: Tri-County Area, SC (Specific ZIP code coverages TBD) Job Type: Full-Time / Weekend Only Schedule: 40 Hours/Week ( 13 hrs / 13 hrs / 14 hrs ...

EVERY OTHER WEEKEND REQUIRED Join the PruittHealth family, where the health and safety of our ... (RN) licensure in the state of practice Family Makes Us Stronger. Our family, your family, one ...

EVERY OTHER WEEKEND REQUIRED Join the PruittHealth family, where the health and safety of our ... (RN) licensure in the state of practice Family Makes Us Stronger. Our family, your family, one ...

Weekend Nurse Supervisor RN

Summerville, SC · On-site

$37 - $40/hr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

If you are a Registered Nurse with strong leadership abilities, compassion for others, and a commitment to teamwork, apply today! Posted Salary Range: USD $37.00 - USD $40.00 /Hr. The wage range for ...

Baylor RN - Weekends

North Charleston, SC · On-site

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Home Health RN - Baylor / Flexible Weekend Full Time Serving Dorchester, Charleston, and Berkeley Counties Interim Healthcare is seeking a Home Health RN - Baylor to work full-time with our clients ...

Baylor RN - Weekends

North Charleston, SC · On-site

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Home Health RN - Baylor / Flexible Weekend Full Time Serving Dorchester, Charleston, and Berkeley Counties Interim Healthcare is seeking a Home Health RN - Baylor to work full-time with our clients ...

Travel Registered Nurse (RN) - Weekend Hospice Location: Tri-County Area, SC (Specific ZIP code coverages TBD) Job Type: Full-Time / Weekend Only Schedule: 40 Hours/Week ( 13 hrs / 13 hrs / 14 hrs ...

Showing results 41-60

Weekend Rn information

See Charleston, SC salary details

$25

$40

$68

How much do weekend rn jobs pay per hour?

As of Aug 20, 2026, the average hourly pay for weekend rn in Charleston, SC is $40.73, according to ZipRecruiter salary data. Most workers in this role earn between $32.32 and $47.02 per hour, depending on experience, location, and employer.

What is a Weekend RN?

A Weekend RN is a registered nurse who primarily works during the weekends, often covering shifts on Saturdays and Sundays. These nurses provide patient care, administer medications, monitor patient progress, and collaborate with doctors and other healthcare staff. Weekend RNs may work in hospitals, nursing homes, or other healthcare facilities, and their schedules are designed to ensure continuous high-quality care throughout the week. Weekend shifts can sometimes offer higher pay rates or shift differentials due to the non-traditional hours.

What does a Weekend RN do?

As a weekend RN, you take shifts on the weekend when other nurses are unavailable, allowing hospitals and other care facilities to provide continuity of care and remain open 24/7. This is usually a part-time position, with most weekend RN's working two 8-12 hour shifts Saturday-Sunday each week. Some facilities also count Friday as a weekend day and offer a three-shift schedule instead. In this role, you may make patient visits, answer telephone calls to provide remote healthcare and address any medical emergencies that occur during your shift as a weekend nurse. As an RN, weekend work usually focuses on hospitals and hospice facilities, but you may find positions that involve traveling to visit patients outside of a clinical setting.

What are the key skills and qualifications needed to thrive as a Weekend RN, and why are they important?

To thrive as a Weekend RN, you need current RN licensure, strong clinical assessment skills, and experience in acute or long-term care settings. Familiarity with electronic health record (EHR) systems and up-to-date certifications such as BLS or ACLS are often required. Excellent time management, adaptability, and communication skills are essential for managing patient care during typically higher-acuity weekend shifts. These competencies ensure patient safety, efficient care delivery, and effective teamwork when staffing levels and resources may be limited.

What are some unique challenges and rewards of working as a Weekend RN compared to a standard weekday nursing position?

Weekend RNs often face a distinct set of challenges, including managing higher patient-to-nurse ratios and handling more acute or urgent cases, as there may be fewer staff and support services available on weekends. However, this role also offers unique rewards, such as greater autonomy, opportunities to hone critical thinking and decision-making skills, and often a more flexible schedule or additional compensation. Weekend RNs typically collaborate closely with a dedicated core team, fostering strong teamwork and communication. This experience can be valuable for career advancement, as it demonstrates adaptability and strong clinical competence in a fast-paced environment.

What is the difference between Weekend Rn vs Weekend Lpn?

