ZipRecruiter

Log In

1

Weekend Rn Jobs in Florence, SC (NOW HIRING)

TNAA TotalMed RN

Travel Operating Room RN

Florence, SC · On-site

TNAA TotalMed RN is seeking a travel nurse RN OR - Operating Room for a travel nursing job in Florence, South Carolina. & Requirements * Specialty: OR - Operating Room * Discipline: RN * Duration: 13 ...

TNAA TotalMed RN

Travel Operating Room RN

Florence, SC · On-site

TNAA TotalMed RN is seeking a travel nurse RN OR - Operating Room for a travel nursing job in Florence, South Carolina. & Requirements * Specialty: OR - Operating Room * Discipline: RN * Duration: 13 ...

Ironside Human Resources

Registered Nurse

Hartsville, SC · On-site

$30/hr

Stackable shift differentials: nights (+$6.00), weekends (+$4.00) * Up to $25,000 Sign-On Bonus * Relocation assistance available Registered Nurse Job Opportunity: * Registered Nurse seeks to provide ...

Ironside HR

Registered Nurse

Hartsville, SC · On-site

$30/hr

Stackable shift differentials: nights (+$6.00), weekends (+$4.00) * Up to $25, 000 Sign-On Bonus * Relocation assistance available Registered Nurse Job Opportunity: * Registered Nurse seeks to ...

next page

Showing results 1-20

All JobsRn JobsWeekend Rn JobsWeekend Rn Jobs in Florence, SC

Weekend Rn information

See Florence, SC salary details

$24

$38

$63

How much do weekend rn jobs pay per hour?

As of Aug 20, 2026, the average hourly pay for weekend rn in Florence, SC is $38.05, according to ZipRecruiter salary data. Most workers in this role earn between $30.20 and $43.92 per hour, depending on experience, location, and employer.

What is a Weekend RN?

A Weekend RN is a registered nurse who primarily works during the weekends, often covering shifts on Saturdays and Sundays. These nurses provide patient care, administer medications, monitor patient progress, and collaborate with doctors and other healthcare staff. Weekend RNs may work in hospitals, nursing homes, or other healthcare facilities, and their schedules are designed to ensure continuous high-quality care throughout the week. Weekend shifts can sometimes offer higher pay rates or shift differentials due to the non-traditional hours.

What does a Weekend RN do?

As a weekend RN, you take shifts on the weekend when other nurses are unavailable, allowing hospitals and other care facilities to provide continuity of care and remain open 24/7. This is usually a part-time position, with most weekend RN's working two 8-12 hour shifts Saturday-Sunday each week. Some facilities also count Friday as a weekend day and offer a three-shift schedule instead. In this role, you may make patient visits, answer telephone calls to provide remote healthcare and address any medical emergencies that occur during your shift as a weekend nurse. As an RN, weekend work usually focuses on hospitals and hospice facilities, but you may find positions that involve traveling to visit patients outside of a clinical setting.

What are the key skills and qualifications needed to thrive as a Weekend RN, and why are they important?

To thrive as a Weekend RN, you need current RN licensure, strong clinical assessment skills, and experience in acute or long-term care settings. Familiarity with electronic health record (EHR) systems and up-to-date certifications such as BLS or ACLS are often required. Excellent time management, adaptability, and communication skills are essential for managing patient care during typically higher-acuity weekend shifts. These competencies ensure patient safety, efficient care delivery, and effective teamwork when staffing levels and resources may be limited.

What are some unique challenges and rewards of working as a Weekend RN compared to a standard weekday nursing position?

Weekend RNs often face a distinct set of challenges, including managing higher patient-to-nurse ratios and handling more acute or urgent cases, as there may be fewer staff and support services available on weekends. However, this role also offers unique rewards, such as greater autonomy, opportunities to hone critical thinking and decision-making skills, and often a more flexible schedule or additional compensation. Weekend RNs typically collaborate closely with a dedicated core team, fostering strong teamwork and communication. This experience can be valuable for career advancement, as it demonstrates adaptability and strong clinical competence in a fast-paced environment.

