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Upstream Process Engineer Jobs (NOW HIRING)

Experience working with bioreactors and upstream process development * Working knowledge of ... Ability to troubleshoot equipment and apply engineering concepts in a lab setting * Strong ...

Experience working with bioreactors and upstream process development * Working knowledge of ... Ability to troubleshoot equipment and apply engineering concepts in a lab setting * Strong ...

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Upstream Process Engineer information

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$49.5K

$92K

$142.5K

How much do upstream process engineer jobs pay per year?

As of Aug 6, 2026, the average yearly pay for upstream process engineer in the United States is $92,018.00, according to ZipRecruiter salary data. Most workers in this role earn between $74,500.00 and $103,000.00 per year, depending on experience, location, and employer.

What does an upstream process engineer do?

An Upstream Process Engineer is responsible for developing, optimizing, and scaling up processes related to the early stages of biopharmaceutical manufacturing, including cell culture and fermentation. They work on improving yield, ensuring process efficiency, and maintaining regulatory compliance. Their role involves troubleshooting, process design, and collaboration with cross-functional teams to support production.

What are the key skills and qualifications needed to thrive as an upstream process engineer, and why are they important?

Upstream Process Engineers require a solid background in chemical or biochemical engineering, process design, and troubleshooting, often backed by a relevant engineering degree. Familiarity with simulation software such as Aspen Plus or HYSYS, as well as knowledge of industry standards and certifications like Six Sigma or API, is highly valued. Strong communication, problem-solving abilities, and teamwork skills help these engineers excel when coordinating across multidisciplinary teams. These competencies are crucial to ensure process efficiency, safety, and innovation in large-scale production environments.

What are the typical daily responsibilities of an upstream process engineer?

An Upstream Process Engineer typically focuses on designing, optimizing, and monitoring processes related to raw material extraction and initial conversion in industries such as oil & gas, biotechnology, or chemicals. Daily tasks might involve analyzing process data, troubleshooting equipment or process issues, implementing efficiency improvements, and ensuring compliance with safety and environmental regulations. Collaboration is a key part of the role, as you’ll work closely with operations, maintenance, quality assurance, and R&D teams to achieve production targets. Engineers also regularly participate in safety meetings, process audits, and project planning sessions to support continuous improvement. This dynamic environment offers exposure to both hands-on technical work and cross-functional project leadership.

More about Upstream Process Engineer jobs
What cities are hiring for Upstream Process Engineer jobs? Cities with the most Upstream Process Engineer job openings:
What states have the most Upstream Process Engineer jobs? States with the most job openings for Upstream Process Engineer jobs include:
Infographic showing various Upstream Process Engineer job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 78% Full Time, 16% Part Time, 4% Contract, and 1% Nights. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $92,018 per year, or $44.2 per hour.

Upstream Biomanufacturing Process Expert

UCB

Atlanta, GA • On-site

$164K/yr

Other

Re-posted 20 days ago


Job description

Make your mark for patients

UCB is embarking on one of the most significant investments in its history through the development of a new state-of-the-art biologics manufacturing campus in Georgia, USA.

Designed to power the future of biologics, this new facility will strengthen UCB's global manufacturing network, expand supply capabilities for future medicines, and support our long-term ambition of bringing innovative treatments to patients around the world. The project combines cutting-edge technology, sustainability, digital innovation, and operational excellence to create a future-ready manufacturing ecosystem.

As a true greenfield initiative, it offers a unique opportunity to help design, build, and launch a world-class biologics manufacturing facility from the ground up while working within a diverse international team spanning the United States and Europe.

We are looking for talented, curious and ambitious individuals who want to make a lasting impact and contribute to shaping the future of biologics manufacturing at UCB.

We are looking for an Upstream Biomanufacturing Process Expert who is collaborative, detail-oriented, and innovative to join us in ourInternal Manufacturing team, based at our UCB campus located in Georgia, United-States.

About the role

This role is part of the internal manufacturing project, contributing to the design and delivery of a future-ready biologics manufacturing facility. You will support the development of a new biologics manufacturing facility, bringing your expertise in upstream production processes such as cell culture and bioreactor operations. You will ensure that manufacturing requirements are fully integrated into the design, enabling efficient, scalable, and future-ready production. You will play a key role in connecting operational knowledge with project execution in a rapidly evolving project environment.

Who you'll work with

You will be working in a team that brings together specialists in manufacturing, engineering, quality, and safety. You will collaborate closely with global manufacturing teams and technical experts to ensure that upstream processes and production needs are fully represented and implemented working across different time zones.

What you'll do

  • Represent upstream manufacturing processes, including cell culture, media preparation, and bioreactor operations, in project design and decision-making.
  • Define and communicate operational requirements to ensure future manufacturing performance and scalability.
  • Collaborate with global sites and technical teams to share best practices in upstream production.
  • Review and analyse technical documentation related to production processes and systems.
  • Identify and integrate new technologies to improve upstream manufacturing capabilities.
  • Promote strong standards in health, safety, environment, and quality across all project activities.

Interested? For this role we're looking for the following education, experience and skills

Mandatory requirements

  • Bachelor's degree in biotechnology, bioprocess engineering, or a related scientific field.
  • Minimum of 7 years of experience in biologics manufacturing, with strong exposure to upstream production processes.
  • Solid understanding of cell culture, bioreactor systems, and production of media and buffer solutions.
  • Minimum of 5 years of experience working in regulated environments with quality and compliance requirements.
  • Ability to collaborate across teams and communicate complex technical topics clearly.
  • Willingness to adapt to project variabilities and a rapidly evolving work environment.
  • Fluent in English, with strong written and verbal communication skills.
  • Occasional travel to Europe may be required.

Strong plus

  • Ability to communicate in French is an advantage.

The reasonably anticipated salary range for this position is $125.600 - 164,900 per year.The actual salary offered will take into account related knowledge, skills, experience and location among other factors and may fall outside the expected range.

Are you ready to 'go beyond' to create value and make your mark for patients? If this sounds like you, then we would love to hear from you!

About us
UCB is a global biopharmaceutical company, focusing on neurology and immunology. We are over 9.000 people in all four corners of the globe, inspired by patients and driven by science.

Why work with us?
At UCB, we don't just complete tasks, we create value. We aren't afraid to push forward, collaborate, and innovate to make our mark for patients. We have a caring, supportive culture where everyone feels included, respected, and has equal opportunities to do their best work. We 'go beyond' to create value for our patients, and always with a human focus, whether that's on our patients, our employees, or our planet. Working for us, you will discover a place where you can grow, and have the freedom to carve your own career path to achieve your full potential.

At UCB, we've embraced a hybrid-first approach to work, bringing teams together in local hubs to foster collaborative curiosity. Unless explicitly stated in the description or precluded by the nature of the position, roles are hybrid with 40% of your time spent in the office.

UCB is an equal opportunity employer.All employment decisions will be made without regard to any characteristic protected by applicable federal, state, or local law. UCB invites you to voluntarily self-identify during the application process. Provision of self-identification information is entirely voluntary and a decision to provide or not provide such information will not have any effect on your application for employment, your employment with UCB, or otherwise subject you to any adverse treatment. Any information you provide will be considered confidential and will be kept separate from your application and/or personnel file and will only be used in accordance with applicable laws, orders, and regulations.


Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on US-Reasonable_Accommodation@ucb.com for application to US based roles. Please note should your enquiry not relate to adjustments; we will not be able to support you through this channel.

Employment Type: OTHER