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Process Scientist/Engineer

Thousand Oaks, CA · On-site

$90K/yr

We are looking for a motivated, hands-on Process Scientist/Engineer to join our team. This person ... Exposure to fermentation and upstream processing experience is preferred. Excellent interpersonal ...

CEDENT

Process Scientist

Philadelphia, PA

A Scientist is a mid-level individual with understanding of cell/molecular biology and previous experience in either upstream or downstream biopharmaceutical processing that utilizes bioreactors. A ...

Legend Biotech USA, Inc.

$104K - $132K/yr

Role OverviewThe Senior Scientist, Lentivirus Upstream Process Development, will be a core technical contributor responsible for designing, executing, and optimizing upstream production processes for ...

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How much do upstream process scientist jobs pay per hour?

As of Sep 8, 2026, the average hourly pay for upstream process scientist in the United States is $42.32, according to ZipRecruiter salary data. Most workers in this role earn between $32.21 and $47.60 per hour, depending on experience, location, and employer.

What is an upstream process scientist?

An Upstream Process Scientist is responsible for developing and optimizing the early stages of biopharmaceutical production, including cell culture, media preparation, and bioreactor operations. They work to improve cell growth, productivity, and scalability of biologics such as monoclonal antibodies or vaccines. Their role involves designing experiments, analyzing data, and troubleshooting issues to ensure efficient and reproducible upstream processes.

What does an upstream process scientist do?

As an Upstream Process Scientist, your daily responsibilities often include designing and executing experiments to optimize cell culture conditions, operating and monitoring bioreactors, and analyzing process data to improve yields or purity. You will collaborate closely with downstream process scientists, quality assurance teams, and manufacturing staff to ensure smooth technology transfer and troubleshoot production issues. Additionally, documenting findings, preparing technical reports, and participating in project meetings are key aspects of the role. This position is dynamic and may also involve scaling up processes from laboratory to pilot or manufacturing scale, providing excellent opportunities to develop both technical expertise and project management skills.

What skills and qualifications are needed to be an upstream process scientist?

To thrive as an Upstream Process Scientist, you need a strong background in bioprocess engineering, cell culture, fermentation, and a relevant scientific degree such as biotechnology, biology, or chemical engineering. Familiarity with bioreactors, process analytical technologies (PAT), statistical analysis software, and GMP/GLP standards is highly valued, and some positions may require certifications like Six Sigma or specific training in biomanufacturing. Excellent problem-solving, communication, and teamwork skills distinguish top performers in this role, as does the ability to adapt quickly to evolving project needs. These skills are essential for developing and optimizing scalable, high-yield biological production processes while ensuring regulatory compliance and effective collaboration across multidisciplinary teams.

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Upstream Process Scientist jobs near you
Infographic showing various Upstream Process Scientist job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 79% Full Time, 16% Part Time, 3% Contract, and 1% Nights. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $88,026 per year, or $42.3 per hour.

Sr. Scientist, Lentivirus Upstream Processing

Legend Biotech US

Somerset, NJ • Hybrid

$96K - $132K/yr

Full-time

Re-posted 9 days ago

Job description

Legend Biotech is seeking a Sr. Scientist, Lentivirus Upstream Processing as part of the Technical Development team based in Somerset, NJ.

Role Overview

The Senior Scientist, Lentivirus Upstream Process Development, will be a core technical contributor responsible for designing, executing, and optimizing upstream production processes for lentiviral vectors (LVV) within our innovative pipeline. This role focuses on delivering high-quality, high-titer vector products to support LVV generation and other advanced cell therapy programs. The successful candidate will apply technical expertise in upstream processing (USP)-including seed train optimization, mammalian cell culture (HEK293/HEK293T), large-scale transient transfection, and bioreactor scale-up-to ensure processes are robust, scalable, and phase-appropriate for GMP manufacturing. This position demands a blend of hands-on technical mastery and strong analytical thinking to support project timelines while maintaining a patient-focused approach.

Key Responsibilities

  • Design and execute experimental strategies for lentiviral vector upstream production.
  • Perform development and optimization of upstream processes, including seed train expansion, suspension mammalian cell culture (HEK293/HEK293T), plasmid transient transfection optimization, and feed batch/perfusion bioprocessing in stir-tank and rocker bioreactors.
  • Support the establishment and validation of bioreactor scale-up and scale-down models to ensure process comparability and predictability.
  • Support the translation of bench-scale processes to GMP manufacturing, assisting in technology transfer and providing troubleshooting support during clinical production runs.
  • Execute study protocols to define operating parameters, feeding strategies, and performance limits; maintain accurate documentation for USP data.
  • Communicate technical findings, issues, and potential delays to project leads in a timely manner.
  • Collaborate with cross-functional team members, including CMC Project Management and other technical leads, to support project goals.
  • Apply scientific knowledge and technology to optimize vector titer, specific productivity, and quality.
  • Support team activities by providing technical guidance to junior staff, fostering a culture of scientific rigor and continuous improvement.
  • Author and review technical documents, including development reports, SOPs, and relevant sections for regulatory submissions (IND).
  • Work closely with Downstream Process Development and Analytical Development teams to ensure integrated process outcomes.
  • Support tech transfer activities to/from other Legend sites or CDMOs.
  • Ensure compliance with all internal and regulatory requirements.

Requirements

  • Advanced degree (PhD preferred, or MS) in Chemical Engineering, Bioengineering, or a related field.
  • Experience: 5-8 years (PhD) or 8+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting
  • Hands-on experience in mammalian cell culture (HEK293, HEK293T), seed train expansion, feeding strategy, and transient transfection optimization specifically for viral vectors (Lentivirus preferred).
  • Demonstrated proficiency in developing and implementing bioreactor scale-up and scale-down models.
  • Solid understanding of GMP manufacturing requirements and CMC strategies for early-phase clinical trials.
  • Direct experience with cell and lentiviral vector technologies within the current emerging field.
  • Working knowledge in engineering modeling, mass transfer, and bioprocess optimization.
  • Strong interpersonal and communication skills; ability to maintain focus and collaborate effectively during challenging development timelines.
  • Analytical and creative thinking.
  • Effective troubleshooting skills.
  • Preferred experience in handling large-scale (>50L, e.g., 200L/500L) upstream bioreactor processes.
  • Language(s):
  • English. Mandarin is a plus.

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