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AA2IT

Upstream Processing Scientist - I

Lansdale, PA · On-site

Upstream Process Scientist Location: 770 Sumneytown Pike, West Point, PA 19486 Basic Minimum Qualifications: * B.S. Chemical/Biomedical/Biological Engineering or B.S. Biological Sciences /Cell ...

Legend Biotech USA, Inc.

Legend Biotech is seeking a Principal Scientist, Lentivirus Upstream Process Development as part of the Technical Development team based in Somerset, NJ.Role OverviewThe Principal Scientist ...

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How much do upstream process scientist jobs pay per hour?

As of Jun 5, 2026, the average hourly pay for upstream process scientist in the United States is $42.32, according to ZipRecruiter salary data. Most workers in this role earn between $32.21 and $47.60 per hour, depending on experience, location, and employer.

What is an Upstream Process Scientist job?

An Upstream Process Scientist is responsible for developing and optimizing the early stages of biopharmaceutical production, including cell culture, media preparation, and bioreactor operations. They work to improve cell growth, productivity, and scalability of biologics such as monoclonal antibodies or vaccines. Their role involves designing experiments, analyzing data, and troubleshooting issues to ensure efficient and reproducible upstream processes.

What are the key skills and qualifications needed to thrive in the Upstream Process Scientist position, and why are they important?

To thrive as an Upstream Process Scientist, you need a strong background in bioprocess engineering, cell culture, fermentation, and a relevant scientific degree such as biotechnology, biology, or chemical engineering. Familiarity with bioreactors, process analytical technologies (PAT), statistical analysis software, and GMP/GLP standards is highly valued, and some positions may require certifications like Six Sigma or specific training in biomanufacturing. Excellent problem-solving, communication, and teamwork skills distinguish top performers in this role, as does the ability to adapt quickly to evolving project needs. These skills are essential for developing and optimizing scalable, high-yield biological production processes while ensuring regulatory compliance and effective collaboration across multidisciplinary teams.

What are typical daily responsibilities for an Upstream Process Scientist in a biopharmaceutical company?

As an Upstream Process Scientist, your daily responsibilities often include designing and executing experiments to optimize cell culture conditions, operating and monitoring bioreactors, and analyzing process data to improve yields or purity. You will collaborate closely with downstream process scientists, quality assurance teams, and manufacturing staff to ensure smooth technology transfer and troubleshoot production issues. Additionally, documenting findings, preparing technical reports, and participating in project meetings are key aspects of the role. This position is dynamic and may also involve scaling up processes from laboratory to pilot or manufacturing scale, providing excellent opportunities to develop both technical expertise and project management skills.
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Upstream Process Scientist jobs near you
Infographic showing various Upstream Process Scientist job openings in the United States as of May 2026, with employment types broken down into 20% Locum Tenens, 20% Full Time, and 60% Contract. Highlights an 90% Physical, 3% Hybrid, and 7% Remote job distribution, with an average salary of $88,026 per year, or $42.3 per hour.
Upstream Processing Scientist - I

Upstream Processing Scientist - I

AA2IT

Lansdale, PA • On-site

Full-time

This job post has expired 1 day ago. Applications are no longer accepted.

Job description

Upstream Process Scientist

Location: 770 Sumneytown Pike, West Point, PA 19486

Basic Minimum Qualifications:

  • B.S. Chemical/Biomedical/Biological Engineering or B.S. Biological Sciences /Cell Biology or B.S. Biochemistry
  • At least six months of laboratory experience in upstream bioprocessing (e.g. bioreactor operations, microbial and/or mammalian cell culture in shake flasks, plates)

The ideal candidate would possess:

  • General laboratory skills, experience with aseptic manipulations, pipettes
  • Experience in operating bioreactors
  • Experience in culturing microbial and/or mammalian cells
  • Experience performing basic cell-based assays (e.g. cell counting, optical density, metabolite analysis, imaging)
  • Experience with solution, reagent, buffer preparation
  • Experience using formulas and linking spreadsheets in Excel
  • Highly computer literate. Capable of quickly learning and adapting to new computer programs. Strong computer, scientific, and organizational skills
  • Excellent communication (oral and written) and attention to detail
  • Ability to work independently and as part of a team, self-motivation, adaptability, and a positive attitude
  • Ability to learn new techniques, perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies
  • Ability to manage and organize experiments with multiple varying parameters and conditions

Additional Preferred Skills: Basic downstream / primary recovery operations (e.g. Lysis, Centrifugation, Filtration) Note this role will be downstream after few months.

Responsibilities:

  • Prepare laboratory reagents, solutions and culture media
  • Perform lab-scale upstream processing of vaccine products and process intermediates (including Biosafety Level-2 organisms)
  • Setup process equipment for lab-scale experiments
  • Perform in-process monitoring assays
  • Analyze, collate, track, and report data back to client staff members
  • Maintain records and test results following good laboratory practices (GLP)
  • Work independently and efficiently
  • Document work clearly and perform tests accurately
  • Communicate effectively with client staff members
  • Occasional off-shift and weekend work (not to typically exceed 40 hours per week cumulative)

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