1

Weekend Rn Jobs in Florence, SC (NOW HIRING)

🌟 Registered Nurse (RN) New Grads Welcome | Experienced Nurses Valued Are you a newly licensed RN ready to launch your career? Or an experienced nurse seeking a supportive, team-focused ...

Registered Nurse (RN) Location: Regency Hospital - Florence Schedule: Full-Time Nights - 7 p.m. - 7 a.m. Compensation: $40.17 to $53.00 per hour, depending on years of experience Sign-on bonus: $20 ...

Registered Nurse (RN) Location: Regency Hospital - Florence Schedule: Full-Time Nights - 7 p.m. - 7 a.m. Compensation: $40.17 to $53.00 per hour, depending on years of experience Sign-on bonus: $20 ...

next page

Showing results 1-20

Weekend Rn information

See Florence, SC salary details

$24

$38

$63

How much do weekend rn jobs pay per hour?

As of May 29, 2026, the average hourly pay for weekend rn in Florence, SC is $38.05, according to ZipRecruiter salary data. Most workers in this role earn between $30.20 and $43.92 per hour, depending on experience, location, and employer.

What Does a Weekend RN Do?

As a weekend RN, you take shifts on the weekend when other nurses are unavailable, allowing hospitals and other care facilities to provide continuity of care and remain open 24/7. This is usually a part-time position, with most weekend RN's working two 8-12 hour shifts Saturday-Sunday each week. Some facilities also count Friday as a weekend day and offer a three-shift schedule instead. In this role, you may make patient visits, answer telephone calls to provide remote healthcare and address any medical emergencies that occur during your shift as a weekend nurse. As an RN, weekend work usually focuses on hospitals and hospice facilities, but you may find positions that involve traveling to visit patients outside of a clinical setting.

What are the key skills and qualifications needed to thrive as a Weekend RN, and why are they important?

To thrive as a Weekend RN, you need current RN licensure, strong clinical assessment skills, and experience in acute or long-term care settings. Familiarity with electronic health record (EHR) systems and up-to-date certifications such as BLS or ACLS are often required. Excellent time management, adaptability, and communication skills are essential for managing patient care during typically higher-acuity weekend shifts. These competencies ensure patient safety, efficient care delivery, and effective teamwork when staffing levels and resources may be limited.

What are some unique challenges and rewards of working as a Weekend RN compared to a standard weekday nursing position?

Weekend RNs often face a distinct set of challenges, including managing higher patient-to-nurse ratios and handling more acute or urgent cases, as there may be fewer staff and support services available on weekends. However, this role also offers unique rewards, such as greater autonomy, opportunities to hone critical thinking and decision-making skills, and often a more flexible schedule or additional compensation. Weekend RNs typically collaborate closely with a dedicated core team, fostering strong teamwork and communication. This experience can be valuable for career advancement, as it demonstrates adaptability and strong clinical competence in a fast-paced environment.

What is a Weekend RN?

A Weekend RN is a registered nurse who primarily works during the weekends, often covering shifts on Saturdays and Sundays. These nurses provide patient care, administer medications, monitor patient progress, and collaborate with doctors and other healthcare staff. Weekend RNs may work in hospitals, nursing homes, or other healthcare facilities, and their schedules are designed to ensure continuous high-quality care throughout the week. Weekend shifts can sometimes offer higher pay rates or shift differentials due to the non-traditional hours.

How to make an extra $1000 a month as a nurse?

Weekend RNs can increase their income by taking on additional shifts, working overtime, or picking up per diem assignments. Gaining specialized certifications, such as in IV therapy or wound care, can also qualify you for higher-paying roles or agency work, helping you reach your income goal more quickly.

What is the difference between Weekend Rn vs Weekend Lpn?

AspectWeekend RnWeekend Lpn
Required CredentialsRegistered Nurse license (RN)Licensed Practical Nurse license (LPN)
Work EnvironmentHospitals, clinics, long-term care facilitiesLong-term care, nursing homes, clinics
Employer & Industry UsageHospitals, healthcare agenciesLong-term care facilities, nursing homes
Common Search & Comparison IntentUnderstanding RN roles on weekendsUnderstanding LPN roles on weekends

Weekend Rn and Weekend Lpn roles differ mainly in credentials, with RNs holding a registered nurse license and LPNs holding a practical nurse license. RNs typically perform more complex medical tasks and have broader responsibilities, while LPNs focus on basic patient care. Both roles are common in healthcare settings that require weekend coverage, but RNs generally have more advanced training and scope of practice.

What are the most commonly searched types of Rn jobs in Florence, SC? The most popular types of Rn jobs in Florence, SC are:
What are popular job titles related to Weekend Rn jobs in Florence, SC? For Weekend Rn jobs in Florence, SC, the most frequently searched job titles are:
What cities near Florence, SC are hiring for Weekend Rn jobs? Cities near Florence, SC with the most Weekend Rn job openings:
Infographic showing various Weekend Rn job openings in Florence, SC as of May 2026, with employment types broken down into 2% As Needed, 62% Full Time, 7% Part Time, and 29% Contract. Highlights an 100% In-person job distribution, with an average salary of $79,149 per year, or $38.1 per hour.

$34/hr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 3 days ago


Job description

Working in harmony with the entire nursing staff, the Registered Nurse RN strives to provide the very best care possible. If you are a Registered Nurse RN with a true passion for patient care and compassion for others, with a commitment to teamwork, apply today!


USD $34.00 - USD $34.00 /Hr.
The wage range for this role takes into account the wide range of factors that are considered in making compensation decisions including, but not limited to, skill sets, experience, education and training, licensure and certifications, and other business and organizational needs.

  • Work under direct supervision using the state-specific Nurse Practice Act, Practice Guidelines and nursing judgment
  • Deliver nursing care to patients requiring care, collecting patient data, making observations and reporting pertinent information to the care of patients
  • Direct and supervise care given by other nursing staff members as needed

  • Must be a licensed RN in good standing with the state (as required)
  • 1+ years of nursing experience in a long-term care facility strongly preferred
  • Reliable transportation required

All of our employees are valued and receive a competitive wage; full time team members are also offered a comprehensive benefit package which includes: 

  • Medical, Dental, Vision, Life and Disability Insurance/ Flexible Spending Accounts
  • Tuition Reimbursement & Nursing Loan Repayment Programs
  • PerkSpot - Local Deals and Weekly Perks Program
  • 401(k)
  • Paid Time Off Plan
  • New Pet Insurance Discount available
  • DailyPay option available! – Get your pay, when you need it.
  • Purchasing Power - online purchase/payroll deduction
  • Tickets at Work - entertainment ticket discounts
  • Employee Assistance Plan - easy-to-use services to help with everyday challenges of life (available for all employees and their families) 
  • Helping Friends Foundation - our employees’ hardship/crisis fund
  • Auto and Home Insurance - employee discount available – payroll deduction!
  • In-facility education programs and more!

Drug Free, Smoke-Free work place. Equal Opportunity Employer, including disability/vets