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Trial Master File Jobs in Raleigh, NC (NOW HIRING)

IQVIA

Clinical Trial Assistant

Durham, NC · On-site

$34.40K - $118.60K/yr

Essential Functions Assist Clinical Research Associates (CRAs) and Regulatory and Start-Up (RSU) team with accurately updating and maintaining clinical documents and systems (e.g., Trial Master File ...

RQM+

Clinical Trial Associate

Cary, NC · On-site

$31.25 - $42.75/hr

Maintain audit ready filing in the (electronic) Trial Master File (eTMF) * Complete routine QC checks of eTMF and corrects discrepancies * Assist with the creation and distribution of Investigator ...

IQVIA, Inc.

TMF Quality Project Manager (Remote)

Durham, NC · On-site +1

$47.40K - $118.60K/yr

Job Overview Serve as the liaison between Records Management and user departments regarding Trial Master Files. Apply clinical research records management expertise to provide project-related ...

IQVIA

TMF Quality Project Manager (Remote)

Durham, NC · Remote

$47.40K - $118.60K/yr

Job Overview Serve as the liaison between Records Management and user departments regarding Trial Master Files. Apply clinical research records management expertise to provide project-related ...

IQVIA

TMF Quality Project Manager (Remote)

Durham, NC · Remote

$47.40K - $118.60K/yr

Job Overview Serve as the liaison between Records Management and user departments regarding Trial Master Files. Apply clinical research records management expertise to provide project-related ...

IQVIA

CRA 2, Oncology, IQVIA

Durham, NC

$87.20K - $145.30K/yr

Ensure copies/originals (as required) site documents are available for filing in the Trial Master File (TMF) and verify that the Investigator's Site File (ISF) is maintained in accordance with GCP ...

Syneos Health

CTM - Future Roles (US)

Morrisville, NC · On-site

Reconciles contents of the ISF with the Trial Master File (TMF). Ensures the investigator/physician site is aware of the requirement of archiving essential documents in accordance with local ...

IQVIA

Clinical Research Associate

Durham, NC

$87.20K - $182K/yr

Ensure copies/originals (as required) site documents are available for filing in the Trial Master File (TMF) and verify that the Investigator's Site File (ISF) is maintained in accordance with GCP ...

IQVIA

Clinical Research Associate, Full Service

Durham, NC · On-site

$47.40K - $169.30K/yr

Ensure copies/originals (as required) site documents are available for filing in the Trial Master File (TMF) verify that the Investigator's Site File (ISF) is maintained in accordance with GCP / ICH ...

IQVIA

Clinical Research Associate

Durham, NC · On-site

$71.90K - $189K/yr

Ensure copies/originals (as required) site documents are available for filing in the Trial Master File (TMF) and verify that the Investigator's Site File (ISF) is maintained in accordance with GCP ...

IQVIA

Sr. CRA 1, Oncology, IQVIA Biotech

Durham, NC · On-site

$87.20K - $169.30K/yr

Ensure copies/originals (as required) site documents are available for filing in the Trial Master File (TMF) and verify that the Investigator's Site File (ISF) is maintained in accordance with GCP ...

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How much do trial master file jobs pay per hour?

As of May 28, 2026, the average hourly pay for trial master file in Raleigh, NC is $38.39, according to ZipRecruiter salary data. Most workers in this role earn between $24.86 and $46.70 per hour, depending on experience, location, and employer.

What is a Trial Master File job?

A Trial Master File (TMF) job involves managing and maintaining essential documents related to clinical trials to ensure compliance with regulatory requirements. Professionals in this role organize, track, and audit critical trial documentation to support inspections and submissions. They work closely with clinical teams, sponsors, and regulatory authorities to ensure proper documentation is accurate, complete, and audit-ready throughout the trial lifecycle.

What are the key skills and qualifications needed to thrive in the Trial Master File position, and why are they important?

To thrive in a Trial Master File (TMF) Specialist role, you need meticulous organizational skills, comprehensive knowledge of regulatory requirements for clinical trials, and often a bachelor's degree in life sciences or a related field. Familiarity with electronic Trial Master File (eTMF) systems, document management platforms, and relevant GCP (Good Clinical Practice) certifications is commonly required. Attention to detail, proactive communication, and the ability to collaborate effectively across clinical research teams are key soft skills. These competencies ensure regulatory compliance and seamless documentation, which are critical for the successful conduct and audit-readiness of clinical trials.

What are the typical responsibilities and daily tasks of a Trial Master File (TMF) Specialist?

