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Upstream Scientist Jobs (NOW HIRING)

Legend Biotech USA, Inc.

$104K - $132K/yr

Legend Biotech is seeking a Sr. Scientist, Lentivirus Upstream Processing as part of the Technical Development team based in Somerset, NJ.Role OverviewThe Senior Scientist, Lentivirus Upstream ...

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How much do upstream scientist jobs pay per hour?

As of Aug 21, 2026, the average hourly pay for upstream scientist in the United States is $43.22, according to ZipRecruiter salary data. Most workers in this role earn between $33.17 and $51.44 per hour, depending on experience, location, and employer.

What is an upstream scientist?

An Upstream Scientist is a professional who specializes in the early stages of biopharmaceutical production, focusing on the cultivation and optimization of biological materials such as cells or microorganisms. Their primary role involves developing and improving processes like cell culture, fermentation, and media design to maximize the yield and quality of desired products, such as proteins or vaccines. Upstream Scientists work closely with downstream teams to ensure smooth transition of materials for further processing, and they play a crucial role in scaling up laboratory processes for commercial manufacturing.

What are the key skills and qualifications needed to thrive as an upstream scientist, and why are they important?

To thrive as an Upstream Scientist, you need a solid background in biology, biochemistry, or chemical engineering, often supported by a relevant degree and experience in cell culture or fermentation processes. Familiarity with bioreactor systems, process analytical technologies (PAT), and data analysis software is typically required, along with knowledge of GMP regulations. Strong problem-solving skills, attention to detail, and effective teamwork are crucial soft skills in this role. These competencies ensure efficient process development and optimization, leading to high-quality biologics production in a regulated environment.

What are some common challenges faced by upstream scientists in bioprocess development, and how can they be addressed?

Upstream Scientists often encounter challenges such as optimizing cell culture conditions, scaling up processes from the laboratory to production levels, and ensuring consistency in yield and product quality. These challenges require strong problem-solving skills, close attention to experimental design, and effective collaboration with downstream and analytical teams. Staying current with new bioprocessing technologies and maintaining clear documentation are also essential for addressing these issues and driving successful project outcomes.

What is the difference between Upstream Scientist vs Downstream Scientist?

AspectUpstream ScientistDownstream Scientist
Primary FocusResearch and develop processes for oil and gas extraction or biopharmaceutical production at the initial stagesRefine, purify, and package products after initial production
Required SkillsProcess engineering, laboratory analysis, biochemistry, geologyPurification techniques, chromatography, formulation, quality control
Work EnvironmentLaboratories, exploration sites, production facilitiesManufacturing plants, labs, quality assurance settings
Industry UsageOil & gas, biotechnology, pharmaceuticalsPharmaceuticals, biotech, chemical manufacturing

Upstream Scientists focus on the initial stages of production, such as exploration and process development, while Downstream Scientists handle the refining, purification, and final product formulation. Both roles require specialized skills and are essential in the production pipeline, often working in related industries like biotech and pharmaceuticals.

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Upstream Scientist jobs near you
Infographic showing various Upstream Scientist job openings in the United States as of August 2026, with employment types broken down into 1% Internship, 1% As Needed, 82% Full Time, 12% Part Time, and 4% Contract. Highlights an 82% Physical, 3% Hybrid, and 15% Remote job distribution, with an average salary of $89,889 per year, or $43.2 per hour.

Sr. Scientist, Lentivirus Upstream Processing

Legend Biotech US

Somerset, NJ

$96K - $132K/yr

Full-time

Posted 21 days ago

Job description

Legend Biotech is seeking a Sr. Scientist, Lentivirus Upstream Processing as part of the Technical Development team based in Somerset, NJ.

Role Overview

The Senior Scientist, Lentivirus Upstream Process Development, will be a core technical contributor responsible for designing, executing, and optimizing upstream production processes for lentiviral vectors (LVV) within our innovative pipeline. This role focuses on delivering high-quality, high-titer vector products to support LVV generation and other advanced cell therapy programs. The successful candidate will apply technical expertise in upstream processing (USP)-including seed train optimization, mammalian cell culture (HEK293/HEK293T), large-scale transient transfection, and bioreactor scale-up-to ensure processes are robust, scalable, and phase-appropriate for GMP manufacturing. This position demands a blend of hands-on technical mastery and strong analytical thinking to support project timelines while maintaining a patient-focused approach.

Key Responsibilities

  • Design and execute experimental strategies for lentiviral vector upstream production.
  • Perform development and optimization of upstream processes, including seed train expansion, suspension mammalian cell culture (HEK293/HEK293T), plasmid transient transfection optimization, and feed batch/perfusion bioprocessing in stir-tank and rocker bioreactors.
  • Support the establishment and validation of bioreactor scale-up and scale-down models to ensure process comparability and predictability.
  • Support the translation of bench-scale processes to GMP manufacturing, assisting in technology transfer and providing troubleshooting support during clinical production runs.
  • Execute study protocols to define operating parameters, feeding strategies, and performance limits; maintain accurate documentation for USP data.
  • Communicate technical findings, issues, and potential delays to project leads in a timely manner.
  • Collaborate with cross-functional team members, including CMC Project Management and other technical leads, to support project goals.
  • Apply scientific knowledge and technology to optimize vector titer, specific productivity, and quality.
  • Support team activities by providing technical guidance to junior staff, fostering a culture of scientific rigor and continuous improvement.
  • Author and review technical documents, including development reports, SOPs, and relevant sections for regulatory submissions (IND).
  • Work closely with Downstream Process Development and Analytical Development teams to ensure integrated process outcomes.
  • Support tech transfer activities to/from other Legend sites or CDMOs.
  • Ensure compliance with all internal and regulatory requirements.

Requirements

  • Advanced degree (PhD preferred, or MS) in Chemical Engineering, Bioengineering, or a related field.
  • Experience: 5-8 years (PhD) or 8+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting
  • Hands-on experience in mammalian cell culture (HEK293, HEK293T), seed train expansion, feeding strategy, and transient transfection optimization specifically for viral vectors (Lentivirus preferred).
  • Demonstrated proficiency in developing and implementing bioreactor scale-up and scale-down models.
  • Solid understanding of GMP manufacturing requirements and CMC strategies for early-phase clinical trials.
  • Direct experience with cell and lentiviral vector technologies within the current emerging field.
  • Working knowledge in engineering modeling, mass transfer, and bioprocess optimization.
  • Strong interpersonal and communication skills; ability to maintain focus and collaborate effectively during challenging development timelines.
  • Analytical and creative thinking.
  • Effective troubleshooting skills.
  • Preferred experience in handling large-scale (>50L, e.g., 200L/500L) upstream bioreactor processes.
  • Language(s):
  • English. Mandarin is a plus.

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