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Director Preclinical Development Jobs in Seattle, WA

Vrtx

Senior Director, Biomarkers (Immunology)

Seattle, WA · On-site

$216K - $325K/yr

The Senior Director, Biomarkers, Immunology is an independent leader with wide-reaching scientific ... sites, including PreClinical Sciences (PCS), Research, Translational, Clinical Development ...

Umoja Biopharma

Senior Medical Director

Seattle, WA

$270K - $333K/yr

Contribute to the clinical development strategy, including indication selection, trial design, and ... Collaborate closely with translational medicine, preclinical, and regulatory teams to align ...

Umoja Biopharma

Senior Medical Director

Seattle, WA · On-site

$270K - $333K/yr

Contribute to the clinical development strategy, including indication selection, trial design, and ... Collaborate closely with translational medicine, preclinical, and regulatory teams to align ...

Umoja Biopharma

Senior Medical Director

Seattle, WA · On-site

$270K - $333K/yr

Contribute to the clinical development strategy, including indication selection, trial design, and ... Collaborate closely with translational medicine, preclinical, and regulatory teams to align ...

Systimmune

Director, Protein Engineering

Redmond, WA · On-site

SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and ... development. We offer an opportunity for you to learn and grow while making significant ...

SystImmune, Inc

Director, Protein Engineering

Redmond, WA · On-site

$180K - $240K/yr

SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and ... development. We offer an opportunity for you to learn and grow while making significant ...

Systimmune

Executive Director, Finance

Redmond, WA · On-site

... strong preclinical pipeline of potential cancer therapeutics in the discovery or IND-enabling stages, representing cutting-edge biologics development. Position Summary : The Executive Director ...

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All JobsPreclinical Development JobsDirector Preclinical Development JobsDirector Preclinical Development Jobs in Seattle, WA

Director Preclinical Development information

See Seattle, WA salary details

$46.1K

$105.1K

$176.4K

How much do director preclinical development jobs pay per year?

As of Sep 2, 2026, the average yearly pay for director preclinical development in Seattle, WA is $105,137.00, according to ZipRecruiter salary data. Most workers in this role earn between $79,700.00 and $123,500.00 per year, depending on experience, location, and employer.

What is a director preclinical development?

A Director of Preclinical Development oversees the early-stage research and testing of drug candidates before they enter clinical trials. They manage preclinical studies, ensuring regulatory compliance, safety, and efficacy assessments. This role involves coordinating with cross-functional teams, external partners, and regulatory agencies to advance promising compounds. Strong expertise in toxicology, pharmacology, and regulatory guidelines is essential. The director plays a key role in shaping the preclinical strategy to support successful drug development.

What are the typical responsibilities and team dynamics for a director preclinical development?

A Director of Preclinical Development is responsible for overseeing the planning, execution, and management of preclinical research programs, ensuring that studies meet scientific, regulatory, and project milestones. You will typically work with cross-functional teams including toxicologists, pharmacologists, regulatory affairs professionals, and external partners, fostering collaboration throughout the drug development process. The role often involves reviewing study designs and data, preparing regulatory submissions, and providing strategic direction to advance compounds toward clinical testing. Working closely with upper management, you'll play a key part in shaping research priorities and resource allocation. This position offers significant influence over drug development strategies and opportunities for advancement to higher executive or scientific leadership roles.

What are the key skills and qualifications needed to thrive in the director preclinical development position, and why are they important?

To thrive as a Director Preclinical Development, you need deep expertise in pharmaceutical or biotechnology research, strong project management abilities, and an advanced degree (Ph.D., Pharm.D., or equivalent) in a life sciences field. Familiarity with regulatory guidelines (such as GLP), experience using data management and statistical analysis software, and prior leadership roles in preclinical studies are essential. Exceptional communication, problem-solving, and team leadership skills set candidates apart in managing multidisciplinary teams and collaborative projects. These competencies are crucial for successfully guiding drug candidates through preclinical stages while ensuring regulatory compliance and timely project delivery.

What are popular job titles related to Director Preclinical Development jobs in Seattle, WA?

