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Weekend Rn Jobs in Florence, SC (NOW HIRING)

Ironside Human Resources

Registered Nurse

Hartsville, SC · On-site

$30 - $45/hr

Stackable shift differentials: nights (+$6.00), weekends (+$4.00) * Up to $25,000 Sign-On Bonus * Relocation assistance available Registered Nurse Job Opportunity: * Registered Nurse seeks to provide ...

CARLYLE SENIOR CARE

Registered Nurse (RN)

Fork, SC · On-site

$33 - $35/hr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

We are currently offering a $5,000 Sign-On Bonus to Full-Time RN's Positions Available: Full Time 1st Shift - works Monday-Friday ONLY from 7am-3pm ( No Weekends ) and eligible for full benefits ...

Ironside Human Resources

Registered Nurse

Hartsville, SC · On-site

$30/hr

Stackable shift differentials: nights (+$6.00), weekends (+$4.00) \n * Up to $25,000 Sign\-On Bonus \n * Relocation assistance available \n Registered Nurse Job Opportunity: \n \n * Registered Nurse ...

HeartCentrix Solutions

Registered Nurse

Florence, SC · On-site

$45.50 - $50.57/hr

  • Medical

M-F, 8 AM-5 PM Hours: 40 hours guaranteed On-call: Every other week/weekend License: SC RN Territory: Florence, Marion, Dillon & Marlboro counties Mileage: $0.48/mile Productivity: 30 units Required ...

MUSC

RN

Florence, SC

  • Medical

  • Retirement

Summary Outstanding opportunity for an experienced Registered Nurse interested in a Weekend Only Program. Eligible for full-time benefits and shift differentials. Please contact Recruiter Shannon ...

Rezult Group, Inc.

AntePartum Registered Nurse RN

Florence, SC · On-site

$56/hr

  • Medical

  • Dental

  • Vision

  • Retirement

M-F 9 am - 9:30 pm (3x12s) plus some weekend shifts and on call · Benefits: Weekly Pay, Medical ... of OR RN experience with general, neuro, ortho, robotics etc. experience · Active RN in SC or ...

New

MUSC

Registered Nurse - Hiring Now!

Florence, SC

  • Medical

  • Retirement

Summary Outstanding opportunity for an experienced Registered Nurse interested in a Weekend Only Program. Eligible for full-time benefits and shift differentials. Please contact Recruiter Shannon ...

Encompass Health

Registered Nurse

Florence, SC

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Registered Nurse Career Opportunity * $10,000 Sign On Bonus for Full Time Night Shift * Short Term ... Weekend + 1 Option Available Encompass Health: Where Nursing Meets Heart, Home, and Healing Are you ...

Encompass Health

Registered Nurse

Florence, SC · On-site

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Registered Nurse Career Opportunity * $10,000 Sign On Bonus for Full Time Night Shift * Short Term ... Weekend + 1 Option Available Encompass Health: Where Nursing Meets Heart, Home, and Healing Are you ...

Encompass Health Corporation

Registered Nurse

Florence, SC · On-site

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Registered Nurse Career Opportunity * $10,000 Sign On Bonus for Full Time Night Shift * Short Term ... Weekend + 1 Option Available Encompass Health: Where Nursing Meets Heart, Home, and Healing Are you ...

Faith Health Care Center

Registered Nurse RN

Florence, SC

$34 - $37/hr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

If you are a Registered Nurse RN with a true passion for patient care and compassion for others, with a commitment to teamwork, apply today! USD $34.00 - USD $37.00 /Hr. The wage range for this role ...

Faith Healthcare Center

Registered Nurse RN

Florence, SC · On-site

$34 - $37/hr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

If you are a Registered Nurse RN with a true passion for patient care and compassion for others, with a commitment to teamwork, apply today! Posted Salary Range USD $34.00 - USD $37.00 /Hr. Wage ...

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All JobsRn JobsWeekend Rn JobsWeekend Rn Jobs in Florence, SC

Weekend Rn information

See Florence, SC salary details

$24

$38

$63

How much do weekend rn jobs pay per hour?

As of Aug 20, 2026, the average hourly pay for weekend rn in Florence, SC is $38.05, according to ZipRecruiter salary data. Most workers in this role earn between $30.20 and $43.92 per hour, depending on experience, location, and employer.

What is a Weekend RN?

A Weekend RN is a registered nurse who primarily works during the weekends, often covering shifts on Saturdays and Sundays. These nurses provide patient care, administer medications, monitor patient progress, and collaborate with doctors and other healthcare staff. Weekend RNs may work in hospitals, nursing homes, or other healthcare facilities, and their schedules are designed to ensure continuous high-quality care throughout the week. Weekend shifts can sometimes offer higher pay rates or shift differentials due to the non-traditional hours.

What does a Weekend RN do?

