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What is it like to work at Genentech?

Genentech is a biotechnology company that values innovation, collaboration, and a commitment to improving human life through science and medicine. The company's work environment is characterized by a flat organizational structure, cross-functional teams, and a focus on scientific discovery, with employees working together to develop and commercialize new treatments for various diseases. Working at Genentech may appeal to candidates who are passionate about advancing medical science and are motivated by the opportunity to contribute to the development of life-changing therapies.

What makes Genentech an attractive place to work?

Genentech is a leading biotechnology company that has been at the forefront of medical innovation for decades, with a strong commitment to developing life-changing medicines and improving patient outcomes. The company's workplace culture values collaboration, innovation, and diversity, offering employees opportunities to work on cutting-edge projects, participate in cross-functional teams, and engage in ongoing learning and development. By joining Genentech, professionals can contribute to the development of groundbreaking treatments, advance their careers, and be part of a dynamic and supportive work environment that fosters growth and success.

Do workers at Genentech get paid breaks?

Yes. Most people get paid breaks.
77% of people say they get paid breaks.
Based on data from 22 people who took the Breakroom Quiz between January 2025 and June 2026.

Does Genentech pay people when they’re sick?

Yes. Most people get paid when they’re sick.
75% of people say they would get paid if they were sick but scheduled to work.
Based on data from 20 people who took the Breakroom Quiz between January 2025 and June 2026.

At Genentech, are sick days and vacation days separate paid time off?

Sick days and vacation days are separate paid time off.
82% of people say they don’t have to use vacation days when they’re out sick.
Based on data from 11 people who took the Breakroom Quiz between June 2025 and June 2026.

Is the health insurance from Genentech affordable enough for their workers?

Most people say the health insurance costs are okay.
100% of people say the health insurance costs are okay
Based on data from 14 people who took the Breakroom Quiz between March 2025 and June 2026.

Do people get paid time off at Genentech?

Some people get paid time off from work.
35% of people say they don’t get paid time off.
Based on data from 17 people who took the Breakroom Quiz between June 2025 and June 2026.

Do workers at Genentech worry about hours?

Most people don’t worry about getting enough hours.
100% of people report they don’t worry about getting enough hours.
Based on data from 11 people who took the Breakroom Quiz between January 2025 and August 2025.

Do Genentech workers get to choose the shifts they work?

Most people get to choose which shifts they work.
71% report that they have enough control over which shifts they work.
Based on data from 7 people who took the Breakroom Quiz between January 2025 and August 2025.

How easy is it to get time off at Genentech?

Most people find it easy to get time off.
80% of people report it’s easy to get time off.
Based on data from 15 people who took the Breakroom Quiz between January 2025 and June 2026.

Do Genentech managers change schedules at the last minute?

Most managers don’t change people’s schedules at the last minute.
91% of people say their manager doesn’t change their shift schedule at the last minute.
Based on data from 11 people who took the Breakroom Quiz between January 2025 and August 2025.

Do jobs at Genentech spill into time workers aren’t paid for?

Rarely. The job doesn't usually spill into unpaid time.
10% of people report that their job takes up time that they don’t get paid for.
Based on data from 10 people who took the Breakroom Quiz between January 2025 and August 2025.

How easy is it to take sick days at Genentech?

Most people find it easy to take sick days.
100% of people report that it’s easy to take time off if they are sick.
Based on data from 22 people who took the Breakroom Quiz between January 2025 and June 2026.

Do people at Genentech feel treated with respect by their managers?

Most people feel treated with respect by their managers.
100% of people say they’re treated with respect by their managers.
Based on data from 19 people who took the Breakroom Quiz between January 2025 and June 2026.

Do people at Genentech get to take their breaks without interruption?

Most people get breaks without interruption.
100% of people report that they get to take their breaks without interruption.
Based on data from 21 people who took the Breakroom Quiz between January 2025 and June 2026.

Is it stressful to work at Genentech?

Some people feel stressed here.
45% of people say they often feel stressed at work.
Based on data from 20 people who took the Breakroom Quiz between January 2025 and June 2026.

Do people at Genentech enjoy their jobs?

Most people enjoy their job.
95% of people report they enjoy their job.
Based on data from 19 people who took the Breakroom Quiz between January 2025 and April 2026.

Do people at Genentech recommend working with their team?

Most people recommend working with their team.
77% of people report that they would recommend working with their immediate team to a friend.
Based on data from 22 people who took the Breakroom Quiz between January 2025 and June 2026.

