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System Administration Manager Jobs in Wisconsin (NOW HIRING)

NFP Corp

HRIS & Reporting Specialist

Madison, WI · On-site

The HRIS & Reporting Specialist serves as the functional owner and subject matter expert for the ... management, reporting and analytics, testing, security administration, and continuous process ...

New

NFP Corp

HRIS & Reporting Specialist

Madison, WI · On-site

The HRIS & Reporting Specialist serves as the functional owner and subject matter expert for the ... management, reporting and analytics, testing, security administration, and continuous process ...

New

Genesis10

System Architect

Waukesha, WI · On-site

$75/hr

Manage technical deliverables for projects, including architectural diagrams, use-cases ... In-depth implementation, configuration, and administration experience with datacenter ...

New

Pwc

Grant Administration Consultant, Manager

Milwaukee, WI · On-site

$99K - $232K/yr

Accounting, Actuarial Science, Analytics/Data Science, Business Administration/Management, Computer Science/Information Systems, Economics, Engineering, Finance, Government/Public Policy, Health ...

New

Standard Imaging Inc

IT Manager

Middleton, WI · Remote

$97K - $119K/yr

What You'll Do Infrastructure & Systems Administration * Provide day-to-day IT administration and support for onsite and remote users across multiple locations * Manage desktop environments, endpoint ...

Standard Imaging, Inc

IT Manager

Middleton, WI · On-site

$97K - $119K/yr

What You'll Do Infrastructure & Systems Administration * Provide day-to-day IT administration and support for onsite and remote users across multiple locations * Manage desktop environments, endpoint ...

Wisconsin

IT Business Analyst II

Green Bay, WI · On-site +1

$65K - $70K/yr

Provides IT business analysis, business process improvement and/or automation, recommendations & guidance, project management, system administration, configuration, technical & functional support ...

Prevea Health

Manager of HRIS

Green Bay, WI

Required Experience Qualifications * 3-5 years HRIS or HR Systems administration experience with hands-on HCM platform management, including exposure to at least one major implementation or upgrade.

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System Administration Manager information

Is system admin a high paying job?

System administration managers typically earn higher salaries than entry-level system administrators due to their leadership responsibilities and experience requirements. Salaries vary based on industry, location, and certifications such as CompTIA or Cisco, but overall, it is considered a well-paying IT role. Advanced skills in network management, security, and automation can further increase earning potential.

What is the difference between System Administration Manager vs Network Administrator?

AspectSystem Administration ManagerNetwork Administrator
CertificationsCompTIA Server+, Microsoft Certified: Windows Server, Cisco CCNACompTIA Network+, Cisco CCNA, Cisco CCNP
Work EnvironmentOversees server infrastructure, data centers, and IT teamsManages network hardware, configurations, and connectivity
ResponsibilitiesMaintains servers, manages IT staff, plans infrastructure upgradesConfigures routers/switches, monitors network performance, troubleshoots connectivity issues

The System Administration Manager typically oversees server and infrastructure management, focusing on IT team leadership and system stability. In contrast, the Network Administrator concentrates on network hardware and connectivity. Both roles require similar certifications and work in IT environments, but their core responsibilities differ, with the manager focusing on broader system oversight and the administrator on network specifics.

What are the key skills and qualifications needed to thrive as a System Administration Manager, and why are they important?

To thrive as a System Administration Manager, you need expertise in server management, network infrastructure, cybersecurity, and a bachelor’s degree in computer science or a related field. Familiarity with system monitoring tools, virtualization platforms, and certifications such as CompTIA Server+ or Microsoft Certified: Windows Server are highly valued. Strong leadership, problem-solving abilities, and effective communication set top candidates apart in this role. These skills ensure reliable IT operations, secure systems, and efficient team management essential for organizational success.

What are some common challenges faced by a System Administration Manager when leading a diverse IT team?

System Administration Managers often encounter challenges in balancing the workloads and strengths of a diverse IT team while ensuring consistent service delivery. Managing varying skill levels, facilitating clear communication across departments, and staying ahead of rapidly evolving technologies are typical hurdles. Additionally, they are responsible for developing team members, resolving conflicts, and aligning individual goals with organizational objectives. Proactive leadership, strong interpersonal skills, and ongoing professional development are key to successfully navigating these challenges.

Is sysadmin a stressful job?

System administration managers often face stress due to the responsibility of maintaining critical IT infrastructure, managing system outages, and ensuring security. The job can involve long hours, on-call duties, and troubleshooting complex issues, which contribute to its stress levels. However, experience, proper training, and effective workload management can help mitigate stress.

Is sysadmin an entry level job?

System Administration Manager is typically a senior role that requires several years of experience in IT, network management, and system maintenance. Entry-level positions in system administration usually involve support or technician roles, with management positions requiring advanced skills, certifications, and leadership experience.

Will AI replace sys admins?

AI is unlikely to fully replace system administration managers, as their roles require complex problem-solving, decision-making, and oversight of IT infrastructure. Instead, AI tools are expected to augment their work by automating routine tasks, allowing managers to focus on strategic planning and system optimization. Continuous learning and familiarity with automation tools remain important for sys admins to stay effective in evolving environments.

