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Weekend Prn Rn Jobs in Greenville, SC (NOW HIRING)

PACS

RN, PRN

Greer, SC · On-site

$35 - $41/hr

... * $8/hour weekend shift differential * On-site management support 24/7 + on-call leadership ... Career advancement & PRN opportunities across our SC network Position Summary As a Registered Nurse ...

PRN Healthcare

Travel MS/Tele RN

Easley, SC · On-site

$1.7K - $2.3K/wk

PRN Healthcare is seeking a travel nurse RN Med Surg / Telemetry for a travel nursing job in Easley, South Carolina. & Requirements * Specialty: Med Surg / Telemetry * Discipline: RN * Start Date: 09 ...

PRN Healthcare

Travel MS/Telemetry RN

Easley, SC · On-site

$1.7K - $2.3K/wk

PRN Healthcare is seeking a travel nurse RN Med Surg / Telemetry for a travel nursing job in Easley, South Carolina. & Requirements * Specialty: Med Surg / Telemetry * Discipline: RN * Start Date: 09 ...

PRN Healthcare

Travel LTAC MS Tele RN

Easley, SC · On-site

$1.7K - $2.3K/wk

PRN Healthcare is seeking a travel nurse RN Med Surg / Telemetry for a travel nursing job in Easley, South Carolina. & Requirements * Specialty: Med Surg / Telemetry * Discipline: RN * Start Date: 09 ...

PRN Healthcare

Travel LTAC Med Surg Tele RN

Easley, SC · On-site

$1.7K - $2.3K/wk

PRN Healthcare is seeking a travel nurse RN Med Surg / Telemetry for a travel nursing job in Easley, South Carolina. & Requirements * Specialty: Med Surg / Telemetry * Discipline: RN * Start Date: 09 ...

PRN Healthcare

Travel LTAC Med Surg Tele RN

Easley, SC · On-site

$1.7K - $2.3K/wk

PRN Healthcare is seeking a travel nurse RN Med Surg / Telemetry for a travel nursing job in Easley, South Carolina. & Requirements * Specialty: Med Surg / Telemetry * Discipline: RN * Start Date: 09 ...

PRN Healthcare

Travel LTAC Med Surg Tele RN

Easley, SC · On-site

$1.7K - $2.3K/wk

PRN Healthcare is seeking a travel nurse RN Med Surg / Telemetry for a travel nursing job in Easley, South Carolina. & Requirements * Specialty: Med Surg / Telemetry * Discipline: RN * Start Date: 09 ...

PRN Healthcare

Travel CCU RN

Easley, SC · On-site

PRN Healthcare is seeking a travel nurse RN CCU - Coronary Care for a travel nursing job in Easley, South Carolina. & Requirements * Specialty: CCU - Coronary Care * Discipline: RN * Start Date: 09 ...

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All JobsPrn Rn JobsWeekend Prn Rn JobsWeekend Prn Rn Jobs in Greenville, SC

Weekend Prn Rn information

See Greenville, SC salary details

$18

$34

$50

How much do weekend prn rn jobs pay per hour?

As of Sep 7, 2026, the average hourly pay for weekend prn rn in Greenville, SC is $34.30, according to ZipRecruiter salary data. Most workers in this role earn between $27.36 and $39.57 per hour, depending on experience, location, and employer.

What is a Weekend PRN RN?

A Weekend PRN RN (As Needed Registered Nurse) is a nursing position where the nurse works primarily on weekends and on an as-needed basis. These roles are typically found in hospitals, nursing homes, and healthcare facilities that require additional weekend staffing. PRN nurses do not usually have a set schedule and may be called to fill in for staff shortages. This role offers flexibility but may not guarantee a certain number of hours. Weekend PRN RNs must still meet licensing and certification requirements like full-time nurses.

What are the typical shift expectations and workload for a Weekend PRN RN?

Weekend PRN RN positions usually require nurses to work flexible hours on Saturdays and Sundays, with potential opportunities for additional shifts based on staffing needs. The workload can vary each weekend, depending on patient census and acuity, so adaptability is important. These roles often involve collaborating with a leaner weekend team, requiring strong teamwork and autonomy. While you may not have a set schedule every week, PRN positions can offer valuable hands-on experience and are ideal for nurses seeking flexibility or supplemental income.

What are the key skills and qualifications needed to thrive in the Weekend PRN RN position, and why are they important?

To thrive as a Weekend PRN RN, you need a current RN license, strong clinical assessment abilities, and experience in acute or long-term care settings. Familiarity with electronic health record (EHR) systems, medication administration protocols, and facility-specific safety procedures is important. Flexibility, excellent communication, and the ability to work independently are valuable soft skills for managing varied shifts and patient needs. These competencies ensure that you can provide high-quality care and respond effectively to weekend staffing and patient demands.

