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Weekend Rn Jobs in Columbia, SC (NOW HIRING)

UHS

Registered Nurse RN Dual Diagnosis

Columbia, SC · On-site

Night Shift RN Behavioral Recovery Unit for adult dual diagnosis program. This position will float ... Weekday 2nd shift $6.25 & Weekend 2nd shift $9.00 Weekday 3rd shift $7.00 & Weekend 3rd shift $10 ...

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Weekend Rn information

See Columbia, SC salary details

$25

$39

$66

How much do weekend rn jobs pay per hour?

As of Sep 10, 2026, the average hourly pay for weekend rn in Columbia, SC is $39.83, according to ZipRecruiter salary data. Most workers in this role earn between $31.61 and $45.98 per hour, depending on experience, location, and employer.

What is a Weekend RN?

A Weekend RN is a registered nurse who primarily works during the weekends, often covering shifts on Saturdays and Sundays. These nurses provide patient care, administer medications, monitor patient progress, and collaborate with doctors and other healthcare staff. Weekend RNs may work in hospitals, nursing homes, or other healthcare facilities, and their schedules are designed to ensure continuous high-quality care throughout the week. Weekend shifts can sometimes offer higher pay rates or shift differentials due to the non-traditional hours.

What does a Weekend RN do?

As a weekend RN, you take shifts on the weekend when other nurses are unavailable, allowing hospitals and other care facilities to provide continuity of care and remain open 24/7. This is usually a part-time position, with most weekend RN's working two 8-12 hour shifts Saturday-Sunday each week. Some facilities also count Friday as a weekend day and offer a three-shift schedule instead. In this role, you may make patient visits, answer telephone calls to provide remote healthcare and address any medical emergencies that occur during your shift as a weekend nurse. As an RN, weekend work usually focuses on hospitals and hospice facilities, but you may find positions that involve traveling to visit patients outside of a clinical setting.

What are the key skills and qualifications needed to thrive as a Weekend RN, and why are they important?

To thrive as a Weekend RN, you need current RN licensure, strong clinical assessment skills, and experience in acute or long-term care settings. Familiarity with electronic health record (EHR) systems and up-to-date certifications such as BLS or ACLS are often required. Excellent time management, adaptability, and communication skills are essential for managing patient care during typically higher-acuity weekend shifts. These competencies ensure patient safety, efficient care delivery, and effective teamwork when staffing levels and resources may be limited.

What are some unique challenges and rewards of working as a Weekend RN compared to a standard weekday nursing position?

Weekend RNs often face a distinct set of challenges, including managing higher patient-to-nurse ratios and handling more acute or urgent cases, as there may be fewer staff and support services available on weekends. However, this role also offers unique rewards, such as greater autonomy, opportunities to hone critical thinking and decision-making skills, and often a more flexible schedule or additional compensation. Weekend RNs typically collaborate closely with a dedicated core team, fostering strong teamwork and communication. This experience can be valuable for career advancement, as it demonstrates adaptability and strong clinical competence in a fast-paced environment.

What is the difference between Weekend Rn vs Weekend Lpn?

AspectWeekend RnWeekend Lpn
Required CredentialsRegistered Nurse license (RN)Licensed Practical Nurse license (LPN)
Work EnvironmentHospitals, clinics, long-term care facilitiesLong-term care, nursing homes, clinics
Employer & Industry UsageHospitals, healthcare agenciesLong-term care facilities, nursing homes
Common Search & Comparison IntentUnderstanding RN roles on weekendsUnderstanding LPN roles on weekends

Weekend Rn and Weekend Lpn roles differ mainly in credentials, with RNs holding a registered nurse license and LPNs holding a practical nurse license. RNs typically perform more complex medical tasks and have broader responsibilities, while LPNs focus on basic patient care. Both roles are common in healthcare settings that require weekend coverage, but RNs generally have more advanced training and scope of practice.

More about Weekend Rn jobs

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What cities near Columbia, SC are hiring for Weekend Rn jobs?

Cities near Columbia, SC with the most Weekend Rn job openings:

Weekend Rn jobs near you
Infographic showing various Weekend Rn job openings in Columbia, SC as of September 2026, with employment types broken down into 6% As Needed, 60% Full Time, 28% Part Time, and 6% Contract. Highlights an 100% In-person job distribution, with an average salary of $82,856 per year, or $39.8 per hour.

Registered Nurse (RN) Weekend Shift - Home Health - $5k Bonus

Columbia, SC • On-site

Interim HealthCare of the Midlands
See more jobs at Interim HealthCare of the Midlandsexternal

$46/hr

Full-time

Medical, Dental, Vision, Retirement

This job post has expired 1 day ago. Applications are no longer accepted.

Job description

As a Home Health Registered Nurse (RN), you play a vital role in strengthening your community—one patient, one home, one relationship at a time. You provide skilled, compassionate care that helps patients recover, manage chronic conditions, and live safely and independently at home, while using your clinical expertise to prevent hospitalizations, empower patients and families, and improve long-term outcomes through trusted relationships and coordinated care. 

Guided by our mission to honor God through the enrichment of human life, Interim HealthCare has been a trusted leader in home health services across South Carolina since 1979 and is proud to be recognized as a 9x Top Workplace. We believe exceptional care begins with supported nurses, and we foster an environment where clinicians are respected, empowered, and equipped to do meaningful work—if you’re ready to make a lasting difference in patients’ lives, we invite you to join our team. 

Shift: Full-time, Friday 4:30pm — Monday 8:30am
Location: Richland County, SC

Why You’ll Love Working with Interim 

As a Registered Nurse (RN) with Interim, you’ll enjoy: 

  • Competitive pay-per-visit compensation starting at $46 per visit, plus mileage reimbursement 
    • $5,000 Sign-on Bonus
  • Flexible scheduling that supports true work-life balance and autonomy 
  • Dedicated 1:1 patient care, allowing you to focus on quality outcomes, not volume 
  • Comprehensive health coverage, including medical, dental, vision, and an HSA with employer contribution 
  • 401(k) with employer match to help you plan confidently for the future 
  • Support for your growth and well being, including free CEUs, tuition assistance, and fitness reimbursement 

What You’ll Do 

As a Registered Nurse (RN), you will: 

  • Provide skilled, patient centered care in the home while partnering with physicians and the interdisciplinary team to support safe recovery and long-term health 
  • Perform comprehensive patient assessments, including accurate OASIS documentation 
  • Develop, implement, and adjust individualized plans of care 
  • Monitor patient condition and communicate changes promptly to physicians to prevent complications 
  • Educate patients and caregivers on medications, treatments, disease management, and home safety 
  • Coordinate care with therapists, aides, and other providers to ensure seamless, compliant care 
  • Prepare patients and families for safe, successful discharge and document care accurately in the EMR 

What You’ll Need 

  • Graduate of an accredited Registered Nurse (RN) program 
  • Active South Carolina RN license or Compact License 
  • Minimum one year of nursing experience 
  • Experience in Home Health, Medical Surgical, Critical Care, or Case Management preferred 
  • Familiarity with OASIS documentation preferred 

Apply Today 

If you are a Registered Nurse (RN) looking for a rewarding Home Health opportunity in Columbia, SC, we encourage you to apply and join a compassionate, patient focused team.  

Interim HealthCare is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws. 

#IHC

PandoLogic. Keywords: Registered Nurse (RN), Location: Columbia, SC - 29202 , PL: 604068552