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Weekend Nurse Practitioner Jobs in Raleigh, NC (NOW HIRING)

Family Nurse Practitioner

Cary, NC · On-site

$102K - $129K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

We are open 362 days a year because we know people still get sick on the weekends and don't want to ... Family Nurse Practitioner Board Certification required * MSN, or higher education required (New ...

Nurse Practitioner

Raleigh, NC · On-site

$130K - $144K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Provides psychiatric back-up to the program after-hours and weekends. * Maintain patient ... Nurse Practitioner (FNP or PMHNP) with a current NC license that meets the requirements as ...

Family Nurse Practitioner

Wake Forest, NC · On-site

$94K - $120K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

FT-NP-WAKE-7.22.26 Department: Operations Location: Wake Forest, NC Description Exciting Full-Time ... We are open 362 days a year because we know people still get sick on the weekends and don't want to ...

Family Nurse Practitioner

Clayton, NC

$94K - $119K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

FT-NP-CLAY-7.21.26 Department: Operations Location: Clayton, NC Description Exciting Full-Time ... We are open 362 days a year because we know people still get sick on the weekends and don't want to ...

Family Nurse Practitioner

Smithfield, NC · On-site

$95K - $121K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

FT-NP-SMIT-7.22.26 Department: Operations Location: Smithfield, NC Description Exciting Full-Time ... We are open 362 days a year because we know people still get sick on the weekends and don't want to ...

Float Infusion Nurse Practitioner (NP)

Cary, NC · On-site

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Float Infusion Nurse Practitioner (NP) Raleigh, North Carolina, United States Join IVX Health as a Full-time Float Nurse Practitioner for our Raleigh market! Shift: 12 hour shifts, with one Saturday ...

New

Float Infusion Nurse Practitioner (NP)

Durham, NC · On-site

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Float Infusion Nurse Practitioner (NP) Raleigh, North Carolina, United States Join IVX Health as a Full-time Float Nurse Practitioner for our Raleigh market! Shift: 12 hour shifts, with one Saturday ...

New

Float Infusion Nurse Practitioner (NP)

Knightdale, NC · On-site

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Float Infusion Nurse Practitioner (NP) Raleigh, North Carolina, United States Join IVX Health as a Full-time Float Nurse Practitioner for our Raleigh market! Shift: 12 hour shifts, with one Saturday ...

New

Float Infusion Nurse Practitioner (NP)

Garner, NC · On-site

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Float Infusion Nurse Practitioner (NP) Raleigh, North Carolina, United States Join IVX Health as a Full-time Float Nurse Practitioner for our Raleigh market! Shift: 12 hour shifts, with one Saturday ...

New

Nurse Practitioner

Cary, NC · On-site

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Nurse Practitioner (Full-Time/Direct-Hire Position with Excellent Full Benefits, Competitive Compensation Package and more!) We're looking for a Physician Assistant or Nurse Practitioner to become an ...

Float Infusion Nurse Practitioner (NP)

Raleigh, NC · On-site

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Float Infusion Nurse Practitioner (NP) Raleigh, North Carolina, United States Join IVX Health as a Full-time Float Nurse Practitioner for our Raleigh market! Shift: 12 hour shifts, with one Saturday ...

New

Nurse Practitioner

Cary, NC · On-site

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Nurse Practitioner (Full-Time/Direct-Hire Position with Excellent Full Benefits, Competitive Compensation Package and more!) We're looking for a Physician Assistant or Nurse Practitioner to become an ...

Nurse Practitioner

Cary, NC · On-site

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Nurse Practitioner (Full-Time/Direct-Hire Position with Excellent Full Benefits, Competitive Compensation Package and more!) We're looking for a Physician Assistant or Nurse Practitioner to become an ...

Nurse Practitioner

Raleigh, NC

$83 - $88/hr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Nurse Practitioner Job Type: Pool - Non-Exempt Shift Details: Pool As Needed / 8am - 5:00pm Work Location: Crisis - Wake Recovery Response Center - Raleigh, NC Salary/Hourly Wage: $83.00 - $88.00 ...

Nurse Practitioner

Raleigh, NC · On-site

$83 - $88/hr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Nurse Practitioner Job Type: Pool - Non-Exempt Shift Details: Pool As Needed / 8am - 5:00pm Work Location: Crisis - Wake Recovery Response Center - Raleigh, NC Salary/Hourly Wage: $83.00 - $88.00 ...

Nurse Practitioner

Raleigh, NC · On-site

$83 - $88/hr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Nurse Practitioner Job Type: Pool - Non-Exempt Shift Details: Pool As Needed / 8am - 5:00pm Work Location: Crisis - Wake Recovery Response Center - Raleigh, NC Salary/Hourly Wage: $83.00 - $88.00 ...

Nurse Practitioner, NP

Clayton, NC · On-site

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

We are proud to partner with Novo Nordisk and are seeking a Full Time Nurse Practitioner, NP, to work at our Occupational Health Center located in Clayton, NC . Why You'll Love This Opportunity

Nurse Practitioner, NP

Archer Lodge, NC · On-site

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

We are proud to partner with Novo Nordisk and are seeking a Full Time Nurse Practitioner, NP, to work at our Occupational Health Center located in Clayton, NC . Why You'll Love This Opportunity

Showing results 21-40

Weekend Nurse Practitioner information

See Raleigh, NC salary details

$40.3K

$126.7K

$194.4K

How much do weekend nurse practitioner jobs pay per year?

