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Trial Master File Jobs in Raleigh, NC (NOW HIRING)

IQVIA

Clinical Research Associate

Durham, NC · On-site

$71K - $189K/yr

Ensure essential study documentation is complete, accurate, and maintained within the Trial Master File (TMF) and Investigator Site File (ISF). * Prepare comprehensive monitoring reports, follow-up ...

IQVIA

Clinical Research Associate 2, IQVIA

Durham, NC · On-site

$71K - $189K/yr

Ensure copies/originals (as required) site documents are available for filing in the Trial Master File (TMF) and verify that the Investigator's Site File (ISF) is maintained in accordance with GCP ...

IQVIA

Clinical Research Associate 2, IQVIA

Durham, NC · On-site

$71K - $189K/yr

Ensure copies/originals (as required) site documents are available for filing in the Trial Master File (TMF) and verify that the Investigator's Site File (ISF) is maintained in accordance with GCP ...

IQVIA Argentina

CRA 2, Oncology, IQVIA Biotech

Durham, NC · On-site

$74K - $175K/yr

Ensure that essential documents are collected and maintained in both the Trial Master File (TMF) and the Investigator Site File (ISF) in accordance with regulatory standards. * Document site ...

New

IQVIA

CRA 2, Oncology, IQVIA Biotech

Durham, NC · On-site

$74K - $175K/yr

Ensure that essential documents are collected and maintained in both the Trial Master File (TMF) and the Investigator Site File (ISF) in accordance with regulatory standards. * Document site ...

IQVIA

CRA 2, Oncology, IQVIA Biotech

Durham, NC · On-site

$74K - $175K/yr

Ensure that essential documents are collected and maintained in both the Trial Master File (TMF) and the Investigator Site File (ISF) in accordance with regulatory standards. * Document site ...

IQVIA

Clinical Research Associate 2, IQVIA

Durham, NC · On-site

$71K - $189K/yr

Ensure copies/originals (as required) site documents are available for filing in the Trial Master File (TMF) and verify that the Investigator's Site File (ISF) is maintained in accordance with GCP ...

IQVIA

Clinical Research Associate 2, IQVIA

Durham, NC · On-site

$71K - $189K/yr

Ensure copies/originals (as required) site documents are available for filing in the Trial Master File (TMF) and verify that the Investigator's Site File (ISF) is maintained in accordance with GCP ...

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All JobsTrial Master File JobsTrial Master File Jobs in Raleigh, NC

Trial Master File information

See Raleigh, NC salary details

$11

$38

$75

How much do trial master file jobs pay per hour?

As of Sep 14, 2026, the average hourly pay for trial master file in Raleigh, NC is $38.39, according to ZipRecruiter salary data. Most workers in this role earn between $24.86 and $46.70 per hour, depending on experience, location, and employer.

What is a trial master file?

A Trial Master File (TMF) job involves managing and maintaining essential documents related to clinical trials to ensure compliance with regulatory requirements. Professionals in this role organize, track, and audit critical trial documentation to support inspections and submissions. They work closely with clinical teams, sponsors, and regulatory authorities to ensure proper documentation is accurate, complete, and audit-ready throughout the trial lifecycle.

What are the typical responsibilities and daily tasks of a trial master file specialist?

As a TMF Specialist, your main responsibilities include managing, organizing, and maintaining all essential clinical trial documentation to ensure compliance with regulatory standards. On a daily basis, you will review and upload documents to eTMF systems, track document status, resolve discrepancies, and support study teams during audits or inspections. You'll collaborate closely with clinical research associates, project managers, and quality assurance teams to ensure the TMF is complete and inspection-ready at all times. The work is detail-oriented and deadline-driven, offering opportunities to develop expertise in regulatory standards and advance into roles such as TMF Manager or Clinical Trial Associate.

What are the key skills and qualifications needed to thrive in the trial master file position, and why are they important?

To thrive in a Trial Master File (TMF) Specialist role, you need meticulous organizational skills, comprehensive knowledge of regulatory requirements for clinical trials, and often a bachelor's degree in life sciences or a related field. Familiarity with electronic Trial Master File (eTMF) systems, document management platforms, and relevant GCP (Good Clinical Practice) certifications is commonly required. Attention to detail, proactive communication, and the ability to collaborate effectively across clinical research teams are key soft skills. These competencies ensure regulatory compliance and seamless documentation, which are critical for the successful conduct and audit-readiness of clinical trials.

