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Weekend Rn Jobs in Lexington, SC (NOW HIRING)

NHC

WEEKEND RN SUPERVISOR-7A-7P

West Columbia, SC · On-site

Weekend Registered Nurse Are you looking to make a difference in the lives of others by sharing your care and compassion? Do you enjoy connecting with your patients while getting to know them and ...

TotalMed RN

Travel ER RN

Columbia, SC · On-site

TotalMed RN is seeking a travel nurse RN ED - Emergency Department for a travel nursing job in Columbia, South Carolina. & Requirements * Specialty: ED - Emergency Department * Discipline: RN * Start ...

Saratoga Ascend

Registered Nurse

Columbia, SC · On-site

Registered Nurse Opportunities Saratoga Medical (DBA Saratoga Ascend) is hiring Registered Nurses ... week | Every other weekend | 13-week commitment Saratoga Medical Center, Inc. is an equal ...

UHS

Registered Nurse RN Adolescent

West Columbia, SC · On-site

Responsibilities NIGHT Shift RN 7pm - 7:30am Adolescent Inpatient Program This position will float ... Weekday 2nd shift $6.25 & Weekend 2nd shift $9.00 Weekday 3rd shift $7.00 & Weekend 3rd shift $10 ...

UHS

Registered Nurse RN Adolescents

Columbia, SC · On-site

Day Shift RN 7am - 7:30pm **$20,000 Bonus for Full Time RN** This position will float as needed to ... Weekday 2nd shift $6.25 & weekend 2nd shift $9.00 weekday 3rd shift $7.00 & weekend 3rd shift $10 ...

UHS

Registered Nurse RN Adolescent

Columbia, SC · On-site

Night Shift RN Adolescent Inpatient Program This position will float as needed to other units based ... Weekday 2nd shift $6.25 & Weekend 2nd shift $9.00 Weekday 3rd shift $7.00 & Weekend 3rd shift $10 ...

UHS

Registered Nurse RN Adolescent

West Columbia, SC · On-site

Responsibilities NIGHT Shift RN 7pm - 7:30am Adolescent Inpatient Program This position will float ... Weekday 2nd shift $6.25 & Weekend 2nd shift $9.00 Weekday 3rd shift $7.00 & Weekend 3rd shift $10 ...

Saratoga Medical

Registered Nurse

Columbia, SC · On-site

Saratoga Medical (DBA Saratoga Ascend) is hiring Registered Nurses (RNs) for onsite opportunities ... week | Every other weekend | 13-week commitment Saratoga Medical Center, Inc. is an equal ...

Saratoga Medical Center

Registered Nurse

Columbia, SC · On-site

Saratoga Medical (DBA Saratoga Ascend) is hiring Registered Nurses (RNs) for onsite opportunities ... week | Every other weekend | 13-week commitment Saratoga Medical Center, Inc. is an equal ...

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All JobsRn JobsWeekend Rn JobsWeekend Rn Jobs in Lexington, SC

Weekend Rn information

What is a Weekend RN?

A Weekend RN is a registered nurse who primarily works during the weekends, often covering shifts on Saturdays and Sundays. These nurses provide patient care, administer medications, monitor patient progress, and collaborate with doctors and other healthcare staff. Weekend RNs may work in hospitals, nursing homes, or other healthcare facilities, and their schedules are designed to ensure continuous high-quality care throughout the week. Weekend shifts can sometimes offer higher pay rates or shift differentials due to the non-traditional hours.

What does a Weekend RN do?

As a weekend RN, you take shifts on the weekend when other nurses are unavailable, allowing hospitals and other care facilities to provide continuity of care and remain open 24/7. This is usually a part-time position, with most weekend RN's working two 8-12 hour shifts Saturday-Sunday each week. Some facilities also count Friday as a weekend day and offer a three-shift schedule instead. In this role, you may make patient visits, answer telephone calls to provide remote healthcare and address any medical emergencies that occur during your shift as a weekend nurse. As an RN, weekend work usually focuses on hospitals and hospice facilities, but you may find positions that involve traveling to visit patients outside of a clinical setting.

What are the key skills and qualifications needed to thrive as a Weekend RN, and why are they important?

To thrive as a Weekend RN, you need current RN licensure, strong clinical assessment skills, and experience in acute or long-term care settings. Familiarity with electronic health record (EHR) systems and up-to-date certifications such as BLS or ACLS are often required. Excellent time management, adaptability, and communication skills are essential for managing patient care during typically higher-acuity weekend shifts. These competencies ensure patient safety, efficient care delivery, and effective teamwork when staffing levels and resources may be limited.

