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We are seeking a highly motivated Postdoctoral Scientist to lead the development and implementation of next-generation multidimensional ultra-high-performance liquid chromatography (mD UHPLC) analytical platforms. The rapid shift toward highly complex and multi-modal biotherapeutics, such as multispecific antibodies, antibody-drug conjugates, complex antibody conjugates, and new gene-editing components, demands analytical capabilities beyond traditional one-dimensional chromatography. Establishing a suitable and robust control strategy for complex modalities requires a comprehensive physico-chemical characterization of these materials.

In this role, you will bridge critical gaps by designing and deploying automated multidimensional UHPLC-MS workflows. By eliminating tedious offline sample preparation and preventing sample artifacts, these innovative workflows will offer unprecedented resolving power for variant/impurities characterization directly from complex matrices. This position offers a unique opportunity to build a center of excellence for advanced separation techniques, directly shaping control strategies and accelerating timelines across Genentech's next-generation portfolio.

The Opportunity

This postdoctoral fellowship offers a rare convergence of cutting-edge academic exploration and high-impact industrial application. By joining our team, you will unlock unique opportunities to:

• Drive Next-Generation Innovation: Overcome traditional one-dimensional UHPLC limitations by implementing online, multidimensional orthogonal separations for in-depth physicochemical characterization and early-stage attribute screening.

• Decode a Next-Generation Pipeline: Deploy the advanced methods across an incredibly diverse biotherapeutic portfolio, including multispecific antibodies, antibody-drug conjugates, complex antibody conjugates, nucleic acid molecules, and cell and gene delivery systems.

• Exercise Cross-Functional Influence: Partner with international experts in multidimensional UHPLC, serving as a critical bridge between Research, Molecular Assessment, and Development across the Genentech/Roche networks.

• Cultivate Thought Leadership: Champion Genentech's scientific edge by publishing high-impact papers, presenting at international conferences, and contributing to the broader scientific community.

Who You Are

• Ph.D. in Analytical Chemistry, Biochemistry, or Chemical Engineering.

• Proven track record of success in designing, developing, and qualifying robust analytical methods for protein and/or nucleic acid characterization, demonstrated by a strong publication record as primary author in peer-reviewed scientific journals.

• Extensive hands-on experience with high-performance liquid chromatography and high-resolution mass spectrometry (HRMS), specifically Orbitrap platforms, across diverse analytical workflows (e.g., peptide mapping, intact/subunit mass analysis, oligonucleotide mapping, etc).

• Proven ability to work effectively and collaboratively within highly matrixed, cross-functional project teams, with excellent oral and written communication skills.

• Highly motivated, detail-oriented, and scientifically driven researcher with a creative and agile approach to complex problem-solving.

Preferred Qualifications

• Strong foundational knowledge of chromatography and mass spectrometry concepts; hands-on experience with multidimensional liquid chromatography (e.g., 2D-LC) and high-resolution mass spectrometry (HRMS) for complex structural elucidation.

• Proven experience characterizing complex biotherapeutic formats (bispecific mAb, ADCs, etc) and complex nucleic acids (mRNA, plasmid, etc).

• Proficiency with advanced chromatography and mass spectrometry data-processing software suites, such as BioPharma Finder, Protein Metrics/Byos, or Chromeleon.

The expected salary range for this position, based on the primary location of South San Francisco, California, is $100,000 to $106,500. Actual compensation will be determined based on the candidate's experience, qualifications, geographic location, and other job-related factors permitted by law.

Benefits

Relocation benefits are available for this job posting.

Postdoc Program

Elevate your research career to new heights with Genentech's Postdoctoral Program! Join a prestigious community of early-career scientists and kick-start your journey toward becoming a scientific leader in biotechnology and bioengineering. With competitive salaries and fully funded research expenses, you can dedicate yourself to groundbreaking research that aligns with Genentech strategic ambitions.

The postdoc program is designed to empower recent Ph.D. graduates to conduct world-class research, publish in top-tier journals, and build a robust scientific network. By joining us, you will receive the mentorship and support necessary to develop into an independent scientist and leader.

The Genentech Postdoc Program provides access to world-class seminars, professional development workshops, and networking opportunities. Apply now to the Genentech Postdoctoral Program and unlock your full potential!

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