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Variant Curation Scientist Jobs (NOW HIRING)

Exact Sciences

Sr Product Owner

San Diego, CA · On-site

Help us change lives At Exact Sciences, we're helping change how the world prevents, detects and ... Understand end-to-end sample to answer workflows, including bioinformatics output, variant curation ...

Exactsciences

Sr Product Owner

San Diego, CA

Help us change lives At Exact Sciences, we're helpingchange how the world prevents, detects and ... Understand end-to-endsampletoanswerworkflows, including bioinformatics output, variant curation ...

Baylor Genetics

Complete gene-disease-variant curation for cases and back-end * Assisting team as needed Duties of ... Focus on the scientific and analytical evaluation of genetic data. * Maintain gene-disease ...

Exact Sciences

Sr Product Owner

San Diego, CA

Help us change lives At Exact Sciences, we're helping change how the world prevents, detects and ... Understand end-to-end sample to answer workflows, including bioinformatics output, variant curation ...

Nationwide Children's Hospital

... Scientists ... Assists with the day-to-day operations of variant assessment, curation, and documentation to ...

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How much do variant curation scientist jobs pay per hour?

As of May 31, 2026, the average hourly pay for variant curation scientist in the United States is $38.99, according to ZipRecruiter salary data. Most workers in this role earn between $33.89 and $42.55 per hour, depending on experience, location, and employer.

What does a Variant Curation Scientist do?

A Variant Curation Scientist analyzes genetic variations to determine their clinical significance, aiding in patient diagnosis and treatment. They review scientific literature, apply bioinformatics tools, and follow established guidelines to classify genetic variants. Their work supports genetic testing laboratories, researchers, and healthcare providers by ensuring accurate interpretation of genetic data. Strong attention to detail, critical thinking, and knowledge of molecular genetics are essential for this role.

What are the key skills and qualifications needed to thrive in the Variant Curation Scientist position, and why are they important?

To thrive as a Variant Curation Scientist, you need a strong background in genetics, molecular biology, and bioinformatics, typically supported by an advanced degree in a relevant field. Experience with tools such as genome browsers, variant annotation software, and familiarity with databases like ClinVar are highly valued, and certification from organizations like the American Board of Medical Genetics and Genomics (ABMGG) is often preferred. Attention to detail, critical thinking, and strong written communication skills set top candidates apart in this role. These abilities are essential for accurately interpreting genetic data, collaborating with clinical teams, and contributing to high-quality patient care and research.

What does a typical workday look like for a Variant Curation Scientist?

A typical workday for a Variant Curation Scientist involves reviewing and interpreting genetic variants found in DNA sequencing data, updating and maintaining variant databases, and preparing detailed reports for clinical or research use. You may spend time collaborating closely with clinical geneticists, laboratory staff, and bioinformaticians to resolve challenging cases or discuss novel findings. Daily responsibilities also include literature review to stay current with emerging data and occasionally participating in team meetings or case conferences. The role is generally structured within a laboratory or research team, promoting a highly collaborative and knowledge-sharing environment.
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Variant Curation Scientist jobs near you
Clinical Genomics Variant Scientist

Clinical Genomics Variant Scientist

UCLA Health

Los Angeles, CA

$105.70K - $234.50K/yr

Full-time

Posted 2 days ago

UCLA Health rating

8.7

Company rating: 8.7 out of 10

Based on 133 frontline employees who took The Breakroom Quiz

6th of 864 rated healthcare providers

Job description

Description

The Molecular Diagnostics Laboratory is seeking an experienced Variant Scientist to join our clinical team. In this critical role, you will curate and interpret germline and somatic variants and prepare high-quality clinical reports derived from exome and targeted cancer sequencing assays. You will contribute to variant classification, test development efforts, and clinical research projects that advance precision medicine for patients across UCLA Health and beyond. Primary duties include:

• Review and assess patient clinical notes and sequencing data from high-complexity molecular assays, including Clinical Exome Sequencing, Solid Tumor Sequencing Panels, and Hematologic Malignancy Sequencing Panels.

• Perform variant curation and interpretation using established guidelines and evidence-based resources.

• Draft and refine clinical reports, ensuring accuracy, clarity, and clinical relevance.

• Develop and update SOPs for variant curation, interpretation, and reclassification workflows

• Participate in submitting curated variants to public databases (e.g. ClinVar) and contribute to quality improvement and test development initiatives.

• Collaborate with clinicians, genetic counselors, and laboratory staff to support accurate and timely reporting.

• Contribute to clinical research projects and assist in implementing new molecular diagnostic assays.

Salary Range: $105,700.00 - $234,500.00/year 

Qualifications
• At least two years’ experience in germline variant curation is required. Somatic variant curation experience is a plus.
• Strong working knowledge of laboratory genetics and genomics, including target capture, amplification, and massively parallel sequencing.
• Familiarity with widely used genomic tools such as IGV and UCSC/COSMIC genome browsers
• Ability to establish effective working relationships with clinicians, genetic counselors, and other team members.
• Programming or bioinformatics experience (e.g. R, SAS, Perl, Python, regex, database design) – preferred.
• PhD in human genetics, molecular genetics, cancer biology, or a related discipline – preferred. Master’s degree in molecular biology, genetics, or a closely related field may be considered with relevant experience.

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About UCLA Health

Sourced by ZipRecruiter

UCLA Health, operating within the healthcare industry, is significantly recognized for its commitment to improving the health and wellbeing of people through the integration of patient care, research, and education. Located in Los Angeles, California, UCLA Health was founded and associated with the University of California, Los Angeles (UCLA) in 1955, entrenching its roots in quality healthcare service provision. Through a broad range of medical services, UCLA Health significantly stands as a cornerstone for comprehensive outpatient, inpatient, and emergency care services, specialized treatments, and wellness checks. Notable for pioneering an integrated, comprehensive medical approach, UCLA Health is consistently ranked among the top health systems in the US and world.

Industry

Health care and social assistance

Company size

10,000+ Employees

Headquarters location

Los Angeles, CA, US

Year founded

1955

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