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Sr Clinical Research Associate Jobs (NOW HIRING)

Pfizer

Senior Clinical Research Associate II

Manhattan, NY · On-site

$99 - $165/hr

The Senior Clinical Research Associate II is responsible for the site management, site monitoring and close-out of assigned clinical trials investigator sites to ensure patient safety and quality ...

Pfizer

Senior Clinical Research Associate II

The Senior Clinical Research Associate II is responsible for the site management, site monitoring and close-out of assigned clinical trials investigator sites to ensure patient safety and quality ...

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Senior Clinical Research Associate

Denver, CO · Hybrid

$110K - $138K/yr

Senior Clinical Research Associate - Oncology Phase I - Denver, CO ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and ...

ICON

Senior Clinical Research Associate

Chicago, IL · On-site +1

$110K - $138K/yr

Senior Clinical Research Associate - Oncology Phase I - Chicago ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments ...

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Senior Clinical Research Associate

Los Angeles, CA · Hybrid

$110K - $138K/yr

Senior Clinical Research Associate - Oncology - Los Angeles, CA ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments ...

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Senior Clinical Research Associate

Washington, DC · Hybrid

$110K - $138K/yr

Senior Clinical Research Associate - Oncology - Washington DC ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to ...

ICON

Senior Clinical Research Associate

Washington, DC · On-site +1

$110K - $138K/yr

Senior Clinical Research Associate - Oncology - Washington DC ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to ...

Icon plc

Senior Clinical Research Associate

Chicago, IL · Hybrid

$110K - $138K/yr

Senior Clinical Research Associate - Oncology Phase I - Chicago ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments ...

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Senior Clinical Research Associate

San Diego, CA · Hybrid

$110K - $138K/yr

Senior Clinical Research Associate - Oncology - Southern California ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and ...

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Sr Clinical Research Associate information

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$36K

$94.3K

$143.5K

How much do sr clinical research associate jobs pay per year?

As of Sep 7, 2026, the average yearly pay for sr clinical research associate in the United States is $94,314.00, according to ZipRecruiter salary data. Most workers in this role earn between $62,500.00 and $128,000.00 per year, depending on experience, location, and employer.

What is a Sr Clinical Research Associate?

A Sr Clinical Research Associate (Senior CRA) is an experienced professional responsible for overseeing clinical trials to ensure they comply with regulatory requirements, protocols, and Good Clinical Practice (GCP) guidelines. They monitor study sites, review data, ensure participant safety, and act as a liaison between the sponsor and clinical sites. Senior CRAs often mentor junior staff, manage multiple studies, and contribute to improving clinical trial processes. Their role is vital in bringing new medical treatments and devices from research to market.

What are the key skills and qualifications needed to thrive as a Sr Clinical Research Associate?

To thrive as a Sr Clinical Research Associate, you need a robust background in clinical research, regulatory compliance, and study monitoring, usually supported by a bachelor's degree in life sciences and significant industry experience. Familiarity with electronic data capture (EDC) systems, Good Clinical Practice (GCP) guidelines, and certifications such as ACRP or SOCRA are highly valued. Outstanding attention to detail, strong organizational skills, and effective communication enable successful oversight of trial sites and collaboration with study teams. These skills are vital for ensuring the integrity, safety, and compliance of clinical trials, directly impacting study outcomes and regulatory approval.

What are some common challenges faced by a Sr Clinical Research Associate when monitoring multiple clinical trial sites?

As a Sr Clinical Research Associate (CRA), juggling multiple trial sites can be challenging due to varying site compliance levels, differing investigator engagement, and diverse patient populations. You may encounter issues such as inconsistent data entry, protocol deviations, and varying levels of site staff training. Effective time management, strong communication skills, and a proactive approach to problem-solving are essential to ensure all sites adhere to protocols and timelines. Additionally, frequent travel and adapting to each site's workflow can add complexity, but these challenges also provide valuable opportunities for professional growth.

What is the difference between Sr Clinical Research Associate vs Clinical Research Associate?

AspectSr Clinical Research AssociateClinical Research Associate
Required credentialsBachelor's degree, experience, often certifications like CCRP or RACBachelor's degree, entry-level or less experience, certifications optional
Work environmentPharmaceutical companies, CROs, clinical trial sitesSimilar settings, often entry-level roles in clinical trials
Employer and industry usageUsed in pharmaceutical and biotech industries, more senior rolesCommon in clinical research, entry to mid-level roles
Search and comparison intentOften searched for career progression or senior rolesOften searched for entry-level positions or understanding roles

The main difference between a Sr Clinical Research Associate and a Clinical Research Associate lies in experience, responsibilities, and qualifications. The senior role typically requires more experience, certifications, and involves overseeing complex trials, while the CRA is often an entry-level or mid-level position focused on supporting clinical trial activities.

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Sr Clinical Research Associate jobs near you
Infographic showing various Sr Clinical Research Associate job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 70% Full Time, 27% Part Time, 1% Temporary, and 1% Contract. Highlights an 97% Physical, 1% Hybrid, and 2% Remote job distribution, with an average salary of $94,314 per year, or $45.3 per hour.

Senior Clinical Research Associate - CNS

Cognitive Research Corporation

Remote

Full-time

Re-posted 21 days ago

Job description

The Senior Clinical Research Associate is responsible for overseeing the execution of clinical trials at Investigative Sites. The Clinical Research Associate acts as a liaison between the study Sponsor, CRC and Investigative Sites. They will proactively identify and resolve clinical project issues and participate in process improvement initiatives as applicable. The CRA facilitates successful execution of studies by Investigative Sites and helps to ensure the rights, safety and welfare of human research participants as well as data integrity in clinical trials.
Essential Duties & Responsibilities
  • Initiates, monitors, and closes-out investigative sites in accordance with FDA/ICH regulations.
  • Tracks and maintains study specific non-Case Report Form database
  • Administers Clinical research projects; collects investigator documentation, site management, clinical contact, and prepare reports as required
  • Ensures appropriate source document review and source document verification as required
  • Reviews Case Report Forms to identify erroneous, missing, or incomplete data
  • Generates queries to resolve problematic data to appropriate personnel, and review responses to assure the database is updated accordingly
  • Verifies study drug accountability; generates and tracks drug shipments and storage
  • Travels as necessary, based on project needs and according to Clinical Monitoring Plan requirements
  • Performs data collection, retrieval, entry and clean up as necessary
  • Develops and maintains strong relationships with Investigator(s) and site staff
  • Independently manages sites resulting in acceptable Quality Assurance reports.
  • Escalates study/site issues/deviations appropriately
  • Serves as lead monitor for a protocol or project by creating study files, arranges monitoring schedules, leads the project team, organize and run meetings and performs other project management duties as assigned by management
  • Writes Clinical Trial Reports, analyzing and presenting trial results in a clear and accurate format
  • Reports, writes narratives, and follows-up on reported serious adverse events
  • Interacts and attends client meetings, as appropriate
  • Mentors junior staff/CRAs
  • Quality oversight checks of monitoring
  • Performs other duties as assigned

Qualifications
  • Bachelor's degree, or RN, in a related field or equivalent combination of education, training and experience
  • Minimum 5 years' experience as a CRA; experience overseeing clinical trials in the pharmaceutical, hospital or CRO industry
  • Ability to work and travel independently with minimal supervision
  • Experience with numerous EDC systems.
  • Advanced knowledge of GCPs, ICH guidelines, FDA and other applicable regulations
  • Specialized knowledge of CNS therapeutic areas
  • Proficiency in Microsoft Office, Zoom and Adobe
  • Excellent writing and verbal skills, English language proficiency
  • Meticulous attention to detail
  • Time management and ability to prioritize tasks
  • Ability to travel up to 70%

Department Clinical Operations Role Senior Clinical Research Associate Locations Remote, US Remote status Fully Remote Employment type Full-time

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