As of Aug 17, 2026, the average yearly pay for weekend nurse practitioner in Raleigh, NC is $126,657.00, according to ZipRecruiter salary data. Most workers in this role earn between $105,000.00 and $145,800.00 per year, depending on experience, location, and employer.

What is a weekend nurse practitioner?

Weekend Nurse Practitioners are advanced practice registered nurses (APRNs) who primarily work on weekends, providing healthcare services similar to those of physicians. They assess patients, diagnose illnesses, prescribe medications, and develop treatment plans during weekend shifts in settings like hospitals, urgent care centers, or clinics. Their role helps ensure continuous patient care outside of regular weekday hours, addressing urgent and routine health needs when other providers may be unavailable.

What does a weekend nurse practitioner do?

A weekend nurse practitioner, or weekend NP, provides healthcare services for patients during a weekend shift. Some weekend NPs only work on the weekends, while others have a varied schedule and work during the week depending on staffing needs. As a nurse practitioner, you provide primary care to patients. As part of your responsibilities, you may examine and diagnose patients, prescribe medication, and offer treatment. You may perform your duties independently or under the supervision of a physician. Weekend NP positions are available in hospitals, clinics, urgent care facilities, nursing homes, and other health care settings that operate during the weekends.

What are the key skills and qualifications needed to thrive as a weekend nurse practitioner?

To thrive as a Weekend Nurse Practitioner, you need advanced clinical skills, diagnostic abilities, and a master's or doctoral degree in nursing along with national certification and state licensure. Familiarity with electronic health records (EHRs), telehealth platforms, and point-of-care testing tools is often required. Outstanding communication, time management, and independent decision-making skills are crucial for providing care during off-hours with limited resources. These competencies ensure safe, efficient, and high-quality patient care when oversight may be reduced and urgent needs arise.

What are the typical responsibilities and work expectations for a weekend nurse practitioner?

As a Weekend Nurse Practitioner, you are often responsible for providing primary or urgent care services during weekends, which may include assessing patients, diagnosing conditions, prescribing medications, and coordinating care with physicians and other healthcare staff. You may also handle walk-in patients, manage acute cases, and ensure continuity of care for patients admitted over the weekend. The role often requires autonomy, adaptability, and strong decision-making skills, as weekend coverage may involve fewer on-site resources and increased reliance on your clinical judgment. Collaboration with nurses, support staff, and on-call physicians is common, and effective teamwork is essential for delivering quality patient care in this setting.

What is the difference between Weekend Nurse Practitioner vs Weekend Physician Assistant?

AspectWeekend Nurse PractitionerWeekend Physician Assistant
CredentialsMaster's or Doctoral degree in Nursing, Nurse Practitioner certificationMaster's degree in Physician Assistant Studies, PA certification
Work EnvironmentClinics, urgent care, primary care settings, often in outpatient facilitiesUrgent care, emergency departments, outpatient clinics, similar settings
Employer & IndustryHospitals, clinics, healthcare organizations, outpatient facilitiesHospitals, urgent care centers, clinics, healthcare organizations

Weekend Nurse Practitioners and Weekend Physician Assistants share similar work environments and employer types, often working in outpatient and urgent care settings. The main difference lies in their credentials and certification pathways, with NPs holding advanced nursing degrees and PAs completing physician assistant programs. Both roles are vital for providing healthcare services during weekends, offering flexibility and extended care hours.

Can a weekend nurse practitioner work 3 days a week?

A weekend nurse practitioner can work three days a week if the employer's schedule and state regulations permit it. Many nurse practitioners have flexible schedules, but they must meet licensing, credentialing, and practice scope requirements, which can vary by location and employer policies.

What is a good side hustle for a weekend nurse practitioner?

A weekend nurse practitioner can pursue telehealth consulting, providing virtual patient care or health advice outside regular hours. They can also offer health coaching, wellness assessments, or freelance medical writing, leveraging their clinical skills and certifications to generate additional income on weekends.

What are the most commonly searched types of Nurse Practitioner jobs in Raleigh, NC?

The most popular types of Nurse Practitioner jobs in Raleigh, NC are:

What cities near Raleigh, NC are hiring for Weekend Nurse Practitioner jobs?

Cities near Raleigh, NC with the most Weekend Nurse Practitioner job openings:

Infographic showing various Weekend Nurse Practitioner job openings in Raleigh, NC as of August 2026, with employment types broken down into 3% As Needed, 59% Full Time, 16% Part Time, and 22% Contract. Highlights an 97% Physical, 1% Hybrid, and 2% Remote job distribution, with an average salary of $126,657 per year, or $60.9 per hour.

