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Ngs Variant Interpretation Jobs (NOW HIRING)

Quest Diagnostics

Sr. Scientist (NGS/LRS)

Marlborough, MA · On-site

$103K/yr

Under the Associate Scientific Director, the Senior Scientist will use technical expertise of NGS ... Deep understanding of genomics and genetics, including variant interpretation and solutioning for ...

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Ngs Variant Interpretation information

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$20.5K

$83.3K

$147K

How much do ngs variant interpretation jobs pay per year?

As of Jul 14, 2026, the average yearly pay for ngs variant interpretation in the United States is $83,348.00, according to ZipRecruiter salary data. Most workers in this role earn between $49,000.00 and $111,000.00 per year, depending on experience, location, and employer.

What is NGS variant interpretation?

NGS variant interpretation is the process of analyzing genetic variants identified through Next-Generation Sequencing (NGS) technology to determine their potential impact on health, disease, or traits. This involves filtering, annotating, and classifying variants according to established guidelines, such as those from the American College of Medical Genetics and Genomics (ACMG). Professionals in this field use bioinformatics tools and databases to interpret the clinical significance of genetic changes and often communicate their findings to clinicians or researchers for decision-making in healthcare or research settings.

What is the difference between Ngs Variant Interpretation vs Genetic Counselor?

AspectNgs Variant InterpretationGenetic Counselor
Required CredentialsCertification in genetics or molecular diagnostics, often a laboratory certificationMaster's degree in genetics, counseling, or related field; certification (ABGC, NSGC)
Work EnvironmentLaboratory setting, analyzing genetic data and variantsClinical setting, providing patient counseling and education
Industry UsageUsed primarily in diagnostic labs and research institutionsUsed in hospitals, clinics, and healthcare facilities
Primary FocusInterpreting genetic variants from NGS dataCommunicating genetic information and implications to patients

While Ngs Variant Interpretation specialists focus on analyzing and interpreting genetic data within laboratories, Genetic Counselors work directly with patients to explain genetic information and its health implications. Both roles require a strong understanding of genetics but serve different functions within the healthcare and diagnostics industry.

What are some of the main challenges faced when interpreting NGS variants, and how can professionals address them?

One of the main challenges in NGS variant interpretation is distinguishing between benign and pathogenic variants, especially when dealing with variants of uncertain significance (VUS). Professionals must stay updated with the latest research, utilize comprehensive databases, and collaborate closely with geneticists, clinicians, and bioinformaticians to ensure accurate interpretation. Regular participation in multidisciplinary team meetings and continuous professional development are essential for overcoming these challenges and delivering clinically actionable insights.

What are the key skills and qualifications needed to thrive as an NGS Variant Interpretation Specialist, and why are they important?

To thrive as an NGS Variant Interpretation Specialist, you need a solid background in genetics, molecular biology, and bioinformatics, often supported by an advanced degree in a life science field. Familiarity with next-generation sequencing (NGS) platforms, databases like ClinVar and HGMD, and analysis tools such as GATK and ANNOVAR is typically required. Strong analytical thinking, attention to detail, and effective communication skills help in interpreting complex genomic data and conveying findings to clinicians or researchers. These skills are crucial for ensuring accurate variant classification, supporting clinical decision-making, and advancing personalized medicine.
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Ngs Variant Interpretation jobs near you
Infographic showing various Ngs Variant Interpretation job openings in the United States as of July 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $83,348 per year, or $40.1 per hour.
Clinical Genomics Scientist