Do PRN registered nurses have to work weekends?

PRN registered nurses are scheduled on an as-needed basis and are not typically required to work weekends unless assigned to weekend shifts. Their work schedule depends on the facility's staffing needs and the nurse's availability, often offering flexibility. However, some PRN positions may include weekend shifts if the facility requires coverage during those times.

What are the most commonly searched types of Prn Rn jobs in Greenville, SC?

The most popular types of Prn Rn jobs in Greenville, SC are:

What are popular job titles related to Weekend Prn Rn jobs in Greenville, SC?

For Weekend Prn Rn jobs in Greenville, SC, the most frequently searched job titles are:

What job categories do people searching Weekend Prn Rn jobs in Greenville, SC look for?

The top searched job categories for Weekend Prn Rn jobs in Greenville, SC are:

What cities near Greenville, SC are hiring for Weekend Prn Rn jobs?

Cities near Greenville, SC with the most Weekend Prn Rn job openings:

Weekend Prn Rn jobs near you
Infographic showing various Weekend Prn Rn job openings in Greenville, SC as of August 2026, with employment types broken down into 1% As Needed, 67% Full Time, 28% Part Time, 3% Contract, and 1% Nights. Highlights an 94% Physical, 1% Hybrid, and 5% Remote job distribution, with an average salary of $71,335 per year, or $34.3 per hour.

Hospice Registered Nurse (RN) - PRN

Interim HealthCare of The Upstate

Central, SC • On-site

$38.60 - $41.50/hr

Full-time

Retirement

Posted 14 days ago

Job description

It’s been said that people will forget what you say and what you do, but never how you make them feel. Hospice nurses are special in that they bring not only strong clinical skills but also a heartfelt commitment to ensuring that patients and their families receive comfort, understanding, and unwavering support during one of life's most meaningful transitions. We are seeking a compassionate and experienced Hospice Registered Nurse (RN) who is dedicated to leading with empathy, clinical excellence, and a deep respect for patient dignity. In this vital role, you will deliver exceptional, patient-centered end-of-life care that honors everyone's journey.

Guided by our mission to honor God through the enrichment of human life, Interim HealthCare has been a trusted leader in home health and hospice services across South Carolina since 1979 and is proud to be recognized as a 9x Top Workplace. We believe exceptional care begins with supported nurses, and we foster an environment where clinicians are respected, empowered, and equipped to do meaningful work—if you’re ready to make a lasting difference in patients’ lives, we invite you to join our team.

Why You’ll Love Working with Interim 

As a PRN Hospice Registered Nurse (RN) with Interim, you’ll enjoy:

  • Competitive hourly rate ranging from $38.60 to $41.50
  • Flexible scheduling that supports true work-life balance and autonomy
  • Dedicated 1:1 patient care, allowing you to focus on quality care, not volume
  • 401(k) with employer match to help you plan confidently for the future
  • Support for your growth and well-being, including free CEUs, tuition assistance, and fitness reimbursement

What You’ll Do 

As a PRN Hospice Registered Nurse (RN), you will:

  • Performs nursing assessments during scheduled and as-needed hospice visits to evaluate the patient’s physical condition, symptoms, comfort, and immediate care needs.
  • Assesses the patient’s and family’s response to the established hospice plan of care and communicates significant changes in condition or needs to the RN Case Manager and appropriate members of the interdisciplinary group (IDG).
  • Provides skilled nursing care in accordance with the established plan of care, physician orders, hospice policies, and nursing standards of practice.
  • Responds to changes in patient condition and provides appropriate nursing interventions to promote comfort, symptom control, and quality of life.
  • Administers medications and treatments as prescribed by the physician and evaluates the patient’s response to treatment.
  • Collaborates with the RN Case Manager, IDG members, physicians, and other care providers to support continuity of care and ensure patient and family needs are addressed.
  • Provides PRN coverage based on patient needs and agency staffing requirements, including visits for symptom changes, medication concerns, changes in condition, and other skilled nursing needs as assigned.

What You’ll Need 

  • Graduate of an accredited Registered Nurse (RN) program 
  • Active South Carolina RN license or Compact License 
  • Minimum one year of nursing experience 
  • Hospice experience preferred 

Apply Today 

If you are a PRN Hospice Registered Nurse (RN) looking for a rewarding Hospice opportunity in Greenville, SC, we encourage you to apply and join a compassionate, patient focused team.  

Interim HealthCare is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws. 

#IHC

PandoLogic. Keywords: Registered Nurse (RN), Location: Central, SC - 29630 , PL: 604138329