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Clinical Operation Manager Jobs (NOW HIRING)

Denali Health

Clinical Operations Manager

Atlanta, GA · On-site

As a Clinical Operations Manager at Denali Health, you'll help create the infrastructure that allows breakthrough therapies to reach patients faster. Your work will influence not just individual ...

Rezilient Health

Clinical Operations Manager

Raleigh, NC · On-site

About the Role The Clinical Operations Manager is responsible for managing and supporting day-to-day CloudClinic operations, staff management, patient scheduling, and inventory control to ensure ...

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BiVACOR Inc

Clinical Operations Manager

Huntington Beach, CA · On-site

$118K - $154K/yr

As Clinical Operations Manager, you will be the organizational backbone of site-level activity, ensuring every participating center is prepared, compliant, and ready to support patients receiving the ...

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ExThera Medical

Clinical Operations Manager

Martinez, CA · On-site

A strategic and hands-on Clinical Operations Manager responsible for overseeing clinical trials for medical devices while driving process remediation and operational excellence. This role requires a ...

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Clinical Operation Manager information

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$35K

$98K

$186.5K

How much do clinical operation manager jobs pay per year?

As of Jul 6, 2026, the average yearly pay for clinical operation manager in the United States is $98,039.00, according to ZipRecruiter salary data. Most workers in this role earn between $72,500.00 and $113,500.00 per year, depending on experience, location, and employer.

What are some common challenges Clinical Operation Managers face when coordinating multi-site clinical trials?

Clinical Operation Managers often encounter challenges such as ensuring consistent protocol adherence across all sites, managing communication among geographically dispersed teams, and maintaining timelines despite unexpected delays. They must also address regulatory differences between sites and troubleshoot issues related to patient recruitment and data collection. Success in this role requires strong organizational skills, adaptability, and effective collaboration with investigators, coordinators, and regulatory personnel.

What are the key skills and qualifications needed to thrive as a Clinical Operation Manager, and why are they important?

To thrive as a Clinical Operation Manager, you need expertise in clinical project management, regulatory compliance, and a background in healthcare or life sciences, often supported by a relevant degree. Familiarity with clinical trial management systems (CTMS), electronic data capture (EDC) tools, and certifications such as PMP or Six Sigma are commonly required. Strong leadership, problem-solving abilities, and excellent communication skills set top performers apart in this role. These competencies are essential for ensuring efficient clinical operations, maintaining regulatory standards, and leading teams to deliver successful trial outcomes.

What are Clinical Operation Managers?

Clinical Operation Managers are professionals responsible for overseeing the daily operations of clinical research sites, medical facilities, or departments. They ensure that clinical trials or healthcare services are conducted efficiently, comply with regulations, and meet quality standards. Their duties often include supervising staff, managing budgets, implementing policies, and coordinating between various teams. Clinical Operation Managers play a crucial role in ensuring that patient care and research activities run smoothly and effectively.

What is the difference between Clinical Operation Manager vs Clinical Research Coordinator?

AspectClinical Operation ManagerClinical Research Coordinator
CredentialsBachelor's degree in health sciences, life sciences, or related field; often with project management certificationsBachelor's degree in health sciences, nursing, or related field; often with research-specific training
Work EnvironmentOversees multiple clinical trials, manages teams, and ensures compliance at a departmental levelCoordinates daily activities of clinical trials, interacts directly with participants and investigators
Employer & IndustryPharmaceutical companies, biotech firms, hospitals, research institutionsResearch sites, hospitals, academic institutions, contract research organizations

The Clinical Operation Manager focuses on overseeing clinical trial operations, managing teams, and ensuring compliance across projects. In contrast, the Clinical Research Coordinator handles the day-to-day activities of specific trials, working closely with participants and investigators. Both roles require relevant healthcare or science credentials, but their scope and responsibilities differ significantly.

More about Clinical Operation Manager jobs
What cities are hiring for Clinical Operation Manager jobs? Cities with the most Clinical Operation Manager job openings:
What are the most commonly searched types of Clinical Operation jobs? The most popular types of Clinical Operation jobs are:
What states have the most Clinical Operation Manager jobs? States with the most job openings for Clinical Operation Manager jobs include:
What job categories do people searching Clinical Operation Manager jobs look for? The top searched job categories for Clinical Operation Manager jobs are:
Clinical Operation Manager jobs near you
Infographic showing various Clinical Operation Manager job openings in the United States as of June 2026, with employment types broken down into 95% Full Time, and 5% Contract. Highlights an 85% In-person, 5% Hybrid, and 10% Remote job distribution, with an average salary of $98,039 per year, or $47.1 per hour.