What are popular job titles related to Trial Master File jobs in Raleigh, NC?

For Trial Master File jobs in Raleigh, NC, the most frequently searched job titles are:

What job categories do people searching Trial Master File jobs in Raleigh, NC look for?

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What cities near Raleigh, NC are hiring for Trial Master File jobs?

Cities near Raleigh, NC with the most Trial Master File job openings:

Trial Master File jobs near you
Infographic showing various Trial Master File job openings in Raleigh, NC as of September 2026, with employment types broken down into 71% Full Time, 10% Temporary, and 19% Contract. Highlights an 82% In-person, and 18% Remote job distribution, with an average salary of $79,855 per year, or $38.4 per hour.

Clinical Research Associate, Sponsor Dedicated, Oncology

Durham, NC • On-site

IQVIA Argentina
See more jobs at IQVIA Argentinaexternal

$90K - $197K/yr

Other

Posted 12 days ago

Key responsibilities

  • Conduct site visits including selection, initiation, monitoring, and close-out to ensure compliance with GCP and ICH guidelines.

  • Collaborate with sites to develop, track, and ensure recruitment plans meet project needs.

  • Maintain essential study documentation and evaluate site practices for protocol adherence.

Job description

Role Overview:

As a Clinical Research Associate, you’ll be at the forefront of ensuring our study sites operate smoothly and efficiently. Your work will be pivotal in advancing groundbreaking research.

Key Responsibilities:
  • Site Visits: Conduct selection, initiation, monitoring, and close-out visits, ensuring compliance with Good Clinical Practice (GCP) and International Conference on Harmonization (ICH) guidelines.
  • Recruitment Drive: Collaborate with sites to develop and track recruitment plans, ensuring project needs are met.
  • Training & Communication: Provide protocol training and maintain regular communication with sites to manage expectations and address issues.
  • Quality Assurance: Evaluate site practices for protocol adherence and elevate quality issues as needed.
  • Study Progress: Track regulatory submissions, recruitment, enrollment, and data management to ensure smooth study progress.
  • Documentation: Maintain essential documents in the Trial Master File (TMF) and Investigator’s Site File (ISF) as per regulatory requirements.
  • Mentorship: Mentor clinical staff through co-monitoring and training visits.
  • Collaboration: Work closely with study team members to support project execution.
  • Financial Management: Manage site finances and retrieve invoices as per local requirements.
Qualifications:
  • Education: BS Degree in a scientific discipline or healthcare preferred.
  • Experience: Minimum 1 year of on-site monitoring experience in oncology; 2 years preferred.
  • Knowledge: Strong understanding of GCP and ICH guidelines, with expertise in oncology protocols.
  • Skills: Proficiency in Microsoft Office, excellent communication skills, and strong organizational and problem-solving abilities.
  • Attributes: Effective time and financial management, and the ability to build strong working relationships.
Why Join Us?

Be part of a team that’s driving innovation in clinical research. Your contributions will help shape the future of healthcare.

IQVIA is a leading global provider of clinical research services, commercial insights and healthcare intelligence to the life sciences and healthcare industries. We create intelligent connections to accelerate the development and commercialization of innovative medical treatments to help improve patient outcomes and population health worldwide. Learn more at https://jobs.iqvia.com

IQVIA is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, status as a protected veteran, or any other status protected by applicable law. https://jobs.iqvia.com/eoe

IQVIA is committed to integrity in our hiring process and maintains a zero tolerance policy for candidate fraud. All information and credentials submitted in your application must be truthful and complete. Any false statements, misrepresentations, or material omissions during the recruitment process will result in immediate disqualification of your application, or termination of employment if discovered later, in accordance with applicable law. We appreciate your honesty and professionalism.

The potential base pay range for this role, when annualized, is $90,200.00 - $197,500.00. The actual base pay offered may vary based on a number of factors including job-related qualifications such as knowledge, skills, education, and experience; location; and/or schedule (full or part-time). Dependent on the position offered, incentive plans, bonuses, and/or other forms of compensation may be offered, in addition to a range of health and welfare and/or other benefits.

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