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Variant Curation Jobs (NOW HIRING)

Nationwide Children's Hospital

Assists with the day-to-day operations of variant assessment, curation, and documentation to accurately identify and classify genomic alterations detected through genomic testing and translational ...

Nationwide Children's Hospital

Assists with the day-to-day operations of variant assessment, curation, and documentation to accurately identify and classify genomic alterations detected through genomic testing and translational ...

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Variant Curation information

What is a Variant Curation job?

A Variant Curation job involves analyzing genetic variants to determine their clinical significance, primarily in the context of diseases like cancer or inherited disorders. Professionals in this role assess data from scientific literature, databases, and bioinformatics tools to classify variants based on established guidelines. Their work supports genetic testing labs, research institutions, and healthcare providers in making informed decisions about patient care. Strong analytical skills, understanding of genetics, and knowledge of bioinformatics tools are essential for success in this field.

What are the key skills and qualifications needed to thrive in the Variant Curation position, and why are they important?

To thrive in Variant Curation, you need a solid background in genetics, molecular biology, and bioinformatics, often supported by a degree in a life science field. Familiarity with genomic databases, variant interpretation software (such as ClinVar or VarSome), and standards like ACMG/AMP guidelines is critical. Attention to detail, analytical thinking, and strong communication skills help you articulate findings and work with interdisciplinary teams. These competencies are essential for accurately interpreting genetic variants and contributing to clinical decision-making or research.

What are the typical responsibilities of a Variant Curation professional on a daily basis?

Variant Curation professionals are primarily responsible for reviewing and interpreting genetic variant data by analyzing scientific literature, databases, and applying industry standards to assess clinical significance. Daily tasks involve collaborating with genetic counselors, laboratory scientists, and clinicians to ensure accurate reporting and supporting patient management. The role also often includes documentation, updating curation databases, and participating in regular team meetings to discuss complex cases. Working in this position offers exposure to the latest developments in genomics and the opportunity to directly impact patient care and diagnostic outcomes.
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Variant Curation jobs near you
Infographic showing various Variant Curation job openings in the United States as of May 2026, with employment types broken down into 94% Full Time, 3% Part Time, and 3% Contract. Highlights an 87% Physical, 3% Hybrid, and 10% Remote job distribution.
Clinical Genomics Scientist: Variant Curation & Analysis

Clinical Genomics Scientist: Variant Curation & Analysis

Baylor Genetics

Manhattan, NY • On-site

Full-time

Posted 12 days ago

Job description

A leading genetics company in the United States is seeking a Clinical Genomic Scientist to analyze clinical genetics data and curate variants for reports. Candidates should have a PhD or MD in a relevant field, with 2-4 years of experience in clinical genomics. The role involves collaboration with lab directors and R&D, contributing to cutting-edge technologies and ensuring compliance with ACMG guidelines.

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