Clinical Operations Manager

Denali Health

Atlanta, GA • On-site

Full-time

Posted 10 days ago

Job description

About Denali:
Denali Health is a fast-growing clinical research organization focused on accelerating therapies to market through operational excellence, exceptional talent, and a participant-centered approach to research.
We are building a network of high-performing clinical research sites and fostering a culture of trust, accountability, ownership, and continuous improvement. Our goal is simple: deliver industry-leading results while creating meaningful opportunities for talented professionals to grow their careers.
Why This Role Matters:
Every successful clinical trial depends on operational excellence. The systems you build, the teams you lead, and the problems you solve directly impact participant enrollment, protocol compliance, data quality, and study execution.
As a Clinical Operations Manager at Denali Health, you'll help create the infrastructure that allows breakthrough therapies to reach patients faster. Your work will influence not just individual studies, but the growth and performance of an entire clinical research network.
What You'll Do:
Build and Optimize Site Operations:
  • Design, implement, and continuously improve clinical research workflows that maximize enrollment, regulatory compliance, and data quality.
  • Lead operational initiatives that expand study capacity, site capabilities, and therapeutic area expertise.
  • Monitor and improve key site performance metrics, including:
    • Enrollment rates
    • Screen failure rates
    • Protocol deviations
    • Data query resolution timelines
    • Sponsor satisfaction
  • Identify operational bottlenecks and implement proactive solutions before they impact study execution.
  • Travel regularly to research sites to assess performance, support teams, and drive continuous improvement.
Lead High-Performing Teams:
  • Manage and develop site-based clinical and administrative staff.
  • Build a culture of accountability, ownership, and operational excellence.
  • Partner with site leadership, Principal Investigators, and research teams to align execution with organizational goals.
  • Serve as a trusted problem solver during operational challenges and study escalations.
  • Create scalable systems and processes that support growth across multiple sites.
Drive Clinical Research Excellence:
  • Ensure exceptional participant experiences from screening through study completion.
  • Maintain compliance with FDA regulations, ICH-GCP guidelines, sponsor requirements, and site SOPs.
  • Implement quality improvement initiatives based on audits, inspections, sponsor feedback, and performance metrics.
  • Support high-quality study execution through strong operational oversight and collaboration.
  • Partner with sponsors, CROs, investigators, and coordinators to deliver successful studies.
Lead Strategic Projects:
  • Own high-priority operational initiatives from planning through execution.
  • Collaborate across departments to improve organizational performance.
  • Introduce innovative ideas and drive implementation.
  • Adapt quickly as priorities evolve in a dynamic clinical research environment.

You're a Good Fit If You Are:
  • An owner who takes responsibility for outcomes.
  • A builder who enjoys creating systems and improving processes.
  • Resourceful and proactive when solving problems.
  • Comfortable making decisions in fast-paced environments.
  • Data-driven and focused on measurable results.
  • Resilient under pressure.
  • Collaborative and committed to helping teams succeed.
  • Passionate about advancing clinical research and improving patient access to new therapies.
Must-Haves:
  • 2-5+ years of progressive experience in clinical research, site management, healthcare operations, or a related field.
  • Strong understanding of clinical research operations and site workflows.
  • Working knowledge of FDA regulations, ICH-GCP guidelines, and sponsor expectations.
  • Demonstrated experience improving operational performance and achieving measurable results.
  • Strong analytical and project management skills.
  • Experience managing multiple priorities simultaneously.
  • Willingness and ability to travel regularly (30-50%).
  • Ability to work hands-on within research sites rather than exclusively in a remote management capacity.
Nice-to-Haves
  • Experience managing multi-site research operations.
  • Experience with participant recruitment and enrollment strategy.
  • Experience supporting site growth and expansion initiatives.
  • Familiarity with CTMS, EDC, and research technology platforms.
  • Experience leading quality improvement initiatives.
  • Healthcare administration, business, or operations leadership experience.

How We'll Support Your Growth:
  • Direct mentorship from experienced healthcare and research leaders.
  • Exposure to multiple therapeutic areas, study phases, and site operations models.
  • Continuing education support, certifications, conferences, and leadership development opportunities.
  • Opportunities to lead increasingly complex operational initiatives.
  • Clear pathways into senior operations leadership roles as Denali continues to grow.

Why Denali?
Do work that matters: Help bring life-changing therapies to patients faster.
Own your impact: Your decisions directly influence enrollment, quality, compliance, and growth.
Grow with purpose: Gain exposure to site operations, strategy, business development, and leadership.
Learn from exceptional people: Work alongside experienced investigators, executives, and clinical research professionals.
Build something meaningful: Join a rapidly growing organization where your ideas and execution shape the future of the company.
Advance your career: High performers have opportunities to grow into Director, VP, and executive leadership roles.

Apply