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Upstream Process Scientist Jobs in California (NOW HIRING)

Lonza

MSAT Senior Scientist

Vacaville, CA · On-site

$107K - $178K/yr

MSAT Senior Scientist will independently lead the technical transfer of multiple concurrent manufacturing processes (Upstream - USP) from Process Development, Pilot Scale and other sites of ...

Lonza

MSAT Senior Scientist

Vacaville, CA

$107K - $178K/yr

MSAT Senior Scientist will independently lead the technical transfer of multiple concurrent manufacturing processes (Upstream - USP) from Process Development, Pilot Scale and other sites of ...

Kinetic Personnel Group

Be Seen First

Upstream, Downstream and Formulation Openings

Tustin, CA · On-site

$20 - $21/hr

... Science graduate to build hands-on experience in biopharmaceutical manufacturing and develop expertise across Upstream, Formulation, or Downstream processing . Successful candidates will work in a ...

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Upstream Process Scientist information

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$18

$41

$75

How much do upstream process scientist jobs pay per hour?

As of Aug 17, 2026, the average hourly pay for upstream process scientist in California is $41.44, according to ZipRecruiter salary data. Most workers in this role earn between $31.54 and $46.61 per hour, depending on experience, location, and employer.

What is an upstream process scientist?

An Upstream Process Scientist is responsible for developing and optimizing the early stages of biopharmaceutical production, including cell culture, media preparation, and bioreactor operations. They work to improve cell growth, productivity, and scalability of biologics such as monoclonal antibodies or vaccines. Their role involves designing experiments, analyzing data, and troubleshooting issues to ensure efficient and reproducible upstream processes.

What does an upstream process scientist do?

As an Upstream Process Scientist, your daily responsibilities often include designing and executing experiments to optimize cell culture conditions, operating and monitoring bioreactors, and analyzing process data to improve yields or purity. You will collaborate closely with downstream process scientists, quality assurance teams, and manufacturing staff to ensure smooth technology transfer and troubleshoot production issues. Additionally, documenting findings, preparing technical reports, and participating in project meetings are key aspects of the role. This position is dynamic and may also involve scaling up processes from laboratory to pilot or manufacturing scale, providing excellent opportunities to develop both technical expertise and project management skills.

What skills and qualifications are needed to be an upstream process scientist?

To thrive as an Upstream Process Scientist, you need a strong background in bioprocess engineering, cell culture, fermentation, and a relevant scientific degree such as biotechnology, biology, or chemical engineering. Familiarity with bioreactors, process analytical technologies (PAT), statistical analysis software, and GMP/GLP standards is highly valued, and some positions may require certifications like Six Sigma or specific training in biomanufacturing. Excellent problem-solving, communication, and teamwork skills distinguish top performers in this role, as does the ability to adapt quickly to evolving project needs. These skills are essential for developing and optimizing scalable, high-yield biological production processes while ensuring regulatory compliance and effective collaboration across multidisciplinary teams.

What are the most commonly searched types of Upstream Process Scientist jobs in California?

The most popular types of Upstream Process Scientist jobs in California are:

What are popular job titles related to Upstream Process Scientist jobs in California?

For Upstream Process Scientist jobs in California, the most frequently searched job titles are:

What job categories do people searching Upstream Process Scientist jobs in California look for?

The top searched job categories for Upstream Process Scientist jobs in California are:

Upstream Process Scientist jobs near you
Infographic showing various Upstream Process Scientist job openings in California as of August 2026, with employment types broken down into 73% Full Time, and 27% Contract. Highlights an 100% In-person job distribution, with an average salary of $86,197 per year, or $41.4 per hour.

Principal Scientist, Late Stage Upstream Process Development

CEDENT

San Francisco, CA • On-site

Full-time

Re-posted 25 days ago

Job description

Client is seeking an experienced and driven scientist/engineer to lead late-stage upstream cell culture process development activities for clinical and commercial-stage large molecule programs. This individual will serve as the upstream lead for scale-up and tech transfer to manufacturing sites, establishing process validation (PV) strategy and PPQ/post-approval process support.
Key Accountabilities/ Core Job Responsibilities
  • Lead scale-up and tech transfer of the upstream process to manufacturing sites, ensuring alignment with control strategy and regulatory filings.
  • Serve as the technical lead, responsible for upstream process activities for a late-stage large molecule programs including commercial manufacturing support
  • Author and review relevant CMC documentation including PV protocols/reports and regulatory sections (e.g., BLA, IND amendments).
  • Develop and execute strategies for process performance qualification (PPQ) and continued process verification (CPV).
  • Collaborate cross-functionally with MSAT, Downstream, Analytical Development, CMC management, Manufacturing Operations, QA, QC, Regulatory, and Contract Manufacturers
  • Represent upstream function in regulatory strategy, technical meetings, and CDMO interactions.
  • Provide technical support for upstream process-related investigations, product impact assessments, change control assessments, CAPA assessments etc.
Qualifications/Skills
  • PhD in biology, biochemistry, chemical engineering or related scientific discipline with minimum 7 years of cell culture process development experience in the biotech/biopharma industry; or BS/MS with 12+ years of experience.
  • In-depth understanding of CHO-based fed-batch processes, scale-up/scale-down principles, and statistical tools.
  • Thorough understanding of cell culture bioreactors including microbioreactors, bench-scale and pilot-scale bioreactors, and scaleup/tech transfer activities
  • Demonstrated experience with late-stage upstream process development, PPQ strategy, tech transfer and BLA authoring
  • Strong knowledge of regulatory expectations for process validation and control strategies.
  • Excellent communication, leadership, and cross-functional collaboration skills.
  • Demonstrated ability for taking initiative, creativity, and innovation in problem solving
  • Experience working with novel large molecule formats such as bispecific antibodies and Fusion proteins/enzymes is a plus
  • Demonstrated technical writing, critical thinking, scientific problem-solving and communication skills
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About Cedent

Sourced by ZipRecruiter

CEDENT strives to attract and retain the best people and provide an environment where they can all develop professionally and build a rewarding career. As a result, we create an inclusive environment that is rich in diversity, acknowledges each individual's uniqueness and promotes respect, personal achievement and stewardship. Our clients are global and so is CEDENT. We build and maintain a global workforce that includes people from different backgrounds, with a vast range of skills and experience all united by a common culture and commitment to help our clients achieve high performance. Cultivating a diverse workforce and inclusive work environment makes business sense. Our peoples varied skills are the talent engine that powers CEDENT, enabling it in turn to deliver the innovative solutions that help our clients outperform competitors.

Industry

It services

Company size

11 - 50 Employees

Headquarters location

Plano, TX, US

Year founded

2008

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