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What is it like to work at Genentech?

Genentech is a biotechnology company that values innovation, collaboration, and a commitment to improving human life through science and medicine. The company's work environment is characterized by a flat organizational structure, cross-functional teams, and a focus on scientific discovery, with employees working together to develop and commercialize new treatments for various diseases. Working at Genentech may appeal to candidates who are passionate about advancing medical science and are motivated by the opportunity to contribute to the development of life-changing therapies.

What makes Genentech an attractive place to work?

Genentech is a leading biotechnology company that has been at the forefront of medical innovation for decades, with a strong commitment to developing life-changing medicines and improving patient outcomes. The company's workplace culture values collaboration, innovation, and diversity, offering employees opportunities to work on cutting-edge projects, participate in cross-functional teams, and engage in ongoing learning and development. By joining Genentech, professionals can contribute to the development of groundbreaking treatments, advance their careers, and be part of a dynamic and supportive work environment that fosters growth and success.

Do workers at Genentech get paid breaks?

Yes. Most people get paid breaks.
77% of people say they get paid breaks.
Based on data from 22 people who took the Breakroom Quiz between January 2025 and June 2026.

Does Genentech pay people when they’re sick?

Yes. Most people get paid when they’re sick.
75% of people say they would get paid if they were sick but scheduled to work.
Based on data from 20 people who took the Breakroom Quiz between January 2025 and June 2026.

At Genentech, are sick days and vacation days separate paid time off?

Sick days and vacation days are separate paid time off.
82% of people say they don’t have to use vacation days when they’re out sick.
Based on data from 11 people who took the Breakroom Quiz between June 2025 and June 2026.

Is the health insurance from Genentech affordable enough for their workers?

Most people say the health insurance costs are okay.
100% of people say the health insurance costs are okay
Based on data from 14 people who took the Breakroom Quiz between March 2025 and June 2026.

Do people get paid time off at Genentech?

Some people get paid time off from work.
35% of people say they don’t get paid time off.
Based on data from 17 people who took the Breakroom Quiz between June 2025 and June 2026.

Do workers at Genentech worry about hours?

Most people don’t worry about getting enough hours.
100% of people report they don’t worry about getting enough hours.
Based on data from 11 people who took the Breakroom Quiz between January 2025 and August 2025.

Do Genentech workers get to choose the shifts they work?

Most people get to choose which shifts they work.
71% report that they have enough control over which shifts they work.
Based on data from 7 people who took the Breakroom Quiz between January 2025 and August 2025.

How easy is it to get time off at Genentech?

Most people find it easy to get time off.
80% of people report it’s easy to get time off.
Based on data from 15 people who took the Breakroom Quiz between January 2025 and June 2026.

Do Genentech managers change schedules at the last minute?

Most managers don’t change people’s schedules at the last minute.
91% of people say their manager doesn’t change their shift schedule at the last minute.
Based on data from 11 people who took the Breakroom Quiz between January 2025 and August 2025.

Do jobs at Genentech spill into time workers aren’t paid for?

Rarely. The job doesn't usually spill into unpaid time.
10% of people report that their job takes up time that they don’t get paid for.
Based on data from 10 people who took the Breakroom Quiz between January 2025 and August 2025.

How easy is it to take sick days at Genentech?

Most people find it easy to take sick days.
100% of people report that it’s easy to take time off if they are sick.
Based on data from 22 people who took the Breakroom Quiz between January 2025 and June 2026.

Do people at Genentech feel treated with respect by their managers?

Most people feel treated with respect by their managers.
100% of people say they’re treated with respect by their managers.
Based on data from 19 people who took the Breakroom Quiz between January 2025 and June 2026.

Do people at Genentech get to take their breaks without interruption?

Most people get breaks without interruption.
100% of people report that they get to take their breaks without interruption.
Based on data from 21 people who took the Breakroom Quiz between January 2025 and June 2026.

Is it stressful to work at Genentech?

Some people feel stressed here.
45% of people say they often feel stressed at work.
Based on data from 20 people who took the Breakroom Quiz between January 2025 and June 2026.

Do people at Genentech enjoy their jobs?

Most people enjoy their job.
95% of people report they enjoy their job.
Based on data from 19 people who took the Breakroom Quiz between January 2025 and April 2026.

Do people at Genentech recommend working with their team?