For Director Preclinical Development jobs in Seattle, WA, the most frequently searched job titles are:

What job categories do people searching Director Preclinical Development jobs in Seattle, WA look for?

The top searched job categories for Director Preclinical Development jobs in Seattle, WA are:

Director Preclinical Development jobs near you
Infographic showing various Director Preclinical Development job openings in Seattle, WA as of August 2026, with employment types broken down into 1% As Needed, 81% Full Time, 15% Part Time, and 3% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $105,137 per year, or $50.5 per hour.

Associate Director/Director, Bioanalytical Laboratory

Systimmune

Redmond, WA • On-site

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 10 days ago

Job description

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.
SystImmune is seeking an experienced and visionary Associate Director/Director of Bioanalytical Laboratories to lead, expand, and inspire our bioanalytical capabilities supporting preclinical and clinical programs in biologics and ADC development.
 

This role combines scientific depth, operational excellence, and people leadership. The Director will oversee assay development, validation, and execution for pharmacokinetic (PK) and anti-drug antibody (ADA) analyses supporting ADCs and other biologics, while building a high-performing team and fostering a culture of scientific rigor and continuous learning. This is a hands-on, high-impact role for a leader who thrives at the intersection of science, strategy, and mentorship.

The position is full-time onsite and based in Redmond, WA.
ResponsibilitiesStrategic & Scientific Leadership
  • Define and execute bioanalytical strategies supporting discovery, preclinical, and clinical development of biologics and ADCs.
  • Lead the design, development, validation, and troubleshooting of PK, ADA, and biomarker assays using ligand-binding, ELISA, ECLIA, LC-MS/MS, and hybrid methods.
  • Serve as the bioanalytical lead in cross-functional project teams and regulatory interactions.
  • Anticipate and adapt to evolving regulatory expectations and scientific advances to ensure SystImmune remains at the forefront of bioanalytical science.
Operational & Laboratory Management
  • Oversee day-to-day laboratory operations to ensure compliance with GLP, GCP, ICH, and 21 CFR Part 11 standards.
  • Direct equipment qualification, calibration, and maintenance programs.
  • Establish and maintain SOPs, safety protocols, data integrity systems, and quality management processes.
  • Partner with Quality Assurance to prepare for audits and regulatory inspections, maintaining a state of perpetual readiness.
Team Leadership & Talent Development
  • Build, inspire, and empower a team of exceptional scientists and analysts.
  • Foster a culture that emphasizes mentorship, growth, and scientific curiosity, helping staff expand their technical expertise and leadership potential.
  • Create individualized development plans and cross-training opportunities to strengthen technical depth and career progression.
  • Promote open communication, shared accountability, and recognition of high performance.
Cross-Functional & Global Collaboration
  • Collaborate closely with Translational Sciences, Clinical Pharmacology, Regulatory Affairs, and Quality to ensure alignment on analytical strategy and regulatory submissions.
  • Partner with global bioanalytical and translational teams to harmonize methods, data standards, and reporting practices.
  • Represent SystImmune’s bioanalytical expertise in internal governance forums and external scientific networks.

Qualifications

  • Ph.D. in Pharmacology, Biochemistry, Analytical Chemistry, Immunology, or related discipline (M.S. with significant experience considered).
  • 10+ years of industry experience in bioanalytical sciences supporting biologics or ADC programs, including 5+ years in a leadership role.
  • Demonstrated expertise in assay development, validation, and regulatory submission for PK/ADA/biomarker methods.
  • Proven success managing GLP/GCP-compliant lab operations and preparing for health authority inspections.
  • Strong understanding of global regulatory requirements (FDA, EMA, NMPA, ICH M10, E6).
  • Exceptional leadership and people management skills with a record of developing scientific talent and fostering high-performance teams.
  • Effective communicator who can translate complex data into strategic decisions.
  • Experience managing CROs or global lab partnerships a plus.

Compensation and Benefits:
The expected base salary range for this position is $150,000 - $230,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s qualifications, experience, and skills.
While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.
 
SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.
 
We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.
 
SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.
 

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