What is the difference between Weekend Rn vs Weekend Lpn?

AspectWeekend RnWeekend Lpn
Required CredentialsRegistered Nurse license (RN)Licensed Practical Nurse license (LPN)
Work EnvironmentHospitals, clinics, long-term care facilitiesLong-term care, nursing homes, clinics
Employer & Industry UsageHospitals, healthcare agenciesLong-term care facilities, nursing homes
Common Search & Comparison IntentUnderstanding RN roles on weekendsUnderstanding LPN roles on weekends

Weekend Rn and Weekend Lpn roles differ mainly in credentials, with RNs holding a registered nurse license and LPNs holding a practical nurse license. RNs typically perform more complex medical tasks and have broader responsibilities, while LPNs focus on basic patient care. Both roles are common in healthcare settings that require weekend coverage, but RNs generally have more advanced training and scope of practice.

More about Weekend Rn jobs

What are the most commonly searched types of Rn jobs in Florence, SC?

The most popular types of Rn jobs in Florence, SC are:

What are popular job titles related to Weekend Rn jobs in Florence, SC?

For Weekend Rn jobs in Florence, SC, the most frequently searched job titles are:

What job categories do people searching Weekend Rn jobs in Florence, SC look for?

The top searched job categories for Weekend Rn jobs in Florence, SC are:

What cities near Florence, SC are hiring for Weekend Rn jobs?

Cities near Florence, SC with the most Weekend Rn job openings:

Weekend Rn jobs near you
Infographic showing various Weekend Rn job openings in Florence, SC as of August 2026, with employment types broken down into 59% Full Time, 14% Part Time, and 27% Contract. Highlights an 98% In-person, and 2% Hybrid job distribution, with an average salary of $79,149 per year, or $38.1 per hour.

Registered Nurse (RN) / Weekend Nights Only

Regency Hospital - Florence

Florence, SC • On-site

$40.17 - $53/hr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 17 hours ago

Job description

Overview

Position: Registered Nurse (RN)

Location: Regency Hospital - Florence 

Schedule: Weekends Only - Friday, Saturday, Sunday 

7pm - 7amCompensation: $40.17 to $53.00 per hour, depending on years of experience + shift differential

Sign-on bonus: $20,000

Regency Hospital - Florence is a critical illness recovery hospital committed to providing world-class inpatient post-ICU services to chronic, critically ill patients who require extended healing and recovery. We help patients during some of the most vulnerable, painful moments of their lives - and Registered Nurses (RNs) play a central role in providing compassionate, excellent treatment every step of the way.

At our company, we support your career growth and personal well-being.

  • Start Strong: Extensive and thorough Registered Nurse (RN) orientation program to ensure a smooth transition into our setting.
  • Advance Your Career:100% company-paid scholarship (BSN), tuition reimbursement, and continuing education.
  • Elevate Your Skills: Clinical ladder program and certifications such as PCCN and CCRN.
  • Ease the Burden: Student Debt benefit program.
  • Recharge & Refresh: Generous PTO for full-time team members to maintain a healthy work-life balance
  • Your Health Matters: Comprehensive medical/RX, health, vision, and dental plan offerings for full-time team members
  • Invest in Your Future: Company-matching 401(k) retirement plan, as well as life and disability protection for full-time team members
  • Your Impact Matters: Join a team of over 44,000 committed to providing exceptional patient care
Responsibilities
  • Receive admissions and/or transfers to the unit
  • Initial and ongoing systematic patient assessment
  • Timely and accurate documentation using appropriate systems
  • Interpret assessment/diagnostic data including labs and telemetry
  • Ensure medical orders are transcribed and processed accurately
  • Competence in Rapid Response and code events
  • Instruct and counsel patients/families
  • Performs other duties as assigned
Qualifications

Minimum Qualifications:

  • Valid State Registered Nurse (RN) License
  • BLS is required at hire.
  • ACLS is required within 6 months of hire

Preferred Qualifications:

  • Clinical experience
Additional Data

Equal Opportunity Employer/including Disabled/Veterans

Employment Type: OTHER

Apply