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Associate Upstream Processing Scientist Jobs (NOW HIRING)

Legend Biotech USA, Inc.

$104K - $132K/yr

Legend Biotech is seeking a Sr. Scientist, Lentivirus Upstream Processing as part of the Technical Development team based in Somerset, NJ.Role OverviewThe Senior Scientist, Lentivirus Upstream ...

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How much do associate upstream processing scientist jobs pay per hour?

As of Sep 9, 2026, the average hourly pay for associate upstream processing scientist in the United States is $35.92, according to ZipRecruiter salary data. Most workers in this role earn between $27.88 and $40.87 per hour, depending on experience, location, and employer.

What is the difference between Associate Upstream Processing Scientist vs Research Associate?

AspectAssociate Upstream Processing ScientistResearch Associate
Required CredentialsBachelor's or Master's in Biotechnology, Biology, or related fieldBachelor's or Master's in similar fields, often with research experience
Work EnvironmentBiopharmaceutical manufacturing, lab settings, process developmentResearch labs, academic or industry research projects
Employer & Industry UsageBiotech and pharma companies, contract manufacturing organizationsUniversities, research institutes, biotech companies
Common Search & ComparisonYesYes

The Associate Upstream Processing Scientist typically focuses on bioprocessing and manufacturing of biologics, requiring hands-on lab work and process optimization. In contrast, a Research Associate often engages in experimental research and data analysis. While both roles require similar educational backgrounds, the Associate Upstream Processing Scientist is more industry and production-oriented, whereas the Research Associate leans toward research and development activities.

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Associate Upstream Processing Scientist jobs near you

Sr. Scientist, Lentivirus Upstream Processing

Somerset, NJ • Hybrid

Legend Biotech US
See more jobs at Legend Biotech USexternal

$96K - $132K/yr

Full-time

Re-posted 10 days ago

Job description

Legend Biotech is seeking a Sr. Scientist, Lentivirus Upstream Processing as part of the Technical Development team based in Somerset, NJ.

Role Overview

The Senior Scientist, Lentivirus Upstream Process Development, will be a core technical contributor responsible for designing, executing, and optimizing upstream production processes for lentiviral vectors (LVV) within our innovative pipeline. This role focuses on delivering high-quality, high-titer vector products to support LVV generation and other advanced cell therapy programs. The successful candidate will apply technical expertise in upstream processing (USP)-including seed train optimization, mammalian cell culture (HEK293/HEK293T), large-scale transient transfection, and bioreactor scale-up-to ensure processes are robust, scalable, and phase-appropriate for GMP manufacturing. This position demands a blend of hands-on technical mastery and strong analytical thinking to support project timelines while maintaining a patient-focused approach.

Key Responsibilities

  • Design and execute experimental strategies for lentiviral vector upstream production.
  • Perform development and optimization of upstream processes, including seed train expansion, suspension mammalian cell culture (HEK293/HEK293T), plasmid transient transfection optimization, and feed batch/perfusion bioprocessing in stir-tank and rocker bioreactors.
  • Support the establishment and validation of bioreactor scale-up and scale-down models to ensure process comparability and predictability.
  • Support the translation of bench-scale processes to GMP manufacturing, assisting in technology transfer and providing troubleshooting support during clinical production runs.
  • Execute study protocols to define operating parameters, feeding strategies, and performance limits; maintain accurate documentation for USP data.
  • Communicate technical findings, issues, and potential delays to project leads in a timely manner.
  • Collaborate with cross-functional team members, including CMC Project Management and other technical leads, to support project goals.
  • Apply scientific knowledge and technology to optimize vector titer, specific productivity, and quality.
  • Support team activities by providing technical guidance to junior staff, fostering a culture of scientific rigor and continuous improvement.
  • Author and review technical documents, including development reports, SOPs, and relevant sections for regulatory submissions (IND).
  • Work closely with Downstream Process Development and Analytical Development teams to ensure integrated process outcomes.
  • Support tech transfer activities to/from other Legend sites or CDMOs.
  • Ensure compliance with all internal and regulatory requirements.

Requirements

  • Advanced degree (PhD preferred, or MS) in Chemical Engineering, Bioengineering, or a related field.
  • Experience: 5-8 years (PhD) or 8+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting
  • Hands-on experience in mammalian cell culture (HEK293, HEK293T), seed train expansion, feeding strategy, and transient transfection optimization specifically for viral vectors (Lentivirus preferred).
  • Demonstrated proficiency in developing and implementing bioreactor scale-up and scale-down models.
  • Solid understanding of GMP manufacturing requirements and CMC strategies for early-phase clinical trials.
  • Direct experience with cell and lentiviral vector technologies within the current emerging field.
  • Working knowledge in engineering modeling, mass transfer, and bioprocess optimization.
  • Strong interpersonal and communication skills; ability to maintain focus and collaborate effectively during challenging development timelines.
  • Analytical and creative thinking.
  • Effective troubleshooting skills.
  • Preferred experience in handling large-scale (>50L, e.g., 200L/500L) upstream bioreactor processes.
  • Language(s):
  • English. Mandarin is a plus.

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