The Associate Director, Oligonucleotide Development will lead the chemical synthesis strategy for PMO and ASO payload molecules, managing execution both internally and across global CDMOs. This role ...
The Associate Director, Oligonucleotide Development will lead the chemical synthesis strategy for PMO and ASO payload molecules, managing execution both internally and across global CDMOs. This role ...
EEC Licensed Teacher
Sudbury, MA · On-site
$18 - $25.50/hr
Child Development Associate Certificate (preferred) * 2+ years previous childcare experience. * Patient and reliable. * Strong communicator with children, staff, and parents. * Can work ...
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EEC Licensed Teacher
Sudbury, MA · On-site
$18 - $25.50/hr
Child Development Associate Certificate (preferred) * 2+ years previous childcare experience. * Patient and reliable. * Strong communicator with children, staff, and parents. * Can work ...
Associate Director, CMC Technical Development The Associate Director, CMC Technical Development provides technical leadership and comprehensive program oversight for oligonucleotide-based therapeutic ...
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Associate Director, CMC Technical Development The Associate Director, CMC Technical Development provides technical leadership and comprehensive program oversight for oligonucleotide-based therapeutic ...
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Associate Director, CMC Technical Development- 20 hours a week (Part-Time) The Associate Director, CMC Technical Development provides technical leadership and comprehensive program oversight for ...
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Associate Director, CMC Technical Development The position is part-time at approximately 20 hours per week, with typical working hours in the morning aligned to Eastern Time to facilitate ...
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The Associate Manager, Category Development turns customer, competitive, financial, and market insights into actionable product and portfolio recommendations that drive growth, profitability, and ...
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The Associate Manager, Category Development turns customer, competitive, financial, and market insights into actionable product and portfolio recommendations that drive growth, profitability, and ...
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Child Care Certified Toddler Teacher
$21 - $30/hr
Associate Degree in Early Childhood Education/related field OR Child Development Associate (CDA) credential OR EEC State of MA Teacher certification required * 2+ years of experience in a licensed ...
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Child Care Certified Toddler Teacher
$21 - $30/hr
Associate Degree in Early Childhood Education/related field OR Child Development Associate (CDA) credential OR EEC State of MA Teacher certification required * 2+ years of experience in a licensed ...
Preschool Lead Teacher
Auburn, MA · On-site
$18 - $22/hr
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Auburn, MA · On-site
$18 - $22/hr
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$14.50 - $18.25/hr
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$14.50 - $18.25/hr
Associate Degree in Early Childhood Education/related field OR Child Development Associate (CDA) credential OR EEC State of MA Teacher certification required * 2+ years of experience in a licensed ...
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Westford, MA · On-site
$21 - $30/hr
Associate Degree in Early Childhood Education/related field OR Child Development Associate (CDA) credential OR EEC State of MA Teacher certification required * 2+ years of experience in a licensed ...
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Child Care Certified Preschool Teacher
Westford, MA · On-site
$21 - $30/hr
Associate Degree in Early Childhood Education/related field OR Child Development Associate (CDA) credential OR EEC State of MA Teacher certification required * 2+ years of experience in a licensed ...
Child Care Certified Infant Teacher
Westford, MA · On-site
$21 - $30/hr
Associate Degree in Early Childhood Education/related field OR Child Development Associate (CDA) credential OR EEC State of MA Teacher certification required * 2+ years of experience in a licensed ...
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Child Care Certified Infant Teacher
Westford, MA · On-site
$21 - $30/hr
Associate Degree in Early Childhood Education/related field OR Child Development Associate (CDA) credential OR EEC State of MA Teacher certification required * 2+ years of experience in a licensed ...
Child Care Certified Toddler Teacher
Medway, MA · On-site
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Child Care Certified Toddler Teacher
Medway, MA · On-site
$14.75 - $18.25/hr
Associate Degree in Early Childhood Education/related field OR Child Development Associate (CDA) credential OR EEC State of MA Teacher certification required * 2+ years of experience in a licensed ...
Child Care Certified Preschool Teacher
Medway, MA · On-site
$21 - $30/hr
Associate Degree in Early Childhood Education/related field OR Child Development Associate (CDA) credential OR EEC State of MA Teacher certification required * 2+ years of experience in a licensed ...
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Child Care Certified Preschool Teacher
Medway, MA · On-site
$21 - $30/hr
Associate Degree in Early Childhood Education/related field OR Child Development Associate (CDA) credential OR EEC State of MA Teacher certification required * 2+ years of experience in a licensed ...
Child Care Certified Toddler Teacher
Westford, MA · On-site
$21 - $30/hr
Associate Degree in Early Childhood Education/related field OR Child Development Associate (CDA) credential OR EEC State of MA Teacher certification required * 2+ years of experience in a licensed ...
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Child Care Certified Toddler Teacher
Westford, MA · On-site
$21 - $30/hr
Associate Degree in Early Childhood Education/related field OR Child Development Associate (CDA) credential OR EEC State of MA Teacher certification required * 2+ years of experience in a licensed ...
Child Care Certified Preschool Teacher
Maynard, MA · On-site
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Child Care Certified Preschool Teacher
Maynard, MA · On-site
$21 - $30/hr
Associate Degree in Early Childhood Education/related field OR Child Development Associate (CDA) credential OR EEC State of MA Teacher certification required * 2+ years of experience in a licensed ...
Child Care Certified Infant Teacher
Maynard, MA · On-site
$21 - $30/hr
Associate Degree in Early Childhood Education/related field OR Child Development Associate (CDA) credential OR EEC State of MA Teacher certification required * 2+ years of experience in a licensed ...
