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Upstream Process Scientist Jobs (NOW HIRING)

Legend Biotech USA, Inc.

Legend Biotech is seeking a Principal Scientist, Lentivirus Upstream Process Development as part of the Technical Development team based in Somerset, NJ.Role OverviewThe Principal Scientist ...

Lonza

Upstream MSAT Scientist I

Portsmouth, NH

Process Scientist I, Upstream MSAT Location : Portsmouth, NH. Relocationassistanceis available for eligible candidates and their families, if needed. This positionis responsible forbeing the primary ...

Lonza

Upstream MSAT Scientist I

Portsmouth, NH · On-site

Process Scientist I, Upstream MSAT Location : Portsmouth, NH. Relocation assistance is available for eligible candidates and their families, if needed. This position is responsible for being the ...

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How much do upstream process scientist jobs pay per hour?

As of Jul 20, 2026, the average hourly pay for upstream process scientist in the United States is $42.32, according to ZipRecruiter salary data. Most workers in this role earn between $32.21 and $47.60 per hour, depending on experience, location, and employer.

What are typical daily responsibilities for an Upstream Process Scientist in a biopharmaceutical company?

As an Upstream Process Scientist, your daily responsibilities often include designing and executing experiments to optimize cell culture conditions, operating and monitoring bioreactors, and analyzing process data to improve yields or purity. You will collaborate closely with downstream process scientists, quality assurance teams, and manufacturing staff to ensure smooth technology transfer and troubleshoot production issues. Additionally, documenting findings, preparing technical reports, and participating in project meetings are key aspects of the role. This position is dynamic and may also involve scaling up processes from laboratory to pilot or manufacturing scale, providing excellent opportunities to develop both technical expertise and project management skills.

What are the key skills and qualifications needed to thrive in the Upstream Process Scientist position, and why are they important?

To thrive as an Upstream Process Scientist, you need a strong background in bioprocess engineering, cell culture, fermentation, and a relevant scientific degree such as biotechnology, biology, or chemical engineering. Familiarity with bioreactors, process analytical technologies (PAT), statistical analysis software, and GMP/GLP standards is highly valued, and some positions may require certifications like Six Sigma or specific training in biomanufacturing. Excellent problem-solving, communication, and teamwork skills distinguish top performers in this role, as does the ability to adapt quickly to evolving project needs. These skills are essential for developing and optimizing scalable, high-yield biological production processes while ensuring regulatory compliance and effective collaboration across multidisciplinary teams.

What is an Upstream Process Scientist job?

An Upstream Process Scientist is responsible for developing and optimizing the early stages of biopharmaceutical production, including cell culture, media preparation, and bioreactor operations. They work to improve cell growth, productivity, and scalability of biologics such as monoclonal antibodies or vaccines. Their role involves designing experiments, analyzing data, and troubleshooting issues to ensure efficient and reproducible upstream processes.

What cities are hiring for Upstream Process Scientist jobs? Cities with the most Upstream Process Scientist job openings:
What are the most commonly searched types of Upstream Process Scientist jobs? The most popular types of Upstream Process Scientist jobs are:
What states have the most Upstream Process Scientist jobs? States with the most job openings for Upstream Process Scientist jobs include:
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Upstream Process Scientist jobs near you
Infographic showing various Upstream Process Scientist job openings in the United States as of July 2026, with employment types broken down into 1% As Needed, 79% Full Time, 16% Part Time, 1% Temporary, and 3% Contract. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $88,026 per year, or $42.3 per hour.
Principal Scientist, Upstream Process Science

Principal Scientist, Upstream Process Science

ImmunityBio, Inc.

Louisville, CO • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 18 days ago