As a TMF Specialist, your main responsibilities include managing, organizing, and maintaining all essential clinical trial documentation to ensure compliance with regulatory standards. On a daily basis, you will review and upload documents to eTMF systems, track document status, resolve discrepancies, and support study teams during audits or inspections. You'll collaborate closely with clinical research associates, project managers, and quality assurance teams to ensure the TMF is complete and inspection-ready at all times. The work is detail-oriented and deadline-driven, offering opportunities to develop expertise in regulatory standards and advance into roles such as TMF Manager or Clinical Trial Associate.
More about Trial Master File jobs
What are the most commonly searched types of Trial Master File jobs in Raleigh, NC? The most popular types of Trial Master File jobs in Raleigh, NC are:
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What job categories do people searching Trial Master File jobs in Raleigh, NC look for? The top searched job categories for Trial Master File jobs in Raleigh, NC are:
What cities near Raleigh, NC are hiring for Trial Master File jobs? Cities near Raleigh, NC with the most Trial Master File job openings:
Trial Master File jobs near you
Infographic showing various Trial Master File job openings in Raleigh, NC as of May 2026, with employment types broken down into 100% Full Time. Highlights an 83% In-person, and 17% Remote job distribution, with an average salary of $79,855 per year, or $38.4 per hour.
Clinical Trial Assistant

Clinical Trial Assistant

IQVIA

Durham, NC • On-site

$34.40K - $118.60K/yr

Full-time

Posted 13 days ago

IQVIA rating

8.1

Company rating: 8.1 out of 10

Based on 51 frontline employees who took The Breakroom Quiz

55th of 204 rated it services

Job description

Essential Functions
Assist Clinical Research Associates (CRAs) and Regulatory and Start-Up (RSU) team with accurately updating and maintaining clinical documents and systems (e.g., Trial Master File (TMF)) that track site compliance and performance within project timelines.
Assist the clinical team with the preparation, handling, distribution, filing, and archiving of clinical documentation and reports according to the scope of work and standard operating procedures.
Assist with periodic review of study files for completeness.
Assist CRAs and RSU with preparation, handling and distribution of Clinical Trial Supplies and maintenance of tracking information.
Assist with the tracking and management of Case Report Forms (CRFs), queries and clinical data flow.
Act as a central contact for the clinical team for designated project communications, correspondence and associated documentation.
May accompany CRAs on site visits to assist with clinical monitoring duties upon completion of required training.
Qualifications
Bachelor's DegreeRequired
3 years administrative support experience.
Equivalent combination of education, training and experience.
Computer skills including working knowledge of Microsoft Word, Excel and PowerPoint.
Written and verbal communication skills including good command of English language.
Effective time management and organizational skills.
Ability to establish and maintain effective working relationships with coworkers, managers, and clients.
Awareness of applicable clinical research regulatory requirements, i.e., Good Clinical Practice (GCP) and International Conference on Harmonization (ICH) guidelines as provided in company training.
Knowledge of applicable protocol requirements as provided in company training.

IQVIA is a leading global provider of clinical research services, commercial insights and healthcare intelligence to the life sciences and healthcare industries. We create intelligent connections to accelerate the development and commercialization of innovative medical treatments to help improve patient outcomes and population health worldwide. Learn more athttps://jobs.iqvia.com

IQVIA is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, status as a protected veteran, or any other status protected by applicable law. https://jobs.iqvia.com/eoe

IQVIA is committed to integrity in our hiring process and maintains a zero tolerance policy for candidate fraud. All information and credentials submitted in your application must be truthful and complete. Any false statements, misrepresentations, or material omissions during the recruitment process will result in immediate disqualification of your application, or termination of employment if discovered later, in accordance with applicable law. We appreciate your honesty and professionalism.

The potential base pay range for this role, when annualized, is $34,400.00 - $118,600.00. The actual base pay offered may vary based on a number of factors including job-related qualifications such as knowledge, skills, education, and experience; location; and/or schedule (full or part-time). Dependent on the position offered, incentive plans, bonuses, and/or other forms of compensation may be offered, in addition to a range of health and welfare and/or other benefits.

What IQVIA employees say

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About IQVIA

Sourced by ZipRecruiter

At IQVIA, we are passionate about helping customers and partners improve results and patient outcomes. Everything we do contributes to this vision for creating a healthier world. In today’s healthcare environment, it’s not only about how much data, information, and technology you have at your fingertips – it’s what you do with it. IQVIA is focused on making intelligent connections for customers across the entire healthcare ecosystem to help you drive healthcare forward. Whether that means partnering with novel technology companies to boost patient engagement, leveraging AI & machine learning to accelerate results, or using decentralized trials to reach the right patients wherever they are – we are always looking for smarter ways to move you forward.

Industry

Health care and social assistance

Company size

10,000+ Employees

Headquarters location

Durham, NC, US

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