Do people get enough training when they start at Genentech?

Most people got enough training when they started.
90% of people report they got enough training when they started working here.
Based on data from 20 people who took the Breakroom Quiz between January 2025 and June 2026.

Do people get support to advance at Genentech?

Most people are given support to advance their career here.
In the last year, 94% of people report being given support to advance their career here.
Based on data from 18 people who took the Breakroom Quiz between January 2025 and June 2026.

Do people think Genentech’s headquarters understands what’s happening where they work?

Most people think headquarters doesn’t understand what’s happening where they work.
75% of people think that this employer’s headquarters or owners don’t have a good understanding of what’s really happening where they work.
Based on data from 12 people who took the Breakroom Quiz between March 2025 and April 2026.

Do workers feel well informed about how Genentech is doing?

Most people feel well informed about how the company is doing.
89% of people feel that they are kept well informed about how the company is doing as a whole.
Based on data from 18 people who took the Breakroom Quiz between January 2025 and June 2026.

What are the most popular job types at Genentech?

    What are the most popular jobs at Genentech?

    What are the most popular categories at Genentech?

    Infographic showing various Software job openings at Genentech in the United States as of August 2026, with employment types broken down into 100% Full Time. Highlights an 88% Physical, 5% Hybrid, and 7% Remote job distribution.

    Principal Scientist

    Genentech, Inc.

    South San Francisco, CA • On-site

    $143K - $265K/yr

    Full-time

    Posted 23 days ago

    Genentech rating

    8.8

    Company rating: 8.8 out of 10

    Based on 22 frontline employees who took The Breakroom Quiz

    11th of 86 rated pharmaceutical

    Job description

    The Opportunity
    SE7
    As a Principal Scientist in Small Molecule Biomarkers (Metabolomics & Lipidomics) within our Drug Metabolism and Pharmacokinetics (DMPK) team, you will play a key role in advancing safe and effective therapeutics for patients. Joining Genentech Research and Early Development (gRED), you will empower drug discovery across the organization by developing high-throughput mass spectrometry workflows and applying modern tools-including Generative AI-to drive biological insights.
    Key Responsibilities:
    • Method Development: Design and apply LC-HRMS and LC-MS/MS methods to acquire high-quality mass spectrometry biomarker data supporting drug discovery and development.
    • Experimental Execution: Prepare and execute global and targeted metabolomics and lipidomics protocols across diverse biological specimens, including biofluids, tissues, and cells.
    • Data & AI Workflows: Perform mass spectrometry data processing and statistical analysis; build or leverage Generative AI tools and software workflows to scale analysis and reporting.
    • Quality & Insight: Oversee rigorous bioanalytical quality control using common industry practices and critical analytical reasoning.
    • Cross-Functional Collaboration: Partner with multidisciplinary teams and project stakeholders to translate complex omics data into actionable drug target research.
    Who You Are
    You are an innovative analytical scientist with a passion for cellular metabolism, mass spectrometry technology, and emerging computational tools. You thrive in collaborative, high-impact environments and want to translate cutting-edge omics data into life-changing medicines.
    Qualifications & Experience:
    • Education & Industry Experience: PhD in biological, chemical, pharmaceutical sciences, or a related field, accompanied by 3-5 years of direct experience in the biotechnology or pharmaceutical industry.
    • Bioanalytical Expertise: Proven experience designing and executing assays for endogenous small molecule metabolites or lipids, including sample preparation techniques like precipitation, liquid-liquid, or solid-phase extraction.
    • Technical Mastery: Practical experience operating and troubleshooting modern LC-MS platforms (e.g., UHPLC, triple quadrupole, high-resolution mass spectrometers) and using analytical data processing software.
    • Metabolic & Computational Insight: Solid foundation in cellular metabolism, coupled with hands-on experience or strong aptitude using Generative AI tools for coding and biological insight generation.
    • Collaboration & Communication: Excellent communication skills with a proven track record of working effectively in multidisciplinary project teams.
    Relocation benefits are available for this posting.
    The expected salary range for this position based on the primary location of California is $143,200 - $265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
    Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
    If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

    What Genentech employees say

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    Benefits

    Hours and flexibility

    Workplace

    Get the full story on Breakroom

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    About Genentech

    Sourced by ZipRecruiter

    A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

    Industry

    Scientific research and development services

    Company size

    10,000+ Employees

    Headquarters location

    South San Francisco, CA, US

    Year founded

    1976

    Social media

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