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Variant Curation Scientist Jobs (NOW HIRING)

Mayo Foundation for Medical Education and Research

$88K - $132K/yr

The Variant Scientist develops and maintains gene-level curation resources to support clinical test interpretation. The Variant Scientist participates as appropriate in gene/variant curation-focused ...

Baylor Genetics

Our scientists assist laboratory directors and R&D with validation of cutting-edge technologies and ... Familiarity with American College of Medical Genetics (ACMG) variant curation guidelines.

Baylor Genetics

Clinical Genomic Scientist - WGS

Familiarity with American College of Medical Genetics (ACMG) variant curation guidelines. Rank: Clinical Genomic Scientist - WGS review I * 1 year of prior experience with whole exome or whole genome ...

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How much do variant curation scientist jobs pay per hour?

As of Sep 12, 2026, the average hourly pay for variant curation scientist in the United States is $38.99, according to ZipRecruiter salary data. Most workers in this role earn between $33.89 and $42.55 per hour, depending on experience, location, and employer.

What does a variant curation scientist do?

A Variant Curation Scientist analyzes genetic variations to determine their clinical significance, aiding in patient diagnosis and treatment. They review scientific literature, apply bioinformatics tools, and follow established guidelines to classify genetic variants. Their work supports genetic testing laboratories, researchers, and healthcare providers by ensuring accurate interpretation of genetic data. Strong attention to detail, critical thinking, and knowledge of molecular genetics are essential for this role.

What are the key skills and qualifications needed to thrive as a variant curation scientist?

To thrive as a Variant Curation Scientist, you need a strong background in genetics, molecular biology, and bioinformatics, typically supported by an advanced degree in a relevant field. Experience with tools such as genome browsers, variant annotation software, and familiarity with databases like ClinVar are highly valued, and certification from organizations like the American Board of Medical Genetics and Genomics (ABMGG) is often preferred. Attention to detail, critical thinking, and strong written communication skills set top candidates apart in this role. These abilities are essential for accurately interpreting genetic data, collaborating with clinical teams, and contributing to high-quality patient care and research.

What does a typical workday look like for a variant curation scientist?

A typical workday for a Variant Curation Scientist involves reviewing and interpreting genetic variants found in DNA sequencing data, updating and maintaining variant databases, and preparing detailed reports for clinical or research use. You may spend time collaborating closely with clinical geneticists, laboratory staff, and bioinformaticians to resolve challenging cases or discuss novel findings. Daily responsibilities also include literature review to stay current with emerging data and occasionally participating in team meetings or case conferences. The role is generally structured within a laboratory or research team, promoting a highly collaborative and knowledge-sharing environment.

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Variant Curation Scientist jobs near you
Infographic showing various Variant Curation Scientist job openings in the United States as of September 2026, with employment types broken down into 95% Full Time, and 5% Part Time. Highlights an 80% In-person, 5% Hybrid, and 15% Remote job distribution, with an average salary of $81,095 per year, or $39 per hour.

Clinical Genomic Scientist- Variant Curation

Remote

Baylor Genetics
Biotechnology Research and Development • 51 - 200 employees
Learn more about Baylor Geneticsexternal

Full-time

Re-posted 3 days ago

Baylor Genetics rating

8.4

Company rating: 8.4 out of 10

Based on 6 frontline employees who took The Breakroom Quiz

Job description

Job Description
Summary:
The "Clinical Genomics Scientist" analyzes clinical genetics data, curates variants and genes, and summarizes findings for clinical reports. Our scientists assist laboratory directors and R&D with validation of cutting-edge technologies and software platforms.
Duties and Responsibilities:
  • Curation (50%): curation of variants, genes, and gene-disease correlation following ACMG guidelines
  • Analysis (30%): analyzing clinical genomics data, selecting variants for curation/confirmation, variant nomenclature following HGVS guidelines
  • Other (20%): may involve clinical report drafting, test validation, process refinement, presenting findings, monitoring test turnaround time

Qualifications/Experience
  • Degree: PhD or MD in clinical medicine, genetics, molecular biology, or equivalent. Or strong candidates with a Master's degree and relevant experience. Desired: MB(ASCP) certification.
  • 2-4 years of experience in clinical genomics or related fields (including postdoctoral appointments)
  • Thorough understanding of the American College of Medical Genetics (ACMG) variant curation guidelines.
  • Knowledge of genomic variation and its correlation with human disease.
  • Expertise in concepts of clinical medicine, genetics, genomics, or molecular biology.
  • Experience in data quality assessment and communicating genetic details effectively.
  • Excellence in reading/writing medical language.
  • Proficiency in Microsoft Office (Excel, Word, PowerPoint, Outlook).
  • Desired: experience in bioinformatics analysis, variant effect prediction algorithms, and scripting languages

Competencies:
Quality Assurance, Analytical, Problem Solving, Technical Skills, Interpersonal Skills, Oral and Written Communication, Teamwork, Organizational Support, Safety and Security, Dependability, Innovation, Adaptability.
Physical Demands and Work Environment:
  • At your Home Office:
    • Frequently required to sit, using screen, keyboard, and mouse.
    • Punctuality attending virtual meetings
    • Occasional weekend rotation may be needed (for example, once a month)

PHYSICAL DEMANDS AND WORK ENVIRONMENT:
  • Frequently required to sit.

  • Frequently required to utilize hand and finger dexterity.

  • Frequently required to talk or hear.

EEO Statement:
Baylor Genetics is proud to be an equal opportunity employer dedicated to building an inclusive and diverse workforce. We do not discriminate based on race, religion, color, national origin, sex, sexual orientation, age, gender identity, veteran status, disability, genetic information, pregnancy, childbirth, or related medical conditions, or any other status protected under applicable federal, state, or local law.
Equal Opportunity Employer
This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.

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