Clinical Operations Assistant Jobs in Minnesota (NOW HIRING)

Company Description Endogenex is a privately held, clinical-stage company based in Minneapolis, MN, dedicated to transforming treatment options for individuals living with type 2 diabetes (T2D). In partnership with Mayo Clinic, Endogenex develops innovations that reset the body’s metabolic signaling system by leveraging natural regenerative capabilities to improve metabolic function. The company’s Endogenex System uses precise, controlled, non-thermal pulsed electric fields to help patients regain better blood glucose control and slow disease progression. By establishing a new era of metabolic therapies, Endogenex offers professionals the opportunity to contribute to impactful, patient-focused clinical innovation.

Role Description The Clinical Operations Financial Analyst is a full-time, on-site role based in Plymouth, MN. This position supports supports the financial management of the Company's clinical trial programs. The primary focus of this role is the review, analysis, and reconciliation of clinical trial site payments — confirming that payments to investigative sites are accurate, supported by source documentation, and consistent with executed clinical trial agreements and site budgets. The position also supports clinical trial budget tracking and accrual development, processes clinical vendor invoices, and assists with month-end close activities. This is an entry-level analyst role that partners closely with Clinical Operations, Accounting, contract research organizations (CROs), and investigative sites.

Primary Responsibilities

•  Review and analyze clinical trial site payment requests, verifying amounts against executed clinical trial agreements, site budgets, and completed study visits or milestones.
• Serve as the primary point of contact for clinical payments and for investigative sites on payment-related questions, and act as the liaison between Clinical Operations and Finance on payment matters.  
• Reconcile site payment activity to enrollment and visit data in the clinical trial management system (CTMS) and electronic data capture (EDC) system, and research discrepancies with Clinical Operations and site staff.
• Track pass-through and reimbursable costs — including patient stipends, travel, overhead, and other invoiceable items — and confirm each is supported by adequate documentation.
• Prepare and maintain site payment schedules and trackers; monitor payment status, aging, and outstanding balances by site.
• Coordinate with Accounts Payable to submit approved site payments for processing and confirm timely disbursement.
• Maintain audit-ready site payment documentation and respond to internal and external audit requests related to clinical trial payments.
• Assist in developing and maintaining clinical trial budgets and forecasts, including enrollment-driven cost projections.
• Prepare monthly clinical trial accruals for unbilled and prepaid site and vendor activity, including supporting calculations and documentation.
• Perform budget-to-actual variance analysis by study, vendor, and cost category, and draft commentary for Finance and Clinical Operations review.
• Support the review of CRO and vendor budgets, work orders, and change orders, comparing invoiced amounts to contracted rates and units.
• Build and maintain reports that give study teams visibility into trial spend, remaining budget, cost per patient, and cost per site.
• Review and process clinical vendor invoices, confirming general ledger coding, approvals, purchase order alignment, and contract compliance before submission for payment.
• Research and resolve invoice discrepancies with vendors, CROs, and internal budget owners.
• Prepare assigned journal entries, account reconciliations, and supporting schedules as part of the month-end close.
• Assist with preparation of month-end reporting packages and clinical accrual roll-forwards for the Controller's review.
• Maintain and improve written documentation of site payment and invoice processing procedures, and identify opportunities to simplify or automate manual steps, with particular emphasis on reducing the manual burden of clinical trial site payment processing.
• Support external audit, tax, and grant or reporting requests related to clinical trial expense.
• Protect the confidentiality of patient, site, and Company information, and follow applicable Company procedures, quality system requirements, and clinical research regulations.
• Perform other duties and responsibilities as assigned by the Controller and Senior Management.

Qualifications

• Bachelor's degree in accounting, finance, business, or a related field, or an equivalent combination of education and work experience.
• 1–3 years of experience in accounting, finance, or financial analysis. Experience in medical device, pharmaceutical, biotechnology, or clinical research is preferred.
• Familiarity with clinical trial agreements, site budgets, and investigator payments, or a demonstrated ability to learn contract-based payment terms quickly.
• Understanding of clinical trial operations and Good Clinical Practice (GCP).
• Strong Excel skills, including lookups, pivot tables, and working with large data sets.
• Experience with an ERP or accounting system, and exposure to a CTMS, EDC, or clinical payment platform, is a plus.
• High attention to detail and comfort reconciling data across multiple systems and documents.
• Strong written and verbal communication skills, with the ability to work effectively with investigative sites, vendors, and internal teams in a fast-paced, collaborative environment.
• Ability to manage multiple priorities, meet recurring close and payment deadlines, and work independently with limited direction.
• Strong organizational, planning, and follow-up skills.
• Strong proficiency with Microsoft Office tools including Word, Excel, PowerPoint, or other relevant software.

CRITICAL SKILLS & ATTRIBUTES

• Retention and continuity: keeps track of many concurrent site conversations and open commitments and resumes each accurately.
• Responsiveness: prompt, dependable follow-up so sites and internal stakeholders get timely resolution.
• Trial fluency: understands study designs – including blinding and the hub-and-spoke model – and how each site’s budget and contract terms determine what is paid, which data trigger payment and where it originates, and when.  
• Systems and data literacy: works fluently across multiple systems and translates a data extract into its payment implications.  
• Process and organization: maintains an accurate, auditable record of what has and has not been paid by site and builds repeatable processes.
• Rigor: sustains accuracy and follow-through across a high-volume, deadline-driven monthly cycle.

Endogenex is an Equal Opportunity Employer.