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Child Care Certified Infant Teacher
Maynard, MA · On-site
$21 - $30/hr
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Preschool Lead Teacher
Auburn, MA · On-site
$15.75 - $20.50/hr
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Preschool Lead Teacher
Auburn, MA · On-site
$15.75 - $20.50/hr
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Certified Infant/Toddler Teacher
$16 - $20/hr
Child Development Associate (CDA) preferred * 1-2 years of previous experience working with young children in a licensed childcare or preschool setting preferred * Has successfully completed state ...
Certified Infant/Toddler Teacher
$16 - $20/hr
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Certified Infant/Toddler Teacher
Northborough, MA · On-site
$18 - $19/hr
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Certified Infant/Toddler Teacher
Northborough, MA · On-site
$18 - $19/hr
Child Development Associate (CDA) preferred * 1-2 years of previous experience working with young children in a licensed childcare or preschool setting preferred * Has successfully completed state ...
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Associate Director, Oligonucleotide Development
Waltham, MA • On-site
Full-time
Re-posted 12 days ago
Key responsibilities
Lead the design, optimization, and execution of process development for PMO and ASO payload molecules to ensure scalability for clinical and commercial supply.
Define and review analytical strategies, including impurity control, raw material specifications, and physicochemical characterization for payloads and conjugated drug substances.
Manage external CDMOs by leading their selection, qualification, and strategic oversight, including technology transfer and issue resolution.
Job description
Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as preclinical programs for facioscapulohumeral muscular dystrophy (FSHD), Pompe disease and multiple DMD mutations. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook.
Role Summary:
The Associate Director, Oligonucleotide Development will lead the chemical synthesis strategy for PMO and ASO payload molecules, managing execution both internally and across global CDMOs. This role spans the full development lifecycle - from preclinical process and analytical development through GMP manufacture for IND-enabling studies. The role will ensure the delivery of robust, scalable, and cost-effective manufacturing processes, serve as the primary technical lead for external CDMOs, driving aggressive timelines while delivering well-characterized products optimized for our proprietary bioconjugation platform. As a core member of multiple CMC teams, the Associate Director of Oligonucleotide Development will steer the development of preclinical assets and define CMC strategies within a matrixed environment. The role will play a critical role in global regulatory filings (IND, IMPD, etc.) by authoring and reviewing key Module 3 sections.
This role is based in Waltham, MA without the possibility of being a remote role. Physical presence onsite is expected on 4-5 days/week.
Primary Responsibilities Include:
Technical Leadership & Strategy
- Drive Process Excellence: Lead the design, optimization, and execution of process development for PMO and ASO payload molecules, ensuring scalability for clinical and commercial supply.
- Define Analytical Strategy: Set the vision for analytical development, focusing on robust impurity control strategies, raw material specifications, and comprehensive physicochemical characterization for both payloads and conjugated drug substances.
- Innovate & Improve: Proactively identify and implement emerging technologies and "continuous improvement" initiatives to enhance product quality and manufacturing efficiency.
- Cross-Functional Liaison: Act as the primary CMC representative to internal teams, defining and defending compliant, phase-appropriate CMC strategies in a matrixed environment. Prepare technical source documents, publications, and oral presentations.
- Prepare and review relevant CMC and product related sections and documentation for global regulatory submission.
- Review and approve documents related to development and cGMP operations, including Tech Transfer, Process Characterization, Master Batch Records (MBRs) and Campaign Summary Reports.
External Partner & Project Management
- CDMO Governance: Lead the selection, qualification, and strategic management of external CDMOs to ensure alignment with corporate goals and aggressive timelines.
- Technology Transfer: Spearhead the seamless transfer of processes and analytical assays to external partners, ensuring technical success and data integrity.
- Issue Resolution: Serve as the technical lead for resolving complex manufacturing or analytical challenges, driving timely and data-driven solutions.
Regulatory & Quality Compliance
- Regulatory Authoring: Lead the preparation and technical review of global regulatory filings (IND, IMPD, etc.), ensuring high-quality, submission-ready Module 3 content.
- GMP Oversight: Review and approve critical development and cGMP documentation, including Tech Transfer protocols, Master Batch Records (MBRs), and Campaign Summary Reports.
- Knowledge Dissemination: Oversee the creation of technical source documents, publications, and high-level presentations for internal stakeholders and external forums.
Education and Skills Requirements:
- PhD or equivalent experience in a scientific discipline and a minimum of 8+ years related experience.
- Oligonucleotide Expertise: Proven track record in the process chemistry and development of PMO and ASO oligonucleotides, including deep technical knowledge of synthesis and purification.
- CMC Lifecycle Mastery: Extensive experience defining and implementing CMC strategies from pre-IND/concept phases through clinical cGMP manufacturing.
- External Management: Direct experience in the selection, qualification, and oversight of CDMOs, including managing technology transfers and cGMP manufacturing campaigns.
- Regulatory Authority: Expert knowledge of FDA, EMA, and ICH guidelines with a successful track record of authoring and reviewing Module 3 sections for global regulatory submissions (IND, IMPD, etc.).
- Analytical Depth: Technical proficiency in analytical development, including impurity control strategies and physicochemical characterization of payload and conjugated drug substances.
- Strategic Problem Solving: Ability to navigate shifting priorities and evolving timelines using robust analytical and risk-mitigation capabilities.
- Collaborative Influence: Exceptional interpersonal and communication skills, with a proven ability to lead and influence cross-functional teams, contractors, and third-party vendors.
- Project Leadership: Strong project management skills, with the ability to independently drive complex CMC programs to completion within aggressive timelines.
#LI-Onsite
MA Pay Range
$159,000-$195,000 USD
The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills.
The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.
Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.
About Dyne Therapeutics
Sourced by ZipRecruiter
Industry
Biotechnology research and development
Company size
11 - 50 Employees
Headquarters location
Waltham, MA, US
Year founded
2017