What does a System Administration Manager do?

A System Administration Manager oversees the team responsible for managing, configuring, and maintaining an organization's computer systems, servers, and networks. They ensure the reliability, security, and optimal performance of IT infrastructure. Their role often includes planning system upgrades, implementing security policies, troubleshooting complex technical issues, and coordinating with other IT departments. They also supervise and mentor system administrators, manage budgets, and help develop disaster recovery strategies.
What cities in Wisconsin are hiring for System Administration Manager jobs? Cities in Wisconsin with the most System Administration Manager job openings:
What are popular job titles related to System Administration Manager jobs in WI? For System Administration Manager jobs in WI, the most frequently searched job titles are:
System Administration Manager jobs near you
Senior Manager, GxP Systems & Validation

Senior Manager, GxP Systems & Validation

Arrowhead Pharmaceuticals

Verona, WI • On-site

Full-time

Re-posted 3 days ago

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

The Senior Manager GxP Systems & Validation provides strategic and operational leadership for GxP-regulated computerized systems across their full lifecycle. This role is accountable for governance, validation strategy, inspection readiness, and compliant system administration, ensuring alignment with global regulatory requirements (FDA, EMA, MHRA, ICH) and evolving industry standards (GAMP 5, CSA).

This leader serves as a key partner to Manufacturing, Quality, CMC, CSA and Compliance, GLP Operations, and external vendors, driving scalable compliance frameworks while enabling business agility. The role combines system ownership and administration, validation project management, and organizational oversight to ensure enterprise-wide data integrity and computerized system compliance.

Responsibilities

Strategic Leadership & Governance

  • Maintain governance frameworks for GxP computerized systems
  • Define validation strategies aligned with GAMP 5 and CSA principles
  • Support modernization initiatives (e.g., SaaS adoption, cloud validation, CSA transition)
  • Serve as system owner and system administrator for critical GxP platforms
  • Maintain validation and system lifecycle policies and standards
  • Participates in continuous improvement of validation methodologies, templates, and risk-based approaches
  • Provide compliance guidance to executive leadership and functional heads

System Lifecycle Oversight

  • Oversee administration and compliant operation of GxP systems (Laboratory systems, LIMS, MES, EDMS, enterprise SaaS platforms)
  • Ensure systems remain validated, secure, and audit-ready throughout implementation, upgrades, and decommissioning
  • Approve system configurations, changes, and access governance frameworks
  • Ensure robust data integrity controls in accordance with ALCOA+ principles
  • Monitor system performance, audit trails, cybersecurity controls, and vendor compliance

Validation Program Leadership

  • Lead enterprise validation initiatives across multiple concurrent projects
  • Oversee development and approval of validation deliverables (URS, Risk Assessments, IQ/OQ/PQ, Traceability, Summary Reports)
  • Ensure appropriate application of risk-based validation and CSA methodologies
  • Manage validation master planning and resource allocation
  • Provide oversight of regression testing and revalidation strategies
  • Ensure validation documentation supports global inspection readiness
  • Act as SME during regulatory inspections and internal audits
  • Oversee remediation efforts related to audit findings, deviations, and CAPAs
  • Maintain awareness of evolving global regulatory expectations

Project & Vendor Management

  • Lead cross-functional teams across CMC, Quality, IS&I, Manufacturing, Engineering, GLP Operations, and external partners
  • Oversee third-party vendors and validation consultants
  • Manage budgets, timelines, risks, and resource planning for validation programs
  • Drive issue resolution and escalation management
  • Ensure vendor deliverables meet compliance and quality standards

People & Organizational Development

  • Lead, mentor, and develop validation and system administration staff
  • Establish performance expectations and competency development plans
  • Build scalable team capabilities to support business growth

Requirements

  • Bachelor's degree in Life Sciences, Engineering, IT, or related discipline (advanced degree preferred)
  • 8+ years of experience in GxP computerized systems and validation
  • 3+ years in a leadership or program management role
  • Deep expertise in CSV/CSA, GAMP 5, 21 CFR Part 11, Annex 11, and global data integrity requirements
  • Demonstrated experience leading complex, enterprise-level system implementations
  • Strong understanding of change control, deviation management, CAPA, and quality systems
  • Proven ability to influence senior stakeholders and drive cross-functional alignment

Preferred

  • PMP or equivalent project management certification
  • GAMP, ITIL, or related compliance certification
  • Experience leading CSA transformation initiatives
  • Extensive experience related to administration, operation, and maintenance of Laboratory Information Management Systems (LIMS) Chromatography Data Systems, Spectrophotometry Systems, and ancillary/supporting laboratory systems in a GxP environment (Openlab, Cary UV systems, Watson)
  • Pharmaceutical or CRO experience
  • Prior regulatory inspection leadership experience
  • Risk-based decision making
  • Continuous improvement mindset
Wisconsin pay range
$145,000—$165,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.

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