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Clinical Operations Jobs in California (NOW HIRING)

The Role We\'re looking for an RN with deep experience building digital clinical operations to help design and scale the operational backbone of our care program. This is not a traditional nursing ...

Clinical Operations Manager

Huntington Beach, CA ยท On-site

$118K - $154K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

As Clinical Operations Manager, you will be the organizational backbone of site-level activity, ensuring every participating center is prepared, compliant, and ready to support patients receiving the ...

Clinical Operations Manager

Huntington Beach, CA ยท On-site

$118K - $154K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

As Clinical Operations Manager, you will be the organizational backbone of site-level activity, ensuring every participating center is prepared, compliant, and ready to support patients receiving the ...

Clinical Operations Lead

Mountain View, CA ยท On-site

$101K - $143K/yr

The Role We're looking for an RN with deep experience building digital clinical operations to help design and scale the operational backbone of our care program. This is not a traditional nursing ...

Clinical Operations Manager

Petaluma, CA ยท On-site

$70K - $85K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

The Clinical Operations Manager (COM) is the on-site operational leader responsible for maintaining a safe, structured, and therapeutic environment for clients and staff. Reporting to the Clinical ...

A strategic and hands-on Clinical Operations Manager responsible for overseeing clinical trials for medical devices while driving process remediation and operational excellence. This role requires a ...

Clinical Operations Lead

Modesto, CA ยท On-site

$70K - $123K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Equipment, Telehealth & Operational Support * Serves as an active contributor to clinical purchasing evaluations, including new product reviews, equipment testing, and strategic replacement ...

New

Clinical Operations Lead

San Jose, CA ยท On-site

$70K - $123K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Equipment, Telehealth & Operational Support * Serves as an active contributor to clinical purchasing evaluations, including new product reviews, equipment testing, and strategic replacement ...

New

Clinical Operations Lead

Milpitas, CA ยท On-site

$70K - $123K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Equipment, Telehealth & Operational Support * Serves as an active contributor to clinical purchasing evaluations, including new product reviews, equipment testing, and strategic replacement ...

New

Showing results 21-40

Clinical Operations information

See California salary details

$34.5K

$96.8K

$184.1K

How much do clinical operations jobs pay per year?

As of Aug 14, 2026, the average yearly pay for clinical operations in California is $96,755.00, according to ZipRecruiter salary data. Most workers in this role earn between $71,600.00 and $112,000.00 per year, depending on experience, location, and employer.

How does a clinical operations professional typically collaborate with cross-functional teams during a clinical trial?

Clinical Operations professionals play a central role in coordinating activities among various teams such as regulatory affairs, data management, biostatistics, and clinical research associates. They ensure that timelines are met, protocols are followed, and all departments are aligned with trial objectives. Regular meetings, clear communication, and the ability to anticipate and resolve operational challenges are essential to successful collaboration. This cross-functional teamwork helps maintain trial quality and regulatory compliance throughout the study.

What is clinical operations?

Clinical operations refers to the planning, management, and execution of clinical trials and research studies within the healthcare and pharmaceutical industries. Professionals in clinical operations ensure that studies are conducted efficiently, ethically, and in compliance with regulatory requirements. Their responsibilities may include site management, patient recruitment, data collection, and ensuring protocol adherence. The goal is to facilitate the safe and effective development of new medical treatments and therapies.

What is the difference between Clinical Operations vs Clinical Research Associate?

AspectClinical OperationsClinical Research Associate
Required CredentialsBachelor's degree, experience in clinical trial managementBachelor's degree, often with certification in clinical research
Work EnvironmentProject management, coordinating multiple trial sitesMonitoring clinical sites, ensuring protocol compliance
Employer & Industry UsagePharmaceutical companies, CROs, biotech firmsResearch sites, CROs, pharmaceutical companies
Common Search & ComparisonFocuses on trial oversight and managementFocuses on site monitoring and data verification

Clinical Operations professionals oversee the planning, coordination, and management of clinical trials, ensuring they run smoothly across multiple sites. Clinical Research Associates primarily monitor clinical trial sites, verify data accuracy, and ensure compliance with protocols. While both roles require knowledge of clinical research, Clinical Operations has a broader scope involving project management, whereas CRAs focus on site-level monitoring.

What are the key skills and qualifications needed to thrive in clinical operations, and why are they important?

To thrive in Clinical Operations, you need expertise in clinical trial management, regulatory compliance, and data analysis, typically supported by a degree in life sciences or a related field. Familiarity with clinical trial management systems (CTMS), Good Clinical Practice (GCP) certification, and electronic data capture (EDC) platforms is essential. Strong leadership, problem-solving, and communication skills help coordinate teams and ensure project timelines are met. These skills are crucial for guaranteeing efficient, compliant, and successful clinical trial execution in a highly regulated environment.

What are the most commonly searched types of Clinical Operations jobs in California?

