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Sr Process Engineer Jobs in Raleigh, NC (NOW HIRING)

Senior Process Engineers routinely assist in the development of detailed proposals for a wide variety of project settings. Your Key Responsibilities * Perform business development/application tasks ...

ERG is seeking a Senior Process Safety Engineer or Chemical Engineer to join our Risk Management Program (RMP) and Process Safety Management (PSM) compliance and enforcement team providing support to ...

ERG is seeking a Senior Process Safety Engineer or Chemical Engineer to join our Risk Management Program (RMP) and Process Safety Management (PSM) compliance and enforcement team providing support to ...

Sr Wastewater Process Engineer

Cary, NC ยท On-site

$96K - $124K/yr

Function in a lead wastewater process engineer role as a technical specialist in the areas of conventional wastewater treatment * Use processes such as physical/chemical primary treatment ...

Sr Wastewater Process Engineer

Cary, NC ยท Hybrid

$96K - $124K/yr

Function in a lead wastewater process engineer role as a technical specialist in the areas of conventional wastewater treatment * Use processes such as physical/chemical primary treatment ...

Sr. PFAS Process Engineer

Cary, NC ยท Hybrid

$96K - $124K/yr

Why BVs Process Engineering Team? * The work is rewarding and meaningful * The team is comprised of supportive and appreciative professionals * Career opportunities exist in many rapidly expanding ...

Participate in basic project system design programming with support from Lead or Senior Engineer ... Process Simulation * Process Descriptions * Equipment Specifications * Hygienic Piping ...

Participate in basic project system design programming with support from Lead or Senior Engineer ... Process Simulation * Process Descriptions * Equipment Specifications * Hygienic Piping ...

Participate in basic project system design programming with support from Lead or Senior Engineer ... Process Simulation * Process Descriptions * Equipment Specifications * Hygienic Piping ...

Process Engineer At Salas O'Brien we tell our clients that we're engineered for impact. This passion for making a difference applies just as much to our team as it does to our projects. That's why we ...

Process Engineer At Salas O'Brien we tell our clients that we're engineered for impact. This passion for making a difference applies just as much to our team as it does to our projects. That's why we ...

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Showing results 1-20

Sr Process Engineer information

See Raleigh, NC salary details

$72.9K

$117.7K

$165.7K

How much do sr process engineer jobs pay per year?

As of Jul 22, 2026, the average yearly pay for sr process engineer in Raleigh, NC is $117,728.00, according to ZipRecruiter salary data. Most workers in this role earn between $101,100.00 and $130,700.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Sr Process Engineer, and why are they important?

To thrive as a Sr Process Engineer, you need a solid background in chemical, mechanical, or industrial engineering, often with a bachelor's or master's degree and relevant industry experience. Familiarity with process simulation software (such as Aspen Plus or HYSYS), Six Sigma or Lean certifications, and knowledge of safety and regulatory standards are typically required. Strong problem-solving, project management, and communication skills help distinguish top performers in this role. These skills and qualifications are vital for optimizing processes, ensuring efficiency and safety, and driving continuous improvement in complex manufacturing environments.

What are Sr Process Engineers?

Senior Process Engineers are experienced professionals responsible for designing, optimizing, and overseeing the processes used in manufacturing or production environments. They analyze workflows, troubleshoot process issues, and implement improvements to increase efficiency, reduce costs, and ensure product quality. Sr Process Engineers often lead teams, manage projects, and work closely with other departments such as quality assurance, maintenance, and operations. Their expertise is crucial in industries like chemicals, pharmaceuticals, oil and gas, and food processing. They typically hold a degree in engineering and have several years of experience in process engineering roles.

How does a Sr Process Engineer typically collaborate with cross-functional teams to improve manufacturing efficiency?

Sr Process Engineers work closely with teams such as production, quality assurance, maintenance, and R&D to identify areas for process optimization. They often lead or participate in cross-functional meetings to gather data, analyze workflow bottlenecks, and implement solutions that enhance efficiency and product quality. Effective communication and project management skills are essential, as Sr Process Engineers must balance technical requirements with practical constraints while ensuring all stakeholders are aligned with proposed changes.

What is the difference between Sr Process Engineer vs Process Engineer?

AspectSr Process EngineerProcess Engineer
QualificationsBachelor's degree in engineering, 5+ years experience, certifications like Six SigmaBachelor's degree in engineering or related field, 1-3 years experience
ResponsibilitiesLead process improvements, optimize manufacturing processes, mentor junior staffAssist in process development, data collection, support process optimization
Work EnvironmentManufacturing plants, industrial facilities, cross-functional teamsManufacturing settings, engineering teams, project-based tasks

The main difference between a Sr Process Engineer and a Process Engineer lies in experience, responsibility level, and scope of work. The Sr Process Engineer typically leads projects, mentors others, and has more advanced qualifications, while the Process Engineer supports and executes process improvements under supervision.

What cities near Raleigh, NC are hiring for Sr Process Engineer jobs? Cities near Raleigh, NC with the most Sr Process Engineer job openings:
Infographic showing various Sr Process Engineer job openings in Raleigh, NC as of July 2026, with employment types broken down into 89% Full Time, and 11% Contract. Highlights an 84% In-person, 7% Hybrid, and 9% Remote job distribution, with an average salary of $117,728 per year, or $56.6 per hour.
Senior Process Engineer - Solution Prep, Upstream, and Downstream

Senior Process Engineer - Solution Prep, Upstream, and Downstream

Amgen, Inc.

