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Variant Curation Jobs (NOW HIRING)

Baylor Genetics

Clinical Genomic Scientist - WGS

Analysis (30%): analyzing clinical genomics data, selecting variants for curation/confirmation, variant nomenclature following HGVS guidelines. * Other (20%): may involve clinical report drafting ...

Washington University of St. Louis

$77K - $120K/yr

  • Medical

  • Retirement

  • PTO

Focus of the position is on all aspects of genetic variant analysis, curation, and interpretation. Participates in i) evaluation of new tools and platforms; ii) clinical test development and ...

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Variant Curation information

What is a variant curation?

A Variant Curation job involves analyzing genetic variants to determine their clinical significance, primarily in the context of diseases like cancer or inherited disorders. Professionals in this role assess data from scientific literature, databases, and bioinformatics tools to classify variants based on established guidelines. Their work supports genetic testing labs, research institutions, and healthcare providers in making informed decisions about patient care. Strong analytical skills, understanding of genetics, and knowledge of bioinformatics tools are essential for success in this field.

What does a variant curation do?

Variant Curation professionals are primarily responsible for reviewing and interpreting genetic variant data by analyzing scientific literature, databases, and applying industry standards to assess clinical significance. Daily tasks involve collaborating with genetic counselors, laboratory scientists, and clinicians to ensure accurate reporting and supporting patient management. The role also often includes documentation, updating curation databases, and participating in regular team meetings to discuss complex cases. Working in this position offers exposure to the latest developments in genomics and the opportunity to directly impact patient care and diagnostic outcomes.

What are the key skills and qualifications needed to thrive in variant curation?

To thrive in Variant Curation, you need a solid background in genetics, molecular biology, and bioinformatics, often supported by a degree in a life science field. Familiarity with genomic databases, variant interpretation software (such as ClinVar or VarSome), and standards like ACMG/AMP guidelines is critical. Attention to detail, analytical thinking, and strong communication skills help you articulate findings and work with interdisciplinary teams. These competencies are essential for accurately interpreting genetic variants and contributing to clinical decision-making or research.

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Variant Curation jobs near you
Infographic showing various Variant Curation job openings in the United States as of August 2026, with employment types broken down into 75% Full Time, 21% Part Time, 1% Temporary, and 3% Contract. Highlights an 64% Physical, 6% Hybrid, and 30% Remote job distribution.

Clinical Genomic Scientist- Variant Curation

Baylor Genetics

Remote

Full-time

Re-posted 8 days ago

Baylor Genetics rating

8.4

Company rating: 8.4 out of 10

Based on 6 frontline employees who took The Breakroom Quiz

28th of 120 rated laboratories

Job description

Summary:
The "Clinical Genomics Scientist" analyzes clinical genetics data, curates variants and genes, and summarizes findings for clinical reports. Our scientists assist laboratory directors and R&D with validation of cutting-edge technologies and software platforms.
Duties and Responsibilities:
  • Curation (50%): curation of variants, genes, and gene-disease correlation following ACMG guidelines
  • Analysis (30%): analyzing clinical genomics data, selecting variants for curation/confirmation, variant nomenclature following HGVS guidelines
  • Other (20%): may involve clinical report drafting, test validation, process refinement, presenting findings, monitoring test turnaround time

Qualifications/Experience
  • Degree: PhD or MD in clinical medicine, genetics, molecular biology, or equivalent. Or strong candidates with a Master's degree and relevant experience. Desired: MB(ASCP) certification.
  • 2-4 years of experience in clinical genomics or related fields (including postdoctoral appointments)
  • Thorough understanding of the American College of Medical Genetics (ACMG) variant curation guidelines.
  • Knowledge of genomic variation and its correlation with human disease.
  • Expertise in concepts of clinical medicine, genetics, genomics, or molecular biology.
  • Experience in data quality assessment and communicating genetic details effectively.
  • Excellence in reading/writing medical language.
  • Proficiency in Microsoft Office (Excel, Word, PowerPoint, Outlook).
  • Desired: experience in bioinformatics analysis, variant effect prediction algorithms, and scripting languages

Competencies:
Quality Assurance, Analytical, Problem Solving, Technical Skills, Interpersonal Skills, Oral and Written Communication, Teamwork, Organizational Support, Safety and Security, Dependability, Innovation, Adaptability.
Physical Demands and Work Environment:
  • At your Home Office:
    • Frequently required to sit, using screen, keyboard, and mouse.
    • Punctuality attending virtual meetings
    • Occasional weekend rotation may be needed (for example, once a month)

EEO Statement:
Baylor Genetics is proud to be an equal opportunity employer dedicated to building an inclusive and diverse workforce. We do not discriminate based on race, religion, color, national origin, sex, sexual orientation, age, gender identity, veteran status, disability, genetic information, pregnancy, childbirth, or related medical conditions, or any other status protected under applicable federal, state, or local law.
Equal Opportunity Employer
This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.

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