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Nucleotide Jobs (NOW HIRING)

Xenon7

Research Advisor, Computational Chemistry

Develop and validate force field parameters for novel nucleotide analogs using quantum mechanical calculations, enabling rapid computational evaluation of new chemistries emerging from the medicinal ...

Centrillion Biosciences, Inc.

Chemist

Palo Alto, CA · On-site

Experience with nucleoside, nucleotide, and oligonucleotide chemistry. * Working knowledge and practical experience with polymer and surface chemistry is also desirable. * Demonstrated ability to ...

Centrillion Biosciences, Inc.

Chemist

Palo Alto, CA

Experience with nucleoside, nucleotide, and oligonucleotide chemistry. * Working knowledge and practical experience with polymer and surface chemistry is also desirable. * Demonstrated ability to ...

Columbia University

Research Coordinator

New York, NY · On-site

$52K - $65K/yr

Hunt Lab is seeking a part-time scientific Research Coordinator position for a project focused on engineering the amino acid and nucleotide sequences of a human protein for use in genetic therapies.

Bachem

Director, Production

Torrance, CA

$129K - $162K/yr

Peptide and/or oligo nucleotide manufacturing experience in upstream or downstream manufacturing * Strong knowledge of chemistry, biological chemistry & chemical engineering along with cGMP ...

Alphazyme

Manager, QA Operations

Jupiter, FL · On-site

Pioneering nucleotide research since its inception, we are now leading the way in the rapidly expanding mRNA market. Your next role as a Miracle Maker Maravai LifeSciences is seeking a #MiracleMaker ...

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$96.2K

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How much do nucleotide jobs pay per year?

As of Jun 8, 2026, the average yearly pay for nucleotide in the United States is $96,169.00, according to ZipRecruiter salary data. Most workers in this role earn between $81,000.00 and $109,500.00 per year, depending on experience, location, and employer.

What are the jobs of nucleic acids?

Nucleic acids, such as DNA and RNA, are essential for storing and transmitting genetic information in biological systems. Jobs related to nucleic acids in a laboratory or research setting include analyzing genetic sequences, developing genetic therapies, and conducting molecular biology experiments using tools like PCR and sequencing technologies.

What is the difference between Nucleotide vs Biologist?

AspectNucleotideBiologist
Required CredentialsHigh school diploma or equivalent; specialized training in molecular biology or geneticsBachelor's degree or higher in biology, genetics, or related field
Work EnvironmentLaboratories, research facilities, biotech companiesResearch labs, universities, environmental agencies
Industry UsageGenetics, molecular biology, biotechnologyResearch, education, environmental science

While a nucleotide is a basic building block of DNA and RNA, a biologist studies living organisms and biological processes. Nucleotides are essential components in genetic research, which biologists often analyze. Understanding nucleotides is crucial for biologists working in genetics and molecular biology, but the roles differ: nucleotides are molecular units, whereas biologists focus on broader biological systems and research.

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What cities are hiring for Nucleotide jobs? Cities with the most Nucleotide job openings:
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Nucleotide jobs near you
Infographic showing various Nucleotide job openings in the United States as of May 2026, with employment types broken down into 100% Full Time. Highlights an 89% Physical, 3% Hybrid, and 8% Remote job distribution, with an average salary of $96,169 per year, or $46.2 per hour.

