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How much do entry level biophysics jobs pay per year?

As of Aug 10, 2026, the average yearly pay for entry level biophysics in the United States is $50,781.00, according to ZipRecruiter salary data. Most workers in this role earn between $39,000.00 and $54,500.00 per year, depending on experience, location, and employer.

What types of projects or research might I be involved with as an entry level biophysics professional?

As an entry-level biophysics professional, you could work on projects ranging from studying protein structures and interactions to analyzing the biophysical properties of cells or designing models of biological systems. Your responsibilities often include running experiments, collecting and analyzing data, and presenting findings to senior scientists or research groups. Many entry-level roles support ongoing research in academic, medical, or industry settings and may involve close collaboration with scientists from physics, biology, chemistry, and engineering backgrounds. This exposure offers a valuable opportunity to broaden your expertise and build a strong foundation for advanced roles or graduate study in the field.

What is an entry level biophysics?

An Entry Level Biophysics job typically involves applying principles of physics and biology to study biological systems at the molecular, cellular, or organismal level. Responsibilities may include conducting experiments, analyzing data, and using computational models to understand biological processes. These roles are commonly found in research laboratories, biotechnology companies, and pharmaceutical firms. Strong analytical skills, programming knowledge, and experience with lab techniques are often required. This position serves as a stepping stone for careers in academia, healthcare, or industry.

Is entry level biophysics in demand?

Entry level biophysics positions are in demand in research institutions, biotech companies, and healthcare organizations, especially for candidates with strong analytical skills and knowledge of laboratory techniques. The field is growing as interdisciplinary approaches to biological and physical sciences expand, requiring familiarity with tools like microscopy, spectroscopy, and data analysis software. Entry-level roles often require a relevant bachelor's degree and may offer opportunities for advancement with additional training or advanced degrees.

Who hires entry level biophysics?

Entry level biophysics positions are typically hired by research institutions, biotechnology companies, pharmaceutical firms, and academic laboratories. These roles often require a strong background in biology, physics, and laboratory skills, and may involve working with specialized tools like microscopes or data analysis software.

What are the key skills and qualifications needed to thrive in the entry level biophysics position, and why are they important?

To thrive as an Entry Level Biophysics professional, you need a foundational knowledge of physics, biology, mathematics, and chemistry, often demonstrated by a bachelor's degree in a related field. Familiarity with laboratory techniques, data analysis software (such as MATLAB or Python), and scientific instrumentation is frequently required. Strong problem-solving skills, attention to detail, and the ability to work both independently and in teams are valued soft skills in this role. These skills and qualities are critical for conducting accurate experiments, interpreting complex data, and contributing effectively to multidisciplinary research projects.

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Entry Level Biophysics jobs near you
Infographic showing various Entry Level Biophysics job openings in the United States as of August 2026, with employment types broken down into 89% Full Time, and 11% Part Time. Highlights an 100% In-person job distribution, with an average salary of $50,781 per year, or $24.4 per hour.

Scientist - Protein Production

Helix Biostructures

Indianapolis, IN • On-site

Full-time

Medical, Dental, Vision, Retirement

Re-posted 4 days ago

Job description

Salary:

Scientist Protein Production

Helix BioStructures, LLC (HBS) is a contract research organization (CRO) based in Indianapolis, Indiana, providing early drug discovery services to the biopharmaceutical industry. HBS maintains a full suite of services that encompass chemical & structural analysis, protein production, computational modeling, and design. HBSs core and most popular services are structural biology imaging techniques: X-ray Crystallography and Cryo-EM. HBS was founded in 2018 and has grown considerably. We are looking to add a Scientist focused on protein production to join our Indianapolis-based team.


Main Responsibilities


This scientist will support our protein production pipeline by expressing and purifying recombinant proteins in bacterial, insect, and mammalian systems; performing biophysical characterization to assess sample quality and stability; developing and optimizing expression and purification protocols; interfacing with our clients; and writing technical project reports. The scientist will also contribute to improving expression and purification methods to accelerate research processes.

