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Weekend Rn Jobs in Florence, SC (NOW HIRING)

CARLYLE SENIOR CARE

Registered Nurse (RN)

Fork, SC

$33 - $35/hr

We are currently offering a $5,000 Sign-On Bonus to Full-Time RN's Positions Available: Full Time 1st Shift - works Monday-Friday ONLY from 7am-3pm ( No Weekends ) and eligible for full benefits ...

MUSC

RN

Florence, SC

Summary Outstanding opportunity for an experienced Registered Nurse interested in a Weekend Only Program. Eligible for full-time benefits and shift differentials. Please contact Recruiter Shannon ...

MUSC

Registered Nurse - Hiring Now!

Florence, SC

Summary Outstanding opportunity for an experienced Registered Nurse interested in a Weekend Only Program. Eligible for full-time benefits and shift differentials. Please contact Recruiter Shannon ...

Encompass Health

Registered Nurse

Florence, SC

Registered Nurse Career Opportunity * $10,000 Sign On Bonus for Full Time Night Shift * Short Term ... Weekend + 1 Option Available Encompass Health: Where Nursing Meets Heart, Home, and Healing Are you ...

Encompass Health

Registered Nurse

Florence, SC · On-site

Registered Nurse Career Opportunity * $10,000 Sign On Bonus for Full Time Night Shift * Short Term ... Weekend + 1 Option Available Encompass Health: Where Nursing Meets Heart, Home, and Healing Are you ...

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Weekend Rn information

See Florence, SC salary details

$24

$38

$63

How much do weekend rn jobs pay per hour?

As of May 30, 2026, the average hourly pay for weekend rn in Florence, SC is $38.05, according to ZipRecruiter salary data. Most workers in this role earn between $30.20 and $43.92 per hour, depending on experience, location, and employer.

What Does a Weekend RN Do?

As a weekend RN, you take shifts on the weekend when other nurses are unavailable, allowing hospitals and other care facilities to provide continuity of care and remain open 24/7. This is usually a part-time position, with most weekend RN's working two 8-12 hour shifts Saturday-Sunday each week. Some facilities also count Friday as a weekend day and offer a three-shift schedule instead. In this role, you may make patient visits, answer telephone calls to provide remote healthcare and address any medical emergencies that occur during your shift as a weekend nurse. As an RN, weekend work usually focuses on hospitals and hospice facilities, but you may find positions that involve traveling to visit patients outside of a clinical setting.

What are the key skills and qualifications needed to thrive as a Weekend RN, and why are they important?

To thrive as a Weekend RN, you need current RN licensure, strong clinical assessment skills, and experience in acute or long-term care settings. Familiarity with electronic health record (EHR) systems and up-to-date certifications such as BLS or ACLS are often required. Excellent time management, adaptability, and communication skills are essential for managing patient care during typically higher-acuity weekend shifts. These competencies ensure patient safety, efficient care delivery, and effective teamwork when staffing levels and resources may be limited.

What are some unique challenges and rewards of working as a Weekend RN compared to a standard weekday nursing position?

Weekend RNs often face a distinct set of challenges, including managing higher patient-to-nurse ratios and handling more acute or urgent cases, as there may be fewer staff and support services available on weekends. However, this role also offers unique rewards, such as greater autonomy, opportunities to hone critical thinking and decision-making skills, and often a more flexible schedule or additional compensation. Weekend RNs typically collaborate closely with a dedicated core team, fostering strong teamwork and communication. This experience can be valuable for career advancement, as it demonstrates adaptability and strong clinical competence in a fast-paced environment.

What is a Weekend RN?

A Weekend RN is a registered nurse who primarily works during the weekends, often covering shifts on Saturdays and Sundays. These nurses provide patient care, administer medications, monitor patient progress, and collaborate with doctors and other healthcare staff. Weekend RNs may work in hospitals, nursing homes, or other healthcare facilities, and their schedules are designed to ensure continuous high-quality care throughout the week. Weekend shifts can sometimes offer higher pay rates or shift differentials due to the non-traditional hours.

How to make an extra $1000 a month as a nurse?

Weekend RNs can increase their income by taking on additional shifts, working overtime, or picking up per diem assignments. Gaining specialized certifications, such as in IV therapy or wound care, can also qualify you for higher-paying roles or agency work, helping you reach your income goal more quickly.

What is the difference between Weekend Rn vs Weekend Lpn?