AspectWeekend RnWeekend Lpn
Required CredentialsRegistered Nurse license (RN)Licensed Practical Nurse license (LPN)
Work EnvironmentHospitals, clinics, long-term care facilitiesLong-term care, nursing homes, clinics
Employer & Industry UsageHospitals, healthcare agenciesLong-term care facilities, nursing homes
Common Search & Comparison IntentUnderstanding RN roles on weekendsUnderstanding LPN roles on weekends

Weekend Rn and Weekend Lpn roles differ mainly in credentials, with RNs holding a registered nurse license and LPNs holding a practical nurse license. RNs typically perform more complex medical tasks and have broader responsibilities, while LPNs focus on basic patient care. Both roles are common in healthcare settings that require weekend coverage, but RNs generally have more advanced training and scope of practice.

What are the most commonly searched types of Rn jobs in Charleston, SC?

The most popular types of Rn jobs in Charleston, SC are:

What are popular job titles related to Weekend Rn jobs in Charleston, SC?

For Weekend Rn jobs in Charleston, SC, the most frequently searched job titles are:

What job categories do people searching Weekend Rn jobs in Charleston, SC look for?

The top searched job categories for Weekend Rn jobs in Charleston, SC are:

What cities near Charleston, SC are hiring for Weekend Rn jobs?

Cities near Charleston, SC with the most Weekend Rn job openings:

Infographic showing various Weekend Rn job openings in Charleston, SC as of August 2026, with employment types broken down into 2% As Needed, 63% Full Time, 24% Part Time, 2% Temporary, and 9% Contract. Highlights an 98% In-person, and 2% Remote job distribution, with an average salary of $84,721 per year, or $40.7 per hour.

Registered Nurse (RN)

UHS

North Charleston, SC • On-site

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 11 days ago


Universal Health Services rating

6.9

Company rating: 6.9 out of 10

Based on 254 frontline employees who took The Breakroom Quiz

456th of 889 rated healthcare providers


Job description

Responsibilities

We are pleased to announce the following available position:  Registered Nurse (RN) - Full Time - $20,000 Sign On Bonus 

Position Summary

The Registered Nurse (RN) will provide primary care coordination for patients and implement a collaborative care plan as prescribed by the physician and treatment team. Duties include: Assess mental health needs; develop nursing diagnoses, identify outcomes, plan and evaluate nursing care; administer and/or monitor the effects and side effects of medications and treatments ordered by a physician; to ensure safety and provide consistent therapeutic milieu management and crisis intervention strategies.

Schedule

Day and night shifts are available.  RNs will be scheduled 7 shifts in a two week period with alternating weekend days.

Day Shift:  7:00am to 7:30pm  

Night Shift: 7:00pm to 7:30am

Benefits include:

• Tuition Assistance

• Career development opportunities across UHS and its 300+ locations!

• Diverse programming to expand your experience and energize your career

• HealthStream online learning catalogue with plenty of free CEU courses

• Competitive Compensation & Generous Paid Time Off

• Excellent Medical, Dental, Vision and Prescription Drug Plans

• 401(K) with company match and discounted stock plan

• SoFi Student Loan Refinancing Program

• We participate in the Dept of Health and Human Services Health Resources and Service Administration (HRSA) Substance Use Disorder Treatment and Recovery (STAR) Program

More information is available on our Benefits Guest Website: benefits.uhsguest.com

About Our Organization

Palmetto Lowcountry Behavioral Health, a subsidiary of UHS, is located on the beautiful Ashley River near Charleston, SC, Palmetto Lowcountry Behavioral Health lends a helping hand to people struggling with mental health and substance use disorders. At Palmetto Behavioral Health we are looking for exceptional people who share our mission of providing superior quality healthcare services and our culture of Service Excellence: treat everyone as a guest, demonstrate professionalism and excellence, practice teamwork.

What do our current nurses value at Palmetto Lowcountry Behavioral Health & UHS?

A safe and supportive environment that puts patient care first and values the nursing profession. One of the most rewarding aspects of working as a Registered Nurse (RN) is providing excellent care, comfort, and security to the patients and families you treat, at their most vulnerable times. You are never alone, as you are part of a large, nationwide network of peer nurses and nursing leaders that educate the field, routinely exchange ideas, and review current topics within the industry. Having the opportunity to grow, learn, and advance in your career through our Charge, Supervisor and Nurse Manager-in-training programs and nursing executive tract. We are proud of our robust continuing education options and opportunities for skills diversification and career advancement as a Registered Nurse (RN) with UHS. We want to help you succeed and grow in your profession and enjoy a sense of belonging and trust that comes through your expanding experience. At UHS, you have a voice.

Please visit us online at www.palmettobehavioralhealth.com. 