Job description

Company Overview
ImmunityBio, Inc. (NASDAQ: IBRX) is a commercial-stage biotechnology company developing cell and immunotherapy products that are designed to help strengthen each patient's natural immune system, potentially enabling it to outsmart the disease and eliminate cancerous or infected cells. We envision a day when we no longer fear cancer, but can conquer it, thanks to the biological wonder that is the human immune system. Our scientists are working to develop novel therapies that harness that inherent power by amplifying both branches of the immune system, attacking cancerous or infected cells today while building immunological memory for tomorrow. The goal: to reprogram the patient's immune system and treat the host rather than just the disease.
Why ImmunityBio?
• ImmunityBio is developing cutting-edge technology with the goal to transform the lives of patients with cancer and develop next-generation therapies and vaccines that complement, harness and amplify the immune system to defeat cancers and infectious diseases.
• Opportunity to join a publicly traded biopharmaceutical company with headquarters in Southern California.
• Work with a collaborative team with the ability to work across different areas of the company.
• Ability to join a growing company with professional development opportunities.
Position Summary
The Principal Scientist, Upstream Process Sciences role will manage the team responsible for upstream process development, process characterization, and scientific support activities for GMP manufacturing. This role serves as a technical expert for specific unit operations within the upstream manufacturing process, including both microbial and cell culture seed expansions and bioreactor operations across multiple cell lines. This role is also responsible for designing and executing process development experiments to design a robust and scalable clinical and commercial production process.
Essential Functions
  • Lead and advise internal and external teams in development of efficient and robust microbial and cell culture production for whole cell products, viral vector, recombinant monoclonal antibodies, Fc-fusion, and other proteins for research, clinical, and commercial manufacturing.
  • Provide high-level technical knowledge in the development of batch, fed batch, and perfusion processes for inoculum expansion and biologics production operations.
  • Manage the day-to-day activities of the team to include the hiring and training of new team members, coaching employees and monitoring performance
  • Provide project coordination and high-level technical expertise in process development, process improvement, scale-up, and tech transfer activities.
  • Guide and advise other technical staff in risk assessment, Design of Experiments (DOE), process characterization, process validation, and process monitoring activities.
  • Provide input for development programs, and collaborate with discovery, formulation, analytical, quality, regulatory and manufacturing teams.
  • Draft, review and approve technical protocols, reports, and manufacturing deviation investigations.
  • Present activities and results interdepartmentally, and to senior management.
  • Perform ad-hoc and cross-functional duties and/or projects, as assigned, to support business needs and provide developmental opportunities.
  • Author and review process-related regulatory submissions.
  • Conducts daily tasks associated with development and characterization of novel human therapeutics.
  • Responsible for laboratory equipment maintenance programs.
  • Create, edit and adhere to Standard Operating Procedures (SOPs).
  • Performs ad-hoc and cross-functional duties and/or projects assigned to support business needs and provide developmental opportunities.

Education & Experience
  • Ph.D. in Cell Biology, Microbiology, Biology, or other life science or related field with 6+ years of experience in biopharmaceutical-based process development and/or GMP manufacturing operations including direct experience in upstream processes required; or
  • MSc in Cell Biology, Microbiology, Biology, or other life science or related field with 9+ years of experience biopharmaceutical-based process development and/or GMP manufacturing operations including direct experience in upstream processes required; or
  • Bachelor's degree in Cell Biology, Microbiology, Biology, or other life science or related field with 12+ years of biopharmaceutical-based process development and/or GMP manufacturing operations including direct experience in upstream processes required.
  • Previous supervisory experience strongly preferred

Knowledge, Skills, & Abilities
  • Fundamental knowledge of cell and molecular biology, immunology, and/or virology
  • Possess a high level of honesty and integrity, highly motivated and detail oriented.
  • Expertise in developing upstream biopharmaceutical production processes.
  • In-depth knowledge of statistical design of experiments (DOE) used in process development.
  • Master-level technical knowledge of microbial, cell culture, and harvest operations affecting product quality.
  • Working knowledge of quality systems related to process development, clinical and commercial manufacturing.
  • Excellent communication skills.
  • Ability to advise and collaborate with colleagues within and across departments and corporate entities.
  • Familiarity with downstream purification operations.
  • Adapts to rapidly changing work environment and shift in priorities.
  • Possess strong written and verbal communication skills.
  • Strong technical writing skills with experience preparing: SOPs, analytical test reports, work instructions, qualification/validation protocols, qualification/validation reports, and summary reports to support FDA and EMA filings

Working Environment / Physical Environment
  • This position works on site, in Louisville, CO.
  • Regular work schedule is Monday - Friday, within standard business hours. Flexibility is available with manager approval.
  • This role works in both lab and cleanroom environments.
  • Occasional travel may be required, up to 10%.

This position is eligible for a discretionary bonus and equity award. The annual base pay range for this position is below. The specific rate will depend on the successful candidate's qualifications, prior experience as well as geographic location.
$150,000 (entry-level qualifications) to $165,000 (highly experienced) annually
The application window is anticipated to close on 60 days from when it is posted or sooner if the position is filled or closed.
ImmunityBio employees are as valuable as the people we serve. We have built a resource of robust benefit offerings to best support the total wellbeing of our team members and their families. Our competitive total rewards benefits package, for eligible employees, include: Medical, Dental and Vision Plan Options • Health and Financial Wellness Programs • Employer Assistance Program (EAP) • Company Paid and Voluntary Life/AD&D, Short-Term and Long-Term Disability • Healthcare and Dependent Care Flexible Spending Accounts • 401(k) Retirement Plan with Company Match • 529 Education Savings Program • Voluntary Legal Services, Identity Theft Protection, Pet Insurance and Employee Discounts, Rewards and Perks • Paid Time Off (PTO) includes: 11 Holidays • Exempt Employees are eligible for Unlimited PTO • Non-Exempt Employees are eligible for 10 Vacation Days, 56 Hours of Health Pay, 2 Personal Days and 1 Cultural Day • We are committed to providing you with the tools and resources you need to optimize your Health and Wellness.
At ImmunityBio, we are an equal opportunity employer dedicated to diversity in the workplace. Our policy is to provide equal employment opportunities to all qualified persons without regard to race, gender, color, disability, national origin, age, religion, union affiliation, sexual orientation, veteran status, citizenship, gender identity and/or expression, or other status protected by law.

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