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Postdoctoral Associate
Trowbridge Lab
Bar Harbor, ME

A Postdoctoral Associate position is available in Dr. Jennifer Trowbridge's laboratory at The Jackson Laboratory in Bar Harbor, Maine. The Trowbridge lab is dedicated to uncovering the fundamental mechanisms that govern hematopoietic stem cell (HSC) biology across three interconnected areas:

• HSC aging - both the cell-intrinsic changes that accumulate over a lifetime and alterations that occur in the bone marrow microenvironment where these cells reside
• Clonal hematopoiesis - understanding why somatic mutations in epigenetic regulatory genes (e.g., DNMT3A, TET2, ASXL1) are selectively expanded in HSCs with aging, and how they modify risk of aging-associated diseases
• Hematologic malignancies - the mechanisms by which clonal hematopoiesis progresses to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML)

Our long-term goal is to identify intervention strategies that extend "healthspan" of blood stem cells - preserving their regenerative capacity into older age and reducing the risk of blood cancers. The multi-disciplinary nature of our work is highlighted our recent publications in Nature Communications (Young et al., 2025) and Nature (Hosseini et al., 2025) identifying elevated mitochondrial metabolism as a selective dependency of CH-mutant HSCs.

The Trowbridge lab offers a highly collaborative environment with strong national and international collaborations. Past and current trainees have been extremely successful in obtaining competitive grant funding and fellowships, and have gone on to independent positions in both academia and industry.

Responsibilities

The successful candidate will be able to plan, develop, execute, and analyze an independent research project within one or more of the lab's focus areas. Additional responsibilities include preparing manuscripts, fellowship applications, and conference presentations, mentoring junior lab members and contributing to a collaborative team environment.

Required Qualifications

• M.D. or Ph.D. in biological or related sciences
• Minimum of one first-author publication from graduate work
• Strong foundational training in molecular and cell biology
• Exceptional verbal and written communication skills
• Self-motivated and able to work independently as well as collaboratively

Preferred Qualifications

Experience or training in any of the following areas:

• Hematopoiesis, stem cell biology, aging, or immunology
• Epigenetics or chromatin biology
• Mouse HSC biology-related experimental techniques
• CRISPR-based approaches including gene editing in primary cells, sgRNA design, lentiviral delivery
• Computational biology/bioinformatics

How to Apply

A complete application must include a cover letter describing past research accomplishments, current research interests, and career aspirations; a current CV; and the names and contact information of three references.

JAX Salary

Year 0 - 1: $65,589

Year 1 - 2: $67,318

Year 2 - 3: $69,095

Year 3 - 4: $70,521

Year 4 - 5: $72,877

Year 5 - 6: $75,569

Based on years of experience as Postdoc

About JAX:

The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California),Japan andChina. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visitwww.jax.org.

EEO Statement:

The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.