One of the nation’s largest and most respected providers of hospital and healthcare services, Universal Health Services, Inc. has built an impressive record of achievement and performance. Growing steadily since its inception into an esteemed Fortune 500 corporation, annual revenues were $11.6 billion in 2020. In 2021, UHS was again recognized as one of the World’s Most Admired Companies by Fortune; in 2020, ranked #281 on the Fortune 500; and listed #330 in Forbes ranking of U.S.’ Largest Public Companies. Headquartered in King of Prussia, PA, UHS has 89,000 employees and through its subsidiaries operates 26 acute care hospitals, 334 behavioral health facilities, 39 outpatient facilities and ambulatory care access points, an insurance offering, a physician network and various related services located in 38 U.S. states, Washington, D.C., Puerto Rico and the United Kingdom.


Qualifications

Education:  Graduate of an accredited college of nursing.  BSN or BS preferred.  Specialty certification also preferred.

Experience:  Minimum of one (1) year of recent experience preferred 

Licensure/Certification:  Current SC RN license or an RN license from a compact state required; CPI training provided upon hire. 

EEO Statement

All UHS subsidiaries are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants and teammates. UHS subsidiaries are equal opportunity employers and as such, openly support and fully commit to recruitment, selection, placement, promotion, and compensation of individuals without regard to race, color, religion, age, sex (including pregnancy, gender identity, and sexual orientation), genetic information, national origin, disability status, protected veteran status or any other characteristic protected by federal, state, or local laws.

We believe that diversity and inclusion among our teammates is critical to our success.

Avoid and Report Recruitment Scams

We are aware of a scam whereby imposters are posing as Recruiters from UHS, and our subsidiary hospitals and facilities. Beware of anyone requesting financial or personal information.

At UHS and all our subsidiaries, our Human Resources departments and recruiters are here to help prospective candidates by matching skill set and experience with the best possible career path at UHS and our subsidiaries. During the recruitment process, no recruiter or employee will request financial or personal information (e.g., Social Security Number, credit card or bank information, etc.) from you via email. Our recruiters will not email you from a public webmail client like Hotmail, Gmail, Yahoo Mail, etc.

If you suspect a fraudulent job posting or job-related email mentioning UHS or its subsidiaries, we encourage you to report such concerns to appropriate law enforcement. We encourage you to refer to legitimate UHS and UHS subsidiary career websites to verify job opportunities and not rely on unsolicited calls from recruiters.

Qualifications:

Education:  Graduate of an accredited college of nursing.  BSN or BS preferred.  Specialty certification also preferred.

Experience:  Minimum of one (1) year of recent experience preferred 

Licensure/Certification:  Current SC RN license or an RN license from a compact state required; CPI training provided upon hire. 

EEO Statement

All UHS subsidiaries are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants and teammates. UHS subsidiaries are equal opportunity employers and as such, openly support and fully commit to recruitment, selection, placement, promotion, and compensation of individuals without regard to race, color, religion, age, sex (including pregnancy, gender identity, and sexual orientation), genetic information, national origin, disability status, protected veteran status or any other characteristic protected by federal, state, or local laws.

We believe that diversity and inclusion among our teammates is critical to our success.

Avoid and Report Recruitment Scams

We are aware of a scam whereby imposters are posing as Recruiters from UHS, and our subsidiary hospitals and facilities. Beware of anyone requesting financial or personal information.

At UHS and all our subsidiaries, our Human Resources departments and recruiters are here to help prospective candidates by matching skill set and experience with the best possible career path at UHS and our subsidiaries. During the recruitment process, no recruiter or employee will request financial or personal information (e.g., Social Security Number, credit card or bank information, etc.) from you via email. Our recruiters will not email you from a public webmail client like Hotmail, Gmail, Yahoo Mail, etc.

If you suspect a fraudulent job posting or job-related email mentioning UHS or its subsidiaries, we encourage you to report such concerns to appropriate law enforcement. We encourage you to refer to legitimate UHS and UHS subsidiary career websites to verify job opportunities and not rely on unsolicited calls from recruiters.

Education:UNAVAILABLEEmployment Type: FULL_TIME

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About Universal Health Services

Sourced by ZipRecruiter

Universal Health Services (UHS) is a major player in the healthcare industry, based in King of Prussia, Pennsylvania, U.S. Founded in 1978, UHS offers hospital and healthcare services. Their diverse services range from acute care hospitals, behavioral health facilities and ambulatory centers nationwide. The company's mission of enhancing the health and well-being of their patients is reflected in their commitment to 'Helping Individuals Live Longer, Healthier and Happier Lives'. Universal Health Services' consistent growth and success in their industry have been recognized on numerous occasions, including being ranked amongst the Fortune 500 list of largest companies.

Industry

Health care and social assistance

Company size

10,000+ Employees

Headquarters location

King of Prussia, PA, US