What are some unique challenges and rewards of working as a Weekend RN compared to a standard weekday nursing position?

Weekend RNs often face a distinct set of challenges, including managing higher patient-to-nurse ratios and handling more acute or urgent cases, as there may be fewer staff and support services available on weekends. However, this role also offers unique rewards, such as greater autonomy, opportunities to hone critical thinking and decision-making skills, and often a more flexible schedule or additional compensation. Weekend RNs typically collaborate closely with a dedicated core team, fostering strong teamwork and communication. This experience can be valuable for career advancement, as it demonstrates adaptability and strong clinical competence in a fast-paced environment.

What is the difference between Weekend Rn vs Weekend Lpn?

AspectWeekend RnWeekend Lpn
Required CredentialsRegistered Nurse license (RN)Licensed Practical Nurse license (LPN)
Work EnvironmentHospitals, clinics, long-term care facilitiesLong-term care, nursing homes, clinics
Employer & Industry UsageHospitals, healthcare agenciesLong-term care facilities, nursing homes
Common Search & Comparison IntentUnderstanding RN roles on weekendsUnderstanding LPN roles on weekends

Weekend Rn and Weekend Lpn roles differ mainly in credentials, with RNs holding a registered nurse license and LPNs holding a practical nurse license. RNs typically perform more complex medical tasks and have broader responsibilities, while LPNs focus on basic patient care. Both roles are common in healthcare settings that require weekend coverage, but RNs generally have more advanced training and scope of practice.

More about Weekend Rn jobs

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The most popular types of Rn jobs in Lexington, SC are:

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For Weekend Rn jobs in Lexington, SC, the most frequently searched job titles are:

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Cities near Lexington, SC with the most Weekend Rn job openings:

Weekend Rn jobs near you
Infographic showing various Weekend Rn job openings in Lexington, SC as of September 2026, with employment types broken down into 63% Full Time, 28% Part Time, and 9% Contract. Highlights an 100% In-person job distribution.

Registered Nurse Home Health - Part-Time/32 Weekend

Lexington, SC • On-site

Medical Services of America
See more jobs at Medical Services of Americaexternal

$66K - $85K/yr

Other

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 2 days ago

Medical Services of America rating

5.5

Company rating: 5.5 out of 10

Based on 20 frontline employees who took The Breakroom Quiz

Job description

Join a Team Where Care Meets Independence

Registered Nurse – Home Health | Lexington, SC

Employment Type: Part-Time/32 Weekend

Salary Range: $66,560 – $85,280


At MSA Home Health, part of the Medical Services of America family, we believe that healing happens best at home. We’re currently seeking a dedicated and experienced Part-Time Weekend Registered Nurse (RN) to join our growing team and provide skilled, patient-centered care to individuals in Lexington and Richland Counties, SC.


As a Home Health RN, you’ll be a trusted guide in a patient’s recovery journey—offering support, clinical expertise, and compassionate care in the comfort of their home. Working under the direction of the Director of Professional Services, you'll help patients regain independence and improve their quality of life while avoiding unnecessary hospital visits.


What You’ll Do:

  • Provide one-on-one skilled nursing care to home health patients.
  • Perform comprehensive initial assessments and develop individualized care plans in coordination with physicians.
  • Monitor, evaluate, and document patient progress and adjust care plans as needed.
  • Deliver education and support to patients and families to empower them in managing care at home.
  • Ensure all care provided aligns with agency policies, clinical guidelines, and physician orders.
  • Participate in rotating on-call responsibilities to ensure continuity of care.


What You Bring:

  • Completion of an accredited nursing program.
  • Active Registered Nurse license in the state of South Carolina.
  • At least 1 year of clinical nursing experience (Home Health experience strongly preferred).
  • A strong sense of independence and a commitment to patient-centered care.
  • Reliable transportation and valid driver’s license.


Why Choose MSA?

We understand that caring for others begins with supporting our own team. That’s why we offer a robust benefits package designed to help you thrive:

  • Generous Paid Time Off
  • Medical, Dental & Vision Insurance
  • Company-Paid Life Insurance
  • Additional Voluntary Benefits (STD, LTD, Accident, etc.)
  • 401(k) with Company Match
  • Profit Sharing Program
  • Ongoing Education & Career Growth Opportunities
  • Supportive Team Environment


At MSA Home Health, you’re not just making visits—you’re making a difference.


Help patients heal where they feel most comfortable: at home.


Medical Services of America is proud to be an Equal Opportunity Employer.

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