AspectWeekend RnWeekend Lpn
Required CredentialsRegistered Nurse license (RN)Licensed Practical Nurse license (LPN)
Work EnvironmentHospitals, clinics, long-term care facilitiesLong-term care, nursing homes, clinics
Employer & Industry UsageHospitals, healthcare agenciesLong-term care facilities, nursing homes
Common Search & Comparison IntentUnderstanding RN roles on weekendsUnderstanding LPN roles on weekends

Weekend Rn and Weekend Lpn roles differ mainly in credentials, with RNs holding a registered nurse license and LPNs holding a practical nurse license. RNs typically perform more complex medical tasks and have broader responsibilities, while LPNs focus on basic patient care. Both roles are common in healthcare settings that require weekend coverage, but RNs generally have more advanced training and scope of practice.

More about Weekend Rn jobs
What are the most commonly searched types of Rn jobs in Florence, SC? The most popular types of Rn jobs in Florence, SC are:
What are popular job titles related to Weekend Rn jobs in Florence, SC? For Weekend Rn jobs in Florence, SC, the most frequently searched job titles are:
What job categories do people searching Weekend Rn jobs in Florence, SC look for? The top searched job categories for Weekend Rn jobs in Florence, SC are:
What cities near Florence, SC are hiring for Weekend Rn jobs? Cities near Florence, SC with the most Weekend Rn job openings:
Weekend Rn jobs near you
Infographic showing various Weekend Rn job openings in Florence, SC as of May 2026, with employment types broken down into 2% As Needed, 62% Full Time, 7% Part Time, and 29% Contract. Highlights an 100% In-person job distribution, with an average salary of $79,149 per year, or $38.1 per hour.
Registered Nurse Weekend Option - Medical Surgical Units (FT)

Registered Nurse Weekend Option - Medical Surgical Units (FT)

MUSC

Florence, SC

Full-time

Medical, Retirement

Posted 18 days ago

MUSC Health rating

6.8

Company rating: 6.8 out of 10

Based on 192 frontline employees who took The Breakroom Quiz

488th of 864 rated healthcare providers

Job description

Job Description Summary

Outstanding opportunity for an experienced Registered Nurse interested in a Weekend Only Program. Eligible for full-time benefits and shift differentials. Please contact Recruiter Shannon Shaw at 843-674-2694 or shawsh@musc.edu for more information!

Entity

Medical University Hospital Authority (MUHA)

Worker Type

Employee

Worker Sub-Type​

Regular

Cost Center

CC003626 FLO - Nursing Administration (FMC)

Pay Rate Type

Hourly

Pay Grade

Health-28

Scheduled Weekly Hours

36

Work Shift

Job Description

MUSC Florence is looking for experienced Registered Nurses to join their Weekend Option Program - Medical/Surgical Units.

Schedule

  • 36 hours per week; choose between a schedule of Friday, Saturday, Sunday or Saturday, Sunday, Monday.
  • Day and Night shift opportunities available.

RN Opportunities

  • General Surgery/GYN
  • Cardiac/Observation
  • Orthopedics/Neurology/Stroke Unit
  • Nephrology

Incentives

  • Up to $25,000 RN Student Loan Repayment for those who qualify
  • Tuition Reimbursement Program if you would like to further your education
  • Great State Health Benefits and Retirement Plan
  • Up to 6 weeks paid parental leave
  • Free Telehealth appointments for you and your family
  • Onsite Pharmacy

Additional Job Description

Qualifications

  • South Carolina or compact state Registered Nurse license
  • BLS from the American Heart Association
  • Hospital RN experience preferred

If you like working with energetic enthusiastic individuals, you will enjoy your career with us!

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.

Medical University of South Carolina participates in the federal E-Verify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program, please click here: http://www.uscis.gov/e-verify/employees

What MUSC Health employees say

Pay

Benefits

Hours and flexibility

Workplace

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About MUSC Health

Sourced by ZipRecruiter

MUSC is located in Charleston, SC, frequently named one of the best places in America to live. If charming, historic, vibrant, cultural, and coastal are adjectives that you find appealing, it's all here. In Charleston, you might find yourself dining at a world class restaurant tonight and relaxing on a boat as you explore our many waterways tomorrow. You might stroll along cobblestone streets, amidst centuries old homes by day and attend a jazz concert by night. Charleston is a place where you can live your life to its fullest.

Industry

Hospitality services

Company size

10,000+ Employees

Headquarters location

Charleston, SC, US

Year founded

1824

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