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Weekend Rn Jobs in Florence, SC (NOW HIRING)

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Weekend Rn information

See Florence, SC salary details

$24

$38

$63

How much do weekend rn jobs pay per hour?

As of May 29, 2026, the average hourly pay for weekend rn in Florence, SC is $38.05, according to ZipRecruiter salary data. Most workers in this role earn between $30.20 and $43.92 per hour, depending on experience, location, and employer.

What Does a Weekend RN Do?

As a weekend RN, you take shifts on the weekend when other nurses are unavailable, allowing hospitals and other care facilities to provide continuity of care and remain open 24/7. This is usually a part-time position, with most weekend RN's working two 8-12 hour shifts Saturday-Sunday each week. Some facilities also count Friday as a weekend day and offer a three-shift schedule instead. In this role, you may make patient visits, answer telephone calls to provide remote healthcare and address any medical emergencies that occur during your shift as a weekend nurse. As an RN, weekend work usually focuses on hospitals and hospice facilities, but you may find positions that involve traveling to visit patients outside of a clinical setting.

What are the key skills and qualifications needed to thrive as a Weekend RN, and why are they important?

To thrive as a Weekend RN, you need current RN licensure, strong clinical assessment skills, and experience in acute or long-term care settings. Familiarity with electronic health record (EHR) systems and up-to-date certifications such as BLS or ACLS are often required. Excellent time management, adaptability, and communication skills are essential for managing patient care during typically higher-acuity weekend shifts. These competencies ensure patient safety, efficient care delivery, and effective teamwork when staffing levels and resources may be limited.

What are some unique challenges and rewards of working as a Weekend RN compared to a standard weekday nursing position?

Weekend RNs often face a distinct set of challenges, including managing higher patient-to-nurse ratios and handling more acute or urgent cases, as there may be fewer staff and support services available on weekends. However, this role also offers unique rewards, such as greater autonomy, opportunities to hone critical thinking and decision-making skills, and often a more flexible schedule or additional compensation. Weekend RNs typically collaborate closely with a dedicated core team, fostering strong teamwork and communication. This experience can be valuable for career advancement, as it demonstrates adaptability and strong clinical competence in a fast-paced environment.

What is a Weekend RN?

A Weekend RN is a registered nurse who primarily works during the weekends, often covering shifts on Saturdays and Sundays. These nurses provide patient care, administer medications, monitor patient progress, and collaborate with doctors and other healthcare staff. Weekend RNs may work in hospitals, nursing homes, or other healthcare facilities, and their schedules are designed to ensure continuous high-quality care throughout the week. Weekend shifts can sometimes offer higher pay rates or shift differentials due to the non-traditional hours.

How to make an extra $1000 a month as a nurse?

Weekend RNs can increase their income by taking on additional shifts, working overtime, or picking up per diem assignments. Gaining specialized certifications, such as in IV therapy or wound care, can also qualify you for higher-paying roles or agency work, helping you reach your income goal more quickly.

What is the difference between Weekend Rn vs Weekend Lpn?

AspectWeekend RnWeekend Lpn
Required CredentialsRegistered Nurse license (RN)Licensed Practical Nurse license (LPN)
Work EnvironmentHospitals, clinics, long-term care facilitiesLong-term care, nursing homes, clinics
Employer & Industry UsageHospitals, healthcare agenciesLong-term care facilities, nursing homes
Common Search & Comparison IntentUnderstanding RN roles on weekendsUnderstanding LPN roles on weekends

Weekend Rn and Weekend Lpn roles differ mainly in credentials, with RNs holding a registered nurse license and LPNs holding a practical nurse license. RNs typically perform more complex medical tasks and have broader responsibilities, while LPNs focus on basic patient care. Both roles are common in healthcare settings that require weekend coverage, but RNs generally have more advanced training and scope of practice.

What are the most commonly searched types of Rn jobs in Florence, SC? The most popular types of Rn jobs in Florence, SC are:
What are popular job titles related to Weekend Rn jobs in Florence, SC? For Weekend Rn jobs in Florence, SC, the most frequently searched job titles are:
What cities near Florence, SC are hiring for Weekend Rn jobs? Cities near Florence, SC with the most Weekend Rn job openings:
Infographic showing various Weekend Rn job openings in Florence, SC as of May 2026, with employment types broken down into 2% As Needed, 62% Full Time, 7% Part Time, and 29% Contract. Highlights an 100% In-person job distribution, with an average salary of $79,149 per year, or $38.1 per hour.
Weekend Registered Nurse (RN) MUSC Florence Inpatient Oncology - FT Days

Weekend Registered Nurse (RN) MUSC Florence Inpatient Oncology - FT Days

IntelyCare

Florence, SC

Other

Medical, Retirement

Posted 22 days ago


Job description

Weekend Only Registered Nurse Opportunity

Outstanding opportunity for an experienced Registered Nurse interested in a Weekend Only Program. Eligible for full-time benefits and shift differentials.

