ZipRecruiter

Log In

1

Upstream Scientist Jobs (NOW HIRING)

Merck & Co.

Our Upstream Cell Culture-department is seeking a passionate and skilled individual to lead the ... The Principal Scientist/ Director position in BDSC-Upstream team is a senior scientific and ...

Legend Biotech USA, Inc.

Legend Biotech is seeking a Principal Scientist, Lentivirus Upstream Process Development as part of the Technical Development team based in Somerset, NJ.Role OverviewThe Principal Scientist ...

next page

Showing results 1-20

People also search for

All JobsUpstream Scientist Jobs

Upstream Scientist information

See salary details

$18

$43

$69

How much do upstream scientist jobs pay per hour?

As of May 31, 2026, the average hourly pay for upstream scientist in the United States is $43.22, according to ZipRecruiter salary data. Most workers in this role earn between $33.17 and $51.44 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as an Upstream Scientist, and why are they important?

To thrive as an Upstream Scientist, you need a solid background in biology, biochemistry, or chemical engineering, often supported by a relevant degree and experience in cell culture or fermentation processes. Familiarity with bioreactor systems, process analytical technologies (PAT), and data analysis software is typically required, along with knowledge of GMP regulations. Strong problem-solving skills, attention to detail, and effective teamwork are crucial soft skills in this role. These competencies ensure efficient process development and optimization, leading to high-quality biologics production in a regulated environment.

What are some common challenges faced by Upstream Scientists in bioprocess development, and how can they be addressed?

Upstream Scientists often encounter challenges such as optimizing cell culture conditions, scaling up processes from the laboratory to production levels, and ensuring consistency in yield and product quality. These challenges require strong problem-solving skills, close attention to experimental design, and effective collaboration with downstream and analytical teams. Staying current with new bioprocessing technologies and maintaining clear documentation are also essential for addressing these issues and driving successful project outcomes.

What is an Upstream Scientist?

An Upstream Scientist is a professional who specializes in the early stages of biopharmaceutical production, focusing on the cultivation and optimization of biological materials such as cells or microorganisms. Their primary role involves developing and improving processes like cell culture, fermentation, and media design to maximize the yield and quality of desired products, such as proteins or vaccines. Upstream Scientists work closely with downstream teams to ensure smooth transition of materials for further processing, and they play a crucial role in scaling up laboratory processes for commercial manufacturing.

What is the difference between Upstream Scientist vs Downstream Scientist?

AspectUpstream ScientistDownstream Scientist
Primary FocusResearch and develop processes for oil and gas extraction or biopharmaceutical production at the initial stagesRefine, purify, and package products after initial production
Required SkillsProcess engineering, laboratory analysis, biochemistry, geologyPurification techniques, chromatography, formulation, quality control
Work EnvironmentLaboratories, exploration sites, production facilitiesManufacturing plants, labs, quality assurance settings
Industry UsageOil & gas, biotechnology, pharmaceuticalsPharmaceuticals, biotech, chemical manufacturing

Upstream Scientists focus on the initial stages of production, such as exploration and process development, while Downstream Scientists handle the refining, purification, and final product formulation. Both roles require specialized skills and are essential in the production pipeline, often working in related industries like biotech and pharmaceuticals.

More about Upstream Scientist jobs
What are the most commonly searched types of Upstream Scientist jobs? The most popular types of Upstream Scientist jobs are:
What states have the most Upstream Scientist jobs? States with the most job openings for Upstream Scientist jobs include:
What job categories do people searching Upstream Scientist jobs look for? The top searched job categories for Upstream Scientist jobs are:
Upstream Scientist jobs near you
Infographic showing various Upstream Scientist job openings in the United States as of May 2026, with employment types broken down into 2% As Needed, 75% Full Time, 11% Part Time, 1% Temporary, 10% Contract, and 1% Nights. Highlights an 95% Physical, 2% Hybrid, and 3% Remote job distribution, with an average salary of $89,889 per year, or $43.2 per hour.
Process Development Upstream Scientist

Process Development Upstream Scientist

Wheeler Bio, Inc.

Oklahoma City, OK • On-site

Full-time

Posted 14 days ago

Job description

Position Summary:

As a Process Development Scientist, you will support the development, optimization, and scale-up of mammalian upstream bioprocesses for the manufacture of biologic drug substances. You will contribute to the design and execution of laboratory experiments, data analysis, and technical documentation.

Key Responsibilities:

· Perform laboratory experiments to support mammalian upstream (cell culture) process development.

· Assist in the optimization of bioprocess parameters for yield, purity, and product quality.

· Support scale-up and technology transfer of processes to manufacturing or pilot facilities.

· Prepare buffers, media, and other solutions according to SOPs and protocols.

· Operate and maintain flask and bioreactor equipment.

· Collect, analyze, and interpret experimental data; maintain accurate lab records and electronic notebooks.

· Present findings in internal and client meetings and contribute to technical reports and regulatory documentation.

· Complete Root Cause Analyses as needed.

· Follow all safety, quality, and compliance requirements.

Qualifications:

Education:

· Bachelor's, master's or PhD degree in Chemical Engineering, Biochemistry, Biotechnology, Biology, or related field.

Experience:

· 4-8 years of hands-on experience in a bioprocessing or biopharmaceutical development environment (academic or industrial); some education qualifications may substitute for some years of experience.

· Experience in a CDMO environment is preferred.

· Experience with suspension mammalian cell culture and stirred tank bioreactors is required.

· Knowledge of protein purification and analytical techniques is a plus.

Skills and Knowledge:

· Understanding of cGMP, GLP, or other regulatory standards (preferred).

· Strong analytical and problem-solving skills.

· Good written and verbal communication skills.

· Ability to work both independently and in a collaborative team environment.