Research Advisor, Computational Chemistry

Xenon7

Remote

Full-time

Posted 14 days ago

Job description

About us:
Shape the Future with AI, Ignite Your Potential
Xenon7 is an inferno where skill, dedication and passion run together.
About our client:
Global healthcare leader headquartered in Indianapolis, Indiana. The Cardiometabolic Research (CMR) Therapeutic Area of our client, focuses on the discovery of biologic, small molecule and genetic therapeutics for the treatment of cardiometabolic diseases and associated complications.
We are seeking a highly motivated computational chemist to join our team and apply physics-based modeling and cheminformatics to the design of chemically modified oligonucleotide therapeutics.
Oligonucleotide therapeutics-including siRNAs, ASOs, and splice-switching oligonucleotides-occupy a unique chemical space between small molecules and biologics. Each position in a therapeutic oligonucleotide can carry distinct sugar, backbone, and base modifications, creating a vast combinatorial design space that is poorly served by conventional computational chemistry tools. This role will bridge molecular simulation, cheminformatics, and machine learning to generate actionable insights that guide the optimization of chemically modified oligonucleotides across our client's RNA therapeutics portfolio.
Key responsibilities include:
  • Perform molecular dynamics simulations of chemically modified oligonucleotide duplexes and single-stranded species to characterize the structural and thermodynamic consequences of sugar, backbone, and base modifications
  • Apply free energy methods (FEP, thermodynamic integration, MM/PBSA, MM/GBSA) to predict modification-dependent binding affinities, duplex stability, and protein-oligonucleotide interactions
  • Develop and validate force field parameters for novel nucleotide analogs using quantum mechanical calculations, enabling rapid computational evaluation of new chemistries emerging from the medicinal chemistry team
  • Build and apply cheminformatics descriptors and QSAR/QSPR models adapted for chemically modified oligonucleotides, moving beyond sequence-only representations to capture the full chemical diversity of the modification space
  • Collaborate with medicinal chemists and biologists to integrate computational predictions with experimental SAR data, contributing to the identification of optimal modification patterns for on-target potency, selectivity, metabolic stability, and safety
  • Contribute to reusable computational workflows, data assets, and modeling platforms that support cross-program learning and integration with the team's unified machine learning models
  • Present findings to cross-functional teams and contribute to scientific strategy discussions, publications, and patent applications

Requirements
Basic Requirements:
  • PhD in computational chemistry, physical chemistry, chemical physics, biophysics, or a closely related field

Additional Skills/Preferences:
  • Demonstrated expertise in molecular dynamics simulation of nucleic acids or chemically modified biopolymers
  • Experience with free energy calculation methods applied to biomolecular systems
  • Proficiency in cheminformatics toolkits (RDKit, OpenEye, or equivalent) and/or commercial CADD platforms (Schrödinger, MOE)
  • Strong programming skills in Python, with experience in scientific computing libraries
  • Familiarity with machine learning and AI methods applied to molecular sciences, including experience with predictive modeling for molecular properties, chemical optimization, or structure-activity relationships
  • Excellent written and oral communication skills with ability to present complex computational results to diverse scientific audiences including medicinal chemists and biologists
  • Experience with high-performance computing and/or cloud-based simulation environments
  • Demonstrated ability to work collaboratively in cross-functional team environments
  • Experience with force field parameterization for non-standard nucleotide analogs, including QM-derived charge fitting (RESP, AM1-BCC) and torsion parameter development
  • Familiarity with quantum chemical methods (DFT, ab initio) for electronic structure analysis of modified nucleotides and their impact on duplex stability and reactivity
  • Understanding of how chemical modifications influence oligonucleotide secondary structure, folding, and conformational dynamics, including modification-dependent effects on duplex geometry and protein recognition
  • Experience with machine learning approaches for molecular property prediction, including graph neural networks, molecular language models, or transformer-based architectures applied to chemical or biopolymer data
  • Familiarity with molecular representations for modified oligonucleotides (HELM, extended SMILES, or similar macromolecular encoding schemes)
  • Knowledge of oligonucleotide-specific ADME properties, including nuclease-mediated metabolism, plasma protein binding of phosphorothioate backbones, and endosomal escape
  • Track record of peer-reviewed publications demonstrating expertise in computational chemistry applied to nucleic acids or modified biopolymers
  • Deep understanding of nucleic acid structure and chemistry, including familiarity with common therapeutic modifications (2'-OMe, 2'-F, 2'-MOE, LNA/cET, phosphorothioate, GalNAc conjugates)
  • Experience designing computational workflows that integrate with automated experimental platforms and high-throughput screening
  • Proficiency in Rust or other systems-level languages for performance-critical scientific computing is a plus

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