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On Call Variant Curation Scientist Jobs (NOW HIRING)

Exactsciences

Sr Product Owner

San Diego, CA · On-site

Help us change lives At Exact Sciences, we're helpingchange how the world prevents, detects and ... Understand end-to-endsampletoanswerworkflows, including bioinformatics output, variant curation ...

Nationwide Children's Hospital

... Scientists ... Assists with the day-to-day operations of variant assessment, curation, and documentation to ...

Nationwide Children's Hospital

... Scientists. Assists with the day-to-day operations of variant assessment, curation, and documentation to accurately identify and classify genomic alterations detected through genomic testing and ...

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On Call Variant Curation Scientist information

What is an On Call Variant Curation Scientist?

An On Call Variant Curation Scientist is a genetics professional who evaluates and interprets genetic variants, often on an as-needed or flexible basis, to determine their clinical significance. They review scientific literature, databases, and laboratory data to classify genetic mutations, particularly in the context of patient care or research projects. Their expertise helps inform diagnostic decisions and supports genetic counseling. The 'on call' aspect means they are available to respond to urgent or time-sensitive variant curation requests outside of standard working hours.

What are the key skills and qualifications needed to thrive as an On Call Variant Curation Scientist, and why are they important?

To thrive as an On Call Variant Curation Scientist, you need a solid background in genetics, molecular biology, and clinical genomics, typically with an advanced degree in a life science field. Familiarity with bioinformatics tools, variant interpretation databases (such as ClinVar), and ACMG/AMP guidelines is essential, and certification from organizations like the American Board of Medical Genetics and Genomics (ABMGG) is often preferred. Excellent analytical thinking, attention to detail, and effective communication skills are crucial for interpreting data and collaborating with clinical teams. These competencies ensure accurate and timely variant classification, directly impacting patient care and genetic diagnosis.

What are the primary challenges faced by an On Call Variant Curation Scientist, and how can these be managed effectively?

On Call Variant Curation Scientists often encounter the challenge of rapidly interpreting complex genetic data while being available outside of standard working hours. This requires staying up-to-date with evolving scientific literature, managing urgent requests, and collaborating with clinical teams to ensure accurate and timely reporting. Effective time management, continuous learning, and strong communication skills are crucial for managing these demands. Leveraging robust databases and established protocols can also help streamline the variant curation process during on-call shifts.
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On Call Variant Curation Scientist jobs near you
Infographic showing various On Call Variant Curation Scientist job openings in the United States as of June 2026, with employment types broken down into 4% Locum Tenens, 2% Internship, 1% Full Time, 92% Contract, and 1% Summer. Highlights an 94% Physical, 1% Hybrid, and 5% Remote job distribution.
Clinical Genomics Variant Scientist

Clinical Genomics Variant Scientist

UCLA Health

Los Angeles, CA

$105K - $234K/yr

Full-time

Posted 15 days ago

UCLA Health rating

8.7

Company rating: 8.7 out of 10

Based on 134 frontline employees who took The Breakroom Quiz

6th of 872 rated healthcare providers

Job description

Description

The Molecular Diagnostics Laboratory is seeking an experienced Variant Scientist to join our clinical team. In this critical role, you will curate and interpret germline and somatic variants and prepare high-quality clinical reports derived from exome and targeted cancer sequencing assays. You will contribute to variant classification, test development efforts, and clinical research projects that advance precision medicine for patients across UCLA Health and beyond. Primary duties include:

• Review and assess patient clinical notes and sequencing data from high-complexity molecular assays, including Clinical Exome Sequencing, Solid Tumor Sequencing Panels, and Hematologic Malignancy Sequencing Panels.

• Perform variant curation and interpretation using established guidelines and evidence-based resources.

• Draft and refine clinical reports, ensuring accuracy, clarity, and clinical relevance.

• Develop and update SOPs for variant curation, interpretation, and reclassification workflows

• Participate in submitting curated variants to public databases (e.g. ClinVar) and contribute to quality improvement and test development initiatives.

• Collaborate with clinicians, genetic counselors, and laboratory staff to support accurate and timely reporting.

• Contribute to clinical research projects and assist in implementing new molecular diagnostic assays.

Salary Range: $105,700.00 - $234,500.00/year 

Qualifications
• At least two years’ experience in germline variant curation is required. Somatic variant curation experience is a plus.
• Strong working knowledge of laboratory genetics and genomics, including target capture, amplification, and massively parallel sequencing.
• Familiarity with widely used genomic tools such as IGV and UCSC/COSMIC genome browsers
• Ability to establish effective working relationships with clinicians, genetic counselors, and other team members.
• Programming or bioinformatics experience (e.g. R, SAS, Perl, Python, regex, database design) – preferred.
• PhD in human genetics, molecular genetics, cancer biology, or a related discipline – preferred. Master’s degree in molecular biology, genetics, or a closely related field may be considered with relevant experience.

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About UCLA Health

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UCLA Health, operating within the healthcare industry, is significantly recognized for its commitment to improving the health and wellbeing of people through the integration of patient care, research, and education. Located in Los Angeles, California, UCLA Health was founded and associated with the University of California, Los Angeles (UCLA) in 1955, entrenching its roots in quality healthcare service provision. Through a broad range of medical services, UCLA Health significantly stands as a cornerstone for comprehensive outpatient, inpatient, and emergency care services, specialized treatments, and wellness checks. Notable for pioneering an integrated, comprehensive medical approach, UCLA Health is consistently ranked among the top health systems in the US and world.

Industry

Health care and social assistance

Company size

10,000+ Employees

Headquarters location

Los Angeles, CA, US

Year founded

1955

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