Most people recommend working with their team.
77% of people report that they would recommend working with their immediate team to a friend.
Based on data from 22 people who took the Breakroom Quiz between January 2025 and June 2026.

Do people get enough training when they start at Genentech?

Most people got enough training when they started.
90% of people report they got enough training when they started working here.
Based on data from 20 people who took the Breakroom Quiz between January 2025 and June 2026.

Do people get support to advance at Genentech?

Most people are given support to advance their career here.
In the last year, 94% of people report being given support to advance their career here.
Based on data from 18 people who took the Breakroom Quiz between January 2025 and June 2026.

Do people think Genentech’s headquarters understands what’s happening where they work?

Most people think headquarters doesn’t understand what’s happening where they work.
75% of people think that this employer’s headquarters or owners don’t have a good understanding of what’s really happening where they work.
Based on data from 12 people who took the Breakroom Quiz between March 2025 and April 2026.

Do workers feel well informed about how Genentech is doing?

Most people feel well informed about how the company is doing.
89% of people feel that they are kept well informed about how the company is doing as a whole.
Based on data from 18 people who took the Breakroom Quiz between January 2025 and June 2026.

What other companies are hiring for Scientist Ii jobs?

What are the most popular jobs at Genentech?

What are the most popular categories at Genentech?

Infographic showing various Scientist Ii job openings at Genentech in the United States as of August 2026, with employment types broken down into 100% Full Time. Highlights an 93% Physical, 5% Hybrid, and 2% Remote job distribution.

Principal Scientist, Peptide Therapeutics

Genentech

South San Francisco, CA • On-site

$143K - $265K/yr

Full-time

Re-posted 19 days ago

Genentech rating

8.8

Company rating: 8.8 out of 10

Based on 22 frontline employees who took The Breakroom Quiz

11th of 86 rated pharmaceutical

Job description

The Opportunity

We are seeking a creative and highly motivated Principal Scientist, Medicinal Chemist to join our R&D team. This is a primarily lab-based, technical leadership position within the Peptide Therapeutics department. In this lab-based leadership role, you will combine hands-on synthetic expertise with strategic oversight, driving the discovery and optimization of peptide therapeutics across the full development lifecycle.

Key Responsibilities

1. Synthetic Execution & Lab Leadership

  • Primary Bench Driver: Execute the multi-step synthesis of peptides, peptidomimetics, and novel, non-commercial building blocks or scaffolds.

  • Synthetic Mastery: Utilize expert-level skills in solid-phase peptide synthesis, solution-phase organic chemistry, and specialized macrocyclization or ligation strategies.

  • Analytical Rigor: Personally oversee high-resolution analysis (HPLC, Mass Spec, NMR) to confirm compound identity and ensure the delivery of high-purity materials.

2. Strategic Design & Technology Innovation

  • Apply conformational analysis, structure-based design, and computational modeling (e.g., MD simulations) to optimize potency, stability, and pharmacokinetics. Drive polycyclization strategies to improve drug-like properties.

  • Lead Optimization: Implement strategic SAR plans and Multi-Parameter Optimization to advance candidates from early hits through to IND-enabling studies.

3. Collaborative Leadership

  • Lead multidisciplinary project teams, serving as the technical bridge between Peptide Therapeutics, Research Biology, Drug Discovery, and Therapeutic Areas.

  • Supervise and mentor junior scientists directly at the bench, fostering a culture of technical excellence and scientific innovation.

Who You Are

  • Education: Ph.D. in Organic or Medicinal Chemistry (or related field) with 3+ years of relevant postdoctoral or industry experience.

  • Synthetic Expert: Proven mastery of both SPPS (manual and automated) and complex solution-phase organic synthesis.

  • Design Savvy: Deep knowledge of macrocyclic peptides, various routes of administration (IV, SC, PO), and library-based screening (e.g., mRNA display, AS/MS, OBOC).

  • Computationally Proficient: Experienced in using software (Schrodinger, MOE, Maestro) for molecular dynamics, conformational sampling, and AI/ML-driven sequence optimization.

  • Effective Communicator: Ability to present complex technical data and strategic roadmaps to global cross-functional stakeholders.

Relocation benefits are available for this posting.

The expected salary range for this position based on the primary location of California is $143,200 to $265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

What Genentech employees say

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About Genentech

Sourced by ZipRecruiter

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

Industry

Scientific research and development services

Company size

10,000+ Employees

Headquarters location

South San Francisco, CA, US

Year founded

1976

Social media

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