Clinical Genomics Scientist

Phoenix Children's Hospital

Phoenix, AZ • On-site

Full-time

Posted 25 days ago

Job description

Position Details
Department: PCH-MAIN | Lab Genomics
Location: Phoenix
Shift: Mon-Fri, Shifts Vary, 8am-5pm
Category: Laboratory/Pathology
Posting #: 1027389
Employee Type: Full-Time
Position Summary
The Clinical Genomics Scientist plays a critical role in variant interpretation, classification, and reporting to support clinical genomic testing. This position provides high-level scientific expertise in the analysis of genetic testing data including next-generation sequencing (NGS) such including NGS panels, whole exome sequencing (WES), and whole genome sequencing (WGS). The Clinical Genomics Scientist will work closely with Clinical Genomics physician leadership to ensure high-quality, clinically reliable genomic results and to advance the adoption of cutting-edge innovations in genomic testing. Responsibilities include supporting the director's efforts in test development, implementation, optimization, and validation, as well as contributing to the growth and development of Phoenix Children's Clinical Genomics Laboratory. This is a laboratory staff position with accountability to laboratory leadership for operational and administrative matters and to physician leadership for all clinical, scientific, and laboratory interpretation activities. The Clinical Genomics Scientist is expected to work within the priorities, direction, and defined scope established by laboratory leadership. Activities or commitments outside the defined scope of this role require advanced approval from laboratory leadership.
Position Duties
  • Variant Interpretation and Reporting
    Interpret and classify genetic variants for all assays including NGS assays (WES, WGS, targeted panels); apply ACMG/AMP guidelines and prepare evidence-based summaries.
  • Data Review and Quality Control
    Review sequencing data to identify artifacts and ensure high-confidence variant calls; maintain documentation and compliance.
  • Validation and Implementation of New Technologies
    Support validation and launch of new NGS and bioinformatics platforms, assuring accuracy and efficiency.
  • Clinical Reporting Collaboration
    Collaborate with laboratory medical director(s), genetic counselor(s) to prepare and finalize clinical reports for patient care.
  • Workflow Development and Optimization
    Work with bioinformatics and technical teams to troubleshoot pipelines and optimize variant analysis performance.
  • Gene and Variant Curation
    Contribute to curation initiatives and update panel content to enhance clinical relevance and data consistency.
  • Quality Assurance and Compliance
    Participate in internal audits, proficiency testing, and ongoing QC processes to uphold CLIA/CAP standards.
  • Training and Mentorship
    Train and mentor technologists, fellows, and bioinformaticians in variant interpretation and workflow best practices.
  • Scientific Engagement
    Stay current on emerging genomic technologies and present findings at internal meetings or conferences.
  • Performs miscellaneous job related duties as requested.

Phoenix Children's Mission, Vision, & Values
Mission
To advance hope, healing and the best healthcare for children and their families
Vision
Phoenix Children's will be the leading pediatric health system in the Southwest, nationally recognized for exceptional care, innovative research and advanced medical education.
We realize this vision by:
  • Offering the most comprehensive care across ages, communities and specialties
  • Investing in innovative research, including emerging treatments, tools and technologies
  • Advancing education and training to shape the next generation of clinical leaders
  • Advocating for the health and well-being of children and families
Values
  • We place children and families at the center of all we do
  • We deliver exceptional care, every day and in every way
  • We collaborate with colleagues, partners and communities to amplify our impact
  • We set the standards of pediatric healthcare today, and innovate for the future
  • We are accountable for making the highest quality care accessible and affordable
Phoenix Children's Hospital logo

About Phoenix Children's Hospital

Sourced by ZipRecruiter

Phoenix Children's Hospital, located in Phoenix, AZ, is a prominent establishment within the healthcare industry. Known for its commitment to pediatric healthcare, the hospital provides a vast range of services catering to the unique health needs of children. Originally founded in 1983, Phoenix Children's Hospital prides itself on being one of the largest and most respected children's hospitals in the country. Guided by its mission–"to provide hope, healing and the best healthcare for children and their families"–the hospital holds strong on its core values of family-centered care, excellence in clinical care, innovation, and stewardship.

Industry

Health care and social assistance

Company size

1,001 - 5,000 Employees

Headquarters location

Phoenix, AZ, US

Year founded

1983

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