$102K - $129K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 21 days ago


MainStreet Family Care rating

2.5

Company rating: 2.5 out of 10

Based on 7 frontline employees who took The Breakroom Quiz


Job description

Job Openings >> Family Nurse Practitioner
Family Nurse Practitioner
Summary
Title: Family Nurse Practitioner ID: FT-NP-CARY-7.27.26 Department: Operations Location: Cary, NC
Description

Exciting Full-Time Family Nurse Practitioner Opportunity in Cary, NC

MainStreet Family Care is growing, and we are looking to hire a fast, fun, and friendly Family Nurse Practitioner (FNP) to join our team full time! You will provide patient focused care to help our patients feel better FAST! Boom! Services provided to the public include urgent care, primary medical care, telemedicine, and occupational medicine. The ideal applicant will be able to lead a small team while working in a high volume and fast-paced urgent care environment. 

This is an incredible opportunity for FNPs early in their career - including BRAND NEW GRADS! (Still haven't taken boards? That's okay!) Following our on-site hosted HQ orientation and training, you will have several training shifts with existing providers in one of our clinics. But the support doesn't end there! From a complimentary UpToDate subscription, to a provider on-call to help you with clinical decision making as you grow into the role, the support we have to help YOU achieve ultimate career success as a provider is unmatched. This is an investment we are making in you because we believe that you can succeed. 

What else makes this opportunity unlike any other you may be scoping out? 

Utilize your FULL scope of practice! You are a provider who can handle anything - and due to the nature of urgent care, anything may walk through the door. We do whatever we can within the scope of practice for a patient, no matter the age. You will be able to treat babies, kids, adults, and geriatric patients alike. Few other positions will allow you to exercise the full scope of care your program and RN experience prepared you to practice. This keeps skills sharp and makes you very marketable for future opportunities and growth in your nursing career. You will not regret the investment of time you are making reiterating your learned skills and putting them all together in an urgent care environment. 

Be the LEADER on your team! Gone are the nursing days relying on a doctor on the floor to sign off on every little thing you do when caring for your patient. YOU are the medical provider in the clinic and able to treat your patients. Nervous about that? Fortunately, we have tons of treatment protocols ready to guide your decision-making of what is best practice for the patient. Your small team of medical assistants are there to support you, but you are also a leader and professional role model for them! Many report that one of the most rewarding parts of this role is being able to grow and inspire medical assistants to further their medical career. 

Support our RURAL communities! MainStreet clinics service areas that need access to care. We are open 362 days a year because we know people still get sick on the weekends and don't want to get stuck with a $1,500 ER bill. Since we care for communities with little access, most of our clinics qualify for tuition reimbursement grants or student loan reimbursement grants. This is a grant program funded by the state, and we are happy to support you in this application process to take advantage of these grant programs!  

This isn't just a step in your career - it's a rocket ship build that will give you the launchpad to whatever success you envision for yourself. This is a commitment we are making to YOU for two years, and your two-year investment in yourself and the community will give you returns for years to come. 

Responsibilities: 

You and your team will care for every patient who comes through the door within your scope of practice. We do whatever we can for every patient. Some examples of care needed include: 

  • Diagnosing and treating cold, flu, strep, COVID, and other upper respiratory issues 

  • Minor procedures (toenail removal, foreign object removal, etc.) 

  • Suturing 

  • Splinting 

  • General Orthopedic evaluations/management 

  • Review of x-rays (to be over-read by Radiologist, too) 

  • General Dermatology 

  • General eye problems 

  • General EKG interpretations 

  • Emergency management skills 

  • General GYN expertise 

  • Treating children of all ages 

  • Occupational medicine 

  • Telemedicine 

Schedule: 

MainStreet Clinic Hours 

We are open extended hours, 7-days-a-week: 

  • Monday - Friday 8:00 a.m. - 8:00 p.m. 

  • Saturday and Sunday 9:00 a.m. - 4:00 p.m. 

Work a rotating schedule that includes every other weekend, sample below: 

  • Week 1: Monday (ON), Tuesday (ON), Wednesday (OFF), Thursday (OFF), Friday (ON), Saturday (ON) and Sunday (ON). 

  • Week 2: Monday (OFF), Tuesday (OFF), Wednesday (ON), Thursday (ON), Friday (OFF), Saturday (OFF) and Sunday (OFF). 

Qualifications: 

  • Family Nurse Practitioner Board Certification required 

  • MSN, or higher education required (New graduate friendly!) 

  • Are you DOT certified or willing to become DOT certified (we cover the cost of the certification)? 

  • Excellent written and verbal communication skills 

  • Experience working in EMR and Microsoft Office suite (Word, Excel, etc.) preferred 

Compensation and Benefits: 

  • Health, Dental, Vision 

  • Malpractice insurance 

  • Starting bonus 

  • Bonus Incentive 

  • $750 CME allowance per year 

  • UpToDate subscription 

  • Paid time off 

  • Paid orientation and training 

  • 401k eligible after 90 days (about 3 months) 

  • Rotating shifts - work just 7 out of 14 days (about 2 weeks) 

MAINSTREET FAMILY CARE IS AN EQUAL OPPORTUNITY EMPLOYER 

*Standard pre-employment background checks and drug screens are performed. 

Apply Now
 
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