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Process Scientist

Philadelphia, PA · On-site

A Scientist is a mid-level individual with understanding of cell/molecular biology and previous experience in either upstream or downstream biopharmaceutical processing that utilizes bioreactors. A ...

Legend Biotech USA, Inc.

$104K - $132K/yr

Role OverviewThe Senior Scientist, Lentivirus Upstream Process Development, will be a core technical contributor responsible for designing, executing, and optimizing upstream production processes for ...

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How much do upstream process scientist jobs pay per hour?

As of Sep 9, 2026, the average hourly pay for upstream process scientist in the United States is $42.32, according to ZipRecruiter salary data. Most workers in this role earn between $32.21 and $47.60 per hour, depending on experience, location, and employer.

What is an upstream process scientist?

An Upstream Process Scientist is responsible for developing and optimizing the early stages of biopharmaceutical production, including cell culture, media preparation, and bioreactor operations. They work to improve cell growth, productivity, and scalability of biologics such as monoclonal antibodies or vaccines. Their role involves designing experiments, analyzing data, and troubleshooting issues to ensure efficient and reproducible upstream processes.

What does an upstream process scientist do?

As an Upstream Process Scientist, your daily responsibilities often include designing and executing experiments to optimize cell culture conditions, operating and monitoring bioreactors, and analyzing process data to improve yields or purity. You will collaborate closely with downstream process scientists, quality assurance teams, and manufacturing staff to ensure smooth technology transfer and troubleshoot production issues. Additionally, documenting findings, preparing technical reports, and participating in project meetings are key aspects of the role. This position is dynamic and may also involve scaling up processes from laboratory to pilot or manufacturing scale, providing excellent opportunities to develop both technical expertise and project management skills.

What skills and qualifications are needed to be an upstream process scientist?

To thrive as an Upstream Process Scientist, you need a strong background in bioprocess engineering, cell culture, fermentation, and a relevant scientific degree such as biotechnology, biology, or chemical engineering. Familiarity with bioreactors, process analytical technologies (PAT), statistical analysis software, and GMP/GLP standards is highly valued, and some positions may require certifications like Six Sigma or specific training in biomanufacturing. Excellent problem-solving, communication, and teamwork skills distinguish top performers in this role, as does the ability to adapt quickly to evolving project needs. These skills are essential for developing and optimizing scalable, high-yield biological production processes while ensuring regulatory compliance and effective collaboration across multidisciplinary teams.

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Upstream Process Scientist jobs near you
Infographic showing various Upstream Process Scientist job openings in the United States as of September 2026, with employment types broken down into 1% As Needed, 79% Full Time, 16% Part Time, 3% Contract, and 1% Nights. Highlights an 90% Physical, 2% Hybrid, and 8% Remote job distribution, with an average salary of $88,026 per year, or $42.3 per hour.

Scientist III, Upstream Process Development

Plainville, MA • On-site

Thermo Fisher Scientific
Biotechnology Research and Development • 10K+ employees
Learn more about Thermo Fisher Scientificexternal

$91K - $137K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 7 days ago

Thermo Fisher Scientific rating

7.8

Company rating: 7.8 out of 10

Based on 430 frontline employees who took The Breakroom Quiz

171st of 547 rated manufacturers

Job description

Work Schedule
Standard (Mon-Fri)
Environmental Conditions
Adherence to all Good Manufacturing Practices (GMP) Safety Standards, Cold Room/Freezers -22degreesF/-6degrees C, Laboratory Setting, Office, Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)
Job Description
As part of the Thermo Fisher Scientific team, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life every single day to enable our customers to make the world healthier, cleaner and safer. We provide our global teams with the resources needed to achieve individual career goals while helping to take science a step beyond by developing solutions for some of the world's toughest challenges, like protecting the environment, making sure our food is safe or helping find cures for cancer.
DESCRIPTION:
As an Upstream Process Development Scientist III, you will help our clients to deliver lifesaving therapies to patients. This position will provide direct labor within multiple work centers and will provide indirect support for projects/troubleshooting, maintenance, engineering and/or training initiatives.
This is a hands-on bench scientist position. The ideal candidate shall have excellent lab skills, strong documentation skills, demonstrated ability to analyze and interpret data to draw conclusions and make recommendations, and strong collaboration and teamwork skills.
As a member of the Process Development team, you will work with project leads to support the successful execution of experiments and technical transfer activities. This will include supporting the technical transfer process assessments, Pilot Plant activities and transfer into cGMP manufacturing. This will also include late-phase process characterization of viral vector manufacturing processes.
What will you do?
  • Participate in the design, planning and execution of tech transfer, process development and scale up activities (both bench and pilot scale) and preparing summary reports/presentations.
  • Prepare and modify documents (development plans, batch records, SOPs, protocols, summary reports), including deviation and/or investigational reports.
  • Serve as project lead on multiple programs with minimal direction. Manage project timelines and tasks.
  • Technically review data, collaborate with customers on data and experimental design, prepare documents and experiments, participate in investigations.
  • Serve as a SME in process development and train junior scientists.

How will you get there?
  • Degree in biology, chemistry, biochemistry, (bio)chemical engineering, biomedical engineering, or a related field.
  • B.S with 5+ years' experience in a process development/manufacturing environment, Master's with 2+ years of experience or Ph.D.
  • Expertise in gene therapy product and/or process development is required. Knowledge of lentivirus upstream process development is strongly preferred.
  • Hands-on experience in aseptic technique, cell culture, stirred tank bioreactor, wave reactors and harvest/clarification operations.
  • Experience in technical writing, GDP compliance, and data compilation/analyses.
  • Strong computer skills as well as ability to collect, organize, analyze, interpret and summarize complex scientific data.
  • Strong written and verbal communications skills; ability to interpret, summarize, and present scientific results in a clear, concise, accurate manner.
  • Must be a self-starter, have excellent time management, planning and organization skills.
  • Good knowledge of quality by design (QbD) and regulatory needs in the pharmaceutical industry,
  • A flexible work schedule may be required, including weekends and evenings as needed to complete client work.

While performing the duties of this job, the employee:
  • Will work in a dynamic environment and balance multiple priorities simultaneously!
  • Will be self-motivated and proactively drive efficient execution.
  • Will be encouraged to learn new software, processes, and tools quickly!
  • Will use outstanding equipment and instrumentation in daily manufacturing.
  • Will demonstrate flexibility with changes to working environment and deliver high-quality results.
  • Will critically review processes and recommend improvements to supervisor/manager.

Compensation and Benefits
The salary range estimated for this position based in Massachusetts is $91,700.00-$137,525.00.
This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:
  • A choice of national medical and dental plans, and a national vision plan, including health incentive programs
  • Employee assistance and family support programs, including commuter benefits and tuition reimbursement
  • At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
  • Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
  • Employees' Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount

For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards

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