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Tmf Manager Jobs in Raleigh, NC (NOW HIRING)

PSI CRO

Site Management Associate II

Durham, NC · On-site

Manages records flow with sites and off-site facilities * Prepares regulatory and ethics committee ... Files trial records in the TMF and performs regular TMF checks on a site and country level

PSI CRO

Site Management Associate II

Durham, NC · On-site

Manages records flow with sites and off-site facilities * Prepares regulatory and ethics committee ... Files trial records in the TMF and performs regular TMF checks on a site and country level

PSI CRO

Site Management Associate II

Durham, NC · On-site

Manages records flow with sites and off-site facilities * Prepares regulatory and ethics committee ... Files trial records in the TMF and performs regular TMF checks on a site and country level

PSI CRO

Site Management Associate II

Durham, NC

Manages records flow with sites and off-site facilities * Prepares regulatory and ethics committee ... Files trial records in the TMF and performs regular TMF checks on a site and country level

PSI CRO

Site Management Associate II

Durham, NC · On-site

Manages records flow with sites and off-site facilities * Prepares regulatory and ethics committee ... Files trial records in the TMF and performs regular TMF checks on a site and country level

Fortrea

Clinical Trial Manager

Durham, NC · On-site

Ensure inspection-readiness through quality oversight of TMF, monitoring reports, protocol deviations and issue management. * Oversight and approval of site payments, including payment reconciliation.

Actalent

Clinical Trial Manager- Hybrid

Durham, NC · Hybrid

Background in TMF management, audit and inspection readiness, and clinical study documentation is preferred. * Strong project management capabilities, including planning, tracking, and reporting on ...

Actalent

Clinical Trial Manager- Hybrid

Raleigh, NC · Hybrid

Background in TMF management, audit and inspection readiness, and clinical study documentation is preferred. * Strong project management capabilities, including planning, tracking, and reporting on ...

aicpa

Associate Manager - Payroll

Durham, NC · On-site

$80K - $90K/yr

You will report to the Senior Manager - Payroll and use a hybrid work schedule. You Will ... Experience working with payroll vendors (e.g., ADP SmartCompliance, TMF, local providers)

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All JobsTmf JobsTmf Manager JobsTmf Manager Jobs in Raleigh, NC

Tmf Manager information

See Raleigh, NC salary details

$28

$60

$93

How much do tmf manager jobs pay per hour?

As of Jul 15, 2026, the average hourly pay for tmf manager in Raleigh, NC is $60.77, according to ZipRecruiter salary data. Most workers in this role earn between $49.33 and $68.46 per hour, depending on experience, location, and employer.

What are some typical challenges a TMF Manager might face in their role?

TMF Managers often encounter challenges such as ensuring consistent TMF document quality across multiple studies, meeting tight regulatory submission deadlines, and facilitating communication among global project teams. Keeping the TMF up to date and audit-ready requires strong organizational skills and proactive problem-solving, as studies can involve large volumes of documentation and frequent protocol amendments. Effective TMF Managers routinely collaborate with clinical, regulatory, and quality assurance teams to ensure document accuracy and regulatory compliance. Overcoming these challenges is key to maintaining smooth clinical trial operations and supporting successful regulatory inspections.

What are the key skills and qualifications needed to thrive in the Tmf Manager position, and why are they important?

To excel as a TMF Manager (Trial Master File Manager), you need a solid understanding of clinical trial documentation, GCP (Good Clinical Practice) guidelines, and regulatory requirements—typically supported by a degree in life sciences or a related field. Familiarity with electronic TMF (eTMF) systems, document management software, and relevant industry certifications such as RAC or DIA TMF certificates is important. Exceptional attention to detail, organizational skills, and the ability to communicate effectively across cross-functional teams distinguish top TMF Managers. These competencies are essential for ensuring the integrity, completeness, and audit-readiness of clinical trial documentation throughout the study lifecycle.

What is a TMF Manager job?