Medical University Hospital Authority (MUHA)

Worker Type: Employee

Worker Sub-Type: Regular

Cost Center: CC003592 FLO - MedSurg 6th Floor (FMC)

Pay Rate Type: Hourly

Pay Grade: Health-28

Scheduled Weekly Hours: 36

Work Shift: Job Description

MUSC Florence is looking for experienced Registered Nurses to join their Weekend Option Program - Inpatient Oncology Unit.

Schedule:

  • 36 hours per week; choose between a schedule of Friday, Saturday, Sunday or Saturday, Sunday, Monday.
  • Day and Night shift opportunities available.

Incentives:

  • Up to $25,000 RN Student Loan Repayment for those who qualify
  • Tuition Reimbursement Program if you would like to further your education
  • Great State Health Benefits and Retirement Plan
  • Up to 6 weeks paid parental leave
  • Free Telehealth appointments for you and your family
  • Onsite Pharmacy
  • Education Assistance

Registered Nurses for non-MAGNET facilities. Provides nursing care to patients using the nursing process (assessment, planning, implementation, and evaluation). Directs and leads other assigned team members and collaborates with multidisciplinary team members to provide age/developmentally appropriate care in accordance with nursing standards of care and practice. Provide patient/family centered care using the nursing process and focusing on the physical, emotional, spiritual, cultural, religious, and environmental needs. This includes providing for the assessment, development of nursing diagnoses, outcome identification, planning, implementation of interventions, coordination of care, health teaching and promotion and evaluation of goals and interventions consistent with the policies of MUSC. Maintains a safe, therapeutic, and healing environment through ensuring patient privacy and responsive, respectful, accepting, and professional behavior. Demonstrates the ability to function in a professional setting through active participation in a professional practice model. This includes participating in shared governance, adherence to standards of care, participation in peer review and professional development promoting leadership and clinical excellence, effective team skills, autonomous practice and acknowledgment of accountability for actions and critical thinking. Coordinates the effective and efficient delivery of patient care services through the application of care management principles. Identifies clinical priorities and initiates action to improve patient outcomes. Demonstrates ability to function in a professional practice model through active participation in shared governance, promotion of a healthy work environment and acceptance of personal responsibility for professional growth.

Minimum Requirements: Associate's Degree, and a minimum of one year of work experience as a registered nurse required. Licensure as a registered nurse by the South Carolina Board of Nursing or a compact state. Current American Heart Association (AHA) Basic Life Support (BLS) certification or American Red Cross BLS for Healthcare Providers certification is required.

Qualifications:

  • South Carolina or compact state Registered Nurse license
  • BLS from the American Heart Association
  • Hospital RN experience preferred

Physical Requirements:

  • Ability to stand or sit for extended periods of time.
  • Proficiency in manual dexterity and fine motor skills for tasks such as taking patient vitals, administering injections, or conducting physical exams.
  • Capacity to lift and move patients or medical equipment as needed.
  • Visual acuity and color perception to accurately read medical charts, documents, and monitors.
  • Auditory ability to effectively communicate with patients and colleagues, as well as to perceive important sounds such as alarms or patient instructions.
  • Stamina and resilience to handle the physical and emotional demands of providing patient care, including long shifts and potentially stressful situations.
  • Mobility to navigate clinical environments, including moving between patient rooms, offices, and other areas of the facility.
  • Compliance with infection control protocols and proper use of personal protective equipment to maintain a safe and healthy work environment.

If you like working with energetic enthusiastic individuals, you will enjoy your career with us!

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.


IntelyCare logo

About IntelyCare

Sourced by ZipRecruiter

At IntelyCare, we're empowering healthcare heroes to transform the way they work. IntelyCare simplifies the scheduling and staffing process to match qualified nursing professionals like you with shifts at our nursing facilities. Available shift options include per-diem, contract, short-term, long-term, temporary to permanent and in some cases, travel. With IntelyCare, you'll get the pay, freedom, and flexibility you deserve--all from one intelligent and easy-to-use mobile app.

Industry

Recruiting and staffing services

Company size

10,000+ Employees

Headquarters location

Quincy, MA, US

Year founded

2014