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Upstream Scientist Jobs (NOW HIRING)

Lonza

R&D Upstream Scientist/Engineer

Bend, OR

R&D Upstream Scientist/Engineer Bend, OR Today, Lonza is a global leader in life sciences operating across five continents. While we work in science, there's no magic formula to how we do it. Our ...

Lonza

R&D Upstream Scientist/Engineer

Bend, OR · On-site

R&D Upstream Scientist/Engineer Bend, OR Today, Lonza is a global leader in life sciences operating across five continents. While we work in science, there's no magic formula to how we do it. Our ...

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How much do upstream scientist jobs pay per hour?

As of Aug 21, 2026, the average hourly pay for upstream scientist in the United States is $43.22, according to ZipRecruiter salary data. Most workers in this role earn between $33.17 and $51.44 per hour, depending on experience, location, and employer.

What is an upstream scientist?

An Upstream Scientist is a professional who specializes in the early stages of biopharmaceutical production, focusing on the cultivation and optimization of biological materials such as cells or microorganisms. Their primary role involves developing and improving processes like cell culture, fermentation, and media design to maximize the yield and quality of desired products, such as proteins or vaccines. Upstream Scientists work closely with downstream teams to ensure smooth transition of materials for further processing, and they play a crucial role in scaling up laboratory processes for commercial manufacturing.

What are the key skills and qualifications needed to thrive as an upstream scientist, and why are they important?

To thrive as an Upstream Scientist, you need a solid background in biology, biochemistry, or chemical engineering, often supported by a relevant degree and experience in cell culture or fermentation processes. Familiarity with bioreactor systems, process analytical technologies (PAT), and data analysis software is typically required, along with knowledge of GMP regulations. Strong problem-solving skills, attention to detail, and effective teamwork are crucial soft skills in this role. These competencies ensure efficient process development and optimization, leading to high-quality biologics production in a regulated environment.

What are some common challenges faced by upstream scientists in bioprocess development, and how can they be addressed?

Upstream Scientists often encounter challenges such as optimizing cell culture conditions, scaling up processes from the laboratory to production levels, and ensuring consistency in yield and product quality. These challenges require strong problem-solving skills, close attention to experimental design, and effective collaboration with downstream and analytical teams. Staying current with new bioprocessing technologies and maintaining clear documentation are also essential for addressing these issues and driving successful project outcomes.

What is the difference between Upstream Scientist vs Downstream Scientist?

AspectUpstream ScientistDownstream Scientist
Primary FocusResearch and develop processes for oil and gas extraction or biopharmaceutical production at the initial stagesRefine, purify, and package products after initial production
Required SkillsProcess engineering, laboratory analysis, biochemistry, geologyPurification techniques, chromatography, formulation, quality control
Work EnvironmentLaboratories, exploration sites, production facilitiesManufacturing plants, labs, quality assurance settings
Industry UsageOil & gas, biotechnology, pharmaceuticalsPharmaceuticals, biotech, chemical manufacturing

Upstream Scientists focus on the initial stages of production, such as exploration and process development, while Downstream Scientists handle the refining, purification, and final product formulation. Both roles require specialized skills and are essential in the production pipeline, often working in related industries like biotech and pharmaceuticals.

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Upstream Scientist jobs near you
Infographic showing various Upstream Scientist job openings in the United States as of August 2026, with employment types broken down into 1% Internship, 1% As Needed, 82% Full Time, 12% Part Time, and 4% Contract. Highlights an 82% Physical, 3% Hybrid, and 15% Remote job distribution, with an average salary of $89,889 per year, or $43.2 per hour.

R&D Upstream Scientist/Engineer

Lonza

Bend, OR

Full-time

Posted 7 days ago

Lonza rating

8.3

Company rating: 8.3 out of 10

Based on 42 frontline employees who took The Breakroom Quiz

25th of 86 rated pharmaceutical

Job description

R&D Upstream Scientist/Engineer

Bend, OR

Today, Lonza is a global leader in life sciences operating across five continents. While we work in science, there's no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that's the kind of work we want to be part of.

As a R&D Upstream Scientist/Engineer at Lonza, you will join a dynamic and ambitious team dedicated to delivering world-class solutions to biomanufacturing challenges. Located in the beautiful Bend, OR, USA, this role offers an outstanding opportunity to contribute to groundbreaking advancements in life sciences. You will work alongside exceptionally hard-working colleagues, conducting experiments, analyzing data, and presenting results to drive innovation within the industry. This position is ideal for individuals who are passionate about science, collaboration, and making a meaningful impact.

What you will do:

  • Completing experiments in a mammalian bioreactor setting

  • Applying knowledge of biological, chemical, or engineering fundamentals including mass and energy conservation, heat and mass transfer, biochemistry, cell and molecular biology, and basic mathematical modeling

  • Learning and understanding how to safely operate a range of unit operations and demonstrating proficiency for achieving quality results

  • Maintaining an accurate and detailed laboratory notebook to document the execution and results of experiments

  • Collaborating with computational science teams to improve data management tools

  • Evaluating instruments, equipment, processes, and systems to improve safety, quality, and performance

  • Communicating technical information to internal teams and clients through oral and written correspondence, presentations, and reports

  • Preparing written documents such as technical memos, reports, and technology transfer documentation

  • Leading the execution of basic lab functions and suggesting operational improvements to laboratory practices

What we are looking for:

  • B.S. or equivalent experience in Chemical Engineering or Bioengineering, or B.S. or equivalent experience in Cell or Molecular Biology, or Biochemistry

  • Effective verbal and written communication abilities

  • Growth mindset

  • A strong drive to learn and contribute outside of your educational specialty

  • Previous experience in a biology lab is preferred; previous experience with mammalian cell culture is desirable

  • A bias towards collaboration

About Lonza

At Lonza, our people are our greatest strength. With 30+ sites across five continents, our globally connected teams work together every day to manufacture the medicines of tomorrow. Our core values of Collaboration, Accountability, Excellence, Passion and Integrity reflect who we are and how we work together. Everyone's ideas, big or small, have the potential to improve millions of lives, and that's the kind of work we want you to be part of.

Innovation thrives when people from all backgrounds bring their unique perspectives to the table. At Lonza, we value diversity and are committed to creating an inclusive environment for all employees. If you're ready to help turn our customers' breakthrough ideas into viable therapies, we look forward to welcoming you on board.

Ready to shape the future of life sciences? Apply now.

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