As a weekend RN, you take shifts on the weekend when other nurses are unavailable, allowing hospitals and other care facilities to provide continuity of care and remain open 24/7. This is usually a part-time position, with most weekend RN's working two 8-12 hour shifts Saturday-Sunday each week. Some facilities also count Friday as a weekend day and offer a three-shift schedule instead. In this role, you may make patient visits, answer telephone calls to provide remote healthcare and address any medical emergencies that occur during your shift as a weekend nurse. As an RN, weekend work usually focuses on hospitals and hospice facilities, but you may find positions that involve traveling to visit patients outside of a clinical setting.

What are the key skills and qualifications needed to thrive as a Weekend RN, and why are they important?

To thrive as a Weekend RN, you need current RN licensure, strong clinical assessment skills, and experience in acute or long-term care settings. Familiarity with electronic health record (EHR) systems and up-to-date certifications such as BLS or ACLS are often required. Excellent time management, adaptability, and communication skills are essential for managing patient care during typically higher-acuity weekend shifts. These competencies ensure patient safety, efficient care delivery, and effective teamwork when staffing levels and resources may be limited.

What are some unique challenges and rewards of working as a Weekend RN compared to a standard weekday nursing position?

Weekend RNs often face a distinct set of challenges, including managing higher patient-to-nurse ratios and handling more acute or urgent cases, as there may be fewer staff and support services available on weekends. However, this role also offers unique rewards, such as greater autonomy, opportunities to hone critical thinking and decision-making skills, and often a more flexible schedule or additional compensation. Weekend RNs typically collaborate closely with a dedicated core team, fostering strong teamwork and communication. This experience can be valuable for career advancement, as it demonstrates adaptability and strong clinical competence in a fast-paced environment.

What is the difference between Weekend Rn vs Weekend Lpn?

AspectWeekend RnWeekend Lpn
Required CredentialsRegistered Nurse license (RN)Licensed Practical Nurse license (LPN)
Work EnvironmentHospitals, clinics, long-term care facilitiesLong-term care, nursing homes, clinics
Employer & Industry UsageHospitals, healthcare agenciesLong-term care facilities, nursing homes
Common Search & Comparison IntentUnderstanding RN roles on weekendsUnderstanding LPN roles on weekends

Weekend Rn and Weekend Lpn roles differ mainly in credentials, with RNs holding a registered nurse license and LPNs holding a practical nurse license. RNs typically perform more complex medical tasks and have broader responsibilities, while LPNs focus on basic patient care. Both roles are common in healthcare settings that require weekend coverage, but RNs generally have more advanced training and scope of practice.

More about Weekend Rn jobs

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For Weekend Rn jobs in Florence, SC, the most frequently searched job titles are:

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The top searched job categories for Weekend Rn jobs in Florence, SC are:

What cities near Florence, SC are hiring for Weekend Rn jobs?

Cities near Florence, SC with the most Weekend Rn job openings:

Weekend Rn jobs near you
Infographic showing various Weekend Rn job openings in Florence, SC as of August 2026, with employment types broken down into 59% Full Time, 14% Part Time, and 27% Contract. Highlights an 98% In-person, and 2% Hybrid job distribution, with an average salary of $79,149 per year, or $38.1 per hour.

Registered Nurse

Ironside Human Resources

Hartsville, SC • On-site

$30 - $45/hr

Full-time

Re-posted yesterday

Job description

A medical facility located near Hartsville, SC is seeking a full-time Registered Nurse to join their team. New graduates welcome! Details are below.

Starting Pay: $30/Hour, increasing with experience

  • Stackable shift differentials: nights (+$6.00), weekends (+$4.00)
  • Up to $25,000 Sign-On Bonus
  • Relocation assistance available

Registered Nurse Job Opportunity:

  • Registered Nurse seeks to provide quality compassionate care, assessing patient conditions, recording medical histories, administering medications and treatments, operating medical equipment, and educating patients on at-home care
  • Full-time, permanent position
  • Day or night shifts available
  • Three, 12 hour shifts per week
  • Openings in multiple departments
  • Great comprehensive benefits package

Registered Nurse Qualifications:

  • Active RN license
  • BLS and ACLS certifications preferred
  • Open to new grad Registered Nurses

South Carolina Location:

  • Walkable downtown district with local dining, small businesses, galleries, and lively community festivals
  • Quiet, friendly neighborhoods within a calm atmosphere
  • Notably lower cost of living, making it an attractive area for relocation
  • Nature and outdoor spaces are easy to find, with parks, trails, and access to the broader Pee Dee region’s rural landscapes


Ironside Human Resources logo

About Ironside Human Resources

Sourced by ZipRecruiter

Ironside Human Resources, based in Dallas, TX, US, is a national healthcare recruitment company that offers staffing solutions to hospitals and healthcare providers across the United States. With an official website located at ironsidehr.com, the firm specializes in direct-hire recruitment for diverse sectors, including nursing, allied health, ancillary, administrative and executive-level roles in the healthcare industry. The company was founded in 2011 and has since committed to solving the healthcare staffing shortage through their unique, cost-effective recruitment strategies. Their core commitment is defined by their professional integrity, exceptional customer service, and dedication to delivering value and effective solutions.

Industry

Recruiting and staffing services

Company size

1 - 10 Employees

Headquarters location

Dallas, TX, US

Year founded

2011

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