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How much do director preclinical development jobs pay per year?

As of Sep 13, 2026, the average yearly pay for director preclinical development in the United States is $92,386.00, according to ZipRecruiter salary data. Most workers in this role earn between $70,000.00 and $108,500.00 per year, depending on experience, location, and employer.

What is a director preclinical development?

A Director of Preclinical Development oversees the early-stage research and testing of drug candidates before they enter clinical trials. They manage preclinical studies, ensuring regulatory compliance, safety, and efficacy assessments. This role involves coordinating with cross-functional teams, external partners, and regulatory agencies to advance promising compounds. Strong expertise in toxicology, pharmacology, and regulatory guidelines is essential. The director plays a key role in shaping the preclinical strategy to support successful drug development.

What are the typical responsibilities and team dynamics for a director preclinical development?

A Director of Preclinical Development is responsible for overseeing the planning, execution, and management of preclinical research programs, ensuring that studies meet scientific, regulatory, and project milestones. You will typically work with cross-functional teams including toxicologists, pharmacologists, regulatory affairs professionals, and external partners, fostering collaboration throughout the drug development process. The role often involves reviewing study designs and data, preparing regulatory submissions, and providing strategic direction to advance compounds toward clinical testing. Working closely with upper management, you'll play a key part in shaping research priorities and resource allocation. This position offers significant influence over drug development strategies and opportunities for advancement to higher executive or scientific leadership roles.

What are the key skills and qualifications needed to thrive in the director preclinical development position, and why are they important?

To thrive as a Director Preclinical Development, you need deep expertise in pharmaceutical or biotechnology research, strong project management abilities, and an advanced degree (Ph.D., Pharm.D., or equivalent) in a life sciences field. Familiarity with regulatory guidelines (such as GLP), experience using data management and statistical analysis software, and prior leadership roles in preclinical studies are essential. Exceptional communication, problem-solving, and team leadership skills set candidates apart in managing multidisciplinary teams and collaborative projects. These competencies are crucial for successfully guiding drug candidates through preclinical stages while ensuring regulatory compliance and timely project delivery.

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Director Preclinical Development jobs near you
Infographic showing various Director Preclinical Development job openings in the United States as of September 2026, with employment types broken down into 1% Internship, 1% As Needed, 81% Full Time, 15% Part Time, and 2% Contract. Highlights an 85% Physical, 3% Hybrid, and 12% Remote job distribution, with an average salary of $92,386 per year, or $44.4 per hour.

Director/Sr Director, Toxicology & Preclinical Pharmacology

San Diego, CA • On-site

Scorpion Therapeutics
51 - 200 employees
Learn more about Scorpion Therapeuticsexternal

Other

Posted 14 days ago

Job description

Director or Senior Director, Preclinical Pharmacology/ToxicologyResponsibilities
  • Lead nonclinical in vitro and in vivo pharmacology and toxicology strategies for obesity and metabolic disease programs.
  • Design, monitor, and interpret GLP and non-GLP toxicology, safety pharmacology, exploratory mechanistic studies, and juvenile/reproductive toxicology programs as applicable.
  • Serve as scientific lead for CRO interactions, study oversight, and data review.
  • Integrate pharmacology, pharmacokinetic, toxicokinetic, pathology, and biomarker data to support lead selection, optimization, and development decisions.
  • Contribute to INDs, Investigator’s Brochures, briefing books, NDAs, and other regulatory submissions.
  • Collaborate with clinical and translational teams to support dose selection and risk assessment.
  • Evaluate emerging literature and the competitive landscape in obesity and metabolic disease therapeutics.
  • Mentor junior scientists and build scientific capabilities.
  • Support strategic planning for combination and next-generation metabolic therapies.
  • Other duties as assigned.
Requirements
  • PhD, DVM, PharmD, or equivalent degree in Pharmacology, Toxicology, Physiology, or related discipline.
  • 10+ years of experience in biotechnology or pharmaceutical industry.
  • Preferred: metabolic disease pharmacology/obesity therapeutics; GLP-compliant toxicology; translational science.
  • Experience supporting IND-enabling programs.
  • Familiarity with ICH nonclinical guidelines and other regulatory guidance.
  • Understanding of peptide therapeutics and small-molecule drug development.
Skills
  • Experience with GLP-1/GIP/amylin or related metabolic pathways; combination therapies; acute/chronic toxicology; DMPK/TK interpretation.
  • Prior interactions with FDA and global regulatory agencies.
  • Experience managing external CRO networks and budgets.
  • Ability to thrive in a fast-paced biotech environment managing multiple concurrent programs.
  • Self-motivated; excellent written and verbal communication.
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