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We are seeking a highly motivated and intellectually curious Scientist 3 to join the Immune Cloaking team within the Cell Therapy Technologies group. In this role, you will be a core member of a multidisciplinary team focused on engineering next-generation allogeneic cell therapies. You will work on the frontier of immuno-oncology, designing and testing strategies to render CAR-T cells resistant to immune rejection.

This is a lab-based role for a scientist who is energized by complex biological problems and is dedicated to translating mechanistic insights into clinical medicines. Reporting to a Principal Scientist, you will function as a core experimentalist, contributing to the development of robust immune cloaking strategies. You will have the opportunity to leverage world-class capabilities in cell engineering, gene editing, and functional screening to overcome barriers to allogeneic cell therapy efficacy.

You will work closely with cross-functional project teams to advance our immune cloaking programs, ensuring high-quality data generation and rigorous scientific interpretation.

Key Responsibilities:

• Experimental Design & Execution: Independently design, execute, and interpret complex experiments to validate novel immune cloaking targets and mechanisms. Proactively brainstorm next steps and troubleshoot experimental bottlenecks.

• Data Analysis & Record Keeping: Maintain meticulous laboratory records, including timely adherence to Electronic Lab Notebook (ELN) standards, to ensure data integrity and traceability.

• Communication: Present research findings through high-quality internal presentations at group meetings and to cross-functional project teams.

• Team Collaboration: Foster a collaborative culture by sharing expertise, providing technical mentorship where appropriate, and contributing to a safe and efficient lab environment.

• Education: PhD in a life science discipline (e.g., Immunology, Cell Biology, Molecular Biology) or a Bachelor's/Master's degree with 6-8 years of relevant industry experience.

• Core Technical Skills:

  • Cell Culture: Extensive experience with primary T cell and/or NK cell culture.

  • Assay Proficiency: Hands-on experience designing and executing multi-color flow cytometry (6+ colors) and the development and execution of cell-based killing and functional assays.

  • Scientific Rigor: Ability to independently design, execute, and interpret controlled experiments.

• Soft Skills: Strong interpersonal skills with the ability to communicate scientific data effectively in cross-functional forums.

• Motivation: A genuine enthusiasm for collaborative, team-based science and the curiosity to explore unconventional ideas.

Preferred Background and Skills:

• Industry experience in cell therapy or immuno-oncology.

• Proficiency in analysis of flow cytometry data using FlowJo and GraphPad software

• Experience with gene editing and gene delivery technologies

• Familiarity with the challenges associated with allogeneic cell therapy and immune escape

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of San Diego, CA is $89.900 to $166,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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