Holly Springs, NC โ€ข On-site

$90K - $116K/yr

Full-time

Posted 27 days ago


Job description

Career Category
Engineering
Job Description
Join Amgen's Mission of Serving Patients
At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.
Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the Amgen FleX batch facility will combine the latest in disposable technologies with traditional stainless steel equipment to allow for maximum flexibility in operations The FleX Batch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.
Senior Process Engineer - Solution Prep, Upstream, and Downstream
What you will do
In this vital role you will be joining the Facilities & Engineering (F&E) group to partner closely with the corporate engineering team to design, build, commission, and qualify new equipment and systems needed for drug substance production. This role will develop domain expertise and system ownership to support process operations, focusing on Solution Prep, Upstream, and Downstream Process engineering and plant equipment.
Site design, construction, start-up, and operational readiness:
  • Support the design and build of manufacturing equipment systems by aligning design review processes and documents with site requirements, including equipment design and sizing, architecture and electrical distribution, and piping and instrumentation diagrams.

  • Support factory acceptance testing working in partnership with global engineering during site installation, including reviewing protocols and resolving punch list items.

  • Work with capital project team to ensure systems are installed and operating safely and comply with pertinent environmental health/safety practice, rules and regulations as well as Amgen global engineering requirements. Ensure that systems are installed per the design requirements.

  • Execute and guide the commissioning and validation of systems to ensure their operational capability is aligned with manufacturing requirements and GMP regulation and on-time project delivery. Support execution of engineering and performance qualification runs while providing hypercare support as needed.

  • Perform engineering assessments for plant equipment operations, implementing equipment modifications, and supporting engineering runs in support of new product/technology introductions as required.

Site Operations:
  • Responsible system owner for Solution Prep, Upstream, and Downstream Drug substance process equipment, areas, and systems providing end-to-end support for operations.

  • Effectively collaborate with key customers and support groups (e.g. Manufacturing, Quality, Process Development, Maintenance, network partners) to ensure reliable plant operations.

  • Work with original equipment manufacturers for breakdown and planned maintenance of process equipment as applicable.

  • Lead identifying and implementing engineering-based improvements or upgrades to process equipment systems. This may include developing business cases for improvements, identifying design requirements, and translating these requirements into process equipment/system design, specifications, and supporting the construction, startup, and validation of equipment.

  • Develop master maintenance programs for equipment, ensure the availability of spare parts, and coordinate maintenance activities to ensure systems are in proper working order.

  • Ensure plant readiness and quality and regulatory compliance for internal audits, external agency audits, and partner audits for the process equipment.

  • Provide technical mastery and problem-solving leadership to proactively reduce production downtime. This includes leading technical root cause analysis and implementation of corrective/preventive actions for families of systems.

  • Lead new product/technology introductions by performing engineering assessments, equipment performance risk assessments, identifying gaps and owning their remediation, implementing equipment modifications, and supporting engineering runs.

  • Provide rotational on-call support and/or shift support based on business needs to ensure 24x7 day-to-day reliability of Solution Prep, Upstream and Downstream systems for plant operations.

  • On-site and up to 10% domestic/international travel.

What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The engineering professional we seek enjoys challenges and is motivated to help serve patients with these qualifications.
Basic Qualifications:
Doctorate degree
OR
Master's degree and 2 years of Engineering experience
OR
Bachelor's degree and 4 years of Engineering experience
OR
Associate's degree and 8 years of Engineering experience
OR
High school diploma / GED and 10 years of Engineering experience
Preferred Qualifications:
  • Degree in Chemical or Mechanical Engineering or similar engineering discipline.

  • 6+ years' of relevant work experience with 5+ years' experience in Biopharmaceutical operations/manufacturing environment

  • Direct knowledge of design and troubleshooting with GMP Biopharmaceutical Production facility equipment/systems with direct experience with Solution Prep, Upstream, and Downstream purification equipment such as weigh and dispense equipment, solution preparation vessels, cell culture reactors, centrifugation, chromatography, viral filtration skids, and UFDF skids as well as other equipment needed to support these processes such as autoclaves, clean in place (CIP) systems, washers, clean steam, water for injection, etc.

  • Experience with Tech Transfer, Process Design, and Commissioning & Qualification.

  • Experience working in a regulated environment (e.g. cGMP, OSHA, EPA, etc.) and familiarity with GMP quality systems/processes such as change control, non-conformances, corrective and preventative actions, and qualifications/validation

  • Understanding of safety requirements working in a GMP Biopharmaceutical production facility.

  • Independent, ambitious, organized, able to multi-task in project environments, and skilled in communication, facilitation, and teamwork.

  • Strong leadership, technical writing, and communication/presentation skills

  • Work schedule flexibility as required to support 24/7 operations.

  • Ability for domestic/international travel.

What you can expect of us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.
Apply now and make a lasting impact with the Amgen team!
careers.amgen.com
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Salary Range
115,494.60USD -156,257.40 USD