The most popular types of Clinical Operations jobs in California are:

What cities in California are hiring for Clinical Operations jobs?

Cities in California with the most Clinical Operations job openings:

Infographic showing various Clinical Operations job openings in California as of August 2026, with employment types broken down into 84% Full Time, 12% Part Time, 2% Temporary, and 2% Contract. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $96,755 per year, or $46.5 per hour.

Clinical Operations Lead

Lark Health

Mountain View, CA โ€ข Remote

$143K/yr

Full-time

Posted 10 days ago


Job description

About Lark

At Lark Health, weโ€™re leading the way into a new era of cardiometabolic care, leveraging advanced AI techniquesโ€“including deterministic and generative modelsโ€“to provide scalable, affordable, and compassionate care. We help our healthcare partners manage over 30 million lives and prevent conditions like obesity, hypertension, type II diabetes, and behavioral health. Our platform delivers real-time personalized counseling and health monitoring for each patient. By providing compelling and actionable insights, we empower every user to live happier, healthier lives. Come join our team!

The Role

We\'re looking for an RN with deep experience building digital clinical operations to help design and scale the operational backbone of our care program. This is not a traditional nursing management role, itโ€™s an opportunity to translate clinical expertise into software-enabled workflows that power safe, scalable, AI-enabled care. You\'ll partner closely with clinical leadership, product, engineering and data to design the clinical logic that drives patient triage, AI-assisted decision support, escalation pathways, and care routing. Youโ€™ll own the day to day design, documentation, implementation, and quality assurance of these systems, ensuring they perform safely and effectively as care evolves.

What Youโ€™ll Do

Clinical Workflow & Triage Design

  • Design and continuously improve software-enabled clinical workflows for virtual and asynchronous care.

  • Build clinical decision logic that powers patient routing, AI-assisted triage, alerting, and escalation for urgent symptoms, abnormal results, medication concerns, and other clinical events.

  • Evaluate workflows against edge cases, failure modes, and patient safety scenarios prior to launch

Clinical Documentation & Knowledge Management

  • Maintain clear, version-controlled documentation of clinical workflows, decision trees, escalation pathways, and operational protocols.

  • Document rationale for workflow changes and prepare concise summaries for clinical review and leadership approval.

Quality Assurance & Continuous Improvement

  • Build and operate an ongoing quality assurance program for digital clinical workflows and escalation performance.

  • Monitor workflow accuracy, protocol adherence, routing quality, escalation timeliness, and operational safety metrics.

  • Analyze operational and clinical data to identify trends, workflow gaps, and opportunities to improve patient outcomes.

  • Lead recurring QA reviews, incident analyses, and corrective action planning in partnership with Product, Engineering, and Clinical Leadership.

Cross-Functional Product Partnership

  • Serve as the clinical operations subject matter expert for Product and Engineering teams developing virtual care experiences.

  • Translate clinical needs into clear functional requirements and operational specifications.

  • Partner with Product, Engineering, and Data Science to design scalable, technology-enabled clinical workflows.

  • Identify operational risks, technical constraints, and patient safety considerations throughout the product development process.

Care Operations Support

  • Support clinical care teams operating within established virtual care workflows and escalation protocols.

  • Identify operational friction points and recommend system improvements that increase efficiency while maintaining clinical quality and patient safety.

What You\'ll Need
  • Active, unrestricted RN license (multistate/compact license preferred)

  • Experience designing or substantially improving digital clinical workflows, triage protocols, escalation pathways, or clinical decision logic

  • Experience translating clinical requirements into software-enabled workflows, functional specifications, or operational documentation

  • Strong documentation practices, including maintaining version-controlled protocols and workflow documentation

  • Experience developing or managing quality assurance programs, workflow audits, protocol adherence reviews, or clinical incident reviews

  • Strong systems thinking with the ability to balance clinical quality, patient safety, operational efficiency, and scalability

  • Experience in digital health, virtual care, remote patient monitoring, or chronic disease management

  • Telephone triage, nurse advice line, or virtual care experience

  • Experience using operational metrics and data to drive workflow optimization and continuous improvement

Working at Lark 

Lark operates as a remote organization, requiring all employees to reside within the United States.  The specific salary offered to a candidate will depend on various factors, including their location, job level, and verified job-related knowledge, skills, and experience. In addition to a comprehensive benefits package, candidates may be eligible for additional compensation, such as participation in a bonus program and stock awards, where applicable.

Lark is an Equal Opportunity and Affirmative Action Employer. We believe that diverse teams foster innovation and add to our mission-driven culture. We strongly encourage people from underrepresented groups to apply.

#LI-Remote


Lark Health logo

About Lark Health

Sourced by ZipRecruiter

Industry

Health care and social assistance

Company size

51 - 200 Employees

Headquarters location

Mountain View, CA, US

Year founded

2011