A TMF (Trial Master File) Manager is responsible for overseeing the management, maintenance, and compliance of clinical trial documentation. They ensure that the TMF is accurate, complete, and inspection-ready in accordance with regulatory requirements, such as ICH-GCP and FDA guidelines. TMF Managers collaborate with clinical teams, quality assurance, and regulatory authorities to support audit and inspection activities. Their role is critical in ensuring data integrity and regulatory compliance throughout the clinical trial lifecycle.

What are the most commonly searched types of Tmf jobs in Raleigh, NC? The most popular types of Tmf jobs in Raleigh, NC are:
What are popular job titles related to Tmf Manager jobs in Raleigh, NC? For Tmf Manager jobs in Raleigh, NC, the most frequently searched job titles are:
What job categories do people searching Tmf Manager jobs in Raleigh, NC look for? The top searched job categories for Tmf Manager jobs in Raleigh, NC are:
What cities near Raleigh, NC are hiring for Tmf Manager jobs? Cities near Raleigh, NC with the most Tmf Manager job openings:
Tmf Manager jobs near you
Infographic showing various Tmf Manager job openings in Raleigh, NC as of July 2026, with employment types broken down into 81% Full Time, 16% Part Time, 1% Temporary, and 2% Contract. Highlights an 86% Physical, 1% Hybrid, and 13% Remote job distribution, with an average salary of $126,404 per year, or $60.8 per hour.

Site Management Associate II

PSI CRO

Durham, NC • On-site

Full-time

Re-posted 6 days ago

Job description

Company Description
We are the company that cares - for our staff, for our clients, for our partners and for the quality of the work we do. A dynamic, global company founded in 1995, we bring together more 3,000 driven, dedicated and passionate individuals. We work on the frontline of medical science, changing lives, and bringing new medicines to those who need them.
Job Description
Start your career in clinical research, streamlining communication, maintaining systems and managing documents.
The scope of responsibilities will include:
  • Main site contact for all non-trial-participant related and non-protocol
    related issues, including vendors, trial supplies and access management
  • Manages records flow with sites and off-site facilities
  • Prepares regulatory and ethics committee submission/ notification
    documents and records
  • Coordinates payments to sites and off-site facilities
  • Prepares for and follows up on site audits and inspections
  • Reviews and coordinates site-specific query resolution with Monitors and
    sites
  • Reviews site-specific EDC completion progress and provides the Monitor
    with regular updates
  • Serves as the main contact point for other company departments in
    administrative site-related issues
  • Organizes, participates in, and prepares reports of internal project team
    meetings
  • Collaborates with sites and project team on Investigator Meetings'
    organization
  • Under supervision, provides on-the-job coaching of Site Management
    Associates I and Clinical Operations Administrative Support staff
  • Arranges and tracks initial and ongoing trial training for investigator site
    teams in all vendor-related systems
  • Provides training in courier management and trial supplies ordering to the
    investigator sites
  • Files trial records in the TMF and performs regular TMF checks on a site and country level
  • Participates in and follows up on TMF and systems audits
  • Prepares, distributes, and updates Investigator Site Files (ISF) and ISF
    checklists
  • Coordinates the translation process for trial records on a site and country
    level
  • Collects IP-REDs and compiles IP-RED packages for further review

Qualifications
  • College or university degree or an equivalent combination of education, training and experience that presents the required knowledge, skills and abilities is considered sufficient.
  • Minimum 2 year experience within the clinical research industry, corporate or academic environment where administrative experience and technical skills have been gained.
  • Basic proficiency in MS Word.
  • Basic proficiency in MS Excel.
  • Basic proficiency in MS Outlook.
  • Basic proficiency in MS Power Point.
  • Knowledge (following proper training) of applicable software and project specific systems.
  • Basic typing skills in English (min. 40 words per minute)

Additional Information
Make the right call and take your career to a whole new level. Join the company that focuses on its people and invests in their professional development and success.
For this position, PSI is not hiring individuals who require work visa for employment or continued employment now or anytime in the future.
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