Highly desirable hands-on experiences include:

(a) Experience in recombinant protein expression and purification across bacterial, insect, and mammalian cell lines.

(b) Use of biophysical and analytical techniques (e.g., SDS-PAGE, SEC, Western Blot, TSA, DLS, Mass Spectrometry, and others) to assess protein quality, purity, and stability.

This scientist will employ a range of experimental methods (biochemical, biophysical, and/or computational) to support our clients structure-based drug discovery, antibody discovery, and/or protein engineering. Accordingly, proficiency in recombinant protein expression and purification and a passion for generating high-quality, well-characterized protein reagents are essential. Any structural biology experience (X-ray crystallography or Cryo-EM) is a plus, but is not required for this role. The successful candidate will be a strong technical contributor who can execute reliably at the bench and collaborate with colleagues on multiple projects in parallel. This role is open to candidates ranging from entry-level to experienced scientists; the level of hire, scope, and degree of independence will be determined by the candidates experience and qualifications, with the opportunity to help drive discovery projects from inception through early development.

Additional Responsibilities

  • Express and purify proteins to target quality and yield within industrial timeframes.
  • Document experimental data and communicate research priorities, progress, and results with clients/project teams.
  • Provide technical and scientific input to project teams, with the scope of guidance to other members of the Protein Sciences group, scaling with seniority and experience.
  • The candidate will be responsible for timely updates on project statuses, reporting to their supervisor informally and to Helixs customers by formal report writing and oral presentations.

Required Qualifications

This position is open to candidates ranging from entry-level to experienced scientists. The qualifications below represent the minimum requirements for the role; the final level of hire will be determined based on the candidates experience and qualifications.


  • D. in biochemistry, biophysics, molecular biology, protein engineering, or a related field; OR a Masters degree with 25 years of relevant industrial experience; OR a Bachelors degree with 510 years of relevant industrial experience.
  • Demonstrated competency in recombinant protein expression and purification using bacterial, insect, and mammalian cell lines; hands-on experience across all three systems is strongly preferred.
  • Ability to generate and characterize milligram to gram quantities of high-quality protein reagents for downstream studies.
  • Experience with standard analytical and biophysical techniques (e.g., SDS-PAGE, SEC, Western Blot, TSA, DLS, Mass Spectrometry, and others) for assessing protein quality, purity, and stability during purification.
  • Strong written and oral communication skills.


Additional qualifications


  • Hands-on experience in engineering protein constructs and optimizing the production of protein targets for structural and functional studies.
  • Experience in structural biology is a plus but not required, including protein X-ray crystallography (sample assessment, crystallization, optimization, data collection, and structure determination/refinement) and familiarity with software such as Phenix, CCP4, Coot, and PyMOL.
  • Experience with protein engineering and/or design approaches.
  • Analysis, design, and/or computational approaches to investigate ligand-protein complexes.
  • Experience with Cryo-EM is a plus, especially grid vitrification and screening.
  • Excellent communication, interpersonal, and organizational skills.
  • Willingness to tackle challenging technical problems.

Location



This position is based in Indianapolis, Indiana, and does NOT offer a hybrid option. Interaction with external service vendors is also expected. Candidates must be authorized to work in the United States; Helix BioStructures does NOT provide visa sponsorship for this position.


Physical Requirements

Able to lift 30 lb objects with dimensions 30 inches in height and 18 inches in width.

Able to visualize microscopic objects under microscopes.

Non-standard work schedule, travel, and lab safety


Able to adhere to safe work practices and perform lab work with appropriate personal protective equipment, such as but not limited to safety goggles, facial mask, gloves, lab coat/ protective gowning, and closed-toe shoes. Able to work at flexible hours occasionally when performing time-sensitive experiments.

Other job details

  • Eligible for Relocation Package
  • Competitive Salary + annual bonus
  • Retirement (matching 401K)
  • Health/Dental/Vision Insurance
  • Company Apple Computer

Helix BioStructures, LLC is an equal opportunity employer, and we embrace the increasingly diverse world around us. Helix